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Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]

 FA7_MOUSE               Reviewed;         446 AA.
P70375; Q61109;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
23-FEB-2022, entry version 206.
RecName: Full=Coagulation factor VII;
EC=3.4.21.21;
AltName: Full=Serum prothrombin conversion accelerator;
Contains:
RecName: Full=Factor VII light chain;
Contains:
RecName: Full=Factor VII heavy chain;
Flags: Precursor;
Name=F7; Synonyms=Cf7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Liver;
PubMed=8701412;
Idusogie E., Rosen E., Geng J.P., Carmeliet P., Collen D., Castellino F.J.;
"Characterization of a cDNA encoding murine coagulation factor VII.";
Thromb. Haemost. 75:481-487(1996).
[2]
NUCLEOTIDE SEQUENCE.
PubMed=8972017;
Idusogie E., Rosen E.D., Carmeliet P., Collen D., Castellino F.J.;
"Nucleotide structure and characterization of the murine blood coagulation
factor VII gene.";
Thromb. Haemost. 76:957-964(1996).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[4]
INDUCTION.
PubMed=18316400; DOI=10.1128/mcb.01931-07;
Bertolucci C., Cavallari N., Colognesi I., Aguzzi J., Chen Z., Caruso P.,
Foa A., Tosini G., Bernardi F., Pinotti M.;
"Evidence for an overlapping role of CLOCK and NPAS2 transcription factors
in liver circadian oscillators.";
Mol. Cell. Biol. 28:3070-3075(2008).
-!- FUNCTION: Initiates the extrinsic pathway of blood coagulation. Serine
protease that circulates in the blood in a zymogen form. Factor VII is
converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or
thrombin by minor proteolysis. In the presence of tissue factor and
calcium ions, factor VIIa then converts factor X to factor Xa by
limited proteolysis. Factor VIIa will also convert factor IX to factor
IXa in the presence of tissue factor and calcium (By similarity).
{ECO:0000250}.
-!- CATALYTIC ACTIVITY:
Reaction=Selective cleavage of Arg-|-Ile bond in factor X to form
factor Xa.; EC=3.4.21.21;
-!- SUBUNIT: Heterodimer of a light chain and a heavy chain linked by a
disulfide bond. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Plasma and liver.
-!- INDUCTION: Expression in the liver and plasma oscillates in a circadian
manner. {ECO:0000269|PubMed:18316400}.
-!- PTM: The vitamin K-dependent, enzymatic carboxylation of some glutamate
residues allows the modified protein to bind calcium. {ECO:0000250}.
-!- PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate
and asparagine is (R) stereospecific within EGF domains. {ECO:0000250}.
-!- PTM: Can be either O-glucosylated or O-xylosylated at Ser-93 by
POGLUT1. {ECO:0000250}.
-!- SIMILARITY: Belongs to the peptidase S1 family. {ECO:0000255|PROSITE-
ProRule:PRU00274}.
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EMBL; U44795; AAC52570.1; -; mRNA.
EMBL; U66079; AAC33796.1; -; Genomic_DNA.
EMBL; BC061149; AAH61149.1; -; mRNA.
CCDS; CCDS22104.1; -.
RefSeq; NP_034302.2; NM_010172.4.
PDB; 5KXH; X-ray; 1.33 A; B=87-126.
PDB; 5KY2; X-ray; 1.47 A; B=87-126.
PDB; 5KY3; X-ray; 1.53 A; B=87-126.
PDBsum; 5KXH; -.
PDBsum; 5KY2; -.
PDBsum; 5KY3; -.
SMR; P70375; -.
BioGRID; 199575; 8.
ComplexPortal; CPX-279; Coagulation factor VIIa - tissue factor complex.
STRING; 10090.ENSMUSP00000033820; -.
GlyGen; P70375; 3 sites.
PhosphoSitePlus; P70375; -.
SwissPalm; P70375; -.
CPTAC; non-CPTAC-3914; -.
PaxDb; P70375; -.
PeptideAtlas; P70375; -.
PRIDE; P70375; -.
ProteomicsDB; 271849; -.
Antibodypedia; 11679; 661 antibodies from 37 providers.
DNASU; 14068; -.
Ensembl; ENSMUST00000033820; ENSMUSP00000033820; ENSMUSG00000031443.
GeneID; 14068; -.
KEGG; mmu:14068; -.
UCSC; uc009kwr.2; mouse.
CTD; 2155; -.
MGI; MGI:109325; F7.
VEuPathDB; HostDB:ENSMUSG00000031443; -.
eggNOG; ENOG502QRGI; Eukaryota.
GeneTree; ENSGT00940000154474; -.
HOGENOM; CLU_006842_19_5_1; -.
InParanoid; P70375; -.
OMA; MAIDVPR; -.
OrthoDB; 1314811at2759; -.
PhylomeDB; P70375; -.
TreeFam; TF327329; -.
Reactome; R-MMU-140834; Extrinsic Pathway of Fibrin Clot Formation.
Reactome; R-MMU-159740; Gamma-carboxylation of protein precursors.
Reactome; R-MMU-159763; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus.
Reactome; R-MMU-159782; Removal of aminoterminal propeptides from gamma-carboxylated proteins.
BioGRID-ORCS; 14068; 0 hits in 64 CRISPR screens.
PRO; PR:P70375; -.
Proteomes; UP000000589; Chromosome 8.
RNAct; P70375; protein.
Bgee; ENSMUSG00000031443; Expressed in liver and 88 other tissues.
ExpressionAtlas; P70375; baseline and differential.
Genevisible; P70375; MM.
GO; GO:0005576; C:extracellular region; TAS:Reactome.
GO; GO:0005615; C:extracellular space; ISO:MGI.
GO; GO:1905286; C:serine-type peptidase complex; ISO:MGI.
GO; GO:0031982; C:vesicle; ISO:MGI.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0004175; F:endopeptidase activity; ISO:MGI.
GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-EC.
GO; GO:0005102; F:signaling receptor binding; ISO:MGI.
GO; GO:0031100; P:animal organ regeneration; IEA:Ensembl.
GO; GO:0007596; P:blood coagulation; IMP:MGI.
GO; GO:0007623; P:circadian rhythm; IEA:Ensembl.
GO; GO:0030194; P:positive regulation of blood coagulation; ISO:MGI.
GO; GO:0002690; P:positive regulation of leukocyte chemotaxis; ISO:MGI.
GO; GO:0010641; P:positive regulation of platelet-derived growth factor receptor signaling pathway; ISO:MGI.
GO; GO:0050927; P:positive regulation of positive chemotaxis; ISO:MGI.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; ISO:MGI.
GO; GO:0016485; P:protein processing; ISO:MGI.
GO; GO:1904612; P:response to 2,3,7,8-tetrachlorodibenzodioxine; IEA:Ensembl.
GO; GO:0061476; P:response to anticoagulant; ISO:MGI.
GO; GO:1905217; P:response to astaxanthin; ISO:MGI.
GO; GO:0010037; P:response to carbon dioxide; IEA:Ensembl.
GO; GO:0070723; P:response to cholesterol; ISO:MGI.
GO; GO:0032355; P:response to estradiol; IEA:Ensembl.
GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
GO; GO:0033595; P:response to genistein; IEA:Ensembl.
GO; GO:0060416; P:response to growth hormone; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0031667; P:response to nutrient levels; ISO:MGI.
GO; GO:1904400; P:response to Thyroid stimulating hormone; IEA:Ensembl.
GO; GO:1905225; P:response to thyrotropin-releasing hormone; IEA:Ensembl.
GO; GO:0097068; P:response to thyroxine; IEA:Ensembl.
GO; GO:0032571; P:response to vitamin K; IEA:Ensembl.
CDD; cd00190; Tryp_SPc; 1.
Gene3D; 2.40.10.10; -; 2.
Gene3D; 4.10.740.10; -; 1.
InterPro; IPR017857; Coagulation_fac-like_Gla_dom.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR018097; EGF_Ca-bd_CS.
InterPro; IPR033190; F7.
InterPro; IPR035972; GLA-like_dom_SF.
InterPro; IPR000294; GLA_domain.
InterPro; IPR012224; Pept_S1A_FX.
InterPro; IPR009003; Peptidase_S1_PA.
InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
InterPro; IPR001314; Peptidase_S1A.
InterPro; IPR001254; Trypsin_dom.
InterPro; IPR018114; TRYPSIN_HIS.
InterPro; IPR033116; TRYPSIN_SER.
PANTHER; PTHR24278:SF26; PTHR24278:SF26; 1.
Pfam; PF00008; EGF; 1.
Pfam; PF00594; Gla; 1.
Pfam; PF00089; Trypsin; 1.
PIRSF; PIRSF001143; Factor_X; 1.
PRINTS; PR00722; CHYMOTRYPSIN.
PRINTS; PR00001; GLABLOOD.
SMART; SM00181; EGF; 2.
SMART; SM00179; EGF_CA; 1.
SMART; SM00069; GLA; 1.
SMART; SM00020; Tryp_SPc; 1.
SUPFAM; SSF50494; SSF50494; 1.
SUPFAM; SSF57630; SSF57630; 1.
PROSITE; PS00010; ASX_HYDROXYL; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS50026; EGF_3; 1.
PROSITE; PS01187; EGF_CA; 1.
PROSITE; PS00011; GLA_1; 1.
PROSITE; PS50998; GLA_2; 1.
PROSITE; PS50240; TRYPSIN_DOM; 1.
PROSITE; PS00134; TRYPSIN_HIS; 1.
PROSITE; PS00135; TRYPSIN_SER; 1.
1: Evidence at protein level;
3D-structure; Blood coagulation; Calcium;
Cleavage on pair of basic residues; Disulfide bond; EGF-like domain;
Gamma-carboxyglutamic acid; Glycoprotein; Hemostasis; Hydrolase;
Hydroxylation; Protease; Reference proteome; Repeat; Secreted;
Serine protease; Signal; Zymogen.
SIGNAL 1..24
/evidence="ECO:0000255"
PROPEP 25..41
/evidence="ECO:0000255"
/id="PRO_0000027732"
CHAIN 42..193
/note="Factor VII light chain"
/id="PRO_0000027733"
CHAIN 194..446
/note="Factor VII heavy chain"
/id="PRO_0000027734"
DOMAIN 42..86
/note="Gla"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00463"
DOMAIN 87..123
/note="EGF-like 1; calcium-binding"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
DOMAIN 128..169
/note="EGF-like 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
DOMAIN 194..433
/note="Peptidase S1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00274"
ACT_SITE 234
/note="Charge relay system"
/evidence="ECO:0000250"
ACT_SITE 283
/note="Charge relay system"
/evidence="ECO:0000250"
ACT_SITE 385
/note="Charge relay system"
/evidence="ECO:0000250"
BINDING 379
/note="Substrate"
/evidence="ECO:0000250"
SITE 193..194
/note="Cleavage; by factor Xa, factor XIIa, factor IXa, or
thrombin"
/evidence="ECO:0000250"
MOD_RES 47
/note="4-carboxyglutamate"
/evidence="ECO:0000250|UniProtKB:P22457,
ECO:0000255|PROSITE-ProRule:PRU00463"
MOD_RES 48
/note="4-carboxyglutamate"
/evidence="ECO:0000250|UniProtKB:P22457,
ECO:0000255|PROSITE-ProRule:PRU00463"
MOD_RES 55
/note="4-carboxyglutamate"
/evidence="ECO:0000250|UniProtKB:P22457,
ECO:0000255|PROSITE-ProRule:PRU00463"
MOD_RES 57
/note="4-carboxyglutamate"
/evidence="ECO:0000250|UniProtKB:P22457,
ECO:0000255|PROSITE-ProRule:PRU00463"
MOD_RES 60
/note="4-carboxyglutamate"
/evidence="ECO:0000250|UniProtKB:P22457,
ECO:0000255|PROSITE-ProRule:PRU00463"
MOD_RES 61
/note="4-carboxyglutamate"
/evidence="ECO:0000250|UniProtKB:P22457,
ECO:0000255|PROSITE-ProRule:PRU00463"
MOD_RES 66
/note="4-carboxyglutamate"
/evidence="ECO:0000250|UniProtKB:P22457,
ECO:0000255|PROSITE-ProRule:PRU00463"
MOD_RES 67
/note="4-carboxyglutamate"
/evidence="ECO:0000250|UniProtKB:P22457,
ECO:0000255|PROSITE-ProRule:PRU00463"
MOD_RES 70
/note="4-carboxyglutamate"
/evidence="ECO:0000250|UniProtKB:P22457,
ECO:0000255|PROSITE-ProRule:PRU00463"
MOD_RES 76
/note="4-carboxyglutamate"
/evidence="ECO:0000250|UniProtKB:P22457,
ECO:0000255|PROSITE-ProRule:PRU00463"
MOD_RES 104
/note="(3R)-3-hydroxyaspartate"
/evidence="ECO:0000250"
CARBOHYD 93
/note="O-linked (Glc...) serine; alternate"
/evidence="ECO:0000250|UniProtKB:P08709"
CARBOHYD 93
/note="O-linked (Xyl...) serine; alternate"
/evidence="ECO:0000250|UniProtKB:P08709"
CARBOHYD 186
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 244
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 58..63
/evidence="ECO:0000250"
DISULFID 91..102
/evidence="ECO:0000250"
DISULFID 96..111
/evidence="ECO:0000250"
DISULFID 113..122
/evidence="ECO:0000250"
DISULFID 132..143
/evidence="ECO:0000250"
DISULFID 139..153
/evidence="ECO:0000250"
DISULFID 155..168
/evidence="ECO:0000250"
DISULFID 176..303
/evidence="ECO:0000250"
DISULFID 200..205
/evidence="ECO:0000250"
DISULFID 219..235
/evidence="ECO:0000250"
DISULFID 351..370
/evidence="ECO:0000250"
DISULFID 381..409
/evidence="ECO:0000250"
CONFLICT 99
/note="G -> V (in Ref. 2; AAC52570)"
/evidence="ECO:0000305"
HELIX 91..93
/evidence="ECO:0007829|PDB:5KXH"
STRAND 101..105
/evidence="ECO:0007829|PDB:5KXH"
STRAND 108..112
/evidence="ECO:0007829|PDB:5KXH"
STRAND 117..119
/evidence="ECO:0007829|PDB:5KXH"
SEQUENCE 446 AA; 50276 MW; 2512E44A45CBC96E CRC64;
MVPQAHGLLL LCFLLQLQGP LGTAVFITQE EAHGVLHRQR RANSLLEELW PGSLERECNE
EQCSFEEARE IFKSPERTKQ FWIVYSDGDQ CASNPCQNGG TCQDHLKSYV CFCLLDFEGR
NCEKSKNEQL ICANENGDCD QYCRDHVGTK RTCSCHEDYT LQPDEVSCKP KVEYPCGRIP
VVEKRNSSSR QGRIVGGNVC PKGECPWQAV LKINGLLLCG AVLLDARWIV TAAHCFDNIR
YWGNITVVMG EHDFSEKDGD EQVRRVTQVI MPDKYIRGKI NHDIALLRLH RPVTFTDYVV
PLCLPEKSFS ENTLARIRFS RVSGWGQLLD RGATALELMS IEVPRLMTQD CLEHAKHSSN
TPKITENMFC AGYMDGTKDA CKGDSGGPHA THYHGTWYLT GVVSWGEGCA AIGHIGVYTR
VSQYIDWLVR HMDSKLQVGV FRLPLL


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WP313: Signaling of Hepatocyte Growth Factor Receptor
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP2148: Brain derived neurotrophic factor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP810: Signaling of Hepatocyte Growth Factor Receptor
WP927: Signaling of Hepatocyte Growth Factor Receptor
WP272: Blood Clotting Cascade
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP444: Signaling of Hepatocyte Growth Factor Receptor
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1983: Splicing factor NOVA regulated synpatic proteins
WP94: Signaling of Hepatocyte Growth Factor Receptor
WP1002: Electron Transport Chain
WP1654: gamma-Hexachlorocyclohexane degradation
WP1708: Terpenoid backbone biosynthesis
WP542: Electron Transport Chain
WP59: Electron Transport Chain
WP1614: 1- and 2-Methylnaphthalene degradation
WP2347: vitamin B5 (pantothenate) and CoA biosynthesis Pathway
WP295: Electron Transport Chain
WP1647: Fatty acid biosynthesis
WP1673: Naphthalene and anthracene degradation

Related Genes :
[F7] Coagulation factor VII (EC 3.4.21.21) (Proconvertin) (Serum prothrombin conversion accelerator) (SPCA) (Eptacog alfa) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F7 Cf7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F2] Prothrombin (EC 3.4.21.5) (Coagulation factor II) [Cleaved into: Activation peptide fragment 1; Activation peptide fragment 2; Thrombin light chain; Thrombin heavy chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator) [Cleaved into: Factor VII light chain; Factor VII heavy chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Stuart-Prower factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[] Venom prothrombin activator pseutarin-C catalytic subunit (PCCS) (vPA) (EC 3.4.21.6) (Venom coagulation factor Xa-like protease) [Cleaved into: Pseutarin-C catalytic subunit light chain; Pseutarin-C catalytic subunit heavy chain]
[F12] Coagulation factor XII (EC 3.4.21.38) (Hageman factor) (HAF) [Cleaved into: Coagulation factor XIIa heavy chain; Beta-factor XIIa part 1; Coagulation factor XIIa light chain (Beta-factor XIIa part 2)]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F9] Coagulation factor IX (EC 3.4.21.22) (Christmas factor) (Plasma thromboplastin component) (PTC) [Cleaved into: Coagulation factor IXa light chain; Coagulation factor IXa heavy chain]
[F7] Coagulation factor VII (EC 3.4.21.21) (Serum prothrombin conversion accelerator)
[F11] Coagulation factor XI (FXI) (EC 3.4.21.27) (Plasma thromboplastin antecedent) (PTA) [Cleaved into: Coagulation factor XIa heavy chain; Coagulation factor XIa light chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[F10 FX] Coagulation factor X (EC 3.4.21.6) (Stuart factor) (Virus-activating protease) (VAP) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[PROC] Vitamin K-dependent protein C (EC 3.4.21.69) (Anticoagulant protein C) (Autoprothrombin IIA) (Blood coagulation factor XIV) [Cleaved into: Vitamin K-dependent protein C light chain; Vitamin K-dependent protein C heavy chain; Activation peptide]
[HABP2 HGFAL PHBP] Hyaluronan-binding protein 2 (EC 3.4.21.-) (Factor VII-activating protease) (Factor seven-activating protease) (FSAP) (Hepatocyte growth factor activator-like protein) (Plasma hyaluronan-binding protein) [Cleaved into: Hyaluronan-binding protein 2 50 kDa heavy chain; Hyaluronan-binding protein 2 50 kDa heavy chain alternate form; Hyaluronan-binding protein 2 27 kDa light chain; Hyaluronan-binding protein 2 27 kDa light chain alternate form]
[] Clotting factor B (EC 3.4.21.85) (Coagulation factor B) [Cleaved into: Clotting factor B light chain; Clotting factor B heavy chain]
[F5] Coagulation factor V (Activated protein C cofactor) (Proaccelerin, labile factor) [Cleaved into: Coagulation factor V heavy chain; Coagulation factor V light chain]
[PLG] Plasminogen (EC 3.4.21.7) [Cleaved into: Plasmin heavy chain A; Activation peptide; Angiostatin; Plasmin heavy chain A, short form; Plasmin light chain B]
[MASP1 CRARF CRARF1 PRSS5] Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
[F8 F8C] Coagulation factor VIII (Antihemophilic factor) (AHF) (Procoagulant component) [Cleaved into: Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain]
[Masp1 Crarf Masp3] Mannan-binding lectin serine protease 1 (EC 3.4.21.-) (Complement factor MASP-3) (Complement-activating component of Ra-reactive factor) (Mannose-binding lectin-associated serine protease 1) (MASP-1) (Mannose-binding protein-associated serine protease) (Ra-reactive factor serine protease p100) (RaRF) (Serine protease 5) [Cleaved into: Mannan-binding lectin serine protease 1 heavy chain; Mannan-binding lectin serine protease 1 light chain]
[KLKB1 KLK3] Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) (PKK) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]
[F10] Coagulation factor X (EC 3.4.21.6) (Stuart factor) [Cleaved into: Factor X light chain; Factor X heavy chain; Activated factor Xa heavy chain]
[CFI IF] Complement factor I (EC 3.4.21.45) (C3B/C4B inactivator) [Cleaved into: Complement factor I heavy chain; Complement factor I light chain]
[] Coagulation factor X-activating enzyme heavy chain (EC 3.4.24.58) (Coagulation factor X-activating enzyme chain alpha) (Snake venom metalloproteinase) (SVMP) (VL factor X activator) (VLFXA heavy chain) [Cleaved into: Coagulation factor X-activating enzyme heavy chain alternate form]

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