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Cullin 1

 E2R1V2_CANLF            Unreviewed;       776 AA.
E2R1V2;
30-NOV-2010, integrated into UniProtKB/TrEMBL.
31-OCT-2012, sequence version 2.
02-JUN-2021, entry version 80.
SubName: Full=Cullin 1 {ECO:0000313|Ensembl:ENSCAFP00000005151};
Name=CUL1 {ECO:0000313|Ensembl:ENSCAFP00000005151,
ECO:0000313|VGNC:VGNC:39728};
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
NCBI_TaxID=9615 {ECO:0000313|Ensembl:ENSCAFP00000005151, ECO:0000313|Proteomes:UP000002254};
[1] {ECO:0000313|Ensembl:ENSCAFP00000005151, ECO:0000313|Proteomes:UP000002254}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000005151,
ECO:0000313|Proteomes:UP000002254};
PubMed=16341006; DOI=10.1038/nature04338;
Broad Sequencing Platform;
Lindblad-Toh K., Wade C.M., Mikkelsen T.S., Karlsson E.K., Jaffe D.B.,
Kamal M., Clamp M., Chang J.L., Kulbokas E.J. III, Zody M.C., Mauceli E.,
Xie X., Breen M., Wayne R.K., Ostrander E.A., Ponting C.P., Galibert F.,
Smith D.R., deJong P.J., Kirkness E.F., Alvarez P., Biagi T., Brockman W.,
Butler J., Chin C.-W., Cook A., Cuff J., Daly M.J., DeCaprio D., Gnerre S.,
Grabherr M., Kellis M., Kleber M., Bardeleben C., Goodstadt L., Heger A.,
Hitte C., Kim L., Koepfli K.-P., Parker H.G., Pollinger J.P.,
Searle S.M.J., Sutter N.B., Thomas R., Webber C., Baldwin J., Abebe A.,
Abouelleil A., Aftuck L., Ait-Zahra M., Aldredge T., Allen N., An P.,
Anderson S., Antoine C., Arachchi H., Aslam A., Ayotte L., Bachantsang P.,
Barry A., Bayul T., Benamara M., Berlin A., Bessette D., Blitshteyn B.,
Bloom T., Blye J., Boguslavskiy L., Bonnet C., Boukhgalter B., Brown A.,
Cahill P., Calixte N., Camarata J., Cheshatsang Y., Chu J., Citroen M.,
Collymore A., Cooke P., Dawoe T., Daza R., Decktor K., DeGray S.,
Dhargay N., Dooley K., Dooley K., Dorje P., Dorjee K., Dorris L.,
Duffey N., Dupes A., Egbiremolen O., Elong R., Falk J., Farina A., Faro S.,
Ferguson D., Ferreira P., Fisher S., FitzGerald M., Foley K., Foley C.,
Franke A., Friedrich D., Gage D., Garber M., Gearin G., Giannoukos G.,
Goode T., Goyette A., Graham J., Grandbois E., Gyaltsen K., Hafez N.,
Hagopian D., Hagos B., Hall J., Healy C., Hegarty R., Honan T., Horn A.,
Houde N., Hughes L., Hunnicutt L., Husby M., Jester B., Jones C., Kamat A.,
Kanga B., Kells C., Khazanovich D., Kieu A.C., Kisner P., Kumar M.,
Lance K., Landers T., Lara M., Lee W., Leger J.-P., Lennon N., Leuper L.,
LeVine S., Liu J., Liu X., Lokyitsang Y., Lokyitsang T., Lui A.,
Macdonald J., Major J., Marabella R., Maru K., Matthews C., McDonough S.,
Mehta T., Meldrim J., Melnikov A., Meneus L., Mihalev A., Mihova T.,
Miller K., Mittelman R., Mlenga V., Mulrain L., Munson G., Navidi A.,
Naylor J., Nguyen T., Nguyen N., Nguyen C., Nguyen T., Nicol R., Norbu N.,
Norbu C., Novod N., Nyima T., Olandt P., O'Neill B., O'Neill K., Osman S.,
Oyono L., Patti C., Perrin D., Phunkhang P., Pierre F., Priest M.,
Rachupka A., Raghuraman S., Rameau R., Ray V., Raymond C., Rege F.,
Rise C., Rogers J., Rogov P., Sahalie J., Settipalli S., Sharpe T.,
Shea T., Sheehan M., Sherpa N., Shi J., Shih D., Sloan J., Smith C.,
Sparrow T., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C.,
Stone S., Sykes S., Tchuinga P., Tenzing P., Tesfaye S., Thoulutsang D.,
Thoulutsang Y., Topham K., Topping I., Tsamla T., Vassiliev H.,
Venkataraman V., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
Wilson A., Yadav S., Yang S., Yang X., Young G., Yu Q., Zainoun J.,
Zembek L., Zimmer A., Lander E.S.;
"Genome sequence, comparative analysis and haplotype structure of the
domestic dog.";
Nature 438:803-819(2005).
[2] {ECO:0000313|Ensembl:ENSCAFP00000005151}
IDENTIFICATION.
STRAIN=Boxer {ECO:0000313|Ensembl:ENSCAFP00000005151};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- PATHWAY: Protein modification; protein ubiquitination.
{ECO:0000256|ARBA:ARBA00004906}.
-!- SIMILARITY: Belongs to the cullin family.
{ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
ECO:0000256|RuleBase:RU003829}.
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EMBL; AAEX03010158; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_848402.1; XM_843309.4.
SMR; E2R1V2; -.
STRING; 9612.ENSCAFP00000005151; -.
PaxDb; E2R1V2; -.
Ensembl; ENSCAFT00000005562; ENSCAFP00000005151; ENSCAFG00000003440.
GeneID; 475512; -.
KEGG; cfa:475512; -.
CTD; 8454; -.
VGNC; VGNC:39728; CUL1.
eggNOG; KOG2166; Eukaryota.
GeneTree; ENSGT00940000154774; -.
HOGENOM; CLU_004747_6_1_1; -.
InParanoid; E2R1V2; -.
OMA; WLWHLCK; -.
OrthoDB; 1040292at2759; -.
TreeFam; TF101151; -.
Reactome; R-CFA-1169091; Activation of NF-kappaB in B cells.
Reactome; R-CFA-187577; SCF(Skp2)-mediated degradation of p27/p21.
Reactome; R-CFA-195253; Degradation of beta-catenin by the destruction complex.
Reactome; R-CFA-2565942; Regulation of PLK1 Activity at G2/M Transition.
Reactome; R-CFA-5607761; Dectin-1 mediated noncanonical NF-kB signaling.
Reactome; R-CFA-5676590; NIK-->noncanonical NF-kB signaling.
Reactome; R-CFA-68949; Orc1 removal from chromatin.
Reactome; R-CFA-69231; Cyclin D associated events in G1.
Reactome; R-CFA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
Reactome; R-CFA-8951664; Neddylation.
Reactome; R-CFA-917937; Iron uptake and transport.
Reactome; R-CFA-983168; Antigen processing: Ubiquitination & Proteasome degradation.
UniPathway; UPA00143; -.
Proteomes; UP000002254; Chromosome 16.
Bgee; ENSCAFG00000003440; Expressed in thymus and 54 other tissues.
GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IBA:GO_Central.
GO; GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
Gene3D; 1.10.10.10; -; 2.
InterPro; IPR016157; Cullin_CS.
InterPro; IPR016158; Cullin_homology.
InterPro; IPR036317; Cullin_homology_sf.
InterPro; IPR001373; Cullin_N.
InterPro; IPR019559; Cullin_neddylation_domain.
InterPro; IPR016159; Cullin_repeat-like_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00888; Cullin; 1.
Pfam; PF10557; Cullin_Nedd8; 1.
SMART; SM00182; CULLIN; 1.
SMART; SM00884; Cullin_Nedd8; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF74788; SSF74788; 1.
SUPFAM; SSF75632; SSF75632; 1.
PROSITE; PS01256; CULLIN_1; 1.
PROSITE; PS50069; CULLIN_2; 1.
3: Inferred from homology;
Coiled coil {ECO:0000256|SAM:Coils};
Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
Reference proteome {ECO:0000313|Proteomes:UP000002254};
Ubl conjugation {ECO:0000256|ARBA:ARBA00022843};
Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
DOMAIN 417..644
/note="CULLIN_2"
/evidence="ECO:0000259|PROSITE:PS50069"
COILED 261..281
/evidence="ECO:0000256|SAM:Coils"
SEQUENCE 776 AA; 89661 MW; 3E023DB1516EB9B1 CRC64;
MSSNRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY NYCTSVHQSN
QARGAGVPPS KSKKGQTPGG AQFVGLELYK RLKEFLKNYL TNLLKDGEDL MDESVLKFYT
QQWEDYRFSS KVLNGICAYL NRHWVRRECD EGRKGIYEIY SLALVTWRDC LFRPLNKQVT
NAVLKLIEKE RNGETINTRL ISGVVQSYVE LGLNEDDAFA KGPTLTVYKE SFESQFLADT
ERFYTRESTE FLQQNPVTEY MKKAEARLLE EQRRVQVYLH ESTQDELARK CEQVLIEKHL
EIFHTEFQNL LDADKNEDLG RMYNLVSRIQ DGLGELKKLL ETHIHNQGLA AIEKCGEAAL
NDPKMYVQTV LDVHKKYNAL VMSAFNNDAG FVAALDKACG RFINNNAVTK MAQSSSKSPE
LLARYCDSLL KKSSKNPEEA ELEDTLNQVM VVFKYIEDKD VFQKFYAKML AKRLVHQNSA
SDDAEASMIS KLKQACGFEY TSKLQRMFQD IGVSKDLNEQ FKKHLTNSEP LDLDFSIQVL
SSGSWPFQQS CTFALPSELE RSYQRFTAFY ASRHSGRKLT WLYQLSKGEL VTNCFKNRYT
LQASTFQMAI LLQYNTEDAY AVQQLTDSTQ IKMDILAQVL QILLKSKLLV LEDENANVDE
VELKPDTLIK LYLGYKNKKL RVNINVPMKT EQKQEQETTH KNIEEDRKLL IQAAIVRIMK
MRKVLKHQQL LGEVLTQLSS RFKPRVPVIK KCIDILIEKE YLERVDGEKD TYSYLA


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Related Genes :
[CAND1 KIAA0829 TIP120 TIP120A] Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
[Cand1 Tip120 Tip120a] Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
[CAND1 ETA2 HVE At2g02560 T8K22.14] Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (AtCAND1) (Protein ENHANCER OF TIR1-1 AUXIN RESISTANCE 2) (Protein HEMIVENATA)
[RTT101 CUL8 YJL047C J1166] Cullin-8 (Cullin-C) (Regulator of Ty1 transposition protein 101)
[DCUN1D1 DCN1 DCUN1L1 RP42 SCCRO] DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)
[CUL1] Cullin-1 (CUL-1)
[CUL5 VACM1] Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
[DCUN1D2 C13orf17 DCUN1L2] DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2)
[Cul1] Cullin-1 (CUL-1)
[DCUN1D5 SCCRO5] DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)
[Cul1 cul-1 lin19 CG1877] Cullin homolog 1 (Lin-19 homolog protein)
[Cul5 Vacm1] Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
[DCUN1D3 SCCRO3] DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3)
[cul-1 lin-19 D2045.6] Cullin-1 (CUL-1) (Abnormal cell lineage protein 19)
[DCUN1D4 KIAA0276] DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4)
[CUL1 At4g02570 T10P11.26] Cullin-1
[CUL9 H7AP1 KIAA0708 PARC] Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein)
[cul1 pcu1 SPAC17G6.12] Cullin-1 (Cul-1) (Cell division control 53 homolog)
[cul-3 Y108G3AL.1] Cullin-3 (CUL-3)
[Cul3 BG:DS07851.2 br34 CG11861 CG31829 CUL-3 Cul-3 cul-3 Cul-3-RF CUL3 cul3 Cullin3 dCul-3 dCul3 DMcul-3 Dmel\CG42616 gft guftagu l(2)06430 l(2)35Cd l(2)br34 l35Cd mds CG42616 Dmel_CG42616] Cullin 3, isoform F (FI19425p1)
[CACUL1 C10orf46 CAC1] CDK2-associated and cullin domain-containing protein 1 (Cdk-associated cullin 1)
[candA-C AN2458] Cullin-associated NEDD8-dissociated protein 1, C-terminal part (Cullin-associated and neddylation-dissociated protein 1, C-terminal part)
[Cul3 BG:DS07851.2 br34 CG11861 CG31829 CUL-3 Cul-3 cul-3 CUL3 cul3 Cullin3 dCul-3 dCul3 DMcul-3 Dmel\CG42616 gft guftagu l(2)06430 l(2)35Cd l(2)br34 l35Cd mds CG42616 Dmel_CG42616] Cullin 3, isoform C (Cullin 3, isoform D) (Cullin 3, isoform E) (LD10516p)
[CUL3A CUL3 At1g26830 T2P11.2] Cullin-3A (AtCUL3a)
[culA cul1 DDB_G0291972] Cullin-1 (CUL-1) (Cullin-A)
[LAG2 YOL025W] Cullin-associated NEDD8-dissociated protein 1 homolog (CAND1 homolog) (Longevity-assurance protein 2)
[CUL3] CULLIN_2 domain-containing protein
[Dcun1d5] DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)
[CAND2 KIAA0667 TIP120B] Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (Epididymis tissue protein Li 169) (TBP-interacting protein of 120 kDa B) (TBP-interacting protein 120B) (p120 CAND2)
[CUL3 KIAA0617] Cullin-3 (CUL-3)

Bibliography :
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