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Cofilin-1 (Cofilin, non-muscle isoform)

 COF1_PIG                Reviewed;         166 AA.
P10668; Q29374;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 3.
16-JAN-2019, entry version 135.
RecName: Full=Cofilin-1;
AltName: Full=Cofilin, non-muscle isoform;
Name=CFL1;
Sus scrofa (Pig).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
Sus.
NCBI_TaxID=9823;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
TISSUE=Brain;
PubMed=3403546;
Matsuzaki F., Matsumoto S., Yahara I., Yonezawa N., Nishida E.,
Sakai H.;
"Cloning and characterization of porcine brain cofilin cDNA. Cofilin
contains the nuclear transport signal sequence.";
J. Biol. Chem. 263:11564-11568(1988).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-104.
TISSUE=Small intestine;
PubMed=8672129; DOI=10.1007/s003359900153;
Winteroe A.K., Fredholm M., Davies W.;
"Evaluation and characterization of a porcine small intestine cDNA
library: analysis of 839 clones.";
Mamm. Genome 7:509-517(1996).
[3]
ACTIN-BINDING.
PubMed=6509022; DOI=10.1021/bi00317a032;
Nishida E., Maekawa S., Sakai H.;
"Cofilin, a protein in porcine brain that binds to actin filaments and
inhibits their interactions with myosin and tropomyosin.";
Biochemistry 23:5307-5313(1984).
[4]
ACTIN-BINDING, AND PHOSPHORYLATION AT SER-3.
PubMed=9078368; DOI=10.1046/j.1365-2443.1996.05005.x;
Moriyama K., Iida K., Yahara I.;
"Phosphorylation of Ser-3 of cofilin regulates its essential function
on actin.";
Genes Cells 1:73-86(1996).
-!- FUNCTION: Binds to F-actin and exhibits pH-sensitive F-actin
depolymerizing activity. Regulates actin cytoskeleton dynamics
(PubMed:6509022, PubMed:9078368). Important for normal progress
through mitosis and normal cytokinesis. Plays a role in the
regulation of cell morphology and cytoskeletal organization.
Required for the up-regulation of atypical chemokine receptor
ACKR2 from endosomal compartment to cell membrane, increasing its
efficiency in chemokine uptake and degradation. Required for
neural tube morphogenesis and neural crest cell migration (By
similarity). {ECO:0000250|UniProtKB:P18760,
ECO:0000250|UniProtKB:P23528, ECO:0000269|PubMed:6509022,
ECO:0000269|PubMed:9078368}.
-!- SUBUNIT: Can bind G- and F-actin in a 1:1 ratio of cofilin to
actin. It is a major component of intranuclear and cytoplasmic
actin rods. {ECO:0000269|PubMed:6509022,
ECO:0000269|PubMed:9078368}.
-!- SUBCELLULAR LOCATION: Nucleus matrix
{ECO:0000250|UniProtKB:P23528}. Cytoplasm, cytoskeleton
{ECO:0000250|UniProtKB:P23528}. Cell projection, ruffle membrane
{ECO:0000250|UniProtKB:P23528}; Peripheral membrane protein
{ECO:0000250|UniProtKB:P23528}; Cytoplasmic side
{ECO:0000250|UniProtKB:P23528}. Cell projection, lamellipodium
membrane {ECO:0000250|UniProtKB:P23528}; Peripheral membrane
protein {ECO:0000250|UniProtKB:P23528}; Cytoplasmic side
{ECO:0000250|UniProtKB:P23528}. Cell projection, lamellipodium
{ECO:0000250|UniProtKB:P18760}. Note=Colocalizes with the actin
cytoskeleton in membrane ruffles and lamellipodia. Detected at the
cleavage furrow and contractile ring during cytokinesis. Almost
completely in nucleus in cells exposed to heat shock.
{ECO:0000250|UniProtKB:P23528}.
-!- TISSUE SPECIFICITY: Widely distributed in various tissues.
-!- PTM: Inactivated by phosphorylation on Ser-3 (PubMed:9078368).
Phosphorylated on Ser-3 in resting cells (By similarity).
Dephosphorylated by PDXP/chronophin; this restores its activity in
promoting actin filament depolymerization. The phosphorylation of
Ser-24 may prevent recognition of the nuclear localization signal
(By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1
cascade upon active ligand stimulation of atypical chemokine
receptor ACKR2 (By similarity). {ECO:0000250|UniProtKB:P45695,
ECO:0000269|PubMed:9078368}.
-!- SIMILARITY: Belongs to the actin-binding proteins ADF family.
{ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; M20866; AAA31020.1; -; mRNA.
EMBL; F14577; CAA23134.1; -; mRNA.
PIR; A29240; A29240.
RefSeq; NP_001004043.1; NM_001004043.1.
UniGene; Ssc.716; -.
ProteinModelPortal; P10668; -.
STRING; 9823.ENSSSCP00000030314; -.
iPTMnet; P10668; -.
PaxDb; P10668; -.
PeptideAtlas; P10668; -.
PRIDE; P10668; -.
Ensembl; ENSSSCT00000043957; ENSSSCP00000031883; ENSSSCG00000012974.
GeneID; 445532; -.
KEGG; ssc:445532; -.
CTD; 1072; -.
GeneTree; ENSGT00940000153214; -.
HOGENOM; HOG000039697; -.
HOVERGEN; HBG000381; -.
InParanoid; P10668; -.
KO; K05765; -.
OrthoDB; 1370477at2759; -.
Proteomes; UP000008227; Chromosome 2.
ExpressionAtlas; P10668; baseline and differential.
GO; GO:0015629; C:actin cytoskeleton; IEA:InterPro.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
GO; GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
GO; GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO; GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.
GO; GO:0051015; F:actin filament binding; IDA:UniProtKB.
GO; GO:0030042; P:actin filament depolymerization; IEA:InterPro.
GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
GO; GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
CDD; cd11286; ADF_cofilin_like; 1.
Gene3D; 3.40.20.10; -; 1.
InterPro; IPR002108; ADF-H.
InterPro; IPR029006; ADF-H/Gelsolin-like_dom_sf.
InterPro; IPR017904; ADF/Cofilin.
InterPro; IPR027234; Cofilin_1.
PANTHER; PTHR11913; PTHR11913; 1.
PANTHER; PTHR11913:SF17; PTHR11913:SF17; 1.
Pfam; PF00241; Cofilin_ADF; 1.
PRINTS; PR00006; COFILIN.
SMART; SM00102; ADF; 1.
PROSITE; PS51263; ADF_H; 1.
1: Evidence at protein level;
Acetylation; Actin-binding; Cell membrane; Cell projection;
Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing;
Isopeptide bond; Membrane; Nucleus; Phosphoprotein;
Reference proteome; Ubl conjugation.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:P23528}.
CHAIN 2 166 Cofilin-1.
/FTId=PRO_0000214901.
DOMAIN 4 153 ADF-H. {ECO:0000255|PROSITE-
ProRule:PRU00599}.
MOTIF 30 34 Nuclear localization signal.
{ECO:0000255}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:P23528}.
MOD_RES 3 3 Phosphoserine.
{ECO:0000250|UniProtKB:P23528}.
MOD_RES 8 8 Phosphoserine.
{ECO:0000250|UniProtKB:P18760}.
MOD_RES 13 13 N6-acetyllysine.
{ECO:0000250|UniProtKB:P23528}.
MOD_RES 25 25 Phosphothreonine.
{ECO:0000250|UniProtKB:P23528}.
MOD_RES 41 41 Phosphoserine.
{ECO:0000250|UniProtKB:P23528}.
MOD_RES 68 68 Phosphotyrosine.
{ECO:0000250|UniProtKB:P23528}.
MOD_RES 73 73 N6-acetyllysine.
{ECO:0000250|UniProtKB:P23528}.
MOD_RES 140 140 Phosphotyrosine.
{ECO:0000250|UniProtKB:P23528}.
MOD_RES 144 144 N6-acetyllysine.
{ECO:0000250|UniProtKB:P23528}.
MOD_RES 156 156 Phosphoserine.
{ECO:0000250|UniProtKB:P23528}.
CROSSLNK 132 132 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P23528}.
MUTAGEN 112 112 K->Q: Slight modification of activity.
Abolishes ability to depolymerize or bind
F-actin; when associated with Q-114.
MUTAGEN 114 114 K->Q: Impairs interaction with actin.
Abolishes ability to depolymerize or bind
F-actin; when associated with Q-112.
SEQUENCE 166 AA; 18519 MW; 589EE8EC1ED12719 CRC64;
MASGVAVSDG VIKVFNDMKV RKSSTPEEVK KRKKAVLFCL SEDKKNIILE EGKEILVGDV
GQTVDDPYAT FVKMLPDKDC RYALYDATYE TKESKKEDLV FIFWAPECAP LKSKMIYASS
KDAIKKKLTG IKHELQANCY EEVKDRCTLA EKLGGSAVIS LEGKPL


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Kits Elisa; taq POLYMERASE

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Pathways :
WP215: noncanonical wnt pathway
WP1088: Striated Muscle Contraction
WP1316: Striated Muscle Contraction
WP1403: AMPK signaling
WP1864: Muscle contraction
WP1946: Cori Cycle
WP1991: SRF and miRs in Smooth Muscle Differentiation and Proliferation
WP2005: Muscle cell TarBase
WP2012: miRs in Muscle Cell Differentiation
WP2076: miRs in Muscle Cell Differentiation
WP2081: SRF and miRs in Smooth Muscle Differentiation and Proliferation
WP2118: Arrhythmogenic right ventricular cardiomyopathy
WP216: Striated Muscle Contraction
WP316: Striated Muscle Contraction
WP383: Striated Muscle Contraction
WP745: Striated Muscle Contraction
WP850: Striated Muscle Contraction
WP969: Striated Muscle Contraction

Related Genes :
[CFL2] Cofilin-2 (Cofilin, muscle isoform)
[CFL1 CFL] Cofilin-1 (18 kDa phosphoprotein) (p18) (Cofilin, non-muscle isoform)
[CFL1] Cofilin-1 (Cofilin, non-muscle isoform)
[tsr Cadf CG4254] Cofilin/actin-depolymerizing factor homolog (Protein D61) (Protein twinstar)
[CFL1 QtrA-12052] Cofilin-1 (Cofilin, non-muscle isoform)
[CSRP3 CLP MLP] Cysteine and glycine-rich protein 3 (Cardiac LIM protein) (Cysteine-rich protein 3) (CRP3) (LIM domain protein, cardiac) (Muscle LIM protein)
[PPP3CA CALNA CNA] Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform)
[CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Smooth muscle calcium channel blocker receptor) (CACB-receptor) (Voltage-gated calcium channel subunit alpha Cav1.2)
[Ppp3ca Calna] Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha)
[SSH1 KIAA1298 SSH1L] Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (hSSH-1L)
[CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Voltage-gated calcium channel subunit alpha Cav1.2)
[Cacna1s Cach1 Cacn1 Cacnl1a3 Cchl1a3] Voltage-dependent L-type calcium channel subunit alpha-1S (Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle) (ROB1) (Voltage-gated calcium channel subunit alpha Cav1.1)
[ATP2A2 ATP2B] Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA2) (SR Ca(2+)-ATPase 2) (EC 7.2.2.10) (Calcium pump 2) (Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
[PPP3CA] Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform)
[Cacna1c Cach2 Cacn2 Cacnl1a1 Cchl1a1] Voltage-dependent L-type calcium channel subunit alpha-1C (Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle) (Rat brain class C) (RBC) (Voltage-gated calcium channel subunit alpha Cav1.2)
[PHKG1 PHKG] Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (PHK-gamma-M) (EC 2.7.11.19) (Phosphorylase kinase subunit gamma-1) (Serine/threonine-protein kinase PHKG1) (EC 2.7.11.1) (EC 2.7.11.26)
[Ssh1 Kiaa1298 Ssh1l] Protein phosphatase Slingshot homolog 1 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 1) (SSH-1L) (mSSH-1L)
[Ppp3ca Calna] Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calmodulin-dependent calcineurin A subunit alpha isoform)
[MYLK MLCK MLCK1 MYLK1] Myosin light chain kinase, smooth muscle (MLCK) (smMLCK) (EC 2.7.11.18) (Kinase-related protein) (KRP) (Telokin) [Cleaved into: Myosin light chain kinase, smooth muscle, deglutamylated form]
[MYBPC1 MYBPCS] Myosin-binding protein C, slow-type (Slow MyBP-C) (C-protein, skeletal muscle slow isoform)
[PHKA1] Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit)
[PAK1] Serine/threonine-protein kinase PAK 1 (EC 2.7.11.1) (Alpha-PAK) (p21-activated kinase 1) (PAK-1) (p65-PAK)
[MYL2 MLC2] Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Cardiac myosin light chain 2) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v) (Ventricular myosin light chain 2)
[Myl2 Mylpc] Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) (MLC-2v) (Myosin light chain 2, slow skeletal/ventricular muscle isoform) (MLC-2s/v)
[GTF2IRD1 CREAM1 GTF3 MUSTRD1 RBAP2 WBSCR11 WBSCR12] General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein)
[ATP2A1] Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (SR Ca(2+)-ATPase 1) (EC 7.2.2.10) (Calcium pump 1) (Calcium-transporting ATPase sarcoplasmic reticulum type, fast twitch skeletal muscle isoform) (Endoplasmic reticulum class 1/2 Ca(2+) ATPase)
[PHKA1 PHKA] Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (Phosphorylase kinase alpha M subunit)
[RYR1 RYDR] Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)
[ACTN1] Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
[RYR1] Ryanodine receptor 1 (RYR-1) (RyR1) (Skeletal muscle calcium release channel) (Skeletal muscle ryanodine receptor) (Skeletal muscle-type ryanodine receptor) (Type 1 ryanodine receptor)

Bibliography :
[30858759] miR-182-5p affects human bladder cancer cell proliferation, migration and invasion through regulating Cofilin 1.
[30817901] Baicalein improves cognitive deficits and hippocampus impairments in temporal lobe epilepsy rats.
[30622602] Zuo Jin Wan Reverses DDP Resistance in Gastric Cancer through ROCK/PTEN/PI3K Signaling Pathway.
[30598868] Meningeal Bmps Regulate Cortical Layer Formation.
[30587509] Identification of Novel Protein Targets of Dimethyl Fumarate Modification in Neurons and Astrocytes Reveals Actions Independent of Nrf2 Stabilization.
[30580573] Dynamic Actin Reorganization and Vav/Cdc42-Dependent Actin Polymerization Promote Macrophage Aggregated LDL (Low-Density Lipoprotein) Uptake and Catabolism.
[30572138] Novel autoantibodies in Sjögren's syndrome: A comprehensive review.
[30550624] Detection of malignancy-associated phosphoproteome changes in human colorectal cancer induced by cell surface binding of growth-inhibitory galectin-4.
[30542401] Identification and validation of differentially expressed proteins in serum of CSU patients with different duration of wheals using an iTRAQ labeling, 2D-LC-MS/MS.
[30523239] [Role of cofilin in kidney disease].
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