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Cell cycle protein kinase DBF2 (EC 2.7.11.1) (Dumbbell forming protein 2)

 DBF2_YEAST              Reviewed;         572 AA.
P22204; D6VUM4;
01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 3.
12-AUG-2020, entry version 198.
RecName: Full=Cell cycle protein kinase DBF2;
EC=2.7.11.1;
AltName: Full=Dumbbell forming protein 2;
Name=DBF2; OrderedLocusNames=YGR092W;
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND INDUCTION.
PubMed=2181271; DOI=10.1128/mcb.10.4.1358;
Johnston L.H., Eberly S.L., Chapman J.W., Araki H., Sugino A.;
"The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has
homology with protein kinases and is periodically expressed in the cell
cycle.";
Mol. Cell. Biol. 10:1358-1366(1990).
[2]
SEQUENCE REVISION TO N-TERMINUS.
PubMed=1916278; DOI=10.1016/0378-1119(91)90465-n;
Toyn J.H., Araki H., Sugino A., Johnston L.H.;
"The cell-cycle-regulated budding yeast gene DBF2, encoding a putative
protein kinase, has a homologue that is not under cell-cycle control.";
Gene 104:63-70(1991).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=9169869;
Tettelin H., Agostoni-Carbone M.L., Albermann K., Albers M., Arroyo J.,
Backes U., Barreiros T., Bertani I., Bjourson A.J., Brueckner M.,
Bruschi C.V., Carignani G., Castagnoli L., Cerdan E., Clemente M.L.,
Coblenz A., Coglievina M., Coissac E., Defoor E., Del Bino S., Delius H.,
Delneri D., de Wergifosse P., Dujon B., Durand P., Entian K.-D., Eraso P.,
Escribano V., Fabiani L., Fartmann B., Feroli F., Feuermann M.,
Frontali L., Garcia-Gonzalez M., Garcia-Saez M.I., Goffeau A.,
Guerreiro P., Hani J., Hansen M., Hebling U., Hernandez K., Heumann K.,
Hilger F., Hofmann B., Indge K.J., James C.M., Klima R., Koetter P.,
Kramer B., Kramer W., Lauquin G., Leuther H., Louis E.J., Maillier E.,
Marconi A., Martegani E., Mazon M.J., Mazzoni C., McReynolds A.D.K.,
Melchioretto P., Mewes H.-W., Minenkova O., Mueller-Auer S., Nawrocki A.,
Netter P., Neu R., Nombela C., Oliver S.G., Panzeri L., Paoluzi S.,
Plevani P., Portetelle D., Portillo F., Potier S., Purnelle B., Rieger M.,
Riles L., Rinaldi T., Robben J., Rodrigues-Pousada C.,
Rodriguez-Belmonte E., Rodriguez-Torres A.M., Rose M., Ruzzi M.,
Saliola M., Sanchez-Perez M., Schaefer B., Schaefer M., Scharfe M.,
Schmidheini T., Schreer A., Skala J., Souciet J.-L., Steensma H.Y.,
Talla E., Thierry A., Vandenbol M., van der Aart Q.J.M., Van Dyck L.,
Vanoni M., Verhasselt P., Voet M., Volckaert G., Wambutt R., Watson M.D.,
Weber N., Wedler E., Wedler H., Wipfli P., Wolf K., Wright L.F.,
Zaccaria P., Zimmermann M., Zollner A., Kleine K.;
"The nucleotide sequence of Saccharomyces cerevisiae chromosome VII.";
Nature 387:81-84(1997).
[4]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
G3 (Bethesda) 4:389-398(2014).
[5]
FUNCTION, PHOSPHORYLATION, AND INDUCTION.
PubMed=8131744; DOI=10.1002/j.1460-2075.1994.tb06359.x;
Toyn J.H., Johnston L.H.;
"The Dbf2 and Dbf20 protein kinases of budding yeast are activated after
the metaphase to anaphase cell cycle transition.";
EMBO J. 13:1103-1113(1994).
[6]
INTERACTION WITH MOB1, AND FUNCTION OF THE DBF2-MOB1 COMPLEX.
PubMed=9528782; DOI=10.1128/mcb.18.4.2100;
Komarnitsky S.I., Chiang Y.-C., Luca F.C., Chen J., Toyn J.H., Winey M.,
Johnston L.H., Denis C.L.;
"DBF2 protein kinase binds to and acts through the cell cycle-regulated
MOB1 protein.";
Mol. Cell. Biol. 18:2100-2107(1998).
[7]
FUNCTION.
PubMed=9613578; DOI=10.1007/s004380050712;
Grandin N., de Almeida A., Charbonneau M.;
"The Cdc14 phosphatase is functionally associated with the Dbf2 protein
kinase in Saccharomyces cerevisiae.";
Mol. Gen. Genet. 258:104-116(1998).
[8]
FUNCTION, AND ACTIVITY REGULATION.
PubMed=10228157; DOI=10.1093/emboj/18.9.2424;
Fesquet D., Fitzpatrick P.J., Johnson A.L., Kramer K.M., Toyn J.H.,
Johnston L.H.;
"A Bub2p-dependent spindle checkpoint pathway regulates the Dbf2p kinase in
budding yeast.";
EMBO J. 18:2424-2434(1999).
[9]
SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=10984431;
Frenz L.M., Lee S.E., Fesquet D., Johnston L.H.;
"The budding yeast Dbf2 protein kinase localises to the centrosome and
moves to the bud neck in late mitosis.";
J. Cell Sci. 113:3399-3408(2000).
[10]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=11378390; DOI=10.1016/s0960-9822(01)00228-7;
Lee S.E., Frenz L.M., Wells N.J., Johnson A.L., Johnston L.H.;
"Order of function of the budding-yeast mitotic exit-network proteins Tem1,
Cdc15, Mob1, Dbf2, and Cdc5.";
Curr. Biol. 11:784-788(2001).
[11]
SUBCELLULAR LOCATION.
PubMed=11434459; DOI=10.1266/ggs.76.141;
Yoshida S., Toh-e A.;
"Regulation of the localization of Dbf2 and Mob1 during cell division of
Saccharomyces cerevisiae.";
Genes Genet. Syst. 76:141-147(2001).
[12]
SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=11598184; DOI=10.1091/mbc.12.10.2961;
Visintin R., Amon A.;
"Regulation of the mitotic exit protein kinases Cdc15 and Dbf2.";
Mol. Biol. Cell 12:2961-2974(2001).
[13]
FUNCTION, ACTIVITY REGULATION, AND PHOSPHORYLATION AT SER-374 AND THR-544.
PubMed=11404483; DOI=10.1073/pnas.141098998;
Mah A.S., Jang J., Deshaies R.J.;
"Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex.";
Proc. Natl. Acad. Sci. U.S.A. 98:7325-7330(2001).
[14]
FUNCTION, AND ACTIVITY REGULATION.
PubMed=14551257; DOI=10.1091/mbc.e03-02-0095;
Visintin R., Stegmeier F., Amon A.;
"The role of the polo kinase Cdc5 in controlling Cdc14 localization.";
Mol. Biol. Cell 14:4486-4498(2003).
[15]
SUBCELLULAR LOCATION.
PubMed=12937277; DOI=10.1091/mbc.e03-04-0238;
Hwa Lim H., Yeong F.M., Surana U.;
"Inactivation of mitotic kinase triggers translocation of MEN components to
mother-daughter neck in yeast.";
Mol. Biol. Cell 14:4734-4743(2003).
[16]
FUNCTION, AND ACTIVITY REGULATION.
PubMed=12832486; DOI=10.1128/mcb.23.14.5018-5030.2003;
Bardin A.J., Boselli M.G., Amon A.;
"Mitotic exit regulation through distinct domains within the protein kinase
Cdc15.";
Mol. Cell. Biol. 23:5018-5030(2003).
[17]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[18]
FUNCTION OF THE DBF2-MOB1 COMPLEX.
PubMed=16242037; DOI=10.1186/1471-2091-6-22;
Mah A.S., Elia A.E., Devgan G., Ptacek J., Schutkowski M., Snyder M.,
Yaffe M.B., Deshaies R.J.;
"Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by
peptide library and proteome array screening.";
BMC Biochem. 6:22-22(2005).
[19]
SUBCELLULAR LOCATION, AND FUNCTION OF THE DBF2-MOB1 COMPLEX.
PubMed=16176976; DOI=10.1091/mbc.e05-04-0337;
Stoepel J., Ottey M.A., Kurischko C., Hieter P., Luca F.C.;
"The mitotic exit network Mob1p-Dbf2p kinase complex localizes to the
nucleus and regulates passenger protein localization.";
Mol. Biol. Cell 16:5465-5479(2005).
[20]
FUNCTION.
PubMed=18048916; DOI=10.1099/mic.0.2007/010298-0;
Makrantoni V., Dennison P., Stark M.J., Coote P.J.;
"A novel role for the yeast protein kinase Dbf2p in vacuolar H+-ATPase
function and sorbic acid stress tolerance.";
Microbiology 153:4016-4026(2007).
[21]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-374, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
"A multidimensional chromatography technology for in-depth phosphoproteome
analysis.";
Mol. Cell. Proteomics 7:1389-1396(2008).
[22]
FUNCTION IN PHOSPHORYLATION OF CDC14.
PubMed=19221193; DOI=10.1083/jcb.200812022;
Mohl D.A., Huddleston M.J., Collingwood T.S., Annan R.S., Deshaies R.J.;
"Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the
cytoplasm during exit from mitosis.";
J. Cell Biol. 184:527-539(2009).
[23]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-17; SER-20 AND SER-74, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19779198; DOI=10.1126/science.1172867;
Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
"Global analysis of Cdk1 substrate phosphorylation sites provides insights
into evolution.";
Science 325:1682-1686(2009).
[24]
FUNCTION, AND ACTIVITY REGULATION.
PubMed=20123997; DOI=10.1083/jcb.200911128;
Konig C., Maekawa H., Schiebel E.;
"Mutual regulation of cyclin-dependent kinase and the mitotic exit
network.";
J. Cell Biol. 188:351-368(2010).
[25]
FUNCTION.
PubMed=20442249; DOI=10.1242/jcs.063891;
Meitinger F., Petrova B., Lombardi I.M., Bertazzi D.T., Hub B.,
Zentgraf H., Pereira G.;
"Targeted localization of Inn1, Cyk3 and Chs2 by the mitotic-exit network
regulates cytokinesis in budding yeast.";
J. Cell Sci. 123:1851-1861(2010).
[26]
FUNCTION, AND RNA-BINDING.
PubMed=22196726; DOI=10.1016/j.cell.2011.11.051;
Trcek T., Larson D.R., Moldon A., Query C.C., Singer R.H.;
"Single-molecule mRNA decay measurements reveal promoter- regulated mRNA
stability in yeast.";
Cell 147:1484-1497(2011).
[27]
FUNCTION.
PubMed=22573892; DOI=10.1091/mbc.e12-01-0033;
Oh Y., Chang K.J., Orlean P., Wloka C., Deshaies R., Bi E.;
"Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to
regulate cytokinesis in budding yeast.";
Mol. Biol. Cell 23:2445-2456(2012).
[28]
FUNCTION.
PubMed=23447700; DOI=10.1091/mbc.e12-08-0608;
Meitinger F., Palani S., Hub B., Pereira G.;
"Dual function of the NDR-kinase Dbf2 in the regulation of the F-BAR
protein Hof1 during cytokinesis.";
Mol. Biol. Cell 24:1290-1304(2013).
-!- FUNCTION: Ser/Thr-protein kinase involved in the mitotic exit network
(MEN) and required after the metaphase to anaphase cell cycle
transition. Phosphorylates CHS2 to regulate its dynamics and chitin
synthesis at the division site during cytokinesis. Coordinates septin
and actomyosin ring (AMR) functions during cytokinesis through the
phosphorylation of HOF1. In complex with MOB1, phosphorylates CDC14 at
sites adjacent to its nuclear localization sequence, thereby retaining
CDC14 in the cytoplasm. Binds also to SWI5 and CLB2 mRNAs
cotranscriptionally to regulate their decay. In the nucleus, the DBF2-
MOB1 complex regulates passenger protein localization during anaphase.
Mediates sorbic acid stress tolerance through promoting vacuolar H(+)-
ATPase function, probably through phosphorylation of VMA1 and VMA2
subunits. {ECO:0000269|PubMed:10228157, ECO:0000269|PubMed:10984431,
ECO:0000269|PubMed:11378390, ECO:0000269|PubMed:11404483,
ECO:0000269|PubMed:11598184, ECO:0000269|PubMed:12832486,
ECO:0000269|PubMed:14551257, ECO:0000269|PubMed:16176976,
ECO:0000269|PubMed:16242037, ECO:0000269|PubMed:18048916,
ECO:0000269|PubMed:19221193, ECO:0000269|PubMed:20123997,
ECO:0000269|PubMed:20442249, ECO:0000269|PubMed:22196726,
ECO:0000269|PubMed:22573892, ECO:0000269|PubMed:23447700,
ECO:0000269|PubMed:8131744, ECO:0000269|PubMed:9528782,
ECO:0000269|PubMed:9613578}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.11.1;
-!- ACTIVITY REGULATION: Kinase activity is regulated by BUB2, CDC15 and
CDC5, and is maximal during nuclear division. CDK1 kinase inhibits
cellular DBF2-MOB1 kinase activity via phosphorylation of both CDC15
and MOB1. {ECO:0000269|PubMed:10228157, ECO:0000269|PubMed:11404483,
ECO:0000269|PubMed:12832486, ECO:0000269|PubMed:14551257,
ECO:0000269|PubMed:20123997}.
-!- SUBUNIT: Interacts with MOB1. MOB1-binding is required for a late
mitotic event. {ECO:0000269|PubMed:9528782}.
-!- INTERACTION:
P22204; P38074: HMT1; NbExp=4; IntAct=EBI-5569, EBI-8394;
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
center, spindle pole body. Bud neck. Nucleus. Note=Localizes on spindle
ole body (SPB) for much of the cell cycle and migrates from there to
the bud neck in late mitosis. SPB localization during anaphase
coincides with activation kinase activity and depends on TEM1 and
CDC15. In absence of BUB2, localizes to SPB in cell cycle stages other
than anaphase and telophase.
-!- INDUCTION: Periodically expressed in the cell cycle, with a peak before
the onset of budding. {ECO:0000269|PubMed:2181271,
ECO:0000269|PubMed:8131744}.
-!- PTM: Phosphorylation of Ser-374 and Thr-544 by CDC15 is essential for
activation of DBF2 kinase activity. {ECO:0000269|PubMed:11404483,
ECO:0000269|PubMed:8131744}.
-!- MISCELLANEOUS: Present with 3500 molecules/cell in log phase SD medium.
{ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
-!- SEQUENCE CAUTION:
Sequence=AAA34559.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
---------------------------------------------------------------------------
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EMBL; M34146; AAA34559.1; ALT_INIT; Genomic_DNA.
EMBL; Z72877; CAA97095.1; -; Genomic_DNA.
EMBL; BK006941; DAA08185.1; -; Genomic_DNA.
PIR; S64387; S64387.
RefSeq; NP_011606.3; NM_001181221.3.
PDB; 5NCN; X-ray; 3.50 A; B=85-173.
PDBsum; 5NCN; -.
SMR; P22204; -.
BioGRID; 33335; 911.
ComplexPortal; CPX-1683; DBF2-MOB1 kinase complex.
DIP; DIP-2319N; -.
IntAct; P22204; 70.
MINT; P22204; -.
STRING; 4932.YGR092W; -.
iPTMnet; P22204; -.
MaxQB; P22204; -.
PaxDb; P22204; -.
PRIDE; P22204; -.
EnsemblFungi; YGR092W_mRNA; YGR092W; YGR092W.
GeneID; 852984; -.
KEGG; sce:YGR092W; -.
EuPathDB; FungiDB:YGR092W; -.
SGD; S000003324; DBF2.
eggNOG; KOG0605; Eukaryota.
GeneTree; ENSGT00940000176430; -.
HOGENOM; CLU_000288_67_4_1; -.
InParanoid; P22204; -.
KO; K06684; -.
OMA; FPYEDTS; -.
BioCyc; YEAST:G3O-30802-MONOMER; -.
BRENDA; 2.7.11.1; 984.
Reactome; R-SCE-2028269; Signaling by Hippo.
PRO; PR:P22204; -.
Proteomes; UP000002311; Chromosome VII.
RNAct; P22204; protein.
GO; GO:0005935; C:cellular bud neck; IDA:SGD.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0034973; C:Sid2-Mob1 complex; IDA:SGD.
GO; GO:0005816; C:spindle pole body; IDA:SGD.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004672; F:protein kinase activity; HDA:SGD.
GO; GO:1901916; F:protein kinase activity involved in regulation of protein localization to cell division site involved in cytokinesis; IMP:SGD.
GO; GO:0004674; F:protein serine/threonine kinase activity; IDA:SGD.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0035556; P:intracellular signal transduction; IBA:GO_Central.
GO; GO:0000280; P:nuclear division; IMP:SGD.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IBA:GO_Central.
GO; GO:0006468; P:protein phosphorylation; IDA:SGD.
GO; GO:0032465; P:regulation of cytokinesis; IMP:SGD.
GO; GO:0032880; P:regulation of protein localization; IMP:SGD.
GO; GO:0007035; P:vacuolar acidification; IMP:SGD.
InterPro; IPR000961; AGC-kinase_C.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00133; S_TK_X; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS51285; AGC_KINASE_CTER; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
3D-structure; ATP-binding; Cell cycle; Cytoplasm; Cytoskeleton; Kinase;
Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
RNA-binding; Serine/threonine-protein kinase; Transferase.
CHAIN 1..572
/note="Cell cycle protein kinase DBF2"
/id="PRO_0000085918"
DOMAIN 177..477
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
DOMAIN 478..555
/note="AGC-kinase C-terminal"
NP_BIND 183..191
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
ACT_SITE 300
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 206
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
MOD_RES 17
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:19779198"
MOD_RES 20
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:19779198"
MOD_RES 74
/note="Phosphoserine"
/evidence="ECO:0000244|PubMed:19779198"
MOD_RES 374
/note="Phosphoserine; by CDC15"
/evidence="ECO:0000244|PubMed:18407956,
ECO:0000269|PubMed:11404483"
MOD_RES 544
/note="Phosphothreonine; by CDC15"
/evidence="ECO:0000269|PubMed:11404483"
CONFLICT 11..12
/note="LL -> YM (in Ref. 1; AAA34559)"
/evidence="ECO:0000305"
CONFLICT 114
/note="H -> Y (in Ref. 1; AAA34559)"
/evidence="ECO:0000305"
CONFLICT 246
/note="D -> E (in Ref. 1; AAA34559)"
/evidence="ECO:0000305"
SEQUENCE 572 AA; 66148 MW; 648C565D5CE7117D CRC64;
MLSKSEKNVD LLAGNMSNLS FDGHGTPGGT GLFPNQNITK RRTRPAGIND SPSPVKPSFF
PYEDTSNMDI DEVSQPDMDV SNSPKKLPPK FYERATSNKT QRVVSVCKMY FLEHYCDMFD
YVISRRQRTK QVLEYLQQQS QLPNSDQIKL NEEWSSYLQR EHQVLRKRRL KPKNRDFEMI
TQVGQGGYGQ VYLARKKDTK EVCALKILNK KLLFKLNETK HVLTERDILT TTRSEWLVKL
LYAFQDLQSL YLAMEFVPGG DFRTLLINTR CLKSGHARFY ISEMFCAVNA LHDLGYTHRD
LKPENFLIDA KGHIKLTDFG LAAGTISNER IESMKIRLEK IKDLEFPAFT EKSIEDRRKM
YNQLREKEIN YANSMVGSPD YMALEVLEGK KYDFTVDYWS LGCMLFESLV GYTPFSGSST
NETYDNLRRW KQTLRRPRQS DGRAAFSDRT WDLITRLIAD PINRLRSFEH VKRMSYFADI
NFSTLRSMIP PFTPQLDSET DAGYFDDFTS EADMAKYADV FKRQDKLTAM VDDSAVSSKL
VGFTFRHRNG KQGSSGILFN GLEHSDPFST FY


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EIAAB06263 CDC2L2,CDC2L3,CDK11A,Cell division cycle 2-like protein kinase 2,Cell division protein kinase 11A,Cyclin-dependent kinase 11A,Galactosyltransferase-associated protein kinase p58_GTA,Homo sapiens,Human
EIAAB41607 Cell cycle progression protein 2,Cell cycle progression restoration protein 2,CPR2,FAST kinase domain-containing protein 4,FASTKD4,Homo sapiens,Human,KIAA0948,Protein TBRG4,TBRG4,Transforming growth f
EIAAB06506 Bos taurus,Bovine,CDC2L,CDC2L5,CDC2-related protein kinase 5,CDK13,Cell division cycle 2-like protein kinase 5,Cell division protein kinase 13,Cyclin-dependent kinase 13
EIAAB06505 Cdc2l5,CDC2-related protein kinase 5,Cdk13,Cell division cycle 2-like protein kinase 5,Cell division protein kinase 13,Cyclin-dependent kinase 13,Kiaa1791,Mouse,Mus musculus
EIAAB06521 Cdc2l6,CDC2-related protein kinase 6,Cdk19,Cell division cycle 2-like protein kinase 6,Cell division protein kinase 19,Cyclin-dependent kinase 19,Kiaa1028,Mouse,Mus musculus
EIAAB06500 Cdc2l1,Cdk11,Cell division cycle 2-like protein kinase 1,Cell division protein kinase 11,Cyclin-dependent kinase 11,Galactosyltransferase-associated protein kinase p58_GTA,Mouse,Mus musculus,PITSLRE s
EIAAB06264 CDC2L1,CDK11,CDK11B,Cell division cycle 2-like protein kinase 1,Cell division protein kinase 11B,CLK-1,Cyclin-dependent kinase 11B,Galactosyltransferase-associated protein kinase p58_GTA,Homo sapiens,
EIAAB06499 Cdc2l1,Cdk11,Cell division cycle 2-like protein kinase 1,Cell division protein kinase 11,Cyclin-dependent kinase 11,Galactosyltransferase-associated protein kinase p58_GTA,PITSLRE serine_threonine-pro
18-003-44328 Cell division protein kinase 9 - EC 2.7.11.22; EC 2.7.11.23; Cyclin-dependent kinase 9; Serine_threonine-protein kinase PITALRE; C-2K; Cell division cycle 2-like protein kinase 4 Polyclonal 0.1 mg Protein A
EIAAB06507 CDC2L,CDC2L5,CDC2-related protein kinase 5,CDK13,Cell division cycle 2-like protein kinase 5,Cell division protein kinase 13,CHED,Cholinesterase-related cell division controller,Cyclin-dependent kinas
EIAAB06522 CDC2L6,CDC2-related protein kinase 6,CDK11,CDK19,Cell division cycle 2-like protein kinase 6,Cell division protein kinase 19,Cyclin-dependent kinase 11,Cyclin-dependent kinase 19,Death-preventing kina
EIAAB40153 Homo sapiens,Human,KIAA0965,NDR2,NDR2 protein kinase,Nuclear Dbf2-related kinase 2,Serine_threonine-protein kinase 38-like,STK38L
EIAAB40322 Homo sapiens,Human,NDR1,NDR1 protein kinase,Nuclear Dbf2-related kinase 1,Serine_threonine-protein kinase 38,STK38
EIAAB40154 Mouse,Mus musculus,Ndr2,NDR2 protein kinase,Nuclear Dbf2-related kinase 2,Serine_threonine-protein kinase 38-like,Stk38l
EIAAB40321 Mouse,Mus musculus,Ndr1,NDR1 protein kinase,Nuclear Dbf2-related kinase 1,Serine_threonine-protein kinase 38,Stk38
EIAAB06523 CAK-kinase p42,Ccrk,Cdch,Cdk20,CDK-activating kinase p42,CDK-related protein kinase PNQLARE,Cell cycle-related kinase,Cell division protein kinase 20,Cyclin-dependent kinase 20,Cyclin-dependent protei
EIAAB06525 Ccrk,Cdk20,Cell cycle-related kinase,Cell division protein kinase 20,Cyclin-dependent kinase 20,Rat,Rattus norvegicus
EIAAB06524 CAK-kinase p42,CCRK,CDCH,CDK20,CDK-activating kinase p42,Cell cycle-related kinase,Cell division protein kinase 20,Cyclin-dependent kinase 20,Cyclin-dependent protein kinase H,Cyclin-kinase-activating
EIAAB06502 Cdc2-related kinase, arginine_serine-rich,CDC2-related protein kinase 7,Cdk12,Cell division cycle 2-related protein kinase 7,Cell division protein kinase 12,Crk7,CrkRS,Crkrs,Cyclin-dependent kinase 12
EIAAB06503 Cdc2-related kinase, arginine_serine-rich,CDC2-related protein kinase 7,CDK12,Cell division cycle 2-related protein kinase 7,Cell division protein kinase 12,CRK7,CrkRS,CRKRS,Cyclin-dependent kinase 12
EIAAB06501 Cdc2-related kinase, arginine_serine-rich,CDC2-related protein kinase 7,Cdk12,Cell division cycle 2-related protein kinase 7,Cell division protein kinase 12,Crk7,CrkRS,Crkrs,Cyclin-dependent kinase 12
30-841 HUS1Bis most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. HUS1B can interact with the check point protein RA 0.05 mg
18-272-195263 Cdk9 - Rabbit polyclonal to Cdk9; EC 2.7.11.22; EC 2.7.11.23; Cyclin-dependent kinase 9; Serine_threonine-protein kinase PITALRE; C-2K; Cell division cycle 2-like protein kinase 4 Polyclonal 0.05 ml
EIAAB05873 CARP1,CARP-1,CCAR1,Cell cycle and apoptosis regulatory protein 1,Cell division cycle and apoptosis regulator protein 1,Death inducer with SAP domain,DIS,Homo sapiens,Human
Pathways :
WP414: Cell Cycle and Cell Division
WP1566: Citrate cycle (TCA cycle)
WP1493: Carbon assimilation C4 pathway
WP1616: ABC transporters
WP179: Cell cycle
WP211: BMP signaling pathway
WP348: G1 to S cell cycle control
WP813: G Protein Signaling Pathways
WP1676: Non-homologous end-joining
WP1900: Regulation of mitotic cell cycle
WP1371: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1946: Cori Cycle
WP1049: G Protein Signaling Pathways
WP1625: Base excision repair
WP2203: TSLP Signaling Pathway
WP844: Cell cycle
WP1692: Protein export
WP1083: Cell cycle
WP1700: Selenoamino acid metabolism
WP31: Cell cycle
WP1659: Glycine, serine and threonine metabolism
WP2292: Chemokine signaling pathway
WP1502: Mitochondrial biogenesis
WP2324: AGE/RAGE pathway

Related Genes :
[CDK9 CDC2L4 TAK] Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
[CDC15 LYT1 YAR019C] Cell division control protein 15 (EC 2.7.11.1)
[Taf1 Ccg1] Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
[CDK11B CDC2L1 CDK11 PITSLREA PK58] Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)
[hchA A8C65_13880 A9R57_25255 AMK83_16550 AWB10_10580 AWG90_013200 B7C53_22525 B9M99_11580 B9T59_01945 BJJ90_15205 BMT49_12710 BON65_01250 BON66_15955 BON86_06490 BON95_14610 BUE81_10670 BvCms12BK_01457 BvCms28BK_04168 BvCmsHHP001_02632 BvCmsKKP061_00566 BvCmsKSP045_04450 BvCmsKSP058_03204 BvCmsKSP067_02879 BvCmsNSP006_03750 BvCmsNSP007_03329 BvCmsNSP047_03567 BvCmsSINP011_04162 BW690_17225 BZL69_29425 C2U48_24800 C5715_19445 C5N07_21380 C6669_19295 C7B06_02290 C7B07_03930 C9Z23_21970 C9Z37_00915 C9Z43_06360 C9Z78_05610 CDC27_10055 CDL37_00765 CI693_17820 CI694_25210 CIG45_02340 COD46_23180 CQP61_17160 CRD98_26150 D2188_01360 D4628_09465 D6T98_10515 D6X36_17295 D9D20_21030 D9D43_06110 D9G29_20785 D9G69_01560 D9H68_20750 D9H70_25730 D9I87_15275 D9J58_04360 D9S45_22925 DEN89_24995 DEO04_05510 DL705_18425 DL800_09215 DLU50_17670 DLW88_16170 DLY44_04800 DND16_20085 DNR35_16895 DQP61_11280 DTL43_21780 DTZ20_09315 DU321_04440 DXT73_20690 E2134_24005 E2135_17195 E2855_02503 E2863_02392 E4K55_17625 E4K61_03800 E5P22_21380 E5S46_06650 EA213_19000 EA225_13320 EAX79_27320 EC95NR1_00961 ED648_25045 EG796_17135 EHD79_18540 EI028_00085 ELT20_21515 ELV08_24970 EPT01_11070 EQ825_23250 ERS085379_01273 ERS085386_05041 ExPECSC019_03873 ExPECSC038_01920 EXX71_02385 EXX78_21815 EYD11_09165 F7F11_20115 F7F18_11615 F7F29_22635 FNJ83_13175 FQ915_04255 FQR64_09390 FQZ46_21375 FWK02_18105 FZ043_14730 GIY13_02485 GNZ00_15670 GNZ02_11235 GNZ03_00440 GP712_09450 GQE64_12165 GQL64_10635 GQM17_02800 HmCmsJML079_02678 HMPREF3040_01583 HW43_13705 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC10974_02300 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13216_04667 NCTC8985_00529 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472055_03589 SAMEA3472056_01268 SAMEA3472070_00654 SAMEA3472080_04213 SAMEA3472090_03376 SAMEA3472110_00060 SAMEA3472112_00448 SAMEA3752372_00752 UN91_23615 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[Cdk11b Cdc2l1 Cdk11] Cyclin-dependent kinase 11B (Cell division cycle 2-like protein kinase 1) (Cell division protein kinase 11) (Cyclin-dependent kinase 11) (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1)
[CDK11A CDC2L2 CDC2L3 PITSLREB] Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)
[CDK13 CDC2L CDC2L5 CHED KIAA1791] Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)
[CHEK1 CHK1] Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
[CDC7 CDC7L1] Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1)
[Cdc7 Cdc7l1] Cell division cycle 7-related protein kinase (CDC7-related kinase) (muCdc7) (EC 2.7.11.1)
[hchA hchA_1 AM465_15370 AWF59_019055 AZZ83_004235 B9N33_26475 BFD68_20845 C7B02_06890 C9Z28_17130 CCZ14_26645 CCZ17_22700 CRJUMX01_1140054 CRT43_11430 CUB99_23505 D3C88_02905 D3P02_16265 D9D33_15385 D9D94_15735 D9E49_19020 D9I20_10460 D9J46_03345 DJ487_18960 DJ492_13470 DL251_00505 DL979_00380 DMC44_18755 DMZ50_24495 DNR41_00375 DS966_16070 DU333_03260 DW236_02290 E0L04_20335 EA159_21345 EA167_21075 EA189_00370 EA191_21560 EA198_02280 EA200_00370 EA203_21510 EA222_02305 EA232_20265 EA233_11705 EA242_17410 EA245_13290 EA429_05770 EA435_21775 EA834_21700 ECTO124_02024 EGT48_04930 ELT22_00120 ELT23_21030 ELT33_08025 ELU82_24705 ELU96_05025 ELV13_26065 ELV22_24670 ELX56_18060 ELX70_18575 ELX79_15035 ELX83_25640 ELY23_20490 ELY24_19085 ELY50_24510 EPS76_06485 EPS91_17475 EPS94_00505 ERS085406_02591 EWK56_00075 ExPECSC065_02714 EYX99_25670 FNJ67_10775 FV295_16190 GFU40_00360 GFU45_09680 GFU47_04835 GJ638_18410 GKE92_23545 GKF28_00040 GKF34_00055 GKF47_00040 GKG08_13460 GKG09_11990 GKG11_12245 GKG22_12830 GKG29_13740 GQE47_24120 GQN33_12435 GQS26_09145 HmCmsJML236_01281 NCTC10766_03778 NCTC7928_05955 NCTC8450_02317 NCTC9007_02951 NCTC9075_02834 SY51_11150 U12A_02105 U14A_02105] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[UL97] Serine/threonine protein kinase UL97 (EC 2.7.1.-) (Ganciclovir kinase) (HSRF3 protein)
[TAF1 BA2R CCG1 CCGS TAF2A] Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
[Rad9a Rad9] Cell cycle checkpoint control protein RAD9A (mRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) (Rad9-like protein)
[TAF1 CCG1] Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
[cdk-5 T27E9.3] Cyclin-dependent-like kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5)
[trc CG8637] Serine/threonine-protein kinase tricornered (EC 2.7.11.1) (NDR protein kinase) (Serine/threonine-protein kinase 38-like) (Serine/threonine-protein kinase tricorner)
[CDK1 CDC2 CDC28A CDKN1 P34CDC2] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
[cdk-2 K03E5.3] Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2)
[hchA A9819_11910 ACN81_03425 AML35_08765 AW059_23935 BANRA_00208 BANRA_00433 BANRA_02614 BHF46_18455 BMA87_25350 BMT91_24760 BON76_21885 BvCmsC61A_00149 BvCmsKSNP120_04693 BvCmsKSP026_03873 BvCmsKSP076_04891 C7B08_25495 C9Z39_20510 CR538_10415 D3Y67_22910 D4023_08350 D9G42_11130 D9I97_22010 D9J11_25195 D9J52_16665 DJ503_24045 DLX40_18195 DM267_05215 DN627_18690 DP258_02540 DQE91_25240 EC3234A_36c00010 EC382_21100 ECTO6_01955 EHH55_07135 FORC82_1921 FV293_07100 GHR40_13690 GKE15_01795 GKE22_01795 GKE24_01795 GKE26_01795 GKE29_19015 GKE31_01795 GKE39_01795 GKE46_01795 GKE58_00235 GKE60_01795 GKE64_01795 GKE77_01800 GKE87_19180 GKE93_04790 GKF00_12775 GKF03_06100 GKF74_23075 GKF86_23585 GKF89_24720 GKG12_21690 GP700_02420 GP720_02430 GP727_01495 GP912_03195 NCTC12650_02300 NCTC8500_02249 NCTC9117_02637 NCTC9969_02156 SAMEA3472108_01151 SAMEA3484427_04795 SAMEA3484429_02051 SAMEA3752557_05476 SAMEA3752559_04333] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[cdk1-b cdc2 cdc2x1.2] Cyclin-dependent kinase 1-B (CDK1-B) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog 2) (Cell division control protein 2-B) (Cell division protein kinase 1) (p34 protein kinase 2)
[Cdk1 Cdc2 Cdc2a Cdkn1] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
[cdk1-a cdc2-a cdc2x1.1] Cyclin-dependent kinase 1-A (CDK1-A) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog 1) (Cell division control protein 2-A) (Cell division protein kinase 1-A) (p34 protein kinase 1)
[Cdk1 Cdc2 Cdc2a Cdkn1] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
[CDK1 CDC2 CDKN1] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
[CDK1 CDC2 CDKN1] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
[Cdk1 cdc2 CG5363] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
[CDK7 CAK CAK1 CDKN7 MO15 STK1] Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
[stk-1 bur1 B20D17.070 NCU01435] Serine/threonine-protein kinase bur1 (EC 2.7.11.22) (EC 2.7.11.23) (Serine-threonine kinase 1)

Bibliography :
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