GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Cellular communication network factor 6 (CCN family member 6) (WNT1-inducible-signaling pathway protein 3) (WISP-3)

 CCN6_HUMAN              Reviewed;         354 AA.
O95389; Q3KR29; Q5H8W4; Q6UXH6;
15-AUG-2003, integrated into UniProtKB/Swiss-Prot.
01-MAY-1999, sequence version 1.
13-NOV-2019, entry version 155.
RecName: Full=Cellular communication network factor 6;
AltName: Full=CCN family member 6;
AltName: Full=WNT1-inducible-signaling pathway protein 3 {ECO:0000303|PubMed:9843955};
Short=WISP-3 {ECO:0000303|PubMed:9843955};
Flags: Precursor;
Name=CCN6 {ECO:0000312|HGNC:HGNC:12771};
Synonyms=WISP3 {ECO:0000312|HGNC:HGNC:12771};
ORFNames=UNQ462/PRO790/PRO956;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
TISSUE=Bone marrow, and Fetal kidney;
PubMed=9843955; DOI=10.1073/pnas.95.25.14717;
Pennica D., Swanson T.A., Welsh J.W., Roy M.A., Lawrence D.A., Lee J.,
Brush J., Taneyhill L.A., Deuel B., Lew M., Watanabe C., Cohen R.L.,
Melham M.F., Finley G.G., Quirke P., Goddard A.D., Hillan K.J.,
Gurney A.L., Botstein D., Levine A.J.;
"WISP genes are members of the connective tissue growth factor family
that are up-regulated in wnt-1-transformed cells and aberrantly
expressed in human colon tumors.";
Proc. Natl. Acad. Sci. U.S.A. 95:14717-14722(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
PubMed=12975309; DOI=10.1101/gr.1293003;
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S.,
Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J.,
Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J.,
Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A.,
Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H.,
Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D.,
Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale
effort to identify novel human secreted and transmembrane proteins: a
bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=14574404; DOI=10.1038/nature02055;
Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E.,
Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R.,
Almeida J.P., Ambrose K.D., Andrews T.D., Ashwell R.I.S.,
Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J.,
Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P.,
Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y.,
Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E.,
Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A.,
Frankland J., French L., Garner P., Garnett J., Ghori M.J.,
Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M.,
Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S.,
Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R.,
Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E.,
Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A.,
Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C.,
Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M.,
Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K.,
McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T.,
Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R.,
Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W.,
Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M.,
Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L.,
Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J.,
Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L.,
Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W.,
Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A.,
Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.;
"The DNA sequence and analysis of human chromosome 6.";
Nature 425:805-811(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
SUBCELLULAR LOCATION, AND FUNCTION.
PubMed=27252383; DOI=10.1242/jcs.186247;
Patra M., Mahata S.K., Padhan D.K., Sen M.;
"CCN6 regulates mitochondrial function.";
J. Cell Sci. 129:2841-2851(2016).
[7]
INVOLVEMENT IN PPAC, VARIANTS PPAC ARG-78 AND TYR-145, VARIANT HIS-56,
TISSUE SPECIFICITY, AND FUNCTION.
PubMed=10471507; DOI=10.1038/12699;
Hurvitz J.R., Suwairi W.M., Van Hul W., El-Shanti H.,
Superti-Furga A., Roudier J., Holderbaum D., Pauli R.M., Herd J.K.,
Van Hul E.V., Rezai-Delui H., Legius E., Le Merrer M., Al-Alami J.,
Bahabri S.A., Warman M.L.;
"Mutations in the CCN gene family member WISP3 cause progressive
pseudorheumatoid dysplasia.";
Nat. Genet. 23:94-98(1999).
[8]
VARIANTS PPAC 52-CYS--LEU-354 DEL AND ARG-78, AND VARIANTS HIS-56 AND
GLU-83.
PubMed=16152649; DOI=10.1002/ajmg.a.30906;
Delague V., Chouery E., Corbani S., Ghanem I., Aamar S., Fischer J.,
Levy-Lahad E., Urtizberea J.A., Megarbane A.;
"Molecular study of WISP3 in nine families originating from the
Middle-East and presenting with progressive pseudorheumatoid
dysplasia: identification of two novel mutations, and description of a
founder effect.";
Am. J. Med. Genet. A 138A:118-126(2005).
[9]
VARIANTS PPAC 46-GLN--LEU-354 DEL AND TYR-114.
PubMed=19064006; DOI=10.1016/j.bone.2008.11.005;
Yue H., Zhang Z.L., He J.W.;
"Identification of novel mutations in WISP3 gene in two unrelated
Chinese families with progressive pseudorheumatoid dysplasia.";
Bone 44:547-554(2009).
[10]
VARIANTS PPAC 52-CYS--LEU-354 DEL; TYR-78; ARG-114; 116-TYR--LEU-354
DEL; ARG-145; PRO-228; GLY-268 AND TYR-337, AND VARIANT GLU-83.
PubMed=22987568; DOI=10.1002/ajmg.a.35620;
Dalal A., Bhavani G.S., Togarrati P.P., Bierhals T., Nandineni M.R.,
Danda S., Danda D., Shah H., Vijayan S., Gowrishankar K., Phadke S.R.,
Bidchol A.M., Rao A.P., Nampoothiri S., Kutsche K., Girisha K.M.;
"Analysis of the WISP3 gene in Indian families with progressive
pseudorheumatoid dysplasia.";
Am. J. Med. Genet. A 158A:2820-2828(2012).
[11]
VARIANTS PPAC TRP-114 AND PRO-334.
PubMed=22685593; DOI=10.1371/journal.pone.0038643;
Sun J., Xia W., He S., Zhao Z., Nie M., Li M., Jiang Y., Xing X.,
Wang O., Meng X., Zhou X.;
"Novel and recurrent mutations of WISP3 in two Chinese families with
progressive pseudorheumatoid dysplasia.";
PLoS ONE 7:E38643-E38643(2012).
[12]
VARIANTS PPAC 52-CYS--LEU-354 DEL; TYR-78; PHE-99; SER-100;
116-TYR--LEU-354 DEL; ARG-145; 177-SER--LEU-354 DEL; VAL-226 AND
TYR-337.
PubMed=25988854; DOI=10.1002/ajmg.a.37164;
Bhavani G.S., Shah H., Dalal A.B., Shukla A., Danda S., Aggarwal S.,
Phadke S.R., Gupta N., Kabra M., Gowrishankar K., Gupta A., Bhat M.,
Puri R.D., Bijarnia-Mahay S., Nampoothiri S., Mohanasundaram K.M.,
Rajeswari S., Kulkarni A.M., Kulkarni M.L., Ranganath P.,
Ramadevi A.R., Hariharan S.V., Girisha K.M.;
"Novel and recurrent mutations in WISP3 and an atypical phenotype.";
Am. J. Med. Genet. A 167A:2481-2484(2015).
[13]
VARIANTS PPAC GLY-223 AND 252-CYS--LEU-354 DEL.
PubMed=25794430; DOI=10.1016/j.gene.2015.03.029;
Luo H., Shi C., Mao C., Jiang C., Bao D., Guo J., Du P., Wang Y.,
Liu Y., Liu X., Song B., Xu Y.;
"A novel compound WISP3 mutation in a Chinese family with progressive
pseudorheumatoid dysplasia.";
Gene 564:35-38(2015).
[14]
VARIANTS PPAC 46-GLN--LEU-354 DEL; TRP-114; GLY-223 AND
286-SER--LEU-354 DEL.
PubMed=25738435; DOI=10.3892/mmr.2015.3430;
Yu Y., Hu M., Xing X., Li F., Song Y., Luo Y., Ma H.;
"Identification of a mutation in the WISP3 gene in three unrelated
families with progressive pseudorheumatoid dysplasia.";
Mol. Med. Report. 12:419-425(2015).
[15]
VARIANTS PPAC 52-CYS--LEU-354 DEL; TYR-78; 116-TYR--LEU-354 DEL;
VAL-226 AND TYR-337.
PubMed=27436824; DOI=10.1302/2046-3758.57.2000520;
Madhuri V., Santhanam M., Rajagopal K., Sugumar L.K., Balaji V.;
"WISP3 mutational analysis in Indian patients diagnosed with
progressive pseudorheumatoid dysplasia and report of a novel mutation
at p.Y198.";
Bone Joint Res. 5:301-306(2016).
[16]
VARIANT PPAC 52-CYS--LEU-354 DEL.
PubMed=29092958; DOI=10.1101/mcs.a001990;
Sailani M.R., Chappell J., Jingga I., Narasimha A., Zia A.,
Lynch J.L., Mazrouei S., Bernstein J.A., Aryani O., Snyder M.P.;
"WISP3 mutation associated with pseudorheumatoid dysplasia.";
Cold Spring Harb. Mol. Case Stud. 4:0-0(2018).
-!- FUNCTION: Plays a role in mitochondrial electron transport and
mitochondrial respiration (PubMed:27252383). Through its
regulation of the mitochondrial function may play a role in normal
postnatal skeletal growth and cartilage homeostasis
(PubMed:27252383, PubMed:10471507). {ECO:0000269|PubMed:10471507,
ECO:0000269|PubMed:27252383}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27252383}.
Mitochondrion {ECO:0000269|PubMed:27252383}. Note=Associated with
membranes. {ECO:0000269|PubMed:27252383}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=O95389-1; Sequence=Displayed;
Name=2;
IsoId=O95389-2; Sequence=VSP_037803;
-!- TISSUE SPECIFICITY: Predominant expression in adult kidney and
testis and fetal kidney. Weaker expression found in placenta,
ovary, prostate and small intestine (PubMed:9843955,
PubMed:10471507). Also expressed in skeletally-derived cells such
as synoviocytes and articular cartilage chondrocytes
(PubMed:10471507). {ECO:0000269|PubMed:10471507,
ECO:0000269|PubMed:9843955}.
-!- DISEASE: Progressive pseudorheumatoid arthropathy of childhood
(PPAC) [MIM:208230]: Autosomal recessive disorder characterized by
stiffness and swelling of joints, motor weakness and joint
contractures. Signs and symptoms of the disease develop typically
between three and eight years of age. This progressive disease is
a primary disorder of articular cartilage with continued cartilage
loss and destructive bone changes with aging.
{ECO:0000269|PubMed:10471507, ECO:0000269|PubMed:16152649,
ECO:0000269|PubMed:19064006, ECO:0000269|PubMed:22685593,
ECO:0000269|PubMed:22987568, ECO:0000269|PubMed:25738435,
ECO:0000269|PubMed:25794430, ECO:0000269|PubMed:25988854,
ECO:0000269|PubMed:27436824, ECO:0000269|PubMed:29092958}.
Note=The disease is caused by mutations affecting the gene
represented in this entry.
-!- SIMILARITY: Belongs to the CCN family. {ECO:0000305}.
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/WISP3ID469ch6q22.html";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF100781; AAC96323.1; -; mRNA.
EMBL; AY358349; AAQ88715.1; -; mRNA.
EMBL; AY358350; AAQ88716.1; -; mRNA.
EMBL; Z99289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AL512299; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471051; EAW48273.1; -; Genomic_DNA.
EMBL; CH471051; EAW48275.1; -; Genomic_DNA.
EMBL; BC105941; AAI05942.1; -; mRNA.
CCDS; CCDS5097.1; -. [O95389-1]
CCDS; CCDS5098.1; -. [O95389-1]
RefSeq; NP_003871.1; NM_003880.3. [O95389-1]
RefSeq; NP_937882.1; NM_198239.1. [O95389-1]
RefSeq; XP_011534522.1; XM_011536220.1. [O95389-1]
SMR; O95389; -.
BioGrid; 114365; 6.
IntAct; O95389; 4.
STRING; 9606.ENSP00000357655; -.
iPTMnet; O95389; -.
PhosphoSitePlus; O95389; -.
BioMuta; WISP3; -.
PaxDb; O95389; -.
PeptideAtlas; O95389; -.
PRIDE; O95389; -.
ProteomicsDB; 50840; -. [O95389-1]
ProteomicsDB; 50841; -. [O95389-2]
Ensembl; ENST00000230529; ENSP00000230529; ENSG00000112761. [O95389-1]
Ensembl; ENST00000361714; ENSP00000354734; ENSG00000112761. [O95389-1]
Ensembl; ENST00000368666; ENSP00000357655; ENSG00000112761. [O95389-2]
Ensembl; ENST00000604763; ENSP00000473777; ENSG00000112761. [O95389-1]
GeneID; 8838; -.
KEGG; hsa:8838; -.
UCSC; uc003pvm.4; human. [O95389-1]
CTD; 8838; -.
DisGeNET; 8838; -.
GeneCards; CCN6; -.
GeneReviews; WISP3; -.
HGNC; HGNC:12771; CCN6.
HPA; HPA062438; -.
HPA; HPA078340; -.
MalaCards; CCN6; -.
MIM; 208230; phenotype.
MIM; 603400; gene.
neXtProt; NX_O95389; -.
OpenTargets; ENSG00000112761; -.
Orphanet; 1159; Progressive pseudorheumatoid arthropathy of childhood.
PharmGKB; PA37374; -.
eggNOG; ENOG410IJZE; Eukaryota.
eggNOG; ENOG4110BH0; LUCA.
GeneTree; ENSGT00940000160119; -.
HOGENOM; HOG000231462; -.
InParanoid; O95389; -.
KO; K23090; -.
OMA; LDKRCCV; -.
OrthoDB; 825025at2759; -.
PhylomeDB; O95389; -.
TreeFam; TF326070; -.
GeneWiki; WNT1-inducible-signaling_pathway_protein_3; -.
GenomeRNAi; 8838; -.
Pharos; O95389; -.
PRO; PR:O95389; -.
Proteomes; UP000005640; Chromosome 6.
Bgee; ENSG00000112761; Expressed in 90 organ(s), highest expression level in tibia.
ExpressionAtlas; O95389; baseline and differential.
Genevisible; O95389; HS.
GO; GO:0005783; C:endoplasmic reticulum; IDA:HPA.
GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0008201; F:heparin binding; IBA:GO_Central.
GO; GO:0005520; F:insulin-like growth factor binding; IEA:InterPro.
GO; GO:0005178; F:integrin binding; IBA:GO_Central.
GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
GO; GO:0060548; P:negative regulation of cell death; IBA:GO_Central.
GO; GO:0051881; P:regulation of mitochondrial membrane potential; IMP:UniProtKB.
GO; GO:1903426; P:regulation of reactive oxygen species biosynthetic process; IMP:UniProtKB.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
Gene3D; 2.20.100.10; -; 1.
InterPro; IPR006207; Cys_knot_C.
InterPro; IPR006208; Glyco_hormone_CN.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR000867; IGFBP-like.
InterPro; IPR012395; IGFBP_CNN.
InterPro; IPR017891; Insulin_GF-bd_Cys-rich_CS.
InterPro; IPR000884; TSP1_rpt.
InterPro; IPR036383; TSP1_rpt_sf.
Pfam; PF00007; Cys_knot; 1.
Pfam; PF00219; IGFBP; 1.
PIRSF; PIRSF036495; IGFBP_rP_CNN; 1.
SMART; SM00041; CT; 1.
SMART; SM00121; IB; 1.
SMART; SM00209; TSP1; 1.
SUPFAM; SSF57184; SSF57184; 1.
SUPFAM; SSF82895; SSF82895; 1.
PROSITE; PS01225; CTCK_2; 1.
PROSITE; PS00222; IGFBP_N_1; 1.
PROSITE; PS51323; IGFBP_N_2; 1.
PROSITE; PS50092; TSP1; 1.
1: Evidence at protein level;
Alternative splicing; Complete proteome; Disease mutation;
Disulfide bond; Glycoprotein; Growth factor; Mitochondrion;
Polymorphism; Reference proteome; Secreted; Signal.
SIGNAL 1 23 {ECO:0000255}.
CHAIN 24 354 Cellular communication network factor 6.
/FTId=PRO_0000014412.
DOMAIN 44 117 IGFBP N-terminal. {ECO:0000255|PROSITE-
ProRule:PRU00653}.
DOMAIN 208 253 TSP type-1. {ECO:0000255|PROSITE-
ProRule:PRU00210}.
DOMAIN 268 342 CTCK. {ECO:0000255|PROSITE-
ProRule:PRU00039}.
CARBOHYD 178 178 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 308 308 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 268 305 {ECO:0000250}.
DISULFID 285 319 {ECO:0000250}.
DISULFID 296 335 {ECO:0000250}.
DISULFID 299 337 {ECO:0000250}.
DISULFID 304 341 {ECO:0000250}.
VAR_SEQ 1 1 M -> MNKRRLLYPSGWLHGPSDM (in isoform 2).
{ECO:0000303|PubMed:12975309,
ECO:0000303|PubMed:15489334}.
/FTId=VSP_037803.
VARIANT 46 354 Missing (in PPAC).
{ECO:0000269|PubMed:19064006,
ECO:0000269|PubMed:25738435}.
/FTId=VAR_081483.
VARIANT 52 354 Missing (in PPAC).
{ECO:0000269|PubMed:16152649,
ECO:0000269|PubMed:22987568,
ECO:0000269|PubMed:25988854,
ECO:0000269|PubMed:27436824,
ECO:0000269|PubMed:29092958}.
/FTId=VAR_081484.
VARIANT 56 56 Q -> H (common polymorphism;
dbSNP:rs1230345).
{ECO:0000269|PubMed:10471507,
ECO:0000269|PubMed:16152649}.
/FTId=VAR_016224.
VARIANT 60 60 R -> C (in dbSNP:rs17073260).
/FTId=VAR_049567.
VARIANT 78 78 C -> R (in PPAC; dbSNP:rs121908902).
{ECO:0000269|PubMed:10471507,
ECO:0000269|PubMed:16152649}.
/FTId=VAR_016225.
VARIANT 78 78 C -> Y (in PPAC).
{ECO:0000269|PubMed:22987568,
ECO:0000269|PubMed:25988854,
ECO:0000269|PubMed:27436824}.
/FTId=VAR_081485.
VARIANT 83 83 G -> E (in dbSNP:rs147337485).
{ECO:0000269|PubMed:16152649,
ECO:0000269|PubMed:22987568}.
/FTId=VAR_081486.
VARIANT 99 99 Y -> F (in PPAC; unknown pathological
significance).
{ECO:0000269|PubMed:25988854}.
/FTId=VAR_081652.
VARIANT 100 100 C -> S (in PPAC; unknown pathological
significance).
{ECO:0000269|PubMed:25988854}.
/FTId=VAR_081653.
VARIANT 114 114 C -> R (in PPAC).
{ECO:0000269|PubMed:22987568}.
/FTId=VAR_081487.
VARIANT 114 114 C -> W (in PPAC).
{ECO:0000269|PubMed:22685593,
ECO:0000269|PubMed:25738435}.
/FTId=VAR_081488.
VARIANT 114 114 C -> Y (in PPAC).
{ECO:0000269|PubMed:19064006}.
/FTId=VAR_081654.
VARIANT 116 354 Missing (in PPAC).
{ECO:0000269|PubMed:22987568,
ECO:0000269|PubMed:25988854,
ECO:0000269|PubMed:27436824}.
/FTId=VAR_081489.
VARIANT 145 145 C -> R (in PPAC; unknown pathological
significance).
{ECO:0000269|PubMed:22987568,
ECO:0000269|PubMed:25988854}.
/FTId=VAR_081490.
VARIANT 145 145 C -> Y (in PPAC; unknown pathological
significance; dbSNP:rs121908899).
{ECO:0000269|PubMed:10471507}.
/FTId=VAR_081655.
VARIANT 177 354 Missing (in PPAC).
{ECO:0000269|PubMed:25988854}.
/FTId=VAR_081656.
VARIANT 223 223 C -> G (in PPAC; dbSNP:rs782813346).
{ECO:0000269|PubMed:25738435,
ECO:0000269|PubMed:25794430}.
/FTId=VAR_081491.
VARIANT 226 226 G -> V (in PPAC).
{ECO:0000269|PubMed:25988854,
ECO:0000269|PubMed:27436824}.
/FTId=VAR_081657.
VARIANT 228 228 S -> P (in PPAC; unknown pathological
significance).
{ECO:0000269|PubMed:22987568}.
/FTId=VAR_081492.
VARIANT 252 354 Missing (in PPAC).
{ECO:0000269|PubMed:25794430}.
/FTId=VAR_081658.
VARIANT 268 268 C -> G (in PPAC; unknown pathological
significance).
{ECO:0000269|PubMed:22987568}.
/FTId=VAR_081493.
VARIANT 286 354 Missing (in PPAC).
{ECO:0000269|PubMed:25738435}.
/FTId=VAR_081494.
VARIANT 334 334 S -> P (in PPAC; dbSNP:rs121908903).
{ECO:0000269|PubMed:22685593}.
/FTId=VAR_081659.
VARIANT 337 337 C -> Y (in PPAC).
{ECO:0000269|PubMed:22987568,
ECO:0000269|PubMed:25988854,
ECO:0000269|PubMed:27436824}.
/FTId=VAR_081495.
CONFLICT 200 200 N -> D (in Ref. 2; AAQ88715).
{ECO:0000305}.
SEQUENCE 354 AA; 39293 MW; 67F48D0D5C2F5EE3 CRC64;
MQGLLFSTLL LAGLAQFCCR VQGTGPLDTT PEGRPGEVSD APQRKQFCHW PCKCPQQKPR
CPPGVSLVRD GCGCCKICAK QPGEICNEAD LCDPHKGLYC DYSVDRPRYE TGVCAYLVAV
GCEFNQVHYH NGQVFQPNPL FSCLCVSGAI GCTPLFIPKL AGSHCSGAKG GKKSDQSNCS
LEPLLQQLST SYKTMPAYRN LPLIWKKKCL VQATKWTPCS RTCGMGISNR VTNENSNCEM
RKEKRLCYIQ PCDSNILKTI KIPKGKTCQP TFQLSKAEKF VFSGCSSTQS YKPTFCGICL
DKRCCIPNKS KMITIQFDCP NEGSFKWKML WITSCVCQRN CREPGDIFSE LKIL


Related products :

Catalog number Product name Quantity
U2153r CLIA kit CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
U2153r CLIA CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
E2153r ELISA CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
E2153r ELISA kit CCN family member 5,CCN family protein COP-1,Ccn5,Connective tissue growth factor-like protein,Cop1,Ctgfl,CTGF-L,Rat,Rattus norvegicus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 96T
U2153m CLIA kit CCN family member 5,Ccn5,Connective tissue growth factor-like protein,Ctgfl,CTGF-L,Mouse,Mus musculus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
E2153m ELISA CCN family member 5,Ccn5,Connective tissue growth factor-like protein,Ctgfl,CTGF-L,Mouse,Mus musculus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
U2153m CLIA CCN family member 5,Ccn5,Connective tissue growth factor-like protein,Ctgfl,CTGF-L,Mouse,Mus musculus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
E2153m ELISA kit CCN family member 5,Ccn5,Connective tissue growth factor-like protein,Ctgfl,CTGF-L,Mouse,Mus musculus,Wisp2,WISP-2,WNT1-inducible-signaling pathway protein 2 96T
EIAAB46369 CCN family member 4,Ccn4,Elm1,ELM-1,Rat,Rattus norvegicus,Wisp1,WISP-1,WNT1-inducible-signaling pathway protein 1
EIAAB46371 CCN family member 4,Ccn4,Elm1,ELM-1,Mouse,Mus musculus,Wisp1,WISP-1,WNT1-inducible-signaling pathway protein 1
EIAAB46372 CCN family member 6,CCN6,Homo sapiens,Human,UNQ462_PRO790_PRO956,WISP3,WISP-3,WNT1-inducible-signaling pathway protein 3
EIAAB46370 CCN family member 4,CCN4,Homo sapiens,Human,WISP1,WISP-1,Wnt-1-induced secreted protein,WNT1-inducible-signaling pathway protein 1
E12937h Human WNT1 Inducible Signaling Pathway Protein 1 E 96T
E02W0001 Rat WNT1 Inducible Signaling Pathway Protein 1 ELISA 96T/kit
EM734 WNT1-inducible-signaling pathway protein 2 Elisa Kit 96T
E12936h Human WNT1 Inducible Signaling Pathway Protein 3 E 96T
EH330 WNT1-inducible-signaling pathway protein 1 Elisa Kit 96T
ER158 WNT1-inducible-signaling pathway protein 1 Elisa Kit 96T
EM207 WNT1-inducible-signaling pathway protein 1 Elisa Kit 96T
EH1267 WNT1-inducible-signaling pathway protein 1 Elisa Kit 96T
EH928 WNT1-inducible-signaling pathway protein 3 Elisa Kit 96T
E96894Hu ELISA Kit for WNT1 Inducible Signaling Pathway Protein 2 (WISP2) 96T/Kit
E09W0001 Monkey WNT1 Inducible Signaling Pathway Protein 1 ELISA 96T/kit
I2841 WNT1-inducible-signaling pathway protein 2 (WISP2), Rat, ELISA Kit 96T
CSB-EL026120RA Rat WNT1-inducible-signaling pathway protein 2(WISP2) ELISA kit 96T