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Centromere/microtubule-binding protein CBF5 (Centromere-binding factor 5) (H/ACA snoRNP protein CBF5) (Small nucleolar RNP protein CBF5)

 CBF5_KLULA              Reviewed;         474 AA.
O13473;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-JAN-1998, sequence version 1.
13-FEB-2019, entry version 117.
RecName: Full=H/ACA ribonucleoprotein complex subunit CBF5 {ECO:0000305};
EC=5.4.99.- {ECO:0000250|UniProtKB:P33322};
AltName: Full=Centromere-binding factor 5;
AltName: Full=H/ACA snoRNP protein CBF5;
AltName: Full=Small nucleolar RNP protein CBF5;
Name=CBF5; OrderedLocusNames=KLLA0D04796g;
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC
1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
NCBI_TaxID=284590;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=ATCC MYA-539 / JBD100;
PubMed=9483794;
DOI=10.1002/(SICI)1097-0061(19980115)14:1<37::AID-YEA198>3.3.CO;2-U;
Winkler A.A., Bobok A., Zonneveld B.J.M., Steensma H.Y.,
Hooykaas P.J.J.;
"The lysine-rich C-terminal repeats of the centromere-binding factor 5
(Cbf5) of Kluyveromyces lactis are not essential for function.";
Yeast 14:37-48(1998).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 /
WM37;
PubMed=15229592; DOI=10.1038/nature02579;
Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S.,
Lafontaine I., de Montigny J., Marck C., Neuveglise C., Talla E.,
Goffard N., Frangeul L., Aigle M., Anthouard V., Babour A., Barbe V.,
Barnay S., Blanchin S., Beckerich J.-M., Beyne E., Bleykasten C.,
Boisrame A., Boyer J., Cattolico L., Confanioleri F., de Daruvar A.,
Despons L., Fabre E., Fairhead C., Ferry-Dumazet H., Groppi A.,
Hantraye F., Hennequin C., Jauniaux N., Joyet P., Kachouri R.,
Kerrest A., Koszul R., Lemaire M., Lesur I., Ma L., Muller H.,
Nicaud J.-M., Nikolski M., Oztas S., Ozier-Kalogeropoulos O.,
Pellenz S., Potier S., Richard G.-F., Straub M.-L., Suleau A.,
Swennen D., Tekaia F., Wesolowski-Louvel M., Westhof E., Wirth B.,
Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M., Thierry A.,
Bouchier C., Caudron B., Scarpelli C., Gaillardin C., Weissenbach J.,
Wincker P., Souciet J.-L.;
"Genome evolution in yeasts.";
Nature 430:35-44(2004).
-!- FUNCTION: Catalytic subunit of H/ACA small nucleolar
ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes
pseudouridylation of rRNA. This involves the isomerization of
uridine such that the ribose is subsequently attached to C5,
instead of the normal N1. Pseudouridine ('psi') residues may serve
to stabilize the conformation of rRNAs and play a central role in
ribosomal RNA processing. The H/ACA snoRNP complex also mediates
pseudouridylation of other types of RNAs. Catalyzes
pseudouridylation at position 93 in U2 snRNA. Also catalyzes
pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide
pseudouridylation of mRNAs. {ECO:0000250|UniProtKB:P33322}.
-!- CATALYTIC ACTIVITY:
Reaction=uridine in 5S rRNA = pseudouridine in 5S rRNA;
Xref=Rhea:RHEA:47036, Rhea:RHEA-COMP:11730, Rhea:RHEA-
COMP:11731, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
Evidence={ECO:0000250|UniProtKB:P33322};
-!- CATALYTIC ACTIVITY:
Reaction=uridine in snRNA = pseudouridine in snRNA;
Xref=Rhea:RHEA:51124, Rhea:RHEA-COMP:12891, Rhea:RHEA-
COMP:12892, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
Evidence={ECO:0000250|UniProtKB:P33322};
-!- CATALYTIC ACTIVITY:
Reaction=a uridine in mRNA = a psi-uridine in mRNA;
Xref=Rhea:RHEA:56644, Rhea:RHEA-COMP:14658, Rhea:RHEA-
COMP:14659, ChEBI:CHEBI:65314, ChEBI:CHEBI:65315;
Evidence={ECO:0000250|UniProtKB:P33322};
-!- SUBUNIT: Component of the small nucleolar ribonucleoprotein
particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).
{ECO:0000250|UniProtKB:P33322}.
-!- SUBCELLULAR LOCATION: Nucleus, nucleolus
{ECO:0000250|UniProtKB:P33322}.
-!- SIMILARITY: Belongs to the pseudouridine synthase TruB family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF008563; AAC64862.1; -; Genomic_DNA.
EMBL; CR382124; CAH00369.1; -; Genomic_DNA.
RefSeq; XP_453273.1; XM_453273.1.
ProteinModelPortal; O13473; -.
SMR; O13473; -.
STRING; 284590.XP_453273.1; -.
PRIDE; O13473; -.
EnsemblFungi; CAH00369; CAH00369; KLLA0_D04796g.
GeneID; 2893295; -.
KEGG; kla:KLLA0_D04796g; -.
eggNOG; KOG2529; Eukaryota.
eggNOG; COG0130; LUCA.
HOGENOM; HOG000231224; -.
InParanoid; O13473; -.
KO; K11131; -.
OMA; IYQRPPL; -.
Proteomes; UP000000598; Chromosome D.
GO; GO:0031429; C:box H/ACA snoRNP complex; IEA:EnsemblFungi.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0009982; F:pseudouridine synthase activity; IEA:EnsemblFungi.
GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
GO; GO:0000495; P:box H/ACA snoRNA 3'-end processing; IEA:EnsemblFungi.
GO; GO:1990481; P:mRNA pseudouridine synthesis; IEA:EnsemblFungi.
GO; GO:0031118; P:rRNA pseudouridine synthesis; IEA:EnsemblFungi.
GO; GO:0031120; P:snRNA pseudouridine synthesis; IEA:EnsemblFungi.
InterPro; IPR012960; Dyskerin-like.
InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
InterPro; IPR002501; PsdUridine_synth_N.
InterPro; IPR002478; PUA.
InterPro; IPR015947; PUA-like_sf.
InterPro; IPR004802; tRNA_PsdUridine_synth_B_fam.
InterPro; IPR032819; TruB_C.
InterPro; IPR004521; Uncharacterised_CHP00451.
PANTHER; PTHR23127; PTHR23127; 1.
Pfam; PF08068; DKCLD; 1.
Pfam; PF01472; PUA; 1.
Pfam; PF16198; TruB_C_2; 1.
Pfam; PF01509; TruB_N; 1.
SMART; SM01136; DKCLD; 1.
SMART; SM00359; PUA; 1.
SUPFAM; SSF55120; SSF55120; 1.
SUPFAM; SSF88697; SSF88697; 1.
TIGRFAMs; TIGR00425; CBF5; 1.
TIGRFAMs; TIGR00451; unchar_dom_2; 1.
PROSITE; PS50890; PUA; 1.
3: Inferred from homology;
Complete proteome; DNA-binding; Isomerase; Microtubule; Nucleus;
Reference proteome; Repeat; Ribonucleoprotein; Ribosome biogenesis;
RNA-binding; rRNA processing.
CHAIN 1 474 H/ACA ribonucleoprotein complex subunit
CBF5.
/FTId=PRO_0000121980.
DOMAIN 265 340 PUA. {ECO:0000255|PROSITE-
ProRule:PRU00161}.
REPEAT 431 433 1.
REPEAT 434 436 2.
REPEAT 437 439 3.
REPEAT 440 442 4.
REPEAT 443 445 5.
REPEAT 446 448 6.
REPEAT 449 451 7.
REPEAT 452 454 8.
REPEAT 455 457 9.
REGION 431 460 9 X 3 AA tandem repeats of K-K-[DE].
ACT_SITE 94 94 Nucleophile.
{ECO:0000250|UniProtKB:P60340}.
SEQUENCE 474 AA; 53630 MW; 95306ECE7FEA756C CRC64;
MSDEFVIKPE SVSPSSNTSE WPLLLKDYDK LLVRSGHYTP IPAGASPLKR DLKSYISSGV
INLDKPSNPS SHEVVAWIKR ILRCEKTGHS GTLDPKVTGC LIVCVDRATR LVKSQQGAGK
EYVCIVRLHD ALKDEKELGR GLENLTGALF QRPPLISAVK RQLRVRTIYD SNLIEFDNKR
NLGVFWASCE AGTYMRTLCV HLGMLLGVGG HMQELRRVRS GALSENDNLV TLHDVMDAQW
VYDNTRDESY LRKIIQPLET LLVGYKRIVV KDSAVNAVCY GAKLMIPGLL RYEEGIELYD
EVVLITTKGE AIAVAIAQMS TVDLATCDHG VVAKVKRCIM ERDLYPRRWG LGPIAQKKKQ
MKADGKLDKY GRANENTPET WKKTYVSLEN AEPTTAPASK SEEKPLIKEV EKKEVEQKEE
SKEESKTPEE KKDKKEKKEK KDKKEKKEKK EKKEKKRKAD DDESSEKKKK KSKK


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EIAAB06791 BM-309,C16orf60,CENPN,CENP-N,Centromere protein N,Homo sapiens,Human,ICEN32,Interphase centromere complex protein 32
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Pathways :
WP1531: Vitamin D synthesis
WP1616: ABC transporters
WP2199: Seed Development
WP2292: Chemokine signaling pathway
WP731: Sterol regulatory element binding protein related
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation

Related Genes :
[DKC1 NOLA4] H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (CBF5 homolog) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)
[Dkc1] H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)
[Dkc1 Nap57] H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (Dyskerin) (Nopp140-associated protein of 57 kDa) (Nucleolar protein NAP57) (Nucleolar protein family A member 4) (snoRNP protein DKC1)
[GAR1 NOLA1] H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)
[Gar1 Nola1] H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)
[DKC1 RCJMB04_17p9] H/ACA ribonucleoprotein complex subunit DKC1 (EC 5.4.99.-) (Dyskerin)
[Gar1 Nola1] H/ACA ribonucleoprotein complex subunit 1 (Nucleolar protein family A member 1) (snoRNP protein GAR1)
[NOP10 NOLA3] H/ACA ribonucleoprotein complex subunit 3 (Nucleolar protein 10) (Nucleolar protein family A member 3) (snoRNP protein NOP10)
[CBF1 CEP1 CP1 CPF1 YJR060W J1730] Centromere-binding protein 1 (CBP-1) (Centromere promoter factor 1) (Centromere-binding factor 1)
[NHP2 NOLA2 HSPC286] H/ACA ribonucleoprotein complex subunit 2 (Nucleolar protein family A member 2) (snoRNP protein NHP2)
[KIF2C KNSL6] Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK)
[CENPT C16orf56 ICEN22] Centromere protein T (CENP-T) (Interphase centromere complex protein 22)
[INCENP] Inner centromere protein
[NCU01290] Centromere/microtubule-binding protein CBF5
[CENPF] Centromere protein F (CENP-F) (AH antigen) (Kinetochore protein CENPF) (Mitosin)
[ARHGEF2 KIAA0651 LFP40] Rho guanine nucleotide exchange factor 2 (Guanine nucleotide exchange factor H1) (GEF-H1) (Microtubule-regulated Rho-GEF) (Proliferating cell nucleolar antigen p40)
[Incenp] Inner centromere protein
[incenp-a] Inner centromere protein A (XL-INCENP) (xINC) (xIncenp) (Mitotic phosphoprotein 130)
[RUVBL1 INO80H NMP238 TIP49 TIP49A] RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
[KIF2C KNSL6] Kinesin-like protein KIF2C (Kinesin-like protein 6) (Mitotic centromere-associated kinesin) (MCAK)
[SKP1 CBF3D YDR328C D9798.14] Suppressor of kinetochore protein 1 (Centromere DNA-binding protein complex CBF3 subunit D) (E3 ubiquitin ligase complex SCF subunit SKP1)
[CENPJ CPAP LAP LIP1] Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1)
[CENPI FSHPRH1 ICEN19 LRPR1] Centromere protein I (CENP-I) (FSH primary response protein 1) (Follicle-stimulating hormone primary response protein) (Interphase centromere complex protein 19) (Leucine-rich primary response protein 1)
[Zw10 mit(1)15 CG9900] Centromere/kinetochore protein zw10 (Mitotic 15 protein)
[CENPW C6orf173 CUG2] Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein)
[NPM1 NPM] Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
[MCK1 YPK1 YNL307C N0392] Protein kinase MCK1 (EC 2.7.12.1) (Meiosis and centromere regulatory kinase)
[CTR9 CDP1 YOL145C] RNA polymerase-associated protein CTR9 (Centromere-binding factor 1-dependent protein 1) (Cln three-requiring protein 9)
[EB1B At5g62500 K19B1.11] Microtubule-associated protein RP/EB family member 1B (APC-binding protein EB1B) (End-binding protein 1) (AtEB1) (End-binding protein 1B) (AtEB1B) (Protein ATEB1 homolog 2) (ATEB1H2)
[Kif2c] Kinesin-like protein KIF2C (Mitotic centromere-associated kinesin) (MCAK)

Bibliography :
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