Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection homolog)

 CYREN_RAT               Reviewed;         160 AA.
 Q6AYH4;
 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
 13-SEP-2004, sequence version 1.
 23-FEB-2022, entry version 88.
 RecName: Full=Cell cycle regulator of non-homologous end joining {ECO:0000250|UniProtKB:Q9BWK5};
          Short=Cell cycle regulator of NHEJ {ECO:0000250|UniProtKB:Q9BWK5};
 AltName: Full=Modulator of retrovirus infection homolog {ECO:0000250|UniProtKB:Q09HN1};
 Name=Cyren {ECO:0000312|RGD:1563238};
 Synonyms=Mri {ECO:0000250|UniProtKB:Q09HN1};
 Rattus norvegicus (Rat).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
 Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
 Murinae; Rattus.
 NCBI_TaxID=10116;
 [1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
 TISSUE=Testis;
 PubMed=15489334; DOI=10.1101/gr.2596504;
 The MGC Project Team;
 "The status, quality, and expansion of the NIH full-length cDNA project:
 the Mammalian Gene Collection (MGC).";
 Genome Res. 14:2121-2127(2004).
 -!- FUNCTION: Cell-cycle-specific regulator of classical non-homologous end
     joining (NHEJ) of DNA double-strand break (DSB) repair, which can act
     both as an activator or inhibitor of NHEJ, depending on the cell cycle
     phase (By similarity). Acts as a regulator of DNA repair pathway choice
     by specifically inhibiting classical NHEJ during the S and G2 phases,
     thereby promoting error-free repair by homologous recombination during
     cell cycle phases when sister chromatids are present. Preferentially
     protects single-stranded overhangs at break sites by inhibiting
     classical NHEJ, thereby creating a local environment that favors
     homologous recombination. Acts via interaction with XRCC5/Ku80 and
     XRCC6/Ku70 (By similarity). In contrast, acts as an activator of NHEJ
     during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase
     cells via multivalent interactions that increase the affinity of DNA
     damage response proteins for DSB-associated chromatin. Also involved in
     immunoglobulin V(D)J recombination (By similarity). May also act as an
     indirect regulator of proteasome (By similarity).
     {ECO:0000250|UniProtKB:Q09HN1, ECO:0000250|UniProtKB:Q8BHZ5,
     ECO:0000250|UniProtKB:Q9BWK5}.
 -!- SUBUNIT: Interacts (via KBM motif) with XRCC5/Ku80 and XRCC6/Ku70
     heterodimer. Interacts (via XLF motif) with TRIM28/KAP1, ATM, MRE11,
     NBN and RAD50. {ECO:0000250|UniProtKB:Q8BHZ5}.
 -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BWK5}. Nucleus
     {ECO:0000250|UniProtKB:Q9BWK5}. Chromosome
     {ECO:0000250|UniProtKB:Q8BHZ5}. Note=Nuclear localization may depend
     upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (By
     similarity). Localizes to DNA damage sites (By similarity).
     {ECO:0000250|UniProtKB:Q8BHZ5, ECO:0000250|UniProtKB:Q9BWK5}.
 -!- DOMAIN: The KBM (Ku-binding motif) mediates interaction with XRCC5/Ku80
     and XRCC6/Ku70 and recruitment to DNA damage sites.
     {ECO:0000250|UniProtKB:Q8BHZ5}.
 -!- DOMAIN: The XLM (XLF-like motif) mediates interaction with DNA damage
     response proteins TRIM28/KAP1, ATM and members of the MRN complex
     (MRE11, NBN and RAD50). {ECO:0000250|UniProtKB:Q8BHZ5}.
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 EMBL; BC079043; AAH79043.1; -; mRNA.
 RefSeq; NP_001019496.1; NM_001024325.1.
 STRING; 10116.ENSRNOP00000034483; -.
 PaxDb; Q6AYH4; -.
 Ensembl; ENSRNOT00000029818; ENSRNOP00000034483; ENSRNOG00000026958.
 GeneID; 500077; -.
 KEGG; rno:500077; -.
 UCSC; RGD:1563238; rat.
 CTD; 78996; -.
 RGD; 1563238; Cyren.
 eggNOG; ENOG502SEX2; Eukaryota.
 GeneTree; ENSGT00390000013192; -.
 HOGENOM; CLU_126072_0_0_1; -.
 InParanoid; Q6AYH4; -.
 OMA; AKAPKRM; -.
 OrthoDB; 1349796at2759; -.
 PhylomeDB; Q6AYH4; -.
 TreeFam; TF336925; -.
 PRO; PR:Q6AYH4; -.
 Proteomes; UP000002494; Chromosome 4.
 Bgee; ENSRNOG00000026958; Expressed in testis and 21 other tissues.
 GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO; GO:0005634; C:nucleus; ISS:UniProtKB.
 GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
 GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; ISS:UniProtKB.
 GO; GO:0033152; P:immunoglobulin V(D)J recombination; ISS:UniProtKB.
 GO; GO:2001033; P:negative regulation of double-strand break repair via nonhomologous end joining; ISS:UniProtKB.
 InterPro; IPR028278; MRI.
 PANTHER; PTHR14566; PTHR14566; 1.
 Pfam; PF15325; MRI; 1.
 2: Evidence at transcript level;
 Acetylation; Chromosome; Cytoplasm; DNA damage; DNA repair; Nucleus;
 Reference proteome.
 CHAIN           1..160
                 /note="Cell cycle regulator of non-homologous end joining"
                 /id="PRO_0000320950"
 REGION          78..152
                 /note="Disordered"
                 /evidence="ECO:0000256|SAM:MobiDB-lite"
 MOTIF           1..21
                 /note="KBM"
                 /evidence="ECO:0000250|UniProtKB:Q9BWK5"
 MOTIF           150..160
                 /note="XLM"
                 /evidence="ECO:0000250|UniProtKB:Q9BWK5"
 MOD_RES         1
                 /note="N-acetylmethionine"
                 /evidence="ECO:0000250|UniProtKB:Q9BWK5"
 SEQUENCE   160 AA;  17487 MW;  71E404D667390822 CRC64;
 METLKSDNKK RVLPSWMTAP GNERKVVSVK TAKRKQTAAI RVGAATRAPA KETVYCMNEA
 EMVDVALGIL IEGRKQEKPW EQPSLVAPDK LQLSPPCSES PHTSSPGSSS EEEDSRTDSP
 ALGLSPARGP EASNSPCSRS PEEGKEEEDE LKYVREIFFS

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