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Cullin-1 (CUL-1)

 CUL1_PONAB              Reviewed;         776 AA.
Q5R4G6;
07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
21-DEC-2004, sequence version 1.
02-DEC-2020, entry version 101.
RecName: Full=Cullin-1;
Short=CUL-1;
Name=CUL1;
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Pongo.
NCBI_TaxID=9601;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain cortex;
The German cDNA consortium;
Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-
F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the
ubiquitination of proteins involved in cell cycle progression, signal
transduction and transcription. SCF complexes and ARIH1 collaborate in
tandem to mediate ubiquitination of target proteins. In the SCF
complex, serves as a rigid scaffold that organizes the SKP1-F-box
protein and RBX1 subunits. May contribute to catalysis through
positioning of the substrate and the ubiquitin-conjugating enzyme. The
E3 ubiquitin-protein ligase activity of the complex is dependent on the
neddylation of the cullin subunit and exchange of the substrate
recognition component is mediated by TIP120A/CAND1. The functional
specificity of the SCF complex depends on the F-box protein as
substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct
ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11)
directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs
ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and
probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of
CEP68. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip
and is involved in regulation of G1/S transition. SCF(SKP2) directs
ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and
probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E,
NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs
ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and
DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs
ubiquitination of BCL6 and DTL but does not seem to direct
ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA
at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-
RELA dimer to translocate into the nucleus and to activate
transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3)
and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9)
directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs
ubiquitination of BCL2. Interacts with COPS9. Interacts with KAT7,
probably as part of an SCF complex; the interaction mediates KAT7
ubiquitination. {ECO:0000250|UniProtKB:Q13616,
ECO:0000250|UniProtKB:Q9WTX6}.
-!- PATHWAY: Protein modification; protein ubiquitination.
{ECO:0000250|UniProtKB:Q13616}.
-!- SUBUNIT: Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-
protein ligase complexes formed of CUL1, SKP1, RBX1 and a variable F-
box domain-containing protein as substrate-specific subunit. Component
of the SCF(FBXW11) complex containing FBXW11. Component of the
SCF(SKP2) complex containing SKP2, in which it interacts directly with
SKP1, SKP2 and RBX1. Component of the SCF(FBXW2) complex containing
FBXW2. Component of the SCF(FBXO32) complex containing FBXO32.
Component of the probable SCF(FBXO7) complex containing FBXO7.
Component of the SCF(FBXO10) complex containing FBXO10. Component of
the SCF(FBXO11) complex containing FBXO11. Component of the SCF(FBXO25)
complex containing FBXO25. Component of the SCF(FBXO33) complex
containing FBXO33. Component of the probable SCF(FBXO4) complex
containing FBXO4. Component of the SCF(FBXO44) complex, composed of
SKP1, CUL1 and FBXO44. Component of the SCF(BTRC) complex, composed of
SKP1, CUL1 and BTRC. This complex binds phosphorylated NFKBIA. Part of
a SCF complex consisting of CUL1, RBX1, SKP1 and FBXO2. Component of a
SCF(SKP2)-like complex containing CUL1, SKP1, TRIM21 and SKP2.
Component of the SCF(FBXO17) complex, composed of SKP1, CUL1 and
FBXO17. Component of the SCF(FBXO27) complex, composed of SKP1, CUL1
and FBXO27. Component of the SCF(CCNF) complex consisting of CUL1,
RBX1, SKP1 and CCNF. Component of the SCF(FBXL3) complex composed of
CUL1, SKP1, RBX1 and FBXL3. Component of the SCF(FBXL21) complex
composed of CUL1, SKP1, RBX1 and FBXL21. Component of the SCF(FBXO9)
composed of CUL1, SKP1, RBX1 and FBXO9. Component of the SCF(FBXW7)
composed of CUL1, SKP1, RBX1 and FBXW7. Interacts with CHEK2; mediates
CHEK2 ubiquitination and regulates its function. Part of a complex with
TIP120A/CAND1 and RBX1. The unneddylated form interacts with
TIP120A/CAND1 and the interaction mediates the exchange of the F-box
substrate-specific subunit. Can self-associate. Interacts with FBXW8.
Interacts with RNF7. Interacts with CUL7; the interaction seems to be
mediated by FBXW8. Interacts with TRIM21. Interacts with COPS2.
Interacts with DCUN1D1 and UBE2M. Interacts with DCUN1D3. Interacts
with DCUN1D4. Identified in a complex with RBX1 and GLMN (By
similarity). Interacts with CEP68 as part of the SCF(FBXW11) complex;
the interaction is probably mediated by FBXW11 and the complex also
contains CDK5RAP2 and PCNT. Interacts (when neddylated) with ARIH1;
leading to activate the E3 ligase activity of ARIH1. Interacts with
COPS9. Interacts with UBXN1 (By similarity). Interacts with KAT7,
probably as part of an SCF complex; the interaction mediates KAT7
ubiquitination (By similarity). Interacts with NOTCH2 (By similarity).
Part of a complex that contains DCUN1D5, CUL1 and RBX1; this
interaction is bridged by CUL1 (By similarity). Interacts (unneddylated
form) with DCUN1D1, DCUN1D2, DCUN1D3, DCUN1D4 and DCUN1D5; these
interactions promote the cullin neddylation (By similarity).
{ECO:0000250|UniProtKB:Q13616, ECO:0000250|UniProtKB:Q9WTX6}.
-!- PTM: Neddylated; which enhances the ubiquitination activity of SCF and
prevents binding of the inhibitor CAND1. Deneddylated via its
interaction with the COP9 signalosome (CSN) complex.
{ECO:0000250|UniProtKB:Q13616}.
-!- SIMILARITY: Belongs to the cullin family. {ECO:0000255|PROSITE-
ProRule:PRU00330}.
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EMBL; CR861282; CAH93350.1; -; mRNA.
RefSeq; NP_001126972.1; NM_001133500.1.
RefSeq; NP_001128951.1; NM_001135479.2.
RefSeq; XP_009241654.1; XM_009243379.1.
RefSeq; XP_009241655.1; XM_009243380.1.
SMR; Q5R4G6; -.
STRING; 9601.ENSPPYP00000020352; -.
Ensembl; ENSPPYT00000021153; ENSPPYP00000020352; ENSPPYG00000018146.
GeneID; 100189917; -.
KEGG; pon:100189917; -.
CTD; 8454; -.
eggNOG; KOG2166; Eukaryota.
GeneTree; ENSGT00940000154774; -.
HOGENOM; CLU_004747_6_1_1; -.
InParanoid; Q5R4G6; -.
OMA; WLWHLCK; -.
OrthoDB; 1040292at2759; -.
TreeFam; TF101151; -.
UniPathway; UPA00143; -.
Proteomes; UP000001595; Chromosome 7.
GO; GO:1990452; C:Parkin-FBXW7-Cul1 ubiquitin ligase complex; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO; GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
GO; GO:0009887; P:animal organ morphogenesis; IEA:Ensembl.
GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
GO; GO:0006513; P:protein monoubiquitination; IEA:Ensembl.
GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
Gene3D; 1.10.10.10; -; 2.
InterPro; IPR016157; Cullin_CS.
InterPro; IPR016158; Cullin_homology.
InterPro; IPR036317; Cullin_homology_sf.
InterPro; IPR001373; Cullin_N.
InterPro; IPR019559; Cullin_neddylation_domain.
InterPro; IPR016159; Cullin_repeat-like_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00888; Cullin; 1.
Pfam; PF10557; Cullin_Nedd8; 1.
SMART; SM00182; CULLIN; 1.
SMART; SM00884; Cullin_Nedd8; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF74788; SSF74788; 1.
SUPFAM; SSF75632; SSF75632; 1.
PROSITE; PS01256; CULLIN_1; 1.
PROSITE; PS50069; CULLIN_2; 1.
2: Evidence at transcript level;
Isopeptide bond; Methylation; Reference proteome; Ubl conjugation;
Ubl conjugation pathway.
CHAIN 1..776
/note="Cullin-1"
/id="PRO_0000119789"
MOD_RES 63
/note="Omega-N-methylarginine"
/evidence="ECO:0000250|UniProtKB:Q13616"
CROSSLNK 720
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in NEDD8)"
/evidence="ECO:0000250|UniProtKB:Q13616"
SEQUENCE 776 AA; 89679 MW; 6625A1FFA7799BBA CRC64;
MSSTRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY NYCTSVHQSN
QARGAGVPPS KSKKGQTPGG AQFVGLELYK RLKEFLKNYL TNLLKDGEDL MDESVLKFYT
QQWEDYRFSS KVLNGICAYL NRHWVRRECD EGRKGIYEIY SLALVTWRDC LFRPLNKQVT
NAVLKLIEKE RNGETINTRL ISGVVQSYVE LGLNEDDAFA KGPTLTVYKE SFESQFLADT
ERFYTRESTE FLQQNPVTEY MKKAEARLLE EQRRVQVYLH ESTQDELARK CEQVLIEKHL
EIFHTEFQNL LDADKNEDLG RMYNLVSRIQ DGLGELKKLL ETHIHNQGLA AIEKCGEAAL
NDPKMYVQTV LDVHKKYNAL VMSAFNNDAG FVAALDKACG RFINNNAVTK MAQSSSKSPE
LLARYCDSLL KKSSKNPEEA ELEDTLNQVM VVFKYIEDKD VFQKFYAKML AKRLVHQNSA
SDDAEASMIS KLKQACGFEY TSKLQRMFQD IGVSKDLNEQ FKKHLTNSEP LDLDFSIQVL
SSGSWPFQQS CTFALPSELE RSYQRFTAFY ASRHSGRKLT WLYQLSKGEL VTNCFKNRYT
LQASTFQMAI LLQYNTEDAY TVQQLTDSTQ IKMDILAQVL QILLKSKLLV LEDENANVDE
VELKPDTLIK LYLGYKNKKL RVNINVPMKT EQKQEQETTH KNIEEDRKLL IQAAIVRIMK
MRKVLKHQQL LGEVLTQLSS RFKPRVPVIK KCIDILIEKE YLERVDGEKD TYSYLA


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Pathways :
WP2359: Parkin-Ubiquitin Proteasomal System pathway

Related Genes :
[CUL5 VACM1] Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
[Cul5 Vacm1] Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
[CUL1] Cullin-1 (CUL-1)
[cul-1 lin-19 D2045.6] Cullin-1 (CUL-1) (Abnormal cell lineage protein 19)
[Cul1] Cullin-1 (CUL-1)
[RTT101 CUL8 YJL047C J1166] Cullin-8 (Cullin-C) (Regulator of Ty1 transposition protein 101)
[CUL1 At4g02570 T10P11.26] Cullin-1
[CUL3A CUL3 At1g26830 T2P11.2] Cullin-3A (AtCUL3a)
[CUL3 KIAA0617] Cullin-3 (CUL-3)
[Cul3] Cullin-3 (CUL-3)
[Cul7 Kiaa0076] Cullin-7 (CUL-7) (p185) (p193)
[CUL4A] Cullin-4A (CUL-4A)
[CUL4B KIAA0695] Cullin-4B (CUL-4B)
[CUL7 KIAA0076] Cullin-7 (CUL-7)
[Cul4a] Cullin-4A (CUL-4A)
[Cul7] Cullin-7 (CUL-7)
[Cul4b mKIAA0695] Cullin-4B (CUL-4B)
[CUL2] Cullin-2 (CUL-2)
[Cul3] Cullin-3
[DCUN1D1 DCN1 DCUN1L1 RP42 SCCRO] DCN1-like protein 1 (DCNL1) (DCUN1 domain-containing protein 1) (Defective in cullin neddylation protein 1-like protein 1) (Squamous cell carcinoma-related oncogene)
[DCUN1D2 C13orf17 DCUN1L2] DCN1-like protein 2 (DCNL2) (DCUN1 domain-containing protein 2) (Defective in cullin neddylation protein 1-like protein 2)
[DCUN1D5 SCCRO5] DCN1-like protein 5 (DCNL5) (DCUN1 domain-containing protein 5) (Defective in cullin neddylation protein 1-like protein 5) (Squamous cell carcinoma-related oncogene 5)
[DCUN1D3 SCCRO3] DCN1-like protein 3 (DCNL3) (DCUN1 domain-containing protein 3) (Defective in cullin neddylation protein 1-like protein 3) (Squamous cell carcinoma-related oncogene 3)
[DTL CDT2 CDW1 DCAF2 L2DTL RAMP] Denticleless protein homolog (DDB1- and CUL4-associated factor 2) (Lethal(2) denticleless protein homolog) (Retinoic acid-regulated nuclear matrix-associated protein)
[KLHL12 C3IP1] Kelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
[Cul5] Cullin-5 (CUL-5)
[DCAF15 C19orf72] DDB1- and CUL4-associated factor 15
[Cul2] Cullin-2 (CUL-2)
[CUL7] Cullin-7 (CUL-7)
[CUL3B At1g69670 T6C23.13] Cullin-3B (AtCUL3b)

Bibliography :
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