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Crk-like protein

 F7HYH0_CALJA            Unreviewed;       303 AA.
27-JUL-2011, integrated into UniProtKB/TrEMBL.
27-JUL-2011, sequence version 1.
17-JUN-2020, entry version 62.
SubName: Full=Crk-like protein {ECO:0000313|EMBL:JAB12782.1};
Name=CRKL {ECO:0000313|EMBL:JAB12782.1,
Callithrix jacchus (White-tufted-ear marmoset).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
Callitrichinae; Callithrix; Callithrix.
NCBI_TaxID=9483 {ECO:0000313|EMBL:JAB12782.1};
[1] {ECO:0000313|Ensembl:ENSCJAP00000071541}
Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:JAB12782.1}
TISSUE=Bladder {ECO:0000313|EMBL:JAB04946.1},
Cerebellum {ECO:0000313|EMBL:JAB51955.1},
Cerebral cortex {ECO:0000313|EMBL:JAB25092.1}, and
Hippocampus {ECO:0000313|EMBL:JAB12782.1};
PubMed=25243066; DOI=10.1186/2047-217X-3-14;
Maudhoo M.D., Ren D., Gradnigo J.S., Gibbs R.M., Lubker A.C.,
Moriyama E.N., French J.A., Norgren R.B.Jr.;
"De novo assembly of the common marmoset transcriptome from NextGen mRNA
Gigascience 3:14-14(2014).
[3] {ECO:0000313|Ensembl:ENSCJAP00000071541}
Submitted (OCT-2019) to UniProtKB.
Copyrighted by the UniProt Consortium, see
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; GAMT01006915; JAB04946.1; -; mRNA.
EMBL; GAMS01010354; JAB12782.1; -; mRNA.
EMBL; GAMR01008840; JAB25092.1; -; mRNA.
EMBL; GAMP01000800; JAB51955.1; -; mRNA.
EMBL; GAMP01000799; JAB51956.1; -; mRNA.
EMBL; GAMP01000798; JAB51957.1; -; mRNA.
RefSeq; XP_017833667.1; XM_017978178.1.
STRING; 9483.ENSCJAP00000029210; -.
Ensembl; ENSCJAT00000104961; ENSCJAP00000071541; ENSCJAG00000057682.
GeneID; 100390206; -.
KEGG; cjc:100390206; -.
CTD; 1399; -.
eggNOG; KOG4792; Eukaryota.
eggNOG; ENOG4110574; LUCA.
GeneTree; ENSGT00820000127055; -.
HOGENOM; CLU_060542_0_1_1; -.
KO; K04438; -.
OrthoDB; 1414461at2759; -.
TreeFam; TF321436; -.
Proteomes; UP000008225; Unplaced.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0098890; C:extrinsic component of postsynaptic membrane; IEA:Ensembl.
GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
GO; GO:0095500; P:acetylcholine receptor signaling pathway; IEA:Ensembl.
GO; GO:0090630; P:activation of GTPase activity; IEA:Ensembl.
GO; GO:0000187; P:activation of MAPK activity; IEA:Ensembl.
GO; GO:0009952; P:anterior/posterior pattern specification; IEA:Ensembl.
GO; GO:0001783; P:B cell apoptotic process; IEA:Ensembl.
GO; GO:0001568; P:blood vessel development; IEA:Ensembl.
GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
GO; GO:0098761; P:cellular response to interleukin-7; IEA:Ensembl.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEA:Ensembl.
GO; GO:0098749; P:cerebellar neuron development; IEA:Ensembl.
GO; GO:0021987; P:cerebral cortex development; IEA:Ensembl.
GO; GO:1904888; P:cranial skeletal system development; IEA:Ensembl.
GO; GO:0016358; P:dendrite development; IEA:Ensembl.
GO; GO:0086100; P:endothelin receptor signaling pathway; IEA:Ensembl.
GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0035685; P:helper T cell diapedesis; IEA:Ensembl.
GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
GO; GO:0006629; P:lipid metabolic process; IEA:Ensembl.
GO; GO:0008584; P:male gonad development; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
GO; GO:0001764; P:neuron migration; IEA:Ensembl.
GO; GO:0003151; P:outflow tract morphogenesis; IEA:Ensembl.
GO; GO:0060017; P:parathyroid gland development; IEA:Ensembl.
GO; GO:0060465; P:pharynx development; IEA:Ensembl.
GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:1903977; P:positive regulation of glial cell migration; IEA:Ensembl.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; IEA:Ensembl.
GO; GO:0038026; P:reelin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0033628; P:regulation of cell adhesion mediated by integrin; IEA:Ensembl.
GO; GO:0001558; P:regulation of cell growth; IEA:Ensembl.
GO; GO:0050773; P:regulation of dendrite development; IEA:Ensembl.
GO; GO:1904393; P:regulation of skeletal muscle acetylcholine-gated channel clustering; IEA:Ensembl.
GO; GO:2000404; P:regulation of T cell migration; IEA:Ensembl.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:Ensembl.
GO; GO:0007338; P:single fertilization; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Ensembl.
GO; GO:0048538; P:thymus development; IEA:Ensembl.
GO; GO:0001655; P:urogenital system development; IEA:Ensembl.
CDD; cd11759; SH3_CRK_C; 1.
CDD; cd11758; SH3_CRK_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR035458; CRK_SH3_C.
InterPro; IPR035457; CRK_SH3_N.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
Pfam; PF07653; SH3_2; 1.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
2: Evidence at transcript level;
Reference proteome {ECO:0000313|Proteomes:UP000008225};
SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192,
DOMAIN 14..102
DOMAIN 123..183
DOMAIN 235..296
REGION 184..234
SEQUENCE 303 AA; 33764 MW; C9EC0D0220F36CC7 CRC64;

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WP1892: Protein folding
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1665: Limonene and pinene degradation
WP525: Mitochondrial Unfolded-Protein Response
WP914: NLR proteins
WP1438: Influenza A virus infection
WP813: G Protein Signaling Pathways
WP1531: Vitamin D synthesis
WP2032: TSH signaling pathway
WP1887: Post-translational modification: synthesis of GPI-anchored proteins
WP1675: Nitrogen metabolism
WP1963: The effect of Glucocorticoids on target gene expression
WP1685: Peptidoglycan biosynthesis
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WP1616: ABC transporters
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Related Genes :
[CRK] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[Crk Crko] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[Crk Crko] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[CRK] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[crk1 mcs6 mop1 SPBC19F8.07] Serine/threonine-protein kinase crk1 (EC (Mitotic catastrophe suppressor 6)
[Cdk7 Cak Cdkn7 Crk4 Mo15 Mpk-7] Cyclin-dependent kinase 7 (EC (EC (39 kDa protein kinase) (P39 Mo15) (CDK-activating kinase) (CR4 protein kinase) (CRK4) (Cell division protein kinase 7) (Protein-tyrosine kinase MPK-7) (TFIIH basal transcription factor complex kinase subunit)
[NEDD9 CASL CASS2] Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
[BCAR1 CAS CASS1 CRKAS] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
[DOCK1] Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
[RAPGEF1 GRF2] Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)
[CRK36 At4g04490 T26N6.10] Cysteine-rich receptor-like protein kinase 36 (Cysteine-rich RLK36) (EC
[CRK45 ARCK1 At4g11890] Cysteine-rich receptor-like protein kinase 45 (Cysteine-rich RLK45) (EC (ABA- and osmotic stress-inducible receptor-like cytosolic kinase 1)
[CRKL] Crk-like protein
[Bcar1 Cas Crkas] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)
[Bcar1 Cas Crkas] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)
[Crkl Crkol] Crk-like protein
[Crkl] Crk-like protein
[Nedd9 Casl] Enhancer of filamentation 1 (mEF1) (CRK-associated substrate-related protein) (CAS-L) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (p105)
[CDK12 CRK7 CRKRS KIAA0904] Cyclin-dependent kinase 12 (EC (EC (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)
[CRK5 RLK6 At4g23130 F21P8.20 F7H19.320] Cysteine-rich receptor-like protein kinase 5 (Cysteine-rich RLK5) (EC 2.7.11.-) (Receptor-like protein kinase 6)
[CRK10 RLK4 At4g23180 F21P8.70] Cysteine-rich receptor-like protein kinase 10 (Cysteine-rich RLK10) (EC 2.7.11.-) (Receptor-like protein kinase 4)
[CRK6 RLK5 At4g23140 F21P8.30 F7H19.330] Cysteine-rich receptor-like protein kinase 6 (Cysteine-rich RLK6) (EC 2.7.11.-) (Receptor-like protein kinase 5)
[CRK1 BUR1 CAALFM_C204930CA CaO19.11006 CaO19.3523/3524] Serine/threonine-protein kinase BUR1 (EC (EC
[Dock1] Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
[C3G CG42328] Guanine nucleotide-releasing factor 2 (CRK SH3-binding GNRP) (DC3G)
[CRK19 At4g23270 F21P8.160] Cysteine-rich receptor-like protein kinase 19 (Cysteine-rich RLK19) (EC 2.7.11.-)
[GW7_01813] Crk-like protein
[CRKL] CRK like proto-oncogene, adaptor protein
[CRKL] crk-like protein
[CRKL] Crk-like protein

Bibliography :
[32606017] FYN and ABL regulate the interaction networks of the DCBLD receptor family.
[32238101] Proteomic analysis of desmosomes reveals novel components required for epidermal integrity.
[32041892] Essential role of the family-dosage in DiGeorge-like anomaly and metabolic homeostasis.
[31527084] Phosphorylation of the multifunctional signal transducer B-cell adaptor protein (BCAP) promotes recruitment of multiple SH2/SH3 proteins including GRB2.
[31515267] Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks.
[31323992] Increased Soluble CrkL in Serum of Breast Cancer Patients Is Associated with Advanced Disease.
[31133010] CRKL regulates alternative splicing of cancer-related genes in cervical cancer samples and HeLa cell.
[30015845] Downregulation of miR‑486‑5p in papillary thyroid carcinoma tissue: A study based on microarray and miRNA sequencing.
[29868839] An in silico proteomics screen to predict and prioritize protein-protein interactions dependent on post-translationally modified motifs.
[29698473] Transcriptome reprogramming of resistant and susceptible peach genotypes during Xanthomonas arboricola pv. pruni early leaf infection.