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Cell cycle and apoptosis regulator protein 2 (Cell division cycle and apoptosis regulator protein 2)

 CCAR2_MOUSE             Reviewed;         922 AA.
Q8VDP4; Q6PIB1; Q8BWR5; Q8C0F0; Q8R3G6;
24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
01-MAR-2004, sequence version 2.
12-AUG-2020, entry version 142.
RecName: Full=Cell cycle and apoptosis regulator protein 2;
AltName: Full=Cell division cycle and apoptosis regulator protein 2;
Name=Ccar2;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Liver, and Testis;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=FVB/N; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PROTEIN SEQUENCE OF 226-248, AND IDENTIFICATION BY MASS SPECTROMETRY.
STRAIN=OF1; TISSUE=Hippocampus;
Lubec G., Sunyer B., Chen W.-Q.;
Submitted (JAN-2009) to UniProtKB.
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-677 AND SER-680, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic brain;
PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
"Phosphoproteomic analysis of the developing mouse brain.";
Mol. Cell. Proteomics 3:1093-1101(2004).
[5]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-674; SER-677 AND SER-680, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[6]
FUNCTION AS SUV39H1 INHIBITOR, AND INTERACTION WITH SUV39H1.
PubMed=19218236; DOI=10.1074/jbc.m900956200;
Li Z., Chen L., Kabra N., Wang C., Fang J., Chen J.;
"Inhibition of SUV39H1 methyltransferase activity by DBC1.";
J. Biol. Chem. 284:10361-10366(2009).
[7]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-612; SER-674; SER-677;
SER-680; TYR-684 AND SER-686, AND IDENTIFICATION BY MASS SPECTROMETRY
[LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[8]
FUNCTION, AND INTERACTION WITH HDAC3; HDAC1 AND MEF2D.
PubMed=21030595; DOI=10.1074/jbc.m110.153270;
Chini C.C., Escande C., Nin V., Chini E.N.;
"HDAC3 is negatively regulated by the nuclear protein DBC1.";
J. Biol. Chem. 285:40830-40837(2010).
[9]
FUNCTION, AND INTERACTION WITH NR1D1.
PubMed=23398316; DOI=10.1042/bj20121085;
Chini C.C., Escande C., Nin V., Chini E.N.;
"DBC1 (Deleted in Breast Cancer 1) modulates the stability and function of
the nuclear receptor Rev-erbalpha.";
Biochem. J. 451:453-461(2013).
[10]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=24415752; DOI=10.1074/jbc.m113.512913;
Nin V., Chini C.C., Escande C., Capellini V., Chini E.N.;
"Deleted in breast cancer 1 (DBC1) protein regulates hepatic
gluconeogenesis.";
J. Biol. Chem. 289:5518-5527(2014).
[11]
FUNCTION, INTERACTION WITH TP53, AND DISRUPTION PHENOTYPE.
PubMed=25732823; DOI=10.1016/j.celrep.2015.01.066;
Qin B., Minter-Dykhouse K., Yu J., Zhang J., Liu T., Zhang H., Lee S.,
Kim J., Wang L., Lou Z.;
"DBC1 functions as a tumor suppressor by regulating p53 stability.";
Cell Rep. 10:1324-1334(2015).
-!- FUNCTION: Core component of the DBIRD complex, a multiprotein complex
that acts at the interface between core mRNP particles and RNA
polymerase II (RNAPII) and integrates transcript elongation with the
regulation of alternative splicing: the DBIRD complex affects local
transcript elongation rates and alternative splicing of a large set of
exons embedded in (A + T)-rich DNA regions (By similarity). Inhibits
SIRT1 deacetylase activity leading to increasing levels of p53/TP53
acetylation and p53-mediated apoptosis (By similarity). Inhibits
SUV39H1 methyltransferase activity (PubMed:19218236). Mediates ligand-
dependent transcriptional activation by nuclear hormone receptors (By
similarity). Plays a critical role in maintaining genomic stability and
cellular integrity following UV-induced genotoxic stress (By
similarity). Regulates the circadian expression of the core clock
components NR1D1 and ARNTL/BMAL1 (PubMed:23398316). Enhances the
transcriptional repressor activity of NR1D1 through stabilization of
NR1D1 protein levels by preventing its ubiquitination and subsequent
degradation (PubMed:23398316). Represses the ligand-dependent
transcriptional activation function of ESR2 (By similarity). Acts as a
regulator of PCK1 expression and gluconeogenesis by a mechanism that
involves, at least in part, both NR1D1 and SIRT1 (PubMed:24415752).
Negatively regulates the deacetylase activity of HDAC3 and can alter
its subcellular localization (PubMed:21030595). Positively regulates
the beta-catenin pathway (canonical Wnt signaling pathway) and is
required for MCC-mediated repression of the beta-catenin pathway (By
similarity). Represses ligand-dependent transcriptional activation
function of NR1H2 and NR1H3 and inhibits the interaction of SIRT1 with
NR1H3 (By similarity). Plays an important role in tumor suppression
through p53/TP53 regulation; stabilizes p53/TP53 by affecting its
interaction with ubiquitin ligase MDM2 (PubMed:25732823). Represses the
transcriptional activator activity of BRCA1 (By similarity). Inhibits
SIRT1 in a CHEK2 and PSEM3-dependent manner and inhibits the activity
of CHEK2 in vitro (By similarity). {ECO:0000250|UniProtKB:Q8N163,
ECO:0000269|PubMed:19218236, ECO:0000269|PubMed:21030595,
ECO:0000269|PubMed:23398316, ECO:0000269|PubMed:24415752,
ECO:0000269|PubMed:25732823}.
-!- SUBUNIT: Component of the DBIRD complex (By similarity). Interacts with
ZNF326/ZIRD; the interaction is direct (By similarity). Interacts (via
N-terminus) with SIRT1, which inhibits the deacetylation of substrates
(PubMed:21030595). Interacts (via N-terminus) with SUV39H1; this
interaction abolishes the interaction with SIRT1 (PubMed:19218236).
Component of a nuclear receptor-mediated transcription complex composed
of at least ZNF335, CCAR2 and EMSY; the complex stimulates the
transcription of nuclear receptor target genes such as SOX9 and HOXA1
(By similarity). Within the complex interacts with EMSY and interacts
with ZNF335 (via C-terminus) (By similarity). Components of this
complex may associate with components of a histone methylation complex
to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY,
MKI67, RBBP5, ASH2L and WDR5 (By similarity). Within this complex,
interacts with ASH2L (By similarity). Interacts with NR1D1
(PubMed:23398316). Interacts (via N-terminus) with ESR1 and ESR2 (By
similarity). Interacts (via N-terminus) with HDAC3 (via C-terminus)
(PubMed:21030595). Interacts with HDAC1 and MED2F (PubMed:21030595).
Interacts with MCC (By similarity). Interacts (via N-terminus) with
NR1H2 and NR1H3 in a ligand-independent manner (By similarity).
Interacts with CSNK2A1 (By similarity). Interacts (via N-terminus) with
p53/TP53 (PubMed:25732823). Interacts (via N-terminus) with BRCA1 (via
the BRCT domains) (By similarity). Interacts (via N-terminus) with
CHEK2 (via protein kinase domain) (By similarity). Interacts with PSEM3
(By similarity). Interacts (via N-terminus) with PSIA3 and SENP1 (By
similarity). The sumoylated form shows a preferential interaction with
SIRT1 as compared to its unmodified form (By similarity).
{ECO:0000250|UniProtKB:Q8N163, ECO:0000269|PubMed:19218236,
ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:23398316,
ECO:0000269|PubMed:25732823}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N163}. Cytoplasm
{ECO:0000250|UniProtKB:Q8N163}. Note=Recruited to chromatin, post-UV
irradiation. Sequestered to the cytoplasm in the presence of MCC.
Translocated to the cytoplasm during UV-induced apoptosis.
{ECO:0000250|UniProtKB:Q8N163}.
-!- PTM: Acetylation at Lys-112 and Lys-215 by KAT8 prevents inhibitory
binding to SIRT1 and increases its deacetylase activity.
{ECO:0000250|UniProtKB:Q8N163}.
-!- PTM: Genotoxic stress induces its sumoylation and sumoylation promotes
the SIRT1-CCAR2 interaction which in turn inhibits SIRT1-mediated
deacetylation of p53/TP53. Sumoylation leads to transcriptional
activation of p53/TP53 by sequestering SIRT1 from p53/TP53.
Desumoylated by SENP1. {ECO:0000250|UniProtKB:Q8N163}.
-!- DISRUPTION PHENOTYPE: Mice mimic a fasted state and therefore, display
an increased production of glucose. Display elevated levels of PCK1 and
are glucose-intolerant in both a normal and a high-fat diet
(PubMed:24415752). Mice develop more tumors including lymphomas, liver
tumors, lung tumors (PubMed:25732823). {ECO:0000269|PubMed:24415752,
ECO:0000269|PubMed:25732823}.
-!- SEQUENCE CAUTION:
Sequence=BAC27420.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Sequence=BAC34139.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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EMBL; AK031472; BAC27420.1; ALT_INIT; mRNA.
EMBL; AK050238; BAC34139.2; ALT_INIT; mRNA.
EMBL; BC021475; AAH21475.2; -; mRNA.
EMBL; BC025471; AAH25471.1; -; mRNA.
EMBL; BC038346; AAH38346.1; -; mRNA.
CCDS; CCDS49534.1; -.
RefSeq; NP_666167.3; NM_146055.3.
RefSeq; XP_006518959.1; XM_006518896.3.
SMR; Q8VDP4; -.
BioGRID; 230123; 17.
IntAct; Q8VDP4; 10.
MINT; Q8VDP4; -.
STRING; 10090.ENSMUSP00000036924; -.
iPTMnet; Q8VDP4; -.
PhosphoSitePlus; Q8VDP4; -.
EPD; Q8VDP4; -.
jPOST; Q8VDP4; -.
MaxQB; Q8VDP4; -.
PaxDb; Q8VDP4; -.
PeptideAtlas; Q8VDP4; -.
PRIDE; Q8VDP4; -.
Antibodypedia; 9629; 282 antibodies.
Ensembl; ENSMUST00000035612; ENSMUSP00000036924; ENSMUSG00000033712.
GeneID; 219158; -.
KEGG; mmu:219158; -.
UCSC; uc007unf.1; mouse.
CTD; 57805; -.
MGI; MGI:2444228; Ccar2.
eggNOG; KOG4246; Eukaryota.
GeneTree; ENSGT00530000063672; -.
HOGENOM; CLU_008030_2_0_1; -.
InParanoid; Q8VDP4; -.
OMA; LEMQRMV; -.
OrthoDB; 614048at2759; -.
PhylomeDB; Q8VDP4; -.
TreeFam; TF316387; -.
Reactome; R-MMU-3371453; Regulation of HSF1-mediated heat shock response.
BioGRID-ORCS; 219158; 2 hits in 18 CRISPR screens.
ChiTaRS; Ccar2; mouse.
PRO; PR:Q8VDP4; -.
Proteomes; UP000000589; Chromosome 14.
RNAct; Q8VDP4; protein.
Bgee; ENSMUSG00000033712; Expressed in cardiac ventricle and 269 other tissues.
Genevisible; Q8VDP4; MM.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0044609; C:DBIRD complex; ISS:UniProtKB.
GO; GO:0005759; C:mitochondrial matrix; ISO:MGI.
GO; GO:0000790; C:nuclear chromatin; ISS:UniProtKB.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0019899; F:enzyme binding; ISO:MGI.
GO; GO:0004857; F:enzyme inhibitor activity; IDA:UniProtKB.
GO; GO:0030374; F:nuclear receptor transcription coactivator activity; IBA:GO_Central.
GO; GO:0000993; F:RNA polymerase II complex binding; ISS:UniProtKB.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0006974; P:cellular response to DNA damage stimulus; IEA:UniProtKB-KW.
GO; GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; ISO:MGI.
GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
GO; GO:0043086; P:negative regulation of catalytic activity; IMP:UniProtKB.
GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
GO; GO:1902230; P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; ISS:UniProtKB.
GO; GO:0032435; P:negative regulation of proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
GO; GO:2000003; P:positive regulation of DNA damage checkpoint; ISS:UniProtKB.
GO; GO:0042752; P:regulation of circadian rhythm; IMP:UniProtKB.
GO; GO:0032784; P:regulation of DNA-templated transcription, elongation; ISS:UniProtKB.
GO; GO:0090311; P:regulation of protein deacetylation; ISO:MGI.
GO; GO:0031647; P:regulation of protein stability; ISS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
GO; GO:0009411; P:response to UV; ISS:UniProtKB.
GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
GO; GO:0008380; P:RNA splicing; ISS:UniProtKB.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR025224; CCAR1/CCAR2.
InterPro; IPR028811; CCAR2.
InterPro; IPR025954; DBC1/CARP1_inactive_NUDIX_dom.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR025223; S1-like_RNA-bd_dom.
PANTHER; PTHR14304; PTHR14304; 1.
PANTHER; PTHR14304:SF12; PTHR14304:SF12; 1.
Pfam; PF14443; DBC1; 1.
Pfam; PF14444; S1-like; 1.
SMART; SM01122; DBC1; 1.
SUPFAM; SSF47473; SSF47473; 1.
1: Evidence at protein level;
Acetylation; Activator; Apoptosis; Biological rhythms; Cell cycle;
Coiled coil; Cytoplasm; Direct protein sequencing; DNA damage;
Isopeptide bond; Metalloenzyme inhibitor; Methylation; mRNA processing;
mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repressor;
Transcription; Transcription regulation; Tumor suppressor; Ubl conjugation;
Wnt signaling pathway.
CHAIN 1..922
/note="Cell cycle and apoptosis regulator protein 2"
/id="PRO_0000050814"
REGION 609..669
/note="Interaction with MCC"
/evidence="ECO:0000250|UniProtKB:Q8N163"
REGION 703..922
/note="Interaction with NR1D1"
/evidence="ECO:0000250|UniProtKB:Q8N163"
COILED 573..596
/evidence="ECO:0000255"
COILED 828..898
/evidence="ECO:0000255"
MOD_RES 35
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8N163"
MOD_RES 112
/note="N6-acetyllysine; by KAT8"
/evidence="ECO:0000250|UniProtKB:Q8N163"
MOD_RES 123
/note="N6-methyllysine"
/evidence="ECO:0000250|UniProtKB:Q8N163"
MOD_RES 124
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8N163"
MOD_RES 180
/note="Omega-N-methylarginine"
/evidence="ECO:0000250|UniProtKB:Q8N163"
MOD_RES 215
/note="N6-acetyllysine; by KAT8"
/evidence="ECO:0000250|UniProtKB:Q8N163"
MOD_RES 483
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8N163"
MOD_RES 568
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8N163"
MOD_RES 612
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:21183079"
MOD_RES 626
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8N163"
MOD_RES 674
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:17242355,
ECO:0000244|PubMed:21183079"
MOD_RES 677
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:15345747,
ECO:0000244|PubMed:17242355, ECO:0000244|PubMed:21183079"
MOD_RES 680
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:15345747,
ECO:0000244|PubMed:17242355, ECO:0000244|PubMed:21183079"
MOD_RES 684
/note="Phosphotyrosine"
/evidence="ECO:0000244|PubMed:21183079"
MOD_RES 686
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:21183079"
MOD_RES 807
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8N163"
MOD_RES 896
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8N163"
CROSSLNK 590
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2 and SUMO3); alternate"
/evidence="ECO:0000250|UniProtKB:Q8N163"
CROSSLNK 590
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2); alternate"
/evidence="ECO:0000250|UniProtKB:Q8N163"
CONFLICT 527..529
/note="RPK -> HAS (in Ref. 2; AAH25471)"
/evidence="ECO:0000305"
CONFLICT 720
/note="H -> L (in Ref. 2; AAH38346)"
/evidence="ECO:0000305"
CONFLICT 812
/note="G -> R (in Ref. 1; BAC27420)"
/evidence="ECO:0000305"
SEQUENCE 922 AA; 103002 MW; 19F43ECEE58F461C CRC64;
MSQFKRQRIN PLPGGRNFSG AASTSLLGPP PGLLTPPVAT DLSQNARHLQ SGEKQRVFTG
IVTSLHDYFG VVDEEVFFQL SVVKGRLPQL GEKVLVKAAY NPGQAVPWNA VKVQTLSNQP
LLKSPAPPLL HVAALGQKQG ILGAQPQLIF QPHRIPPLFP QKPLSLFQTS HTLHLSHLNR
FPARGPHGRL DQGRSDDYDS KKRKQRAGGE PWGAKKPRHD LSPYRVHLTP YTVDSPTCDF
LELQRRYRSL LVPSDFLSVH LSWLSAFPLG QPFSLHHPSR IQVSSEKEAA PDTGAEPSPE
DSDPTYSSKV LLLSSPGLEE FYRCCMLFVD DMAEPRETPE HPLKQLKFLL GRKEEEAVLV
GGEWSPSLDG LDPQADPQVL VRTAIRCAQA QTGIDLSTCT KWWRFAEFQY LQPGPPRQLH
TVVVYLPDVW TIMPTLEEWE ALCQQKATEA APQPHEASGE AEATEQAPDV SEQADTSKQN
TETMEATTQQ DVDTDLPEAP PPPLEPAVMA RPRCVNLSLY GIVEDRRPKE RISFEVVVLA
ELFVEMLQRD FGYRIYKTLL SLPEKVVSPP EPEKEEAAKE DAVKEEEAVK EEAVKVSKDE
VQNEGTAAES DSPLKEDGLL PKRPSSGGEE EEKARGEAAE DLCEMALDPD LLLLRDDGED
EFAGAKLEET EVRSVASNQS EMEYSSLQDM PKELDPSTVL PLDCLLAFVF FDANWCGYLH
RRDLERVLLT LGIRLSAEQA KQLVSRVVAQ NICQYRSLQY SRAEVLDDGL PEDVLFGNLD
LLPPSGKSTK PGAAPTEHKG LVPHNGSLIN VGSLLQRAEQ QDSGRLYLEN KIHTLELKLE
ESHNRFSATE VTNKTLAAEM QELRARLAEA EETARTAERQ KNQLQRQMQD FRRRLTPLHL
EMQRIVEKAD SWVEKEEPTP SN


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EIAAB05873 CARP1,CARP-1,CCAR1,Cell cycle and apoptosis regulatory protein 1,Cell division cycle and apoptosis regulator protein 1,Death inducer with SAP domain,DIS,Homo sapiens,Human
EIAAB05874 Carp1,CARP-1,Ccar1,Cell cycle and apoptosis regulatory protein 1,Cell division cycle and apoptosis regulator protein 1,Mouse,Mus musculus
CSB-EL004614HU Human Cell division cycle and apoptosis regulator protein 1(CCAR1) ELISA kit 96T
CSB-EL004614MO Mouse Cell division cycle and apoptosis regulator protein 1(CCAR1) ELISA kit 96T
CSB-EL004614HU Human Cell division cycle and apoptosis regulator protein 1(CCAR1) ELISA kit SpeciesHuman 96T
CSB-EL004614MO Mouse Cell division cycle and apoptosis regulator protein 1(CCAR1) ELISA kit SpeciesMouse 96T
CCAR1_HUMAN ELISA Kit FOR Cell division cycle and apoptosis regulator protein 1; organism: Human; gene name: CCAR1 96T
CCAR1_MOUSE ELISA Kit FOR Cell division cycle and apoptosis regulator protein 1; organism: Mouse; gene name: Ccar1 96T
E14065h Human Cell Division Cycle And Apoptosis Regulator 96T
CCBL1 CCAR1 Gene cell division cycle and apoptosis regulator 1
CSB-EL004614HU Human cell division cycle and apoptosis regulator 1 (CCAR1) ELISA kit, Species Human, Sample Type serum, plasma 96T
CSB-EL004614MO Mouse cell division cycle and apoptosis regulator 1 (CCAR1) ELISA kit, Species Mouse, Sample Type serum, plasma 96T
27-305 In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. CHEK2 is a cell cycle checkpoint regulator and putative tumor 0.05 mg
EIAAB06507 CDC2L,CDC2L5,CDC2-related protein kinase 5,CDK13,Cell division cycle 2-like protein kinase 5,Cell division protein kinase 13,CHED,Cholinesterase-related cell division controller,Cyclin-dependent kinas
26-109 DLG7 is a potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. It is a mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. DLG7 is the key regulator 0.05 mg
EIAAB06263 CDC2L2,CDC2L3,CDK11A,Cell division cycle 2-like protein kinase 2,Cell division protein kinase 11A,Cyclin-dependent kinase 11A,Galactosyltransferase-associated protein kinase p58_GTA,Homo sapiens,Human
EIAAB06533 C-2K,CDC2L4,CDK9,Cell division cycle 2-like protein kinase 4,Cell division protein kinase 9,Cyclin-dependent kinase 9,Homo sapiens,Human,Serine_threonine-protein kinase PITALRE,TAK,Tat-associated kina
EIAAB06506 Bos taurus,Bovine,CDC2L,CDC2L5,CDC2-related protein kinase 5,CDK13,Cell division cycle 2-like protein kinase 5,Cell division protein kinase 13,Cyclin-dependent kinase 13
EIAAB06500 Cdc2l1,Cdk11,Cell division cycle 2-like protein kinase 1,Cell division protein kinase 11,Cyclin-dependent kinase 11,Galactosyltransferase-associated protein kinase p58_GTA,Mouse,Mus musculus,PITSLRE s
EIAAB06264 CDC2L1,CDK11,CDK11B,Cell division cycle 2-like protein kinase 1,Cell division protein kinase 11B,CLK-1,Cyclin-dependent kinase 11B,Galactosyltransferase-associated protein kinase p58_GTA,Homo sapiens,
EIAAB06521 Cdc2l6,CDC2-related protein kinase 6,Cdk19,Cell division cycle 2-like protein kinase 6,Cell division protein kinase 19,Cyclin-dependent kinase 19,Kiaa1028,Mouse,Mus musculus
EIAAB06505 Cdc2l5,CDC2-related protein kinase 5,Cdk13,Cell division cycle 2-like protein kinase 5,Cell division protein kinase 13,Cyclin-dependent kinase 13,Kiaa1791,Mouse,Mus musculus
EIAAB06499 Cdc2l1,Cdk11,Cell division cycle 2-like protein kinase 1,Cell division protein kinase 11,Cyclin-dependent kinase 11,Galactosyltransferase-associated protein kinase p58_GTA,PITSLRE serine_threonine-pro
EIAAB41609 Cell cycle progression protein 2,CPR2,Pig,Protein TBRG4,Sus scrofa,TBRG4,Transforming growth factor beta regulator 4
30-841 HUS1Bis most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. HUS1B can interact with the check point protein RA 0.05 mg
Pathways :
WP414: Cell Cycle and Cell Division
WP2272: Pathogenic Escherichia coli infection
WP429: Cell cycle
WP1195: G1 to S cell cycle control
WP1775: Cell Cycle Checkpoints
WP45: G1 to S cell cycle control
WP2328: Allograft rejection
WP959: G1 to S cell cycle control
WP1078: G1 to S cell cycle control
WP179: Cell cycle
WP1689: Porphyrin and chlorophyll metabolism
WP2435: Quercetin and Nf-kB/ AP-1 induced cell apoptosis
WP840: G1 to S cell cycle control
WP1200: Cell cycle
WP445: G1 to S cell cycle control
WP1900: Regulation of mitotic cell cycle
WP964: Cell cycle
WP1083: Cell cycle
WP844: Cell cycle
WP31: Cell cycle
WP1566: Citrate cycle (TCA cycle)
WP1782: APC/C-mediated degradation of cell cycle proteins
WP190: Cell cycle
WP1792: Cell Cycle, Mitotic
WP348: G1 to S cell cycle control

Related Genes :
[Ccar1 Carp1] Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1)
[CCAR1 CARP1 DIS] Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)
[Cdk11b Cdc2l1 Cdk11] Cyclin-dependent kinase 11B (Cell division cycle 2-like protein kinase 1) (Cell division protein kinase 11) (Cyclin-dependent kinase 11) (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1)
[CDK11A CDC2L2 CDC2L3 PITSLREB] Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)
[CDK11B CDC2L1 CDK11 PITSLREA PK58] Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)
[Asun IntS13 Mat89Bb ovary2 CG6814] Protein asunder (Cell cycle regulator Mat89Bb) (Integrator complex subunit 13) (Maternal transcript 89Bb) (Set apart in position or space protein)
[CDC36 DNA19 NOT2 YDL165W] General negative regulator of transcription subunit 2 (cell division cycle protein 36)
[ced-9 T07C4.8] Apoptosis regulator ced-9 (Cell death protein 9)
[SEPTIN4 ARTS PNUTL2 SEP4 SEPT4 hucep-7] Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Cerebral protein 7) (Peanut-like protein 2)
[CDCA7 JPO1] Cell division cycle-associated protein 7 (Protein JPO1)
[CDK13 CDC2L CDC2L5 CHED KIAA1791] Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)
[cdc-14 C17G10.4] Tyrosine-protein phosphatase cdc-14 (EC 3.1.3.48) (Cell division cycle-related protein 14)
[Bcl2l1 Bcl2l Bclx] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
[cdc-48.1 C06A1.1] Transitional endoplasmic reticulum ATPase homolog 1 (EC 3.6.4.6) (Cell division cycle-related protein 48.1) (p97/CDC48 homolog 1)
[CFLAR CASH CASP8AP1 CLARP MRIT] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[CDK9 CDC2L4 TAK] Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
[cdc-48.2 C41C4.8] Transitional endoplasmic reticulum ATPase homolog 2 (EC 3.6.4.6) (Cell division cycle-related protein 48.2) (p97/CDC48 homolog 2)
[mat-3 apc-8 cdc-23 pod-4 vex-2 F10C5.1] Cell division cycle protein 23 homolog (Anaphase-promoting complex subunit 8) (APC8) (Metaphase-to-anaphase transition defect protein 3)
[CDC39 NOT1 ROS1 YCR093W YCR1151 YCR93W] General negative regulator of transcription subunit 1 (Cell division cycle protein 39)
[INTS13 ASUN C12orf11 GCT1] Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95)
[CDC48 YDL126C] Cell division control protein 48 (EC 3.6.4.6) (Cell division cycle protein 48) (Transitional endoplasmic reticulum ATPase homolog)
[BCL2L1 BCL2L BCLX] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
[BAX BCL2L4] Apoptosis regulator BAX (Bcl-2-like protein 4) (Bcl2-L-4)
[CDCA8 PESCRG3] Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein)
[RCC1 CHC1] Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)
[Bax] Apoptosis regulator BAX
[cdc-48.3 K04G2.3] ATPase family protein 2 homolog (EC 3.6.4.10) (Cell division cycle-related protein 48.3)
[Bcl2 Bcl-2] Apoptosis regulator Bcl-2
[Bcl2l1 Bclx Blc2l] Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
[BCL2] Apoptosis regulator Bcl-2

Bibliography :
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