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Crk-like protein

 A0A250YEU8_CASCN        Unreviewed;       303 AA.
22-NOV-2017, integrated into UniProtKB/TrEMBL.
22-NOV-2017, sequence version 1.
17-JUN-2020, entry version 16.
SubName: Full=Crk-like protein {ECO:0000313|EMBL:JAV42182.1};
Name=CRKL {ECO:0000313|EMBL:JAV42182.1};
Castor canadensis (American beaver).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Castorimorpha; Castoridae;
NCBI_TaxID=51338 {ECO:0000313|EMBL:JAV42182.1};
[1] {ECO:0000313|EMBL:JAV42182.1}
STRAIN=Ward {ECO:0000313|EMBL:JAV42182.1};
TISSUE=Leukocyte {ECO:0000313|EMBL:JAV42182.1};
PubMed=28087693; DOI=10.1534/g3.116.038208;
Lok S., Paton T.A., Wang Z., Kaur G., Walker S., Yuen R.K., Sung W.W.,
Whitney J., Buchanan J.A., Trost B., Singh N., Apresto B., Chen N.,
Coole M., Dawson T.J., Ho K.Y., Hu Z., Pullenayegum S., Samler K.,
Shipstone A., Tsoi F., Wang T., Pereira S.L., Rostami P., Ryan C.A.,
Tong A.H., Ng K., Sundaravadanam Y., Simpson J.T., Lim B.K., Engstrom M.D.,
Dutton C.J., Kerr K.C., Franke M., Rapley W., Wintle R.F., Scherer S.W.;
"De Novo Genome and Transcriptome Assembly of the Canadian Beaver (Castor
G3 (Bethesda) 7:755-773(2017).
Copyrighted by the UniProt Consortium, see
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; GFFW01002606; JAV42182.1; -; Transcribed_RNA.
RefSeq; XP_020016330.1; XM_020160741.1.
GeneID; 109684371; -.
KEGG; ccan:109684371; -.
CTD; 1399; -.
KO; K04438; -.
OrthoDB; 1414461at2759; -.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0098890; C:extrinsic component of postsynaptic membrane; IEA:Ensembl.
GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0095500; P:acetylcholine receptor signaling pathway; IEA:Ensembl.
GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0001783; P:B cell apoptotic process; IEA:Ensembl.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
GO; GO:0098761; P:cellular response to interleukin-7; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0098749; P:cerebellar neuron development; IEA:Ensembl.
GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO; GO:1904888; P:cranial skeletal system development; IEA:Ensembl.
GO; GO:0016358; P:dendrite development; IEA:Ensembl.
GO; GO:0086100; P:endothelin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0035685; P:helper T cell diapedesis; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
GO; GO:0060465; P:pharynx development; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:1903977; P:positive regulation of glial cell migration; IEA:Ensembl.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0038026; P:reelin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0033628; P:regulation of cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl.
GO; GO:0050773; P:regulation of dendrite development; IEA:Ensembl.
GO; GO:1904393; P:regulation of skeletal muscle acetylcholine-gated channel clustering; IEA:Ensembl.
GO; GO:2000404; P:regulation of T cell migration; IEA:Ensembl.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
GO; GO:0007338; P:single fertilization; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
CDD; cd11759; SH3_CRK_C; 1.
CDD; cd11758; SH3_CRK_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR035458; CRK_SH3_C.
InterPro; IPR035457; CRK_SH3_N.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
Pfam; PF07653; SH3_2; 1.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
4: Predicted;
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
DOMAIN 14..102
DOMAIN 123..183
DOMAIN 235..296
REGION 184..204
SEQUENCE 303 AA; 33802 MW; E63FB6D297951C3E CRC64;

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WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
WP1892: Protein folding
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1675: Nitrogen metabolism
WP813: G Protein Signaling Pathways
WP1685: Peptidoglycan biosynthesis
WP1032: NLR proteins
WP1616: ABC transporters
WP2199: Seed Development
WP1963: The effect of Glucocorticoids on target gene expression
WP1644: DNA replication
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Related Genes :
[CRK] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[Crk Crko] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[Crk Crko] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[CRK] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[crk1 mcs6 mop1 SPBC19F8.07] Serine/threonine-protein kinase crk1 (EC (Mitotic catastrophe suppressor 6)
[Cdk7 Cak Cdkn7 Crk4 Mo15 Mpk-7] Cyclin-dependent kinase 7 (EC (EC (39 kDa protein kinase) (P39 Mo15) (CDK-activating kinase) (CR4 protein kinase) (CRK4) (Cell division protein kinase 7) (Protein-tyrosine kinase MPK-7) (TFIIH basal transcription factor complex kinase subunit)
[NEDD9 CASL CASS2] Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
[BCAR1 CAS CASS1 CRKAS] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
[DOCK1] Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
[RAPGEF1 GRF2] Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)
[CRK36 At4g04490 T26N6.10] Cysteine-rich receptor-like protein kinase 36 (Cysteine-rich RLK36) (EC
[CRK45 ARCK1 At4g11890] Cysteine-rich receptor-like protein kinase 45 (Cysteine-rich RLK45) (EC (ABA- and osmotic stress-inducible receptor-like cytosolic kinase 1)
[CRKL] Crk-like protein
[Bcar1 Cas Crkas] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)
[Bcar1 Cas Crkas] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)
[Crkl Crkol] Crk-like protein
[Crkl] Crk-like protein
[Nedd9 Casl] Enhancer of filamentation 1 (mEF1) (CRK-associated substrate-related protein) (CAS-L) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (p105)
[CDK12 CRK7 CRKRS KIAA0904] Cyclin-dependent kinase 12 (EC (EC (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)
[CRK5 RLK6 At4g23130 F21P8.20 F7H19.320] Cysteine-rich receptor-like protein kinase 5 (Cysteine-rich RLK5) (EC 2.7.11.-) (Receptor-like protein kinase 6)
[CRK10 RLK4 At4g23180 F21P8.70] Cysteine-rich receptor-like protein kinase 10 (Cysteine-rich RLK10) (EC 2.7.11.-) (Receptor-like protein kinase 4)
[CRK6 RLK5 At4g23140 F21P8.30 F7H19.330] Cysteine-rich receptor-like protein kinase 6 (Cysteine-rich RLK6) (EC 2.7.11.-) (Receptor-like protein kinase 5)
[CRK1 BUR1 CAALFM_C204930CA CaO19.11006 CaO19.3523/3524] Serine/threonine-protein kinase BUR1 (EC (EC
[Dock1] Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
[C3G CG42328] Guanine nucleotide-releasing factor 2 (CRK SH3-binding GNRP) (DC3G)
[CRK19 At4g23270 F21P8.160] Cysteine-rich receptor-like protein kinase 19 (Cysteine-rich RLK19) (EC 2.7.11.-)
[GW7_01813] Crk-like protein
[CRKL] CRK like proto-oncogene, adaptor protein
[CRKL] crk-like protein
[CRKL] Crk-like protein

Bibliography :
[32606017] FYN and ABL regulate the interaction networks of the DCBLD receptor family.
[32238101] Proteomic analysis of desmosomes reveals novel components required for epidermal integrity.
[32041892] Essential role of the family-dosage in DiGeorge-like anomaly and metabolic homeostasis.
[31527084] Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2.
[31515267] Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks.
[31323992] Increased Soluble CrkL in Serum of Breast Cancer Patients Is Associated with Advanced Disease.
[31133010] CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.
[30015845] Downregulation of miR‑486‑5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing.
[29868839] An in silico proteomics screen to predict and prioritize protein-protein interactions dependent on post-translationally modified motifs.
[29698473] Transcriptome reprogramming of resistant and susceptible peach genotypes during Xanthomonas arboricola pv. pruni early leaf infection.