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Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection homolog)

 CYREN_RAT               Reviewed;         160 AA.
Q6AYH4;
26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
13-SEP-2004, sequence version 1.
23-FEB-2022, entry version 88.
RecName: Full=Cell cycle regulator of non-homologous end joining {ECO:0000250|UniProtKB:Q9BWK5};
Short=Cell cycle regulator of NHEJ {ECO:0000250|UniProtKB:Q9BWK5};
AltName: Full=Modulator of retrovirus infection homolog {ECO:0000250|UniProtKB:Q09HN1};
Name=Cyren {ECO:0000312|RGD:1563238};
Synonyms=Mri {ECO:0000250|UniProtKB:Q09HN1};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Cell-cycle-specific regulator of classical non-homologous end
joining (NHEJ) of DNA double-strand break (DSB) repair, which can act
both as an activator or inhibitor of NHEJ, depending on the cell cycle
phase (By similarity). Acts as a regulator of DNA repair pathway choice
by specifically inhibiting classical NHEJ during the S and G2 phases,
thereby promoting error-free repair by homologous recombination during
cell cycle phases when sister chromatids are present. Preferentially
protects single-stranded overhangs at break sites by inhibiting
classical NHEJ, thereby creating a local environment that favors
homologous recombination. Acts via interaction with XRCC5/Ku80 and
XRCC6/Ku70 (By similarity). In contrast, acts as an activator of NHEJ
during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase
cells via multivalent interactions that increase the affinity of DNA
damage response proteins for DSB-associated chromatin. Also involved in
immunoglobulin V(D)J recombination (By similarity). May also act as an
indirect regulator of proteasome (By similarity).
{ECO:0000250|UniProtKB:Q09HN1, ECO:0000250|UniProtKB:Q8BHZ5,
ECO:0000250|UniProtKB:Q9BWK5}.
-!- SUBUNIT: Interacts (via KBM motif) with XRCC5/Ku80 and XRCC6/Ku70
heterodimer. Interacts (via XLF motif) with TRIM28/KAP1, ATM, MRE11,
NBN and RAD50. {ECO:0000250|UniProtKB:Q8BHZ5}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BWK5}. Nucleus
{ECO:0000250|UniProtKB:Q9BWK5}. Chromosome
{ECO:0000250|UniProtKB:Q8BHZ5}. Note=Nuclear localization may depend
upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (By
similarity). Localizes to DNA damage sites (By similarity).
{ECO:0000250|UniProtKB:Q8BHZ5, ECO:0000250|UniProtKB:Q9BWK5}.
-!- DOMAIN: The KBM (Ku-binding motif) mediates interaction with XRCC5/Ku80
and XRCC6/Ku70 and recruitment to DNA damage sites.
{ECO:0000250|UniProtKB:Q8BHZ5}.
-!- DOMAIN: The XLM (XLF-like motif) mediates interaction with DNA damage
response proteins TRIM28/KAP1, ATM and members of the MRN complex
(MRE11, NBN and RAD50). {ECO:0000250|UniProtKB:Q8BHZ5}.
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EMBL; BC079043; AAH79043.1; -; mRNA.
RefSeq; NP_001019496.1; NM_001024325.1.
STRING; 10116.ENSRNOP00000034483; -.
PaxDb; Q6AYH4; -.
Ensembl; ENSRNOT00000029818; ENSRNOP00000034483; ENSRNOG00000026958.
GeneID; 500077; -.
KEGG; rno:500077; -.
UCSC; RGD:1563238; rat.
CTD; 78996; -.
RGD; 1563238; Cyren.
eggNOG; ENOG502SEX2; Eukaryota.
GeneTree; ENSGT00390000013192; -.
HOGENOM; CLU_126072_0_0_1; -.
InParanoid; Q6AYH4; -.
OMA; AKAPKRM; -.
OrthoDB; 1349796at2759; -.
PhylomeDB; Q6AYH4; -.
TreeFam; TF336925; -.
PRO; PR:Q6AYH4; -.
Proteomes; UP000002494; Chromosome 4.
Bgee; ENSRNOG00000026958; Expressed in testis and 21 other tissues.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; ISS:UniProtKB.
GO; GO:0033152; P:immunoglobulin V(D)J recombination; ISS:UniProtKB.
GO; GO:2001033; P:negative regulation of double-strand break repair via nonhomologous end joining; ISS:UniProtKB.
InterPro; IPR028278; MRI.
PANTHER; PTHR14566; PTHR14566; 1.
Pfam; PF15325; MRI; 1.
2: Evidence at transcript level;
Acetylation; Chromosome; Cytoplasm; DNA damage; DNA repair; Nucleus;
Reference proteome.
CHAIN 1..160
/note="Cell cycle regulator of non-homologous end joining"
/id="PRO_0000320950"
REGION 78..152
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOTIF 1..21
/note="KBM"
/evidence="ECO:0000250|UniProtKB:Q9BWK5"
MOTIF 150..160
/note="XLM"
/evidence="ECO:0000250|UniProtKB:Q9BWK5"
MOD_RES 1
/note="N-acetylmethionine"
/evidence="ECO:0000250|UniProtKB:Q9BWK5"
SEQUENCE 160 AA; 17487 MW; 71E404D667390822 CRC64;
METLKSDNKK RVLPSWMTAP GNERKVVSVK TAKRKQTAAI RVGAATRAPA KETVYCMNEA
EMVDVALGIL IEGRKQEKPW EQPSLVAPDK LQLSPPCSES PHTSSPGSSS EEEDSRTDSP
ALGLSPARGP EASNSPCSRS PEEGKEEEDE LKYVREIFFS


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Related Genes :
[CYREN C7orf49 MRI] Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection homolog)
[Cyren Mri] Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection homolog)
[CYREN MRI] Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection)
[INTS13 ASUN C12orf11 GCT1] Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95)
[Asun IntS13 Mat89Bb ovary2 CG6814] Protein asunder (Cell cycle regulator Mat89Bb) (Integrator complex subunit 13) (Maternal transcript 89Bb) (Set apart in position or space protein)
[Cyren Mri] Cell cycle regulator of non-homologous end joining (Cell cycle regulator of NHEJ) (Modulator of retrovirus infection homolog)
[CCAR1 CARP1 DIS] Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)
[RCC1 CHC1] Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)
[Ccar1 Carp1] Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1)
[NBN NBS NBS1 P95] Nibrin (Cell cycle regulatory protein p95) (Nijmegen breakage syndrome protein 1)
[IntS13 Asun Spata30] Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Protein asunder homolog) (Spermatogenesis-associated protein 30)
[Nhej1 Xlf] Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)
[CDK13 CDC2L CDC2L5 CHED KIAA1791] Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)
[TAF1 BA2R CCG1 CCGS TAF2A] Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
[RAD17 R24L] Cell cycle checkpoint protein RAD17 (hRad17) (RF-C/activator 1 homolog)
[CHEK1 CHK1] Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
[RAD1 REC1] Cell cycle checkpoint protein RAD1 (hRAD1) (EC 3.1.11.2) (DNA repair exonuclease rad1 homolog) (Rad1-like DNA damage checkpoint protein)
[CDC36 DNA19 NOT2 YDL165W] General negative regulator of transcription subunit 2 (cell division cycle protein 36)
[CDC48 YDL126C] Cell division control protein 48 (EC 3.6.4.6) (Cell division cycle protein 48) (Transitional endoplasmic reticulum ATPase homolog)
[ligD MSMEG_5570 MSMEI_5419] Multifunctional non-homologous end joining protein LigD (NHEJ DNA polymerase) [Includes: DNA repair polymerase (Pol) (Polymerase/primase); 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase) (PE); DNA ligase (Lig) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])]
[RAD9A] Cell cycle checkpoint control protein RAD9A (hRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A)
[CDC39 NOT1 ROS1 YCR093W YCR1151 YCR93W] General negative regulator of transcription subunit 1 (Cell division cycle protein 39)
[Rad9a Rad9] Cell cycle checkpoint control protein RAD9A (mRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) (Rad9-like protein)
[ligD Rv0938 MTCY08D9.01c MTCY10D7.36c] Multifunctional non-homologous end joining DNA repair protein LigD (NHEJ DNA repair protein D) (Mt-Lig) (NHEJ DNA polymerase) [Includes: DNA repair polymerase (Pol) (Polymerase/primase); 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase) (PE); DNA ligase (Lig) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])]
[Cdk11b Cdc2l1 Cdk11] Cyclin-dependent kinase 11B (Cell division cycle 2-like protein kinase 1) (Cell division protein kinase 11) (Cyclin-dependent kinase 11) (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1)
[TBRG4 CPR2 FASTKD4 KIAA0948] FAST kinase domain-containing protein 4 (Cell cycle progression restoration protein 2) (Cell cycle progression protein 2) (Protein TBRG4) (Transforming growth factor beta regulator 4)
[NHEJ1 XLF] Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)
[CDK9 CDC2L4 TAK] Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
[cdc-48.1 C06A1.1] Transitional endoplasmic reticulum ATPase homolog 1 (EC 3.6.4.6) (Cell division cycle-related protein 48.1) (p97/CDC48 homolog 1)
[cdc-48.2 C41C4.8] Transitional endoplasmic reticulum ATPase homolog 2 (EC 3.6.4.6) (Cell division cycle-related protein 48.2) (p97/CDC48 homolog 2)

Bibliography :