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Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]

 CASP6_HUMAN             Reviewed;         293 AA.
P55212; Q9BQE7;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
28-NOV-2002, sequence version 2.
13-FEB-2019, entry version 201.
RecName: Full=Caspase-6;
Short=CASP-6;
EC=3.4.22.59;
AltName: Full=Apoptotic protease Mch-2;
Contains:
RecName: Full=Caspase-6 subunit p18;
Contains:
RecName: Full=Caspase-6 subunit p11;
Flags: Precursor;
Name=CASP6; Synonyms=MCH2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA).
TISSUE=T-cell;
PubMed=7796396;
Fernandes-Alnemri T., Litwack G., Alnemri E.S.;
"Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene
family.";
Cancer Res. 55:2737-2742(1995).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT SER-182.
NIEHS SNPs program;
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
PROTEOLYTIC PROCESSING.
TISSUE=Lymphocyte;
PubMed=8900201; DOI=10.1074/jbc.271.43.27099;
Srinivasula S.M., Fernandes-Alnemri T., Zangrilli J., Robertson N.,
Armstrong R.C., Wang L., Trapani J.A., Tomaselli K.J., Litwack G.,
Alnemri E.S.;
"The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and
the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic
mediator CPP32.";
J. Biol. Chem. 271:27099-27106(1996).
[5]
INTERACTION WITH BIRC6/BRUCE.
PubMed=15200957; DOI=10.1016/j.molcel.2004.05.018;
Bartke T., Pohl C., Pyrowolakis G., Jentsch S.;
"Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3
ubiquitin ligase.";
Mol. Cell 14:801-811(2004).
[6]
ACTIVITY REGULATION, PHOSPHORYLATION AT SER-257, AND MUTAGENESIS OF
SER-257.
PubMed=15273717; DOI=10.1038/sj.onc.1207963;
Suzuki A., Kusakai G., Kishimoto A., Shimojo Y., Miyamoto S.,
Ogura T., Ochiai A., Esumi H.;
"Regulation of caspase-6 and FLIP by the AMPK family member ARK5.";
Oncogene 23:7067-7075(2004).
[7]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=21269460; DOI=10.1186/1752-0509-5-17;
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P.,
Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.;
"Initial characterization of the human central proteome.";
BMC Syst. Biol. 5:17-17(2011).
-!- FUNCTION: Involved in the activation cascade of caspases
responsible for apoptosis execution. Cleaves poly(ADP-ribose)
polymerase in vitro, as well as lamins. Overexpression promotes
programmed cell death.
-!- CATALYTIC ACTIVITY:
Reaction=Strict requirement for Asp at position P1 and has a
preferred cleavage sequence of Val-Glu-His-Asp-|-.;
EC=3.4.22.59;
-!- ACTIVITY REGULATION: Activation is suppressed by phosphorylation
at Ser-257. {ECO:0000269|PubMed:15273717}.
-!- SUBUNIT: Heterotetramer that consists of two anti-parallel
arranged heterodimers, each one formed by a 18 kDa (p18) and a 11
kDa (p11) subunit. Interacts with BIRC6/bruce.
{ECO:0000269|PubMed:15200957}.
-!- INTERACTION:
Self; NbExp=6; IntAct=EBI-718729, EBI-718729;
P42574:CASP3; NbExp=2; IntAct=EBI-718729, EBI-524064;
Q01826:SATB1; NbExp=2; IntAct=EBI-718729, EBI-743747;
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=Alpha;
IsoId=P55212-1; Sequence=Displayed;
Name=Beta;
IsoId=P55212-2; Sequence=VSP_000805;
-!- PTM: Cleavages by caspase-3, caspase-8 or -10 generate the two
active subunits.
-!- SIMILARITY: Belongs to the peptidase C14A family. {ECO:0000305}.
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/casp6/";
-----------------------------------------------------------------------
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EMBL; U20536; AAC50168.1; -; mRNA.
EMBL; U20537; AAC50169.1; -; mRNA.
EMBL; AY254046; AAO63494.1; -; Genomic_DNA.
EMBL; BC000305; AAH00305.1; -; mRNA.
EMBL; BC004460; AAH04460.1; -; mRNA.
CCDS; CCDS3684.1; -. [P55212-1]
CCDS; CCDS3685.1; -. [P55212-2]
RefSeq; NP_001217.2; NM_001226.3. [P55212-1]
RefSeq; NP_116787.1; NM_032992.2. [P55212-2]
UniGene; Hs.654616; -.
PDB; 1MI9; Model; -; A=34-175, B=198-290.
PDB; 2WDP; X-ray; 1.95 A; A/B/C/D=1-293.
PDB; 3K7E; X-ray; 3.00 A; A/B/C/D=24-293.
PDB; 3NKF; X-ray; 2.90 A; A/B/C/D=24-293.
PDB; 3NR2; X-ray; 2.90 A; A/B=24-293.
PDB; 3OD5; X-ray; 1.60 A; A/B=24-293.
PDB; 3P45; X-ray; 2.53 A; A/C/E/G/I/K/M/O=1-179, B/D/F/H/J/L/N/P=193-293.
PDB; 3P4U; X-ray; 1.90 A; A/C=23-179, B/D=193-293.
PDB; 3QNW; X-ray; 2.65 A; A/C/E/G=24-179, B/D/F/H=194-293.
PDB; 3S70; X-ray; 1.62 A; A/C=24-293.
PDB; 3S8E; X-ray; 2.88 A; A/B/C/D/E/F/G/H=24-293.
PDB; 3V6L; X-ray; 2.20 A; A/B=21-293.
PDB; 3V6M; X-ray; 2.69 A; A/B/C/D/F/G/I/J=24-293.
PDB; 4EJF; X-ray; 2.65 A; A/B/C/D=24-293.
PDB; 4FXO; X-ray; 2.85 A; A/B/C/D=1-293.
PDB; 4HVA; X-ray; 2.07 A; A/B=24-293.
PDB; 4IYR; X-ray; 2.70 A; A/B=1-293.
PDB; 4N5D; X-ray; 2.06 A; A/B=24-293.
PDB; 4N6G; X-ray; 2.14 A; A/B=24-293.
PDB; 4N7J; X-ray; 1.67 A; A/B=24-293.
PDB; 4N7M; X-ray; 2.12 A; A/B=24-293.
PDB; 4NBK; X-ray; 1.94 A; A/B=24-293.
PDB; 4NBL; X-ray; 1.76 A; A/B=24-293.
PDB; 4NBN; X-ray; 1.75 A; A/B=24-293.
PDBsum; 1MI9; -.
PDBsum; 2WDP; -.
PDBsum; 3K7E; -.
PDBsum; 3NKF; -.
PDBsum; 3NR2; -.
PDBsum; 3OD5; -.
PDBsum; 3P45; -.
PDBsum; 3P4U; -.
PDBsum; 3QNW; -.
PDBsum; 3S70; -.
PDBsum; 3S8E; -.
PDBsum; 3V6L; -.
PDBsum; 3V6M; -.
PDBsum; 4EJF; -.
PDBsum; 4FXO; -.
PDBsum; 4HVA; -.
PDBsum; 4IYR; -.
PDBsum; 4N5D; -.
PDBsum; 4N6G; -.
PDBsum; 4N7J; -.
PDBsum; 4N7M; -.
PDBsum; 4NBK; -.
PDBsum; 4NBL; -.
PDBsum; 4NBN; -.
ProteinModelPortal; P55212; -.
SMR; P55212; -.
BioGrid; 107289; 20.
ComplexPortal; CPX-971; Caspase-6 complex.
DIP; DIP-44649N; -.
ELM; P55212; -.
IntAct; P55212; 18.
MINT; P55212; -.
STRING; 9606.ENSP00000265164; -.
BindingDB; P55212; -.
ChEMBL; CHEMBL3308; -.
GuidetoPHARMACOLOGY; 1622; -.
MEROPS; C14.005; -.
iPTMnet; P55212; -.
PhosphoSitePlus; P55212; -.
SwissPalm; P55212; -.
BioMuta; CASP6; -.
DMDM; 26006981; -.
OGP; P55212; -.
EPD; P55212; -.
jPOST; P55212; -.
MaxQB; P55212; -.
PaxDb; P55212; -.
PeptideAtlas; P55212; -.
PRIDE; P55212; -.
ProteomicsDB; 56817; -.
ProteomicsDB; 56818; -. [P55212-2]
DNASU; 839; -.
Ensembl; ENST00000265164; ENSP00000265164; ENSG00000138794. [P55212-1]
Ensembl; ENST00000352981; ENSP00000285333; ENSG00000138794. [P55212-2]
GeneID; 839; -.
KEGG; hsa:839; -.
UCSC; uc003hzn.2; human. [P55212-1]
CTD; 839; -.
DisGeNET; 839; -.
EuPathDB; HostDB:ENSG00000138794.9; -.
GeneCards; CASP6; -.
HGNC; HGNC:1507; CASP6.
HPA; CAB003775; -.
HPA; HPA011337; -.
HPA; HPA024303; -.
MIM; 601532; gene.
neXtProt; NX_P55212; -.
OpenTargets; ENSG00000138794; -.
PharmGKB; PA26090; -.
eggNOG; KOG3573; Eukaryota.
eggNOG; ENOG410ZQIE; LUCA.
GeneTree; ENSGT00940000155140; -.
HOGENOM; HOG000231878; -.
HOVERGEN; HBG050802; -.
InParanoid; P55212; -.
KO; K04396; -.
OMA; VVDHQTD; -.
OrthoDB; 984395at2759; -.
PhylomeDB; P55212; -.
TreeFam; TF102023; -.
BRENDA; 3.4.22.59; 2681.
Reactome; R-HSA-111465; Apoptotic cleavage of cellular proteins.
Reactome; R-HSA-264870; Caspase-mediated cleavage of cytoskeletal proteins.
Reactome; R-HSA-352238; Breakdown of the nuclear lamina.
Reactome; R-HSA-6803207; TP53 Regulates Transcription of Caspase Activators and Caspases.
SIGNOR; P55212; -.
ChiTaRS; CASP6; human.
EvolutionaryTrace; P55212; -.
GeneWiki; Caspase_6; -.
GenomeRNAi; 839; -.
PMAP-CutDB; P55212; -.
PRO; PR:P55212; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000138794; Expressed in 197 organ(s), highest expression level in intestine.
ExpressionAtlas; P55212; baseline and differential.
Genevisible; P55212; HS.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IDA:UniProtKB.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0004197; F:cysteine-type endopeptidase activity; TAS:Reactome.
GO; GO:0097153; F:cysteine-type endopeptidase activity involved in apoptotic process; IBA:GO_Central.
GO; GO:0097200; F:cysteine-type endopeptidase activity involved in execution phase of apoptosis; IMP:CAFA.
GO; GO:0008234; F:cysteine-type peptidase activity; TAS:ProtInc.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0006915; P:apoptotic process; IBA:GO_Central.
GO; GO:0072734; P:cellular response to staurosporine; IMP:CAFA.
GO; GO:0030855; P:epithelial cell differentiation; IEP:UniProtKB.
GO; GO:0097194; P:execution phase of apoptosis; TAS:Reactome.
GO; GO:0006508; P:proteolysis; IDA:UniProtKB.
GO; GO:0042981; P:regulation of apoptotic process; TAS:Reactome.
CDD; cd00032; CASc; 1.
InterPro; IPR029030; Caspase-like_dom_sf.
InterPro; IPR037554; Caspase_6.
InterPro; IPR033139; Caspase_cys_AS.
InterPro; IPR016129; Caspase_his_AS.
InterPro; IPR002398; Pept_C14.
InterPro; IPR002138; Pept_C14_p10.
InterPro; IPR001309; Pept_C14_p20.
InterPro; IPR015917; Pept_C14A.
PANTHER; PTHR10454; PTHR10454; 1.
PANTHER; PTHR10454:SF164; PTHR10454:SF164; 1.
PRINTS; PR00376; IL1BCENZYME.
SMART; SM00115; CASc; 1.
SUPFAM; SSF52129; SSF52129; 1.
PROSITE; PS01122; CASPASE_CYS; 1.
PROSITE; PS01121; CASPASE_HIS; 1.
PROSITE; PS50207; CASPASE_P10; 1.
PROSITE; PS50208; CASPASE_P20; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Apoptosis; Complete proteome;
Cytoplasm; Hydrolase; Phosphoprotein; Polymorphism; Protease;
Reference proteome; Thiol protease; Zymogen.
PROPEP 1 23
/FTId=PRO_0000004608.
CHAIN 24 179 Caspase-6 subunit p18.
/FTId=PRO_0000004609.
PROPEP 180 193
/FTId=PRO_0000004610.
CHAIN 194 293 Caspase-6 subunit p11.
/FTId=PRO_0000004611.
ACT_SITE 121 121 {ECO:0000250}.
ACT_SITE 163 163 {ECO:0000250}.
MOD_RES 79 79 Phosphoserine.
{ECO:0000250|UniProtKB:O08738}.
MOD_RES 257 257 Phosphoserine; by NUAK1.
{ECO:0000269|PubMed:15273717}.
VAR_SEQ 14 102 Missing (in isoform Beta).
{ECO:0000303|PubMed:7796396}.
/FTId=VSP_000805.
VARIANT 35 35 E -> K (in dbSNP:rs11574697).
/FTId=VAR_029242.
VARIANT 109 109 A -> T (in dbSNP:rs5030674).
/FTId=VAR_016130.
VARIANT 182 182 T -> S (in dbSNP:rs5030593).
{ECO:0000269|Ref.2}.
/FTId=VAR_020126.
MUTAGEN 257 257 S->A: Suppression of caspase-6
activation.
{ECO:0000269|PubMed:15273717}.
CONFLICT 66 66 G -> R (in Ref. 1; AAC50168).
{ECO:0000305}.
STRAND 41 43 {ECO:0000244|PDB:3OD5}.
STRAND 46 51 {ECO:0000244|PDB:3OD5}.
HELIX 57 59 {ECO:0000244|PDB:3OD5}.
HELIX 67 80 {ECO:0000244|PDB:3OD5}.
STRAND 84 90 {ECO:0000244|PDB:3OD5}.
HELIX 93 105 {ECO:0000244|PDB:3OD5}.
STRAND 114 120 {ECO:0000244|PDB:3OD5}.
STRAND 122 124 {ECO:0000244|PDB:4N7J}.
STRAND 126 128 {ECO:0000244|PDB:3OD5}.
STRAND 130 135 {ECO:0000244|PDB:3OD5}.
HELIX 136 141 {ECO:0000244|PDB:3OD5}.
TURN 145 147 {ECO:0000244|PDB:3OD5}.
HELIX 149 151 {ECO:0000244|PDB:3OD5}.
STRAND 156 162 {ECO:0000244|PDB:3OD5}.
STRAND 165 167 {ECO:0000244|PDB:3OD5}.
STRAND 190 194 {ECO:0000244|PDB:4N7J}.
STRAND 197 199 {ECO:0000244|PDB:3S8E}.
TURN 202 205 {ECO:0000244|PDB:3OD5}.
STRAND 206 212 {ECO:0000244|PDB:3OD5}.
STRAND 219 221 {ECO:0000244|PDB:3OD5}.
TURN 222 224 {ECO:0000244|PDB:3OD5}.
HELIX 227 239 {ECO:0000244|PDB:3OD5}.
TURN 240 242 {ECO:0000244|PDB:3OD5}.
HELIX 245 258 {ECO:0000244|PDB:3OD5}.
STRAND 263 265 {ECO:0000244|PDB:4N7J}.
HELIX 267 269 {ECO:0000244|PDB:3OD5}.
STRAND 271 273 {ECO:0000244|PDB:3S8E}.
STRAND 277 280 {ECO:0000244|PDB:3OD5}.
STRAND 283 285 {ECO:0000244|PDB:3QNW}.
SEQUENCE 293 AA; 33310 MW; 0738AE4F9791EBD7 CRC64;
MSSASGLRRG HPAGGEENMT ETDAFYKREM FDPAEKYKMD HRRRGIALIF NHERFFWHLT
LPERRGTCAD RDNLTRRFSD LGFEVKCFND LKAEELLLKI HEVSTVSHAD ADCFVCVFLS
HGEGNHIYAY DAKIEIQTLT GLFKGDKCHS LVGKPKIFII QACRGNQHDV PVIPLDVVDN
QTEKLDTNIT EVDAASVYTL PAGADFLMCY SVAEGYYSHR ETVNGSWYIQ DLCEMLGKYG
SSLEFTELLT LVNRKVSQRR VDFCKDPSAI GKKQVPCFAS MLTKKLHFFP KSN


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Pathways :
WP1965: VEGF-receptor Signal Transduction
WP2359: Parkin-Ubiquitin Proteasomal System pathway
WP88: Toll Like Receptor signaling
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP1626: Benzoate degradation via CoA ligation
WP1634: Butanoate metabolism
WP1644: DNA replication
WP1655: Geraniol degradation
WP1663: Homologous recombination
WP1671: Methane metabolism
WP1672: Mismatch repair
WP1680: Oxidative phosphorylation
WP1693: Purine metabolism
WP1694: Pyrimidine metabolism
WP1711: Trinitrotoluene degradation
WP1718: Vitamin B6 metabolism
WP2272: Pathogenic Escherichia coli infection
WP2292: Chemokine signaling pathway
WP1784: Apoptotic execution phase
WP2199: Seed Development
WP2231: Degradation of apoptotic cells
WP470: Proteasome Degradation
WP712: Estrogen signaling pathway

Related Genes :
[CASP6 MCH2] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[Casp6] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[Casp6 Mch2] Caspase-6 (CASP-6) (EC 3.4.22.59) (Apoptotic protease Mch-2) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[CASP8 MCH5] Caspase-8 (CASP-8) (EC 3.4.22.61) (Apoptotic cysteine protease) (Apoptotic protease Mch-5) (CAP4) (FADD-homologous ICE/ced-3-like protease) (FADD-like ICE) (FLICE) (ICE-like apoptotic protease 5) (MORT1-associated ced-3 homolog) (MACH) [Cleaved into: Caspase-8 subunit p18; Caspase-8 subunit p10]
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[Casp7 Lice2 Mch3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (Cysteine protease LICE2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[Casp2 Ich1 Nedd-2 Nedd2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[CASP2 ICH1 NEDD2] Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[CASP10 MCH4] Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[Casp2 Ich1] Caspase-2 (CASP-2) (EC 3.4.22.55) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[CASP3 CPP32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP4 ICH2] Caspase-4 (CASP-4) (EC 3.4.22.57) (ICE and Ced-3 homolog 2) (ICH-2) (ICE(rel)-II) (Mih1) (Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[Casp3 Cpp32] Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (IRP) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CFLAR CASH CASP8AP1 CLARP MRIT] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[Cflar Cash] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[CASP14] Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
[CASP7 MCH3] Caspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (ICE-like apoptotic protease 3) (ICE-LAP3) (SREBP cleavage activity 2) (SCA-2) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
[CASP3] Caspase-3 (CASP-3) (EC 3.4.22.56) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
[csp-2 Y73B6BL.7] Putative inactive caspase B [Cleaved into: Putative inactive caspase B subunit p31; Putative inactive caspase B subunit p17; Putative inactive caspase subunit p14]
[Dredd DCP2 CG7486] Caspase-8 (EC 3.4.22.61) (Death-related ced-3/NEDD2-like protein) [Cleaved into: Caspase-8 subunit p15; Caspase-8 subunit p10]
[CASP6] Caspase-6 (CASP-6) (EC 3.4.22.59) [Cleaved into: Caspase-6 subunit p18; Caspase-6 subunit p11]
[CASP2 ICH1] Caspase-2 (CASP-2) (EC 3.4.22.55) (ICH-1L/1S) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[csp-1 Y48E1B.13] Caspase A (EC 3.4.22.36) [Cleaved into: Caspase A subunit p16; Caspase A subunit p14]
[ced-3 C48D1.2] Cell death protein 3 (EC 3.4.22.60) (Caspase ced-3) [Cleaved into: Cell death protein 3 subunit p17; Cell death protein 3 subunit p15; Cell death protein 3 subunit p13]
[Nlrc4 Card12 Ipaf] NLR family CARD domain-containing protein 4 (Caspase recruitment domain-containing protein 12) (Ice protease-activating factor) (Ipaf)
[CASP4] Caspase-4 (CASP-4) (EC 3.4.22.57) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]

Bibliography :