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Citrate synthase

 D7GH96_PROFC            Unreviewed;       427 AA.
D7GH96;
10-AUG-2010, integrated into UniProtKB/TrEMBL.
10-AUG-2010, sequence version 1.
02-JUN-2021, entry version 71.
RecName: Full=Citrate synthase {ECO:0000256|PIRNR:PIRNR001369, ECO:0000256|RuleBase:RU003370};
Name=gltA1 {ECO:0000313|EMBL:CBL57907.1};
OrderedLocusNames=PFREUD_23910 {ECO:0000313|EMBL:CBL57907.1};
Propionibacterium freudenreichii subsp. shermanii (strain ATCC 9614 / DSM
4902 / CIP 103027 / NCIMB 8099 / CIRM-BIA1).
Bacteria; Actinobacteria; Propionibacteriales; Propionibacteriaceae;
Propionibacterium.
NCBI_TaxID=754252 {ECO:0000313|EMBL:CBL57907.1, ECO:0000313|Proteomes:UP000000936};
[1] {ECO:0000313|EMBL:CBL57907.1, ECO:0000313|Proteomes:UP000000936}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 9614 / DSM 4902 / CIP 103027 / NCIMB 8099 / CIRM-BIA1
{ECO:0000313|Proteomes:UP000000936};
PubMed=20668525; DOI=10.1371/journal.pone.0011748;
Falentin H., Deutsch S.M., Jan G., Loux V., Thierry A., Parayre S.,
Maillard M.B., Dherbecourt J., Cousin F.J., Jardin J., Siguier P.,
Couloux A., Barbe V., Vacherie B., Wincker P., Gibrat J.F., Gaillardin C.,
Lortal S.;
"The complete genome of Propionibacterium freudenreichii CIRM-BIA1, a hardy
actinobacterium with food and probiotic applications.";
PLoS ONE 5:E11748-E11748(2010).
-!- CATALYTIC ACTIVITY:
Reaction=acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+);
Xref=Rhea:RHEA:16845, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
ChEBI:CHEBI:16452, ChEBI:CHEBI:16947, ChEBI:CHEBI:57287,
ChEBI:CHEBI:57288; EC=2.3.3.16;
Evidence={ECO:0000256|ARBA:ARBA00000308,
ECO:0000256|RuleBase:RU003370};
-!- PATHWAY: Carbohydrate metabolism. {ECO:0000256|ARBA:ARBA00005007}.
-!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle.
{ECO:0000256|ARBA:ARBA00005163}.
-!- PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate
from oxaloacetate: step 1/2. {ECO:0000256|ARBA:ARBA00004751,
ECO:0000256|RuleBase:RU003370}.
-!- SIMILARITY: Belongs to the citrate synthase family.
{ECO:0000256|ARBA:ARBA00010566, ECO:0000256|PIRNR:PIRNR001369,
ECO:0000256|RuleBase:RU003406}.
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EMBL; FN806773; CBL57907.1; -; Genomic_DNA.
STRING; 754252.PFREUD_23910; -.
EnsemblBacteria; CBL57907; CBL57907; PFREUD_23910.
KEGG; pfr:PFREUD_23910; -.
eggNOG; COG0372; Bacteria.
HOGENOM; CLU_025068_0_0_11; -.
OMA; TVGWCAQ; -.
UniPathway; UPA00223; -.
UniPathway; UPA00223; UER00717.
Proteomes; UP000000936; Chromosome.
GO; GO:0005737; C:cytoplasm; IEA:InterPro.
GO; GO:0004108; F:citrate (Si)-synthase activity; IEA:InterPro.
GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway.
CDD; cd06114; EcCS_like; 1.
Gene3D; 1.10.230.10; -; 1.
Gene3D; 1.10.580.10; -; 1.
InterPro; IPR016142; Citrate_synth-like_lrg_a-sub.
InterPro; IPR016143; Citrate_synth-like_sm_a-sub.
InterPro; IPR002020; Citrate_synthase.
InterPro; IPR019810; Citrate_synthase_AS.
InterPro; IPR024176; Citrate_synthase_bac-typ.
InterPro; IPR036969; Citrate_synthase_sf.
InterPro; IPR010953; Citrate_synthase_typ-I.
Pfam; PF00285; Citrate_synt; 1.
PIRSF; PIRSF001369; Citrate_synth; 1.
PRINTS; PR00143; CITRTSNTHASE.
SUPFAM; SSF48256; SSF48256; 1.
TIGRFAMs; TIGR01798; cit_synth_I; 1.
PROSITE; PS00480; CITRATE_SYNTHASE; 1.
3: Inferred from homology;
Acyltransferase {ECO:0000313|EMBL:CBL57907.1};
Reference proteome {ECO:0000313|Proteomes:UP000000936};
Transferase {ECO:0000313|EMBL:CBL57907.1};
Tricarboxylic acid cycle {ECO:0000256|RuleBase:RU003370}.
ACT_SITE 305
/evidence="ECO:0000256|PIRSR:PIRSR001369-1"
ACT_SITE 362
/evidence="ECO:0000256|PIRSR:PIRSR001369-1"
SEQUENCE 427 AA; 47555 MW; 6D2E330DB0981AC0 CRC64;
MEHTAVLSGE GAKAELPIVE SSVGSDGYDI RNLLRTTGNV TYDMGFANTA SCQSAITYID
GEKGVLRYRG YPIEQLADKS TFLETAYLVI YGELPRPAEL ADFEERIKRK TIIDEGMRKF
FETFPRGSHP MPVLAAGVQA LGTFSTTSIG DDPQSIEKAT ERLIAKMPTL AAYGYKNSRG
EPFLYPDNAL SYVQNFERMS FGYPTEPYHF EPEITRALDV LLILHADHEQ NCSSSTVRLV
GSSGANIYAS ISAGINALSG PLHGGANQAV LEMLEAIKAS GISVKEYVQQ VKDRNAGIKL
MGFGHRIYKN YDPRAAIIKQ HADRVLALKS GRRDLLDIAQ ELEQAALADD YFTERKLYPN
VDFYSGLIYE AMGFPKEMFT VLFAIGRLPG WIAQWREQRA DPNSRIGRPR QVYTGVPERD
YVPMDDR


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Pathways :
WP296: TCA Cycle - biocyc
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1403: AMPK signaling
WP1424: Globo Sphingolipid Metabolism
WP668: Octadecanoid Pathway
WP1621: Arginine and proline metabolism
WP1948: Citrate cycle (TCA cycle)
WP2210: Oryzalexin S biosynthesis
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1423: Ganglio Sphingolipid Metabolism
WP626: Abscisic Acid Biosynthesis
WP1566: Citrate cycle (TCA cycle)
WP1945: TCA BCH6203
WP2208: Cardiolipin Biosynthesis
WP2248: anthocyanin biosynthesis
WP1422: Sphingolipid Metabolism
WP1461: Photosynthetic Carbon Reduction
WP677: Momilactone biosynthesis
WP1708: Terpenoid backbone biosynthesis
WP2199: Seed Development
WP2211: Geranylgeranyldiphosphate biosynthesis II (plastidic)

Related Genes :
[CS] Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase)
[ACLY] ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)
[Acly] ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme)
[Acly] ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme)
[CLYBL CLB] Citramalyl-CoA lyase, mitochondrial (EC 4.1.3.25) ((3S)-malyl-CoA thioesterase) (EC 3.1.2.30) (Beta-methylmalate synthase) (EC 2.3.3.-) (Citrate lyase subunit beta-like protein) (Citrate lyase beta-like) (Malate synthase) (EC 2.3.3.9)
[Clybl Clb] Citramalyl-CoA lyase, mitochondrial (EC 4.1.3.25) ((3S)-malyl-CoA thioesterase) (EC 3.1.2.30) (Beta-methylmalate synthase) (EC 2.3.3.-) (Citrate lyase subunit beta-like protein, mitochondrial) (Citrate lyase beta-like) (Malate synthase) (EC 2.3.3.9)
[Clybl] Citramalyl-CoA lyase, mitochondrial (EC 4.1.3.25) ((3S)-malyl-CoA thioesterase) (EC 3.1.2.30) (Beta-methylmalate synthase) (EC 2.3.3.-) (Citrate lyase subunit beta-like protein, mitochondrial) (Citrate lyase beta-like) (Malate synthase) (EC 2.3.3.9)
[mcsA AN6650] 2-methylcitrate synthase, mitochondrial (Methylcitrate synthase) (EC 2.3.3.5) ((2S,3S)-2-methylcitrate synthase) (Citrate synthase 2) (EC 2.3.3.16)
[prpC yahS yzzD b0333 JW0324] 2-methylcitrate synthase (2-MCS) (MCS) (EC 2.3.3.5) ((2S,3S)-2-methylcitrate synthase) (Citrate synthase) (EC 2.3.3.16)
[gltA cisY] 2-methylcitrate synthase (2-MCS) (MCS) (EC 2.3.3.5) (Citrate synthase) (EC 2.3.3.16)
[prpC STM0369] 2-methylcitrate synthase (2-MCS) (mcs) (EC 2.3.3.5) (Citrate synthase) (EC 2.3.3.16)
[prpC Rv1131 RVBD_1131 P425_01180] 2-methylcitrate synthase (2-MCS) (MCS) (EC 2.3.3.5) (Citrate synthase) (EC 2.3.3.16)
[mcsA cit1] 2-methylcitrate synthase, mitochondrial (Methylcitrate synthase) (EC 2.3.3.5) ((2S,3S)-2-methylcitrate synthase) (Citrate synthase 1) (EC 2.3.3.16)
[CIT2 YCR005C YCR043 YCR5C] Citrate synthase, peroxisomal (EC 2.3.3.16)
[CIT1 GLU3 LYS6 YNR001C N2019] Citrate synthase, mitochondrial (EC 2.3.3.1)
[CSKMT METTL12] Citrate synthase-lysine N-methyltransferase CSKMT, mitochondrial (CS-KMT) (EC 2.1.1.-) (Methyltransferase-like protein 12, mitochondrial)
[gltA gluT icdB b0720 JW0710] Citrate synthase (EC 2.3.3.16)
[CSY4 At2g44350 F4I1.16] Citrate synthase 4, mitochondrial (EC 2.3.3.16)
[CS] Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase)
[cshA DDB_G0267426] Citrate synthase, peroxisomal (EC 2.3.3.16)
[ACLY] ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme)
[ACLB-2 At5g49460 K7J8.14] ATP-citrate synthase beta chain protein 2 (ATP-citrate synthase B-2) (EC 2.3.3.8) (ATP-citrate lyase B-2) (Citrate cleavage enzyme B-2)
[ACLA-1 ATP-citrate lyase A-1 At1g10670 F20B24.11 F20B24_11] ATP citrate synthase (EC 2.3.3.8)
[ACLY] ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (Citrate cleavage enzyme)
[YALI0E02684g] 2-methylcitrate synthase, mitochondrial (Methylcitrate synthase) (EC 2.3.3.5) ((2S,3S)-2-methylcitrate synthase) (Citrate synthase 2) (EC 2.3.3.16)
[Cs] Citrate synthase, mitochondrial (EC 2.3.3.1) (Citrate (Si)-synthase)
[gltA1 ERDMAN_1267 Q643_01184] 2-methylcitrate synthase (2-MCS) (MCS) (EC 2.3.3.5) (Citrate synthase) (CS) (EC 2.3.3.16)
[CIT3 YPR001W YP9723.01] Citrate synthase 3, mitochondrial (EC 2.3.3.1)
[CSY2 At3g58750 T20N10.100] Citrate synthase 2, peroxisomal (EC 2.3.3.16)
[mmgD yqiO BSU24140] Citrate/2-methylcitrate synthase (EC 2.3.3.-) (EC 2.3.3.16) (2-methylcitrate synthase) (2-MCS) (MCS) (Citrate synthase)

Bibliography :
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