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Cullin 1

 M3XAR4_FELCA            Unreviewed;       829 AA.
M3XAR4;
01-MAY-2013, integrated into UniProtKB/TrEMBL.
11-DEC-2019, sequence version 3.
02-JUN-2021, entry version 54.
SubName: Full=Cullin 1 {ECO:0000313|Ensembl:ENSFCAP00000023718};
Name=CUL1 {ECO:0000313|Ensembl:ENSFCAP00000023718,
ECO:0000313|VGNC:VGNC:61282};
Felis catus (Cat) (Felis silvestris catus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000023718, ECO:0000313|Proteomes:UP000011712};
[1] {ECO:0000313|Ensembl:ENSFCAP00000023718, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023718,
ECO:0000313|Proteomes:UP000011712};
PubMed=17975172; DOI=10.1101/gr.6380007;
Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
Tesler G., O'Brien S.J.;
"Initial sequence and comparative analysis of the cat genome.";
Genome Res. 17:1675-1689(2007).
[2] {ECO:0000313|Ensembl:ENSFCAP00000023718, ECO:0000313|Proteomes:UP000011712}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023718,
ECO:0000313|Proteomes:UP000011712};
Hillier L.W., Warren W., Obrien S., Wilson R.K.;
"Sequence assembly of the Felis catus genome version 6.2.";
Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSFCAP00000023718}
IDENTIFICATION.
STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000023718};
Ensembl;
Submitted (MAR-2013) to UniProtKB.
-!- PATHWAY: Protein modification; protein ubiquitination.
{ECO:0000256|ARBA:ARBA00004906}.
-!- SIMILARITY: Belongs to the cullin family.
{ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
ECO:0000256|RuleBase:RU003829}.
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EMBL; AANG04000096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9685.ENSFCAP00000023718; -.
Ensembl; ENSFCAT00000028043; ENSFCAP00000023718; ENSFCAG00000008615.
VGNC; VGNC:61282; CUL1.
eggNOG; KOG2166; Eukaryota.
GeneTree; ENSGT00940000154774; -.
HOGENOM; CLU_004747_6_1_1; -.
InParanoid; M3XAR4; -.
UniPathway; UPA00143; -.
Proteomes; UP000011712; Chromosome A2.
Bgee; ENSFCAG00000008615; Expressed in testis and 11 other tissues.
GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IBA:GO_Central.
GO; GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
Gene3D; 1.10.10.10; -; 2.
InterPro; IPR016158; Cullin_homology.
InterPro; IPR036317; Cullin_homology_sf.
InterPro; IPR001373; Cullin_N.
InterPro; IPR019559; Cullin_neddylation_domain.
InterPro; IPR016159; Cullin_repeat-like_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00888; Cullin; 1.
Pfam; PF10557; Cullin_Nedd8; 1.
SMART; SM00182; CULLIN; 1.
SMART; SM00884; Cullin_Nedd8; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF74788; SSF74788; 1.
SUPFAM; SSF75632; SSF75632; 1.
PROSITE; PS50069; CULLIN_2; 1.
3: Inferred from homology;
Coiled coil {ECO:0000256|SAM:Coils};
Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
Reference proteome {ECO:0000313|Proteomes:UP000011712};
Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
SEQUENCE 829 AA; 94569 MW; 243CDFD622960A6A CRC64;
MCGRGCRLLN STGGCPATAH LTTALLGTTK TWTSTKVIVR RVHQQENGGL IVRSKLHVYN
YCTSVHQSNQ ARGAGVPPSK SKKGQTPGGA QFVGLELYKR LKEFLKNYLT NLLKDGEDLM
DESVLKFYTQ QWEDYRFSSK VLNGICAYLN RHWVRRECDE GRKGIYEIYS LALVTWRDCL
FRPLNKQVTN AVLKLIEKER NGETINTRLI SGVVQSYVEL GLNEDDAFAK GPTLTVYKES
FESQFLADTE RFYTRESTEF LQQNPVTEYM KKAEARLLEE QRRVQVYLHE STQDELARKC
EQVLIEKHLE IFHTEFQNLL DADKNEDLGR MYNLVSRIQD GLGELKKLLE THIHNQGLAA
IEKCGEAALN DPKMYVQTVL DVHKKYNALV MSAFNNDAGF VAALDKACGR FINNNAVTKM
AQSSSKSPEL LARYCDSLLK KSSKNPEEAE LEDTLNQVMV VFKYIEDKDV FQKFYAKMLA
KRLVHQNSAS DDAEASMISK LKQACGFEYT SKLQRMFQDI GVSKDLNEQF KKHLTNSEPL
DLDFSIQVLS SGSWPFQQSC TFALPSELER SYQRFTAFYA SRHSGRKLTW LYQLSKGELV
TNCFKNRYTL QASTFQMAIL LQYNTEDAYA VQQLTDSTQI KMDILAQVLQ ILLKSKLLVL
EDENANVDEV ELKPDTLIKL YLGYKNKKLR VNINVPMKTE QKQEQETTHK NIEEDRKLLI
QAAIVRIMKM RKVLKHQQLL GEVLTQLSSR FKPRVPVIKV QEPHGRSCPC VVLGEQGVTK
MRPTAVGISI RTRFLQKEMG LSLKPFIGGA WVAQSVKRPT SARSRSCGP


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WP2233: Immune responses in the epidermis
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Related Genes :
[CAND1 KIAA0829 TIP120 TIP120A] Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
[Cand1 Tip120 Tip120a] Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (TBP-interacting protein of 120 kDa A) (TBP-interacting protein 120A) (p120 CAND1)
[CAND1 ETA2 HVE At2g02560 T8K22.14] Cullin-associated NEDD8-dissociated protein 1 (Cullin-associated and neddylation-dissociated protein 1) (AtCAND1) (Protein ENHANCER OF TIR1-1 AUXIN RESISTANCE 2) (Protein HEMIVENATA)
[RTT101 CUL8 YJL047C J1166] Cullin-8 (Cullin-C) (Regulator of Ty1 transposition protein 101)
[DCUN1D1 DCN1 DCUN1L1 RP42 SCCRO] DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)
[CUL1] Cullin-1 (CUL-1)
[CUL5 VACM1] Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
[DCUN1D2 C13orf17 DCUN1L2] DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2)
[Cul1] Cullin-1 (CUL-1)
[DCUN1D5 SCCRO5] DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)
[Cul1 cul-1 lin19 CG1877] Cullin homolog 1 (Lin-19 homolog protein)
[Cul5 Vacm1] Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
[DCUN1D3 SCCRO3] DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3)
[cul-1 lin-19 D2045.6] Cullin-1 (CUL-1) (Abnormal cell lineage protein 19)
[DCUN1D4 KIAA0276] DCN1-like protein 4 (DCNL4) (DCUN1 domain-containing protein 4) (Defective in cullin neddylation protein 1-like protein 4)
[CUL1 At4g02570 T10P11.26] Cullin-1
[CUL9 H7AP1 KIAA0708 PARC] Cullin-9 (CUL-9) (UbcH7-associated protein 1) (p53-associated parkin-like cytoplasmic protein)
[cul1 pcu1 SPAC17G6.12] Cullin-1 (Cul-1) (Cell division control 53 homolog)
[cul-3 Y108G3AL.1] Cullin-3 (CUL-3)
[Cul3 BG:DS07851.2 br34 CG11861 CG31829 CUL-3 Cul-3 cul-3 Cul-3-RF CUL3 cul3 Cullin3 dCul-3 dCul3 DMcul-3 Dmel\CG42616 gft guftagu l(2)06430 l(2)35Cd l(2)br34 l35Cd mds CG42616 Dmel_CG42616] Cullin 3, isoform F (FI19425p1)
[CACUL1 C10orf46 CAC1] CDK2-associated and cullin domain-containing protein 1 (Cdk-associated cullin 1)
[candA-C AN2458] Cullin-associated NEDD8-dissociated protein 1, C-terminal part (Cullin-associated and neddylation-dissociated protein 1, C-terminal part)
[Cul3 BG:DS07851.2 br34 CG11861 CG31829 CUL-3 Cul-3 cul-3 CUL3 cul3 Cullin3 dCul-3 dCul3 DMcul-3 Dmel\CG42616 gft guftagu l(2)06430 l(2)35Cd l(2)br34 l35Cd mds CG42616 Dmel_CG42616] Cullin 3, isoform C (Cullin 3, isoform D) (Cullin 3, isoform E) (LD10516p)
[CUL3A CUL3 At1g26830 T2P11.2] Cullin-3A (AtCUL3a)
[culA cul1 DDB_G0291972] Cullin-1 (CUL-1) (Cullin-A)
[LAG2 YOL025W] Cullin-associated NEDD8-dissociated protein 1 homolog (CAND1 homolog) (Longevity-assurance protein 2)
[CUL3] CULLIN_2 domain-containing protein
[Dcun1d5] DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)
[CAND2 KIAA0667 TIP120B] Cullin-associated NEDD8-dissociated protein 2 (Cullin-associated and neddylation-dissociated protein 2) (Epididymis tissue protein Li 169) (TBP-interacting protein of 120 kDa B) (TBP-interacting protein 120B) (p120 CAND2)
[CUL3 KIAA0617] Cullin-3 (CUL-3)

Bibliography :
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