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Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1)

 CCAR1_MOUSE             Reviewed;        1146 AA.
Q8CH18; Q05BR1; Q05DK6; Q6AXC9; Q6PAR2; Q80XE4; Q8BJY0; Q8BVN2; Q8CGG1;
Q9CSR5;
02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
12-AUG-2020, entry version 135.
RecName: Full=Cell division cycle and apoptosis regulator protein 1;
AltName: Full=Cell cycle and apoptosis regulatory protein 1;
Short=CARP-1;
Name=Ccar1; Synonyms=Carp1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
STRAIN=Swiss Webster;
Tian Y., Li D., Benjamin T.;
"TAZ binding partners identified by mass spectrometry.";
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Embryo, Testis, and Wolffian duct;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
[LARGE SCALE MRNA] OF 1-833 (ISOFORM 1), AND NUCLEOTIDE SEQUENCE [LARGE
SCALE MRNA] OF 1-797 (ISOFORM 3).
STRAIN=C57BL/6J, Czech II, and FVB/N;
TISSUE=Brain, Kidney, and Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
FUNCTION, AND INTERACTION WITH CALCOCO1; ESR1; NR3C AND TP53.
PubMed=18722177; DOI=10.1016/j.molcel.2008.08.001;
Kim J.H., Yang C.K., Heo K., Roeder R.G., An W., Stallcup M.R.;
"CCAR1, a key regulator of mediator complex recruitment to nuclear receptor
transcription complexes.";
Mol. Cell 31:510-519(2008).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Pancreas, Spleen, and
Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[6]
FUNCTION.
PubMed=23887938; DOI=10.1093/nar/gkt644;
Seo W.Y., Jeong B.C., Yu E.J., Kim H.J., Kim S.H., Lim J.E., Kwon G.Y.,
Lee H.M., Kim J.H.;
"CCAR1 promotes chromatin loading of androgen receptor (AR) transcription
complex by stabilizing the association between AR and GATA2.";
Nucleic Acids Res. 41:8526-8536(2013).
[7]
FUNCTION, AND INTERACTION WITH MED1; GATA1 AND CALCOCO1.
PubMed=24245781; DOI=10.1111/gtc.12104;
Mizuta S., Minami T., Fujita H., Kaminaga C., Matsui K., Ishino R.,
Fujita A., Oda K., Kawai A., Hasegawa N., Urahama N., Roeder R.G., Ito M.;
"CCAR1/CoCoA pair-mediated recruitment of the Mediator defines a novel
pathway for GATA1 function.";
Genes Cells 19:28-51(2014).
-!- FUNCTION: Associates with components of the Mediator and p160
coactivator complexes that play a role as intermediaries transducing
regulatory signals from upstream transcriptional activator proteins to
basal transcription machinery at the core promoter. Recruited to
endogenous nuclear receptor target genes in response to the appropriate
hormone. Also functions as a p53 coactivator. May thus play an
important role in transcriptional regulation. May be involved in
apoptosis signaling in the presence of the retinoid CD437. Apoptosis
induction involves sequestration of 14-3-3 protein(s) and mediated
altered expression of multiple cell cycle regulatory genes including
MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or
cell proliferation (By similarity). In association with CALCOCO1
enhances GATA1- and MED1-mediated transcriptional activation from the
gamma-globin promoter during erythroid differentiation of K562
erythroleukemia cells (PubMed:24245781). Can act as a both a
coactivator and corepressor of AR-mediated transcription. Contributes
to chromatin looping and AR transcription complex assembly by
stabilizing AR-GATA2 association on chromatin and facilitating MED1 and
RNA polymerase II recruitment to AR-binding sites. May play an
important role in the growth and tumorigenesis of prostate cancer cells
(PubMed:23887938). {ECO:0000250|UniProtKB:Q8IX12,
ECO:0000269|PubMed:23887938, ECO:0000269|PubMed:24245781}.
-!- SUBUNIT: Directly interacts with ESR1, NR3C1 and p53/TP53. Interacts
(via N-terminus) with CALCOCO1. Interacts with MED1 and GATA1.
Interacts with AR and GATA2 (By similarity).
{ECO:0000250|UniProtKB:Q8IX12, ECO:0000269|PubMed:18722177,
ECO:0000269|PubMed:24245781}.
-!- SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q8CH18-1; Sequence=Displayed;
Name=2;
IsoId=Q8CH18-2; Sequence=VSP_018054, VSP_018055;
Name=3;
IsoId=Q8CH18-3; Sequence=VSP_037737;
-!- SEQUENCE CAUTION:
Sequence=AAH10199.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=AAH34174.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=AAH39939.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=AAH51052.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=AAH60130.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
Sequence=AAH79652.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
---------------------------------------------------------------------------
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EMBL; AF465615; AAO17318.1; -; mRNA.
EMBL; AK012111; BAB28040.2; -; mRNA.
EMBL; AK077151; BAC36646.1; -; mRNA.
EMBL; AK078424; BAC37267.1; -; mRNA.
EMBL; BC010199; AAH10199.1; ALT_SEQ; mRNA.
EMBL; BC034174; AAH34174.1; ALT_SEQ; mRNA.
EMBL; BC039939; AAH39939.1; ALT_SEQ; mRNA.
EMBL; BC051052; AAH51052.1; ALT_SEQ; mRNA.
EMBL; BC060130; AAH60130.1; ALT_SEQ; mRNA.
EMBL; BC079652; AAH79652.1; ALT_SEQ; mRNA.
CCDS; CCDS35922.1; -. [Q8CH18-1]
RefSeq; NP_080477.1; NM_026201.3. [Q8CH18-1]
RefSeq; XP_006514057.1; XM_006513994.3. [Q8CH18-1]
RefSeq; XP_006514058.1; XM_006513995.3. [Q8CH18-1]
RefSeq; XP_006514059.1; XM_006513996.3. [Q8CH18-1]
RefSeq; XP_006514060.1; XM_006513997.2. [Q8CH18-3]
RefSeq; XP_011241839.1; XM_011243537.2. [Q8CH18-1]
SMR; Q8CH18; -.
BioGRID; 212231; 9.
IntAct; Q8CH18; 6.
MINT; Q8CH18; -.
STRING; 10090.ENSMUSP00000020268; -.
iPTMnet; Q8CH18; -.
PhosphoSitePlus; Q8CH18; -.
EPD; Q8CH18; -.
jPOST; Q8CH18; -.
PaxDb; Q8CH18; -.
PeptideAtlas; Q8CH18; -.
PRIDE; Q8CH18; -.
Antibodypedia; 2118; 192 antibodies.
Ensembl; ENSMUST00000020268; ENSMUSP00000020268; ENSMUSG00000020074. [Q8CH18-1]
Ensembl; ENSMUST00000219527; ENSMUSP00000151895; ENSMUSG00000020074. [Q8CH18-1]
GeneID; 67500; -.
KEGG; mmu:67500; -.
UCSC; uc007fja.2; mouse. [Q8CH18-1]
UCSC; uc007fjc.2; mouse. [Q8CH18-2]
UCSC; uc011xff.1; mouse. [Q8CH18-3]
CTD; 55749; -.
MGI; MGI:1914750; Ccar1.
eggNOG; KOG4246; Eukaryota.
GeneTree; ENSGT00530000063672; -.
HOGENOM; CLU_008030_0_0_1; -.
InParanoid; Q8CH18; -.
OMA; LRYSDMH; -.
OrthoDB; 614048at2759; -.
PhylomeDB; Q8CH18; -.
TreeFam; TF316387; -.
Reactome; R-MMU-72163; mRNA Splicing - Major Pathway.
BioGRID-ORCS; 67500; 5 hits in 18 CRISPR screens.
ChiTaRS; Ccar1; mouse.
PRO; PR:Q8CH18; -.
Proteomes; UP000000589; Chromosome 10.
RNAct; Q8CH18; protein.
Bgee; ENSMUSG00000020074; Expressed in pes and 279 other tissues.
Genevisible; Q8CH18; MM.
GO; GO:0005641; C:nuclear envelope lumen; ISO:MGI.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0030374; F:nuclear receptor transcription coactivator activity; ISO:MGI.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
GO; GO:0003713; F:transcription coactivator activity; IMP:UniProtKB.
GO; GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
Gene3D; 1.10.720.30; -; 1.
InterPro; IPR025224; CCAR1/CCAR2.
InterPro; IPR025954; DBC1/CARP1_inactive_NUDIX_dom.
InterPro; IPR011992; EF-hand-dom_pair.
InterPro; IPR025223; S1-like_RNA-bd_dom.
InterPro; IPR003034; SAP_dom.
InterPro; IPR036361; SAP_dom_sf.
PANTHER; PTHR14304; PTHR14304; 1.
Pfam; PF14443; DBC1; 1.
Pfam; PF14444; S1-like; 1.
Pfam; PF02037; SAP; 1.
SMART; SM01122; DBC1; 1.
SMART; SM00513; SAP; 1.
SUPFAM; SSF47473; SSF47473; 1.
SUPFAM; SSF68906; SSF68906; 1.
PROSITE; PS50800; SAP; 1.
1: Evidence at protein level;
Activator; Alternative splicing; Apoptosis; Cell cycle; Coiled coil;
Cytoplasm; Isopeptide bond; Phosphoprotein; Reference proteome; Repressor;
Transcription; Transcription regulation; Ubl conjugation.
CHAIN 1..1146
/note="Cell division cycle and apoptosis regulator protein
1"
/id="PRO_0000233149"
DOMAIN 633..667
/note="SAP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00186"
REGION 1..246
/note="Interaction with AR"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
REGION 200..657
/note="Interaction with GATA2"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
REGION 640..1146
/note="Interaction with GATA1"
/evidence="ECO:0000269|PubMed:24245781"
COILED 591..615
/evidence="ECO:0000255"
COILED 1029..1110
/evidence="ECO:0000255"
COMPBIAS 3..287
/note="Gln-rich"
COMPBIAS 290..358
/note="Arg-rich"
COMPBIAS 670..886
/note="Glu-rich"
MOD_RES 453
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
MOD_RES 624
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
MOD_RES 664
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
MOD_RES 682
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
MOD_RES 694
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
MOD_RES 858
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
CROSSLNK 634
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in ubiquitin)"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
CROSSLNK 1008
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO1); alternate"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
CROSSLNK 1008
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2); alternate"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
CROSSLNK 1063
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2)"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
CROSSLNK 1131
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2)"
/evidence="ECO:0000250|UniProtKB:Q8IX12"
VAR_SEQ 316..327
/note="SRERDRERRRSR -> RYVLRQCGGLEK (in isoform 2)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_018054"
VAR_SEQ 328..1146
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_018055"
VAR_SEQ 638..699
/note="Missing (in isoform 3)"
/evidence="ECO:0000303|PubMed:15489334"
/id="VSP_037737"
CONFLICT 279
/note="P -> L (in Ref. 3; AAH79652)"
/evidence="ECO:0000305"
CONFLICT 558
/note="T -> A (in Ref. 3; AAH39939)"
/evidence="ECO:0000305"
CONFLICT 802
/note="K -> E (in Ref. 2; BAC37267)"
/evidence="ECO:0000305"
CONFLICT 821
/note="E -> G (in Ref. 2; BAC37267)"
/evidence="ECO:0000305"
SEQUENCE 1146 AA; 132060 MW; 6005A057B4F0BFF0 CRC64;
MAQFGGQKNP PWATQFTATA VSQPAALGVQ QPSLLGASPT IYTQQTALAA AGLTTQTPAN
YQLTQTAALQ QQAAAVLQQQ YSQPQQALYS VQQQLQQPQQ TILTQPAVAL PTSLSLSTPQ
PAAQITVSYP TPRSSQQQTQ PQKQRVFTGV VTKLHDTFGF VDEDVFFQLG AVKGKTPQVG
DRVLVEATYN PNMPFKWNAQ RIQTLPNQNQ SQTQPLLKTP TAVIQPIVPQ TTFGVQAQPQ
PQSLLQAQIS AASITPLLQT QPQPLLQQPQ QKAGLLQPPV RIVSQPQPAR RLDPPSRFSG
RNDRGDQVPN RKDDRSRERD RERRRSRERS PQRKRSRERS PRRERERSPR RVRRVVPRYT
VQFSKFSLDC PSCDMMELRR RYQNLYIPSD FFDAQFTWVD AFPLSRPFQL GNYCNFYVMH
REVESLEKNM AVLDPPDADH LYSAKVMLMA SPSMEDLYHK SCALAEDPQD LRDGFQHPAR
LVKFLVGMKG KDEAMAIGGH WSPSLDGPNP EKDPSVLIKT AIRCCKALTG IDLSVCTQWY
RFAEIRYHRP EETHKGRTVP AHVETVVLFF PDVWHCLPTR SEWETLSRGY KQQLVEKLQG
ERKKADGEQD EEEKDDGEVK EIATPTHWSK LDPKAMKVND LRKELESRAL SSKGLKSQLI
ARLTKQLKIE EQKEEQKELE KSEKEEEDED DKKSEDDKEE EERKRQEEVE RQRQERRYIL
PDEPAIIVHP NWAAKSGKFD CSIMSLSVLL DYRLEDNKEH SFEVSLFAEL FNEMLQRDFG
VRIYKSLLSL PEKEDKKDKE KKSKKEERKD KKEEREDDID EPKPKRRKSG DDKDKKEDRD
ERKKEEKRKD DSKDDDETEE DNNQDEYDPM EAEEAEDEDD DREEEEVKRD DKRDVSRYCK
DRPAKDKEKE KPQMVTVNRD LLMAFVYFDQ SHCGYLLEKD LEEILYTLGL HLSRAQVKKL
LNKVVLRESC FYRKLTDTSK DDENHEESEA LQEDMLGNRL LLPTPTIKQE SKDGEENVGL
IVYNGAMVDV GSLLQKLEKS EKVRAEVEQK LQLLEEKTDE DGKTILNLEN SNKSLSGELR
EVKKDLGQLQ ENLEVSENMN LQFENQLNKT LRNLSTVMDD IHTVLKKDNV KSEDRDEKSK
ENGSGV


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WP179: Cell cycle
WP1078: G1 to S cell cycle control
WP348: G1 to S cell cycle control
WP2152: BDNF
WP2414: Quercetin and Nf-kB/ AP-1 induced cell apoptosis
WP413: G1 to S cell cycle control
WP2272: Pathogenic Escherichia coli infection
WP429: Cell cycle
WP1200: Cell cycle
WP45: G1 to S cell cycle control
WP2328: Allograft rejection
WP959: G1 to S cell cycle control
WP1083: Cell cycle
WP1900: Regulation of mitotic cell cycle
WP840: G1 to S cell cycle control
WP2435: Quercetin and Nf-kB/ AP-1 induced cell apoptosis
WP445: G1 to S cell cycle control
WP1566: Citrate cycle (TCA cycle)
WP1782: APC/C-mediated degradation of cell cycle proteins
WP1792: Cell Cycle, Mitotic

Related Genes :
[CCAR1 CARP1 DIS] Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)
[Ccar1 Carp1] Cell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1)
[Cdk11b Cdc2l1 Cdk11] Cyclin-dependent kinase 11B (Cell division cycle 2-like protein kinase 1) (Cell division protein kinase 11) (Cyclin-dependent kinase 11) (EC 2.7.11.22) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1)
[CDK11B CDC2L1 CDK11 PITSLREA PK58] Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)
[CDCA7 JPO1] Cell division cycle-associated protein 7 (Protein JPO1)
[CFLAR CASH CASP8AP1 CLARP MRIT] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[cdc-48.1 C06A1.1] Transitional endoplasmic reticulum ATPase homolog 1 (EC 3.6.4.6) (Cell division cycle-related protein 48.1) (p97/CDC48 homolog 1)
[RCC1 CHC1] Regulator of chromosome condensation (Cell cycle regulatory protein) (Chromosome condensation protein 1)
[CDC43 CAL1 YGL155W G1864] Geranylgeranyl transferase type-1 subunit beta (GGTase-I-beta) (EC 2.5.1.59) (Cell division cycle protein 43) (Geranylgeranyl transferase type I subunit beta) (RAS proteins geranylgeranyltransferase subunit beta) (Type I protein geranyl-geranyltransferase subunit beta) (PGGTase I beta)
[Aifm1 Aif Pdcd8] Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)
[CDK11A CDC2L2 CDC2L3 PITSLREB] Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)
[tax] Protein Tax-1 (Protein X-LOR) (Protein PX) (Trans-activating transcriptional regulatory protein of HTLV-1)
[AIFM1 AIF PDCD8] Apoptosis-inducing factor 1, mitochondrial (EC 1.6.99.-) (Programmed cell death protein 8)
[CHEK1 CHK1] Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)
[SEPTIN4 ARTS PNUTL2 SEP4 SEPT4 hucep-7] Septin-4 (Apoptosis-related protein in the TGF-beta signaling pathway) (ARTS) (Bradeion beta) (Brain protein H5) (CE5B3 beta) (Cell division control-related protein 2) (hCDCREL-2) (Cerebral protein 7) (Peanut-like protein 2)
[Cflar Cash] CASP8 and FADD-like apoptosis regulator (Caspase homolog) (CASH) (Caspase-eight-related protein) (Casper) (Caspase-like apoptosis regulatory protein) (CLARP) (Cellular FLICE-like inhibitory protein) (c-FLIP) (FADD-like antiapoptotic molecule 1) (FLAME-1) (Inhibitor of FLICE) (I-FLICE) (MACH-related inducer of toxicity) (MRIT) (Usurpin) [Cleaved into: CASP8 and FADD-like apoptosis regulator subunit p43; CASP8 and FADD-like apoptosis regulator subunit p12]
[cdc-14 C17G10.4] Tyrosine-protein phosphatase cdc-14 (EC 3.1.3.48) (Cell division cycle-related protein 14)
[Taf1 Ccg1] Transcription initiation factor TFIID subunit 1 (EC 2.3.1.48) (EC 2.7.11.1) (Cell cycle gene 1 protein) (TBP-associated factor 250 kDa) (p250) (Transcription initiation factor TFIID 250 kDa subunit) (TAF(II)250) (TAFII-250) (TAFII250)
[CDC39 NOT1 ROS1 YCR093W YCR1151 YCR93W] General negative regulator of transcription subunit 1 (Cell division cycle protein 39)
[CDC7 CDC7L1] Cell division cycle 7-related protein kinase (CDC7-related kinase) (HsCdc7) (huCdc7) (EC 2.7.11.1)
[INTS13 ASUN C12orf11 GCT1] Integrator complex subunit 13 (Cell cycle regulator Mat89Bb homolog) (Germ cell tumor 1) (Protein asunder homolog) (Sarcoma antigen NY-SAR-95)
[Asun IntS13 Mat89Bb ovary2 CG6814] Protein asunder (Cell cycle regulator Mat89Bb) (Integrator complex subunit 13) (Maternal transcript 89Bb) (Set apart in position or space protein)
[CDK13 CDC2L CDC2L5 CHED KIAA1791] Cyclin-dependent kinase 13 (EC 2.7.11.22) (EC 2.7.11.23) (CDC2-related protein kinase 5) (Cell division cycle 2-like protein kinase 5) (Cell division protein kinase 13) (hCDK13) (Cholinesterase-related cell division controller)
[Rad9a Rad9] Cell cycle checkpoint control protein RAD9A (mRAD9) (EC 3.1.11.2) (DNA repair exonuclease rad9 homolog A) (Rad9-like protein)
[TRIAP1 15E1.1 HSPC132] TP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV)
[CDK1 CDC2 CDC28A CDKN1 P34CDC2] Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
[BIRC2 API1 MIHB RNF48] Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
[CDK9 CDC2L4 TAK] Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit)
[Cdc7 Cdc7l1] Cell division cycle 7-related protein kinase (CDC7-related kinase) (muCdc7) (EC 2.7.11.1)
[CDC36 DNA19 NOT2 YDL165W] General negative regulator of transcription subunit 2 (cell division cycle protein 36)

Bibliography :
[28115244] Identification, expression pattern and functional characterization of As-kip2 in diapause embryo restarting process of Artemia sinica.
[27687593] CARP-1 functional mimetics are novel inhibitors of drug-resistant triple negative breast cancers.
[26485930] Identification and Testing of Novel CARP-1 Functional Mimetic Compounds as Inhibitors of Non-Small Cell Lung and Triple Negative Breast Cancers.
[26260694] PTHrP attenuates osteoblast cell death and apoptosis induced by a novel class of anti-cancer agents.
[25894788] CARP-1/CCAR1: a biphasic regulator of cancer cell growth and apoptosis.
[25610865] DBC1/CCAR2 and CCAR1 Are Largely Disordered Proteins that Have Evolved from One Common Ancestor.
[25033461] Mechanisms of neuroblastoma cell growth inhibition by CARP-1 functional mimetics.
[24690739] Disulfiram suppresses growth of the malignant pleural mesothelioma cells in part by inducing apoptosis.
[23826121] CARP-1 functional mimetics: a novel class of small molecule inhibitors of medulloblastoma cell growth.
[23764399] Cell cycle and apoptosis regulatory protein (CARP)-1 is expressed in osteoblasts and regulated by PTH.