GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Cullin-1 (CUL-1) (Abnormal cell lineage protein 19)

 CUL1_CAEEL              Reviewed;         780 AA.
Q17389; Q18985;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-NOV-1997, sequence version 1.
07-APR-2021, entry version 147.
RecName: Full=Cullin-1;
Short=CUL-1;
AltName: Full=Abnormal cell lineage protein 19;
Name=cul-1; Synonyms=lin-19; ORFNames=D2045.6;
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=Bristol N2;
PubMed=8681378; DOI=10.1016/s0092-8674(00)81267-2;
Kipreos E.T., Lander L.E., Wing J.P., He W.W., Hedgecock E.M.;
"cul-1 is required for cell cycle exit in C. elegans and identifies a novel
gene family.";
Cell 85:829-839(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for investigating
biology.";
Science 282:2012-2018(1998).
[3]
INTERACTION WITH SKR-1; SKR-2; SKR-3; SKR-4; SKR-7; SKR-8; SKR-9 AND
SKR-10.
PubMed=11864566; DOI=10.1016/s0960-9822(02)00657-7;
Yamanaka A., Yada M., Imaki H., Koga M., Ohshima Y., Nakayama K.;
"Multiple Skp1-related proteins in Caenorhabditis elegans: diverse patterns
of interaction with Cullins and F-box proteins.";
Curr. Biol. 12:267-275(2002).
[4]
INTERACTION WITH RPM-1; FSN-1 AND SKR-1.
PubMed=15208641; DOI=10.1038/nature02647;
Liao E.H., Hung W., Abrams B., Zhen M.;
"An SCF-like ubiquitin ligase complex that controls presynaptic
differentiation.";
Nature 430:345-350(2004).
[5]
FUNCTION.
PubMed=17392428; DOI=10.1073/pnas.0700638104;
Ghazi A., Henis-Korenblit S., Kenyon C.;
"Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase
complex.";
Proc. Natl. Acad. Sci. U.S.A. 104:5947-5952(2007).
-!- FUNCTION: Probable core component of multiple cullin-RING-based SCF
(SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate
the ubiquitination and subsequent proteasomal degradation of target
proteins. As a scaffold protein may contribute to catalysis through
positioning of the substrate and the ubiquitin-conjugating enzyme.
Required for developmentally programmed transitions from the G1 phase
of the cell cycle to the G0 phase or the apoptotic pathway.
{ECO:0000269|PubMed:17392428}.
-!- PATHWAY: Protein modification; protein ubiquitination.
-!- SUBUNIT: Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin
ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1
(PubMed:15208641). Interacts with Skp1-related proteins skr-1, skr-2,
skr-3, skr-4, skr-7, skr-8, skr-9 and skr-10 (PubMed:11864566).
{ECO:0000269|PubMed:11864566, ECO:0000269|PubMed:15208641}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
-!- TISSUE SPECIFICITY: Ubiquitous.
-!- DEVELOPMENTAL STAGE: Highest levels in embryos and lower levels in
larvae and adults.
-!- PTM: Neddylated; which enhances the ubiquitination activity of SCF.
{ECO:0000250|UniProtKB:Q13616}.
-!- SIMILARITY: Belongs to the cullin family. {ECO:0000255|PROSITE-
ProRule:PRU00330}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; U58083; AAC47120.1; -; mRNA.
EMBL; Z35639; CAA84695.2; -; Genomic_DNA.
PIR; T20365; T20365.
RefSeq; NP_499309.1; NM_066908.4.
SMR; Q17389; -.
BioGRID; 41658; 35.
ComplexPortal; CPX-958; SCF-rpm-1 ubiquitin ligase complex.
IntAct; Q17389; 2.
STRING; 6239.D2045.6; -.
EPD; Q17389; -.
PaxDb; Q17389; -.
PeptideAtlas; Q17389; -.
EnsemblMetazoa; D2045.6.1; D2045.6.1; WBGene00000836.
GeneID; 176466; -.
KEGG; cel:CELE_D2045.6; -.
UCSC; D2045.6; c. elegans.
CTD; 176466; -.
WormBase; D2045.6; CE29089; WBGene00000836; cul-1.
eggNOG; KOG2166; Eukaryota.
GeneTree; ENSGT00940000154774; -.
HOGENOM; CLU_004747_6_1_1; -.
InParanoid; Q17389; -.
OMA; WLWHLCK; -.
OrthoDB; 1040292at2759; -.
PhylomeDB; Q17389; -.
Reactome; R-CEL-187577; SCF(Skp2)-mediated degradation of p27/p21.
Reactome; R-CEL-195253; Degradation of beta-catenin by the destruction complex.
Reactome; R-CEL-2565942; Regulation of PLK1 Activity at G2/M Transition.
Reactome; R-CEL-68949; Orc1 removal from chromatin.
Reactome; R-CEL-69231; Cyclin D associated events in G1.
Reactome; R-CEL-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis.
Reactome; R-CEL-8939902; Regulation of RUNX2 expression and activity.
Reactome; R-CEL-8951664; Neddylation.
Reactome; R-CEL-917937; Iron uptake and transport.
Reactome; R-CEL-983168; Antigen processing: Ubiquitination & Proteasome degradation.
UniPathway; UPA00143; -.
PRO; PR:Q17389; -.
Proteomes; UP000001940; Chromosome III.
Bgee; WBGene00000836; Expressed in multi-cellular organism and 5 other tissues.
GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IBA:GO_Central.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0019005; C:SCF ubiquitin ligase complex; IBA:GO_Central.
GO; GO:0031625; F:ubiquitin protein ligase binding; IBA:GO_Central.
GO; GO:0004842; F:ubiquitin-protein transferase activity; IBA:GO_Central.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0008340; P:determination of adult lifespan; IMP:UniProtKB.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
GO; GO:0043066; P:negative regulation of apoptotic process; IMP:WormBase.
GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:WormBase.
GO; GO:0010826; P:negative regulation of centrosome duplication; IMP:UniProtKB.
GO; GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IMP:UniProtKB.
GO; GO:0045930; P:negative regulation of mitotic cell cycle; IMP:WormBase.
GO; GO:0002119; P:nematode larval development; IMP:WormBase.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:WormBase.
GO; GO:0016567; P:protein ubiquitination; IBA:GO_Central.
GO; GO:0008361; P:regulation of cell size; IMP:WormBase.
GO; GO:0031647; P:regulation of protein stability; IMP:UniProtKB.
GO; GO:0000003; P:reproduction; IMP:WormBase.
GO; GO:0042594; P:response to starvation; IMP:UniProtKB.
GO; GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IBA:GO_Central.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR016157; Cullin_CS.
InterPro; IPR016158; Cullin_homology.
InterPro; IPR036317; Cullin_homology_sf.
InterPro; IPR001373; Cullin_N.
InterPro; IPR019559; Cullin_neddylation_domain.
InterPro; IPR016159; Cullin_repeat-like_dom_sf.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00888; Cullin; 1.
Pfam; PF10557; Cullin_Nedd8; 1.
SMART; SM00182; CULLIN; 1.
SMART; SM00884; Cullin_Nedd8; 1.
SUPFAM; SSF46785; SSF46785; 1.
SUPFAM; SSF74788; SSF74788; 1.
SUPFAM; SSF75632; SSF75632; 1.
PROSITE; PS01256; CULLIN_1; 1.
PROSITE; PS50069; CULLIN_2; 1.
1: Evidence at protein level;
Cell cycle; Cell division; Cytoplasm; Isopeptide bond; Reference proteome;
Ubl conjugation; Ubl conjugation pathway.
CHAIN 1..780
/note="Cullin-1"
/id="PRO_0000119780"
CROSSLNK 724
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in NEDD8)"
/evidence="ECO:0000250|UniProtKB:Q13616"
SEQUENCE 780 AA; 89527 MW; 38A5C2EE0A7CC881 CRC64;
MTNSEPRRMT CDSEVVWKKL QDGLDVAYRR ENMAPKDYMT LYTSVYDYCT SITLSTSRRD
GEDGRAESST PARTAGADFV GHEMYQRVEE YVKAYVIAVC EKGAELSGED LLKYYTTEWE
NFRISSKVMD GIFAYLNRHW IRRELDEGHE NIYMVYTLAL VVWKRNLFND LKDKVIDAML
ELIRSERTGS MINSRYISGV VECLVELGVD DSETDAKKDA ETKKLAVYKE FFEVKFLEAT
RGFYTQEAAN FLSNGGNVTD YMIKVETRLN QEDDRCQLYL NSSTKTPLAT CCESVLISNQ
LDFLQRHFGG LLVDKRDDDL SRMFKLCDRV PNGLDELRKS LENHIAKEGH QALERVAMEA
ATDAKLYVKT LLEVHERYQS LVNRSFKNEP GFMQSLDKAA TSFINNNAVT KRAPPQAQLT
KSAELLARYC DQLLRKSSKM PDEAELEELQ TKIMVVFKYI DDKDVFSKFY TKMFSKRLIS
ELSASDEAEA NFITKLKSMC GYEYTARLSK MVNDTQVSKD LTADFKEKKA DMLGQKSVEF
NVLVLSSGSW PTFPTTPITL PQQLSKTIEI FGQFYNEKFN GRRLTWVYSQ SRGEITSTAF
PKKYVFTATT AQMCTMLLFN EQDSYTVEQI AAATKMDEKS APAIVGSLIK NLVLKADTEL
QKEDEVPMTA TVSLNKAYMN KKVRVDLSKF TMKQDAVRDT ENVQKNVEED RKSVISACIV
RIMKTRKRVQ HQQLMTEVIT QLSGRFKPKV EMIKRCIGSL IEKEYMLRTE GQKDLYEYLA


Related products :

Catalog number Product name Quantity
Y050569 Anti_HCLS1(Hematopoietic lineage cell specific protein) 100ug
Y050569 Anti-HCLS1Hematopoietic lineage cell specific protein antibody 250ug
CSB-EL010215MO Mouse Hematopoietic lineage cell-specific protein(HCLS1) ELISA kit 96T
Y050569 Anti-HCLS1(Hematopoietic lineage cell specific protein) Antibody 100ug
CSB-EL010215HU Human Hematopoietic lineage cell-specific protein(HCLS1) ELISA kit 96T
CSB-EL010215HU Human Hematopoietic lineage cell-specific protein(HCLS1) ELISA kit SpeciesHuman 96T
CSB-EL010215MO Mouse Hematopoietic lineage cell-specific protein(HCLS1) ELISA kit SpeciesMouse 96T
ARP32615_T200 Anti-Hematopoietic lineage cell specific protein (HCLS1) Species_Reactivity: Human
ARP31928_T200 Anti-Hematopoietic lineage cell specific protein (HCLS1) Species_Reactivity: Human
HCLS1_MOUSE ELISA Kit FOR Hematopoietic lineage cell-specific protein; organism: Mouse; gene name: Hcls1 96T
18-003-42113 Hematopoietic lineage cell-specific protein - Hematopoietic cell-specific LYN substrate 1; LckBP1; p75 Polyclonal 0.05 mg Aff Pur
18-003-42113 Hematopoietic lineage cell-specific protein - Hematopoietic cell-specific LYN substrate 1; LckBP1; p75 Polyclonal 0.1 mg Protein A
18-003-42114 Hematopoietic lineage cell-specific protein - Hematopoietic cell-specific LYN substrate 1; LckBP1; p75 Polyclonal 0.1 mg Protein A
18-003-42253 Hematopoietic lineage cell-specific protein - Hematopoietic cell-specific LYN substrate 1; LckBP1; p75 Polyclonal 0.1 mg Protein A
18-003-42114 Hematopoietic lineage cell-specific protein - Hematopoietic cell-specific LYN substrate 1; LckBP1; p75 Polyclonal 0.05 mg Aff Pur
EIAAB10615 DCN1-like protein 1,DCUN1 domain-containing protein 1,DCUN1D1,DCUN1L1,Defective in cullin neddylation protein 1-like protein 1,Homo sapiens,Human,RP42,SCCRO,Squamous cell carcinoma-related oncogene
27-647 HS1 which is hematopoietic lineage cell-specific protein 1, is a substrate of protein tyrosine kinases in lymphocytes, it binds to F-actin, and promotes Arp2_3 complex-mediated actin polymerization. H 0.1 mg
18-003-42558 Cullin-associated NEDD8-dissociated protein 1 - Cullin-associated and neddylation-dissociated protein 1; p120 CAND1; TBP-interacting protein TIP120A; TBP-interacting protein of 120 kDa A Polyclonal 0.1 mg Protein A
EIAAB05268 Bos taurus,Bovine,CAND1,Cullin-associated and neddylation-dissociated protein 1,Cullin-associated NEDD8-dissociated protein 1
EIAAB05272 CAND2,Cullin-associated and neddylation-dissociated protein 2,Cullin-associated NEDD8-dissociated protein 2,Homo sapiens,Human,KIAA0667,p120 CAND2,TBP-interacting protein 120B,TBP-interacting protein
EIAAB05270 CAND1,Cullin-associated and neddylation-dissociated protein 1,Cullin-associated NEDD8-dissociated protein 1,Homo sapiens,Human,KIAA0829,p120 CAND1,TBP-interacting protein 120A,TBP-interacting protein
EIAAB05274 Cand2,Cullin-associated and neddylation-dissociated protein 2,Cullin-associated NEDD8-dissociated protein 2,Kiaa0667,Mouse,Mus musculus,p120 CAND2,TBP-interacting protein 120B,TBP-interacting protein
EIAAB46656 C6orf109,Homo sapiens,Human,Killer lineage protein 1,KLIP1,Natural killer cell-specific antigen KLIP1,Protein YIPF3,YIP1 family member 3,YIPF3
EIAAB05271 Cand1,Cullin-associated and neddylation-dissociated protein 1,Cullin-associated NEDD8-dissociated protein 1,p120 CAND1,Rat,Rattus norvegicus,TBP-interacting protein 120A,TBP-interacting protein of 120
EIAAB05273 Cand2,Cullin-associated and neddylation-dissociated protein 2,Cullin-associated NEDD8-dissociated protein 2,p120 CAND2,Rat,Rattus norvegicus,TBP-interacting protein 120B,TBP-interacting protein b,TBP-
Pathways :
WP1694: Pyrimidine metabolism
WP211: BMP signaling pathway
WP445: G1 to S cell cycle control
WP1011: T Cell Receptor Signaling Pathway
WP1654: gamma-Hexachlorocyclohexane degradation
WP1897: Regulation of beta-cell development
WP2375: miRNAs and TFs in iPS Cell Generation
WP840: G1 to S cell cycle control
WP1365: Calcium Regulation in the Cardiac Cell
WP1909: Signal regulatory protein (SIRP) family interactions
WP274: B Cell Receptor Signaling Pathway
WP908: B Cell Receptor Signaling Pathway
WP1393: Cell cycle
WP1714: Tyrosine metabolism
WP2203: TSLP Signaling Pathway
WP525: Mitochondrial Unfolded-Protein Response
WP1049: G Protein Signaling Pathways
WP1661: Glyoxylate and dicarboxylate metabolism
WP2226: Cell engulfment
WP584: test-cell-graphics
WP1083: Cell cycle
WP1672: Mismatch repair
WP2006: Squamous cell TarBase
WP320: test-cell-graphics
WP951: Integrin-mediated cell adhesion

Related Genes :
[cul-1 lin-19 D2045.6] Cullin-1 (CUL-1) (Abnormal cell lineage protein 19)
[lin-44 E01A2.3] Abnormal cell lineage protein 44 (Wnt protein)
[Cul7 Kiaa0076] Cullin-7 (CUL-7) (p185) (p193)
[CUL1] Cullin-1 (CUL-1)
[lin-42 F47F6.1] Period protein homolog lin-42 (Abnormal cell lineage protein 42)
[RTT101 CUL8 YJL047C J1166] Cullin-8 (Cullin-C) (Regulator of Ty1 transposition protein 101)
[CUL1 At4g02570 T10P11.26] Cullin-1
[CUL4B KIAA0695] Cullin-4B (CUL-4B)
[CUL7 KIAA0076] Cullin-7 (CUL-7)
[CUL5 VACM1] Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
[Cul5 Vacm1] Cullin-5 (CUL-5) (Vasopressin-activated calcium-mobilizing receptor 1) (VACM-1)
[Cul1] Cullin-1 (CUL-1)
[lin-18 ryk C16B8.1] Inactive tyrosine-protein kinase RYK (Abnormal cell lineage protein 18)
[lin-10 C09H6.2] Protein lin-10 (Abnormal cell lineage protein 10)
[Cul4b mKIAA0695] Cullin-4B (CUL-4B)
[CUL3A CUL3 At1g26830 T2P11.2] Cullin-3A (AtCUL3a)
[CUL3 KIAA0617] Cullin-3 (CUL-3)
[CUL4A] Cullin-4A (CUL-4A)
[lin-29 lin-29b W03C9.4] Zinc finger transcription factor lin-29 (abnormal cell lineage 29)
[KMT2A ALL1 CXXC7 HRX HTRX MLL MLL1 TRX1] Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.354) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
[lin-35 C32F10.2] Retinoblastoma-like protein homolog lin-35 (Abnormal cell lineage protein 35) (Synthetic multivulva protein lin-35)
[lin-59 T12F5.4] Probable histone-lysine N-methyltransferase lin-59 (EC 2.1.1.-) (Abnormal cell lineage protein 59)
[KMT2B HRX2 KIAA0304 MLL2 MLL4 TRX2 WBP7] Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.354) (Myeloid/lymphoid or mixed-lineage leukemia protein 4) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
[lin-53 rba-2 K07A1.12] Probable histone-binding protein lin-53 (Abnormal cell lineage protein 53) (Synthetic multivulva protein p48)
[lin-3 let-94 F36H1.4] Protein lin-3 (Abnormal cell lineage protein 3) (Lethal protein 94)
[lin-26 F18A1.2] Transcription factor lin-26 (Abnormal cell lineage protein 26)
[Kmt2b Mll2 Trx2 Wbp7] Histone-lysine N-methyltransferase 2B (Lysine N-methyltransferase 2B) (EC 2.1.1.354) (Myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog) (Trithorax homolog 2) (WW domain-binding protein 7) (WBP-7)
[Cul3] Cullin-3 (CUL-3)
[Cul4a] Cullin-4A (CUL-4A)
[CUL2] Cullin-2 (CUL-2)

Bibliography :
No related Items