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Crk-like protein

 CRKL_MOUSE              Reviewed;         303 AA.
P47941; Q3TQ18; Q8BGC5;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-2005, sequence version 2.
17-JUN-2020, entry version 168.
RecName: Full=Crk-like protein;
Name=Crkl; Synonyms=Crkol;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL X CBA; TISSUE=Placenta;
PubMed=7478571;
de Jong R.L., Haataja L., Voncken J.W., Heisterkamp N., Groffen J.;
"Tyrosine phosphorylation of murine Crkl.";
Oncogene 11:1469-1474(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Embryonic head, and Embryonic heart;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
INTERACTION WITH INPP5D.
PubMed=11031258; DOI=10.1074/jbc.m006250200;
Sattler M., Verma S., Pride Y.B., Salgia R., Rohrschneider L.R.,
Griffin J.D.;
"SHIP1, an SH2 domain containing polyinositol-5-phosphatase, regulates
migration through two critical tyrosine residues and forms a novel
signaling complex with DOK1 and CRKL.";
J. Biol. Chem. 276:2451-2458(2001).
[4]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Embryonic brain;
PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
"Phosphoproteomic analysis of the developing mouse brain.";
Mol. Cell. Proteomics 3:1093-1101(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain;
PubMed=18034455; DOI=10.1021/pr0701254;
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.;
"Large-scale identification and evolution indexing of tyrosine
phosphorylation sites from murine brain.";
J. Proteome Res. 7:311-318(2008).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: May mediate the transduction of intracellular signals.
-!- SUBUNIT: Interacts with DOCK2 and EPOR. Interacts with phosphorylated
CBLB and IRS4 (By similarity). Interacts with INPP5D/SHIP1.
{ECO:0000250, ECO:0000269|PubMed:11031258}.
-!- PTM: Phosphorylated on tyrosine. Phosphorylation is prominent during
early development, but decreases at later embryonic stages and in
newborn mice.
-!- SIMILARITY: Belongs to the CRK family. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; X90648; CAA62220.1; -; mRNA.
EMBL; AK048641; BAC33406.1; -; mRNA.
EMBL; AK052315; BAC34933.1; -; mRNA.
EMBL; AK163981; BAE37567.1; -; mRNA.
CCDS; CCDS28002.1; -.
PIR; S58352; S58352.
RefSeq; NP_001264160.1; NM_001277231.1.
RefSeq; NP_031790.2; NM_007764.5.
SMR; P47941; -.
BioGRID; 198888; 18.
CORUM; P47941; -.
IntAct; P47941; 10.
MINT; P47941; -.
STRING; 10090.ENSMUSP00000006293; -.
iPTMnet; P47941; -.
PhosphoSitePlus; P47941; -.
REPRODUCTION-2DPAGE; IPI00113362; -.
EPD; P47941; -.
jPOST; P47941; -.
MaxQB; P47941; -.
PaxDb; P47941; -.
PRIDE; P47941; -.
Antibodypedia; 255; 712 antibodies.
Ensembl; ENSMUST00000006293; ENSMUSP00000006293; ENSMUSG00000006134.
GeneID; 12929; -.
KEGG; mmu:12929; -.
UCSC; uc007ykv.2; mouse.
CTD; 1399; -.
MGI; MGI:104686; Crkl.
eggNOG; KOG4792; Eukaryota.
eggNOG; ENOG4110574; LUCA.
GeneTree; ENSGT00820000127055; -.
HOGENOM; CLU_060542_0_1_1; -.
InParanoid; P47941; -.
KO; K04438; -.
OMA; SWYMGPV; -.
OrthoDB; 1414461at2759; -.
PhylomeDB; P47941; -.
TreeFam; TF321436; -.
Reactome; R-MMU-170968; Frs2-mediated activation.
Reactome; R-MMU-186763; Downstream signal transduction.
Reactome; R-MMU-8875555; MET activates RAP1 and RAC1.
Reactome; R-MMU-8875656; MET receptor recycling.
Reactome; R-MMU-9027284; Erythropoietin activates RAS.
Reactome; R-MMU-912631; Regulation of signaling by CBL.
BioGRID-ORCS; 12929; 3 hits in 12 CRISPR screens.
ChiTaRS; Crkl; mouse.
PRO; PR:P47941; -.
Proteomes; UP000000589; Chromosome 16.
RNAct; P47941; protein.
Bgee; ENSMUSG00000006134; Expressed in cardiac ventricle and 295 other tissues.
ExpressionAtlas; P47941; baseline and differential.
Genevisible; P47941; MM.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0098890; C:extrinsic component of postsynaptic membrane; IDA:SynGO.
GO; GO:0031594; C:neuromuscular junction; IDA:SynGO.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0032991; C:protein-containing complex; IDA:MGI.
GO; GO:0045202; C:synapse; IDA:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0001784; F:phosphotyrosine residue binding; ISO:MGI.
GO; GO:0095500; P:acetylcholine receptor signaling pathway; IGI:MGI.
GO; GO:0090630; P:activation of GTPase activity; IGI:MGI.
GO; GO:0000187; P:activation of MAPK activity; IDA:MGI.
GO; GO:0009887; P:animal organ morphogenesis; IMP:MGI.
GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
GO; GO:0001783; P:B cell apoptotic process; IMP:MGI.
GO; GO:0001568; P:blood vessel development; IGI:MGI.
GO; GO:0060326; P:cell chemotaxis; IGI:MGI.
GO; GO:0035690; P:cellular response to drug; IDA:MGI.
GO; GO:0098761; P:cellular response to interleukin-7; IDA:MGI.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; ISO:MGI.
GO; GO:0098749; P:cerebellar neuron development; IGI:MGI.
GO; GO:0021987; P:cerebral cortex development; IGI:MGI.
GO; GO:1904888; P:cranial skeletal system development; IMP:MGI.
GO; GO:0016358; P:dendrite development; IGI:MGI.
GO; GO:0086100; P:endothelin receptor signaling pathway; IMP:MGI.
GO; GO:0030010; P:establishment of cell polarity; IGI:MGI.
GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IMP:MGI.
GO; GO:0007507; P:heart development; IGI:MGI.
GO; GO:0035685; P:helper T cell diapedesis; IGI:MGI.
GO; GO:0021766; P:hippocampus development; IGI:MGI.
GO; GO:0006629; P:lipid metabolic process; IGI:MGI.
GO; GO:0008584; P:male gonad development; IMP:MGI.
GO; GO:0010629; P:negative regulation of gene expression; ISO:MGI.
GO; GO:0001933; P:negative regulation of protein phosphorylation; ISO:MGI.
GO; GO:0001764; P:neuron migration; IMP:MGI.
GO; GO:0003151; P:outflow tract morphogenesis; IMP:MGI.
GO; GO:0060017; P:parathyroid gland development; IGI:MGI.
GO; GO:0007389; P:pattern specification process; IGI:MGI.
GO; GO:0060465; P:pharynx development; IMP:MGI.
GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:MGI.
GO; GO:1903977; P:positive regulation of glial cell migration; ISO:MGI.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISO:MGI.
GO; GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; ISO:MGI.
GO; GO:0038026; P:reelin-mediated signaling pathway; IMP:MGI.
GO; GO:0033628; P:regulation of cell adhesion mediated by integrin; IGI:MGI.
GO; GO:0001558; P:regulation of cell growth; IDA:MGI.
GO; GO:0050773; P:regulation of dendrite development; IGI:MGI.
GO; GO:0010468; P:regulation of gene expression; IMP:MGI.
GO; GO:0002685; P:regulation of leukocyte migration; IGI:MGI.
GO; GO:1904393; P:regulation of skeletal muscle acetylcholine-gated channel clustering; IGI:MGI.
GO; GO:2000404; P:regulation of T cell migration; IGI:MGI.
GO; GO:0071774; P:response to fibroblast growth factor; IMP:MGI.
GO; GO:0048384; P:retinoic acid receptor signaling pathway; IMP:MGI.
GO; GO:0007338; P:single fertilization; IMP:MGI.
GO; GO:0007283; P:spermatogenesis; IMP:MGI.
GO; GO:0007416; P:synapse assembly; IDA:SynGO.
GO; GO:0050852; P:T cell receptor signaling pathway; IDA:MGI.
GO; GO:0048538; P:thymus development; IGI:MGI.
GO; GO:0001655; P:urogenital system development; IMP:MGI.
CDD; cd11759; SH3_CRK_C; 1.
CDD; cd11758; SH3_CRK_N; 1.
Gene3D; 3.30.505.10; -; 1.
InterPro; IPR035458; CRK_SH3_C.
InterPro; IPR035457; CRK_SH3_N.
InterPro; IPR000980; SH2.
InterPro; IPR036860; SH2_dom_sf.
InterPro; IPR036028; SH3-like_dom_sf.
InterPro; IPR001452; SH3_domain.
Pfam; PF00017; SH2; 1.
Pfam; PF00018; SH3_1; 1.
Pfam; PF07653; SH3_2; 1.
PRINTS; PR00401; SH2DOMAIN.
PRINTS; PR00452; SH3DOMAIN.
SMART; SM00252; SH2; 1.
SMART; SM00326; SH3; 2.
SUPFAM; SSF50044; SSF50044; 2.
SUPFAM; SSF55550; SSF55550; 1.
PROSITE; PS50001; SH2; 1.
PROSITE; PS50002; SH3; 2.
1: Evidence at protein level;
Phosphoprotein; Reference proteome; Repeat; SH2 domain; SH3 domain.
CHAIN 1..303
/note="Crk-like protein"
/id="PRO_0000079348"
DOMAIN 14..102
/note="SH2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
DOMAIN 123..183
/note="SH3 1"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
DOMAIN 235..296
/note="SH3 2"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
MOD_RES 127
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:P46109"
MOD_RES 207
/note="Phosphotyrosine"
/evidence="ECO:0000250|UniProtKB:P46109"
CONFLICT 165
/note="N -> T (in Ref. 1; CAA62220)"
/evidence="ECO:0000305"
SEQUENCE 303 AA; 33830 MW; A8C801F78EF73573 CRC64;
MSSARFDSSD RSAWYMGPVT RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPV GSVSAPNLPT
AEENLEYVRT LYDFPGNDAE DLPFKKGELL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK
LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPTVA STPGAAINPL PSTQNGPVFA
KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD
DNE


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Related Genes :
[CRK] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[Crk Crko] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[Crk Crko] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[CRK] Adapter molecule crk (Proto-oncogene c-Crk) (p38)
[crk1 mcs6 mop1 SPBC19F8.07] Serine/threonine-protein kinase crk1 (EC 2.7.11.23) (Mitotic catastrophe suppressor 6)
[Cdk7 Cak Cdkn7 Crk4 Mo15 Mpk-7] Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (P39 Mo15) (CDK-activating kinase) (CR4 protein kinase) (CRK4) (Cell division protein kinase 7) (Protein-tyrosine kinase MPK-7) (TFIIH basal transcription factor complex kinase subunit)
[NEDD9 CASL CASS2] Enhancer of filamentation 1 (hEF1) (CRK-associated substrate-related protein) (CAS-L) (CasL) (Cas scaffolding protein family member 2) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (Renal carcinoma antigen NY-REN-12) (p105) [Cleaved into: Enhancer of filamentation 1 p55]
[BCAR1 CAS CASS1 CRKAS] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (Cas scaffolding protein family member 1) (p130cas)
[DOCK1] Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
[RAPGEF1 GRF2] Rap guanine nucleotide exchange factor 1 (CRK SH3-binding GNRP) (Guanine nucleotide-releasing factor 2) (Protein C3G)
[CRK36 At4g04490 T26N6.10] Cysteine-rich receptor-like protein kinase 36 (Cysteine-rich RLK36) (EC 2.7.11.1)
[CRK45 ARCK1 At4g11890] Cysteine-rich receptor-like protein kinase 45 (Cysteine-rich RLK45) (EC 2.7.11.1) (ABA- and osmotic stress-inducible receptor-like cytosolic kinase 1)
[CRKL] Crk-like protein
[Bcar1 Cas Crkas] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)
[Bcar1 Cas Crkas] Breast cancer anti-estrogen resistance protein 1 (CRK-associated substrate) (p130cas)
[Crkl Crkol] Crk-like protein
[Crkl] Crk-like protein
[Nedd9 Casl] Enhancer of filamentation 1 (mEF1) (CRK-associated substrate-related protein) (CAS-L) (Neural precursor cell expressed developmentally down-regulated protein 9) (NEDD-9) (p105)
[CDK12 CRK7 CRKRS KIAA0904] Cyclin-dependent kinase 12 (EC 2.7.11.22) (EC 2.7.11.23) (Cdc2-related kinase, arginine/serine-rich) (CrkRS) (Cell division cycle 2-related protein kinase 7) (CDC2-related protein kinase 7) (Cell division protein kinase 12) (hCDK12)
[CRK5 RLK6 At4g23130 F21P8.20 F7H19.320] Cysteine-rich receptor-like protein kinase 5 (Cysteine-rich RLK5) (EC 2.7.11.-) (Receptor-like protein kinase 6)
[CRK10 RLK4 At4g23180 F21P8.70] Cysteine-rich receptor-like protein kinase 10 (Cysteine-rich RLK10) (EC 2.7.11.-) (Receptor-like protein kinase 4)
[CRK6 RLK5 At4g23140 F21P8.30 F7H19.330] Cysteine-rich receptor-like protein kinase 6 (Cysteine-rich RLK6) (EC 2.7.11.-) (Receptor-like protein kinase 5)
[CRK1 BUR1 CAALFM_C204930CA CaO19.11006 CaO19.3523/3524] Serine/threonine-protein kinase BUR1 (EC 2.7.11.22) (EC 2.7.11.23)
[Dock1] Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
[C3G CG42328] Guanine nucleotide-releasing factor 2 (CRK SH3-binding GNRP) (DC3G)
[CRK19 At4g23270 F21P8.160] Cysteine-rich receptor-like protein kinase 19 (Cysteine-rich RLK19) (EC 2.7.11.-)
[GW7_01813] Crk-like protein
[CRKL] CRK like proto-oncogene, adaptor protein
[CRKL] crk-like protein
[CRKL] Crk-like protein

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[31323992] Increased Soluble CrkL in Serum of Breast Cancer Patients Is Associated with Advanced Disease.
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