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Cyclin-D1-binding protein 1 (Grap2 and cyclin-D-interacting protein) (Human homolog of Maid)

 CCDB1_HUMAN             Reviewed;         360 AA.
O95273; A8K3Q0; A8K3U2; Q6ZQN9; Q7Z519; Q8NBS7; Q8NBY2; Q9NS19; Q9NYH3;
Q9UHX9;
18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
18-MAR-2008, sequence version 2.
17-JUN-2020, entry version 135.
RecName: Full=Cyclin-D1-binding protein 1;
AltName: Full=Grap2 and cyclin-D-interacting protein;
AltName: Full=Human homolog of Maid;
Name=CCNDBP1; Synonyms=DIP1, GCIP, HHM;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH CCND1, SUBCELLULAR
LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND PHOSPHORYLATION.
PubMed=10854051; DOI=10.1006/excr.2000.4884;
Yao Y., Doki Y., Jiang W., Imoto M., Venkatraj V.S., Warburton D.,
Santella R.M., Lu B., Yan L., Sun X.-H., Su T., Luo J., Weinstein I.B.;
"Cloning and characterization of DIP1, a novel protein that is related to
the Id family of proteins.";
Exp. Cell Res. 257:22-32(2000).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INTERACTION WITH TCF3, AND TISSUE
SPECIFICITY.
TISSUE=Liver;
PubMed=10915743; DOI=10.1053/jhep.2000.9092;
Terai S., Aoki H., Thorgeirsson S.S.;
"Human homologue of maid: a dominant inhibitory helix-loop-helix protein
associated with liver-specific gene expression.";
Hepatology 32:357-366(2000).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CCND1
AND GRAP2, AND TISSUE SPECIFICITY.
TISSUE=Liver;
PubMed=10801854; DOI=10.1074/jbc.m002598200;
Xia C., Bao Z., Tabassam F., Ma W., Qiu M., Hua S., Liu M.;
"GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-
mediated transcriptional activity.";
J. Biol. Chem. 275:20942-20948(2000).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Gao J., Yu L., Mao N.H., Wan Y.Z., Yang Y.M., Zhao S.Y.;
"Cloning and characterization of a novel human cDNA homologous to murine
Maid mRNA.";
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
TISSUE=Hypothalamus;
PubMed=10931946; DOI=10.1073/pnas.160270997;
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
Chen M.-D., Chen J.-L.;
"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
and full-length cDNA cloning.";
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
TISSUE=Hair follicle dermal papilla, Lung, Retinoblastoma, and Trachea;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Placenta;
PubMed=16303743; DOI=10.1093/dnares/12.2.117;
Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
Isogai T.;
"Signal sequence and keyword trap in silico for selection of full-length
human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
libraries.";
DNA Res. 12:117-126(2005).
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[10]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[11]
INTERACTION WITH SYF2.
PubMed=11118353; DOI=10.1006/bbrc.2000.3992;
Chang M.-S., Chang C.-L., Huang C.-J., Yang Y.-C.;
"p29, a novel GCIP-interacting protein, localizes in the nucleus.";
Biochem. Biophys. Res. Commun. 279:732-737(2000).
[12]
TISSUE SPECIFICITY, AND INTERACTION WITH COPS5.
PubMed=15887118; DOI=10.1053/j.gastro.2005.03.014;
Takami T., Terai S., Yokoyama Y., Tanimoto H., Tajima K., Uchida K.,
Yamasaki T., Sakaida I., Nishina H., Thorgeirsson S.S., Okita K.;
"Human homologue of maid is a useful marker protein in
hepatocarcinogenesis.";
Gastroenterology 128:1369-1380(2005).
[13]
INTERACTION WITH SIRT6, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
INDUCTION.
PubMed=17131381; DOI=10.1002/jcb.21140;
Ma W., Stafford L.J., Li D., Luo J., Li X., Ning G., Liu M.;
"GCIP/CCNDBP1, a helix-loop-helix protein, suppresses tumorigenesis.";
J. Cell. Biochem. 100:1376-1386(2007).
[14]
INTERACTION WITH RPLP0, AND SUBCELLULAR LOCATION.
PubMed=17621266; DOI=10.1038/sj.onc.1210651;
Chang T.-W., Chen C.-C., Chen K.-Y., Su J.-H., Chang J.-H., Chang M.-C.;
"Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0
is associated with cellular proliferation in breast and liver carcinoma
cells.";
Oncogene 27:332-338(2008).
[15]
ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
[LARGE SCALE ANALYSIS].
PubMed=22814378; DOI=10.1073/pnas.1210303109;
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
"N-terminal acetylome analyses and functional insights of the N-terminal
acetyltransferase NatB.";
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
-!- FUNCTION: May negatively regulate cell cycle progression. May act at
least in part via inhibition of the cyclin-D1/CDK4 complex, thereby
preventing phosphorylation of RB1 and blocking E2F-dependent
transcription. {ECO:0000269|PubMed:10801854}.
-!- SUBUNIT: Interacts with CCND1 and GRAP2. May also interact with COPS5,
RPLP0, SIRT6, SYF2 and TCF3. {ECO:0000269|PubMed:10801854,
ECO:0000269|PubMed:10854051, ECO:0000269|PubMed:10915743,
ECO:0000269|PubMed:11118353, ECO:0000269|PubMed:15887118,
ECO:0000269|PubMed:17131381, ECO:0000269|PubMed:17621266}.
-!- INTERACTION:
O95273; Q96PE1-2: ADGRA2; NbExp=3; IntAct=EBI-748961, EBI-12227349;
O95273; Q01433: AMPD2; NbExp=4; IntAct=EBI-748961, EBI-8796759;
O95273; P29972: AQP1; NbExp=3; IntAct=EBI-748961, EBI-745213;
O95273; Q7Z5H3: ARHGAP22; NbExp=3; IntAct=EBI-748961, EBI-3866859;
O95273; P51164: ATP4B; NbExp=3; IntAct=EBI-748961, EBI-3904463;
O95273; Q9BZE7: C22orf23; NbExp=5; IntAct=EBI-748961, EBI-10303102;
O95273; Q5I0X4: C6orf226; NbExp=4; IntAct=EBI-748961, EBI-10244057;
O95273; Q8IYE0: CCDC146; NbExp=3; IntAct=EBI-748961, EBI-10749669;
O95273; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-748961, EBI-10247802;
O95273; Q07002: CDK18; NbExp=3; IntAct=EBI-748961, EBI-746238;
O95273; Q6ZU64-3: CFAP65; NbExp=3; IntAct=EBI-748961, EBI-10255250;
O95273; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-748961, EBI-741032;
O95273; Q92905: COPS5; NbExp=5; IntAct=EBI-748961, EBI-594661;
O95273; Q93034: CUL5; NbExp=4; IntAct=EBI-748961, EBI-1057139;
O95273; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-748961, EBI-9679045;
O95273; Q92608: DOCK2; NbExp=3; IntAct=EBI-748961, EBI-448771;
O95273; Q92731-3: ESR2; NbExp=3; IntAct=EBI-748961, EBI-12259414;
O95273; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-748961, EBI-1752811;
O95273; A0A0S2Z6M9: FAM126A; NbExp=3; IntAct=EBI-748961, EBI-16428876;
O95273; Q9BYI3: FAM126A; NbExp=3; IntAct=EBI-748961, EBI-11065686;
O95273; Q3B820: FAM161A; NbExp=5; IntAct=EBI-748961, EBI-719941;
O95273; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-748961, EBI-10247271;
O95273; A0A0S2Z408: FH; NbExp=3; IntAct=EBI-748961, EBI-16428900;
O95273; Q9ULW2: FZD10; NbExp=3; IntAct=EBI-748961, EBI-8803802;
O95273; Q8NHY3: GAS2L2; NbExp=3; IntAct=EBI-748961, EBI-7960826;
O95273; Q9Y2Q3: GSTK1; NbExp=3; IntAct=EBI-748961, EBI-1053767;
O95273; P02008: HBZ; NbExp=3; IntAct=EBI-748961, EBI-719843;
O95273; P56524-2: HDAC4; NbExp=3; IntAct=EBI-748961, EBI-11953488;
O95273; P09429: HMGB1; NbExp=3; IntAct=EBI-748961, EBI-389432;
O95273; Q02363: ID2; NbExp=4; IntAct=EBI-748961, EBI-713450;
O95273; Q9NV31: IMP3; NbExp=6; IntAct=EBI-748961, EBI-747481;
O95273; Q6NXR0: IRGC; NbExp=3; IntAct=EBI-748961, EBI-12021374;
O95273; Q96GY3: LIN37; NbExp=3; IntAct=EBI-748961, EBI-748884;
O95273; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-748961, EBI-739832;
O95273; P36507: MAP2K2; NbExp=3; IntAct=EBI-748961, EBI-1056930;
O95273; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-748961, EBI-14086479;
O95273; P00540: MOS; NbExp=3; IntAct=EBI-748961, EBI-1757866;
O95273; Q9P015: MRPL15; NbExp=7; IntAct=EBI-748961, EBI-2371967;
O95273; Q69YI7: NAIF1; NbExp=3; IntAct=EBI-748961, EBI-10249231;
O95273; P60321: NANOS2; NbExp=5; IntAct=EBI-748961, EBI-10216569;
O95273; Q9UMY1: NOL7; NbExp=3; IntAct=EBI-748961, EBI-2862609;
O95273; Q6X4W1-2: NSMF; NbExp=3; IntAct=EBI-748961, EBI-12028784;
O95273; O75928: PIAS2; NbExp=4; IntAct=EBI-748961, EBI-348555;
O95273; Q9BSJ6: PIMREG; NbExp=6; IntAct=EBI-748961, EBI-2568609;
O95273; Q6IQ23-2: PLEKHA7; NbExp=3; IntAct=EBI-748961, EBI-12069346;
O95273; P02689: PMP2; NbExp=4; IntAct=EBI-748961, EBI-10193858;
O95273; Q8WUT1: POLDIP3; NbExp=3; IntAct=EBI-748961, EBI-10276663;
O95273; Q9UGP5-2: POLL; NbExp=3; IntAct=EBI-748961, EBI-10320765;
O95273; Q8WWY3: PRPF31; NbExp=5; IntAct=EBI-748961, EBI-1567797;
O95273; P40306: PSMB10; NbExp=5; IntAct=EBI-748961, EBI-603329;
O95273; P10276: RARA; NbExp=3; IntAct=EBI-748961, EBI-413374;
O95273; P10826-2: RARB; NbExp=3; IntAct=EBI-748961, EBI-8583223;
O95273; P82980: RBP5; NbExp=3; IntAct=EBI-748961, EBI-3941274;
O95273; P46779: RPL28; NbExp=7; IntAct=EBI-748961, EBI-366357;
O95273; Q96EH5: RPL39L; NbExp=4; IntAct=EBI-748961, EBI-6658607;
O95273; Q6DKI1: RPL7L1; NbExp=3; IntAct=EBI-748961, EBI-1052408;
O95273; P05388: RPLP0; NbExp=4; IntAct=EBI-748961, EBI-354101;
O95273; P62857: RPS28; NbExp=3; IntAct=EBI-748961, EBI-353027;
O95273; P55042: RRAD; NbExp=5; IntAct=EBI-748961, EBI-3911502;
O95273; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-748961, EBI-11955083;
O95273; Q7RTY0: SLC16A13; NbExp=3; IntAct=EBI-748961, EBI-12243266;
O95273; Q9UQ90: SPG7; NbExp=3; IntAct=EBI-748961, EBI-717201;
O95273; O00506: STK25; NbExp=3; IntAct=EBI-748961, EBI-618295;
O95273; O95926: SYF2; NbExp=3; IntAct=EBI-748961, EBI-2557644;
O95273; Q15170-2: TCEAL1; NbExp=3; IntAct=EBI-748961, EBI-11156070;
O95273; P15923-1: TCF3; NbExp=3; IntAct=EBI-748961, EBI-769645;
O95273; D3DUQ6: TEAD4; NbExp=3; IntAct=EBI-748961, EBI-10176734;
O95273; A0A024R4Q5: TFPT; NbExp=3; IntAct=EBI-748961, EBI-11527449;
O95273; Q9P2Z0: THAP10; NbExp=5; IntAct=EBI-748961, EBI-745404;
O95273; Q9BT49: THAP7; NbExp=4; IntAct=EBI-748961, EBI-741350;
O95273; A0PK00: TMEM120B; NbExp=3; IntAct=EBI-748961, EBI-10171534;
O95273; Q8IUR0: TRAPPC5; NbExp=8; IntAct=EBI-748961, EBI-3246160;
O95273; Q5W5X9: TTC23; NbExp=3; IntAct=EBI-748961, EBI-6447954;
O95273; Q8TAI1: TYMSOS; NbExp=3; IntAct=EBI-748961, EBI-742060;
O95273; O96014: WNT11; NbExp=3; IntAct=EBI-748961, EBI-8058160;
O95273; O43167: ZBTB24; NbExp=3; IntAct=EBI-748961, EBI-744471;
O95273; Q8N5A5: ZGPAT; NbExp=4; IntAct=EBI-748961, EBI-3439227;
O95273; Q15973: ZNF124; NbExp=3; IntAct=EBI-748961, EBI-2555767;
O95273; P52737: ZNF136; NbExp=5; IntAct=EBI-748961, EBI-749129;
O95273; Q12901: ZNF155; NbExp=3; IntAct=EBI-748961, EBI-10747670;
O95273; Q14929: ZNF169; NbExp=3; IntAct=EBI-748961, EBI-10234472;
O95273; P17024: ZNF20; NbExp=6; IntAct=EBI-748961, EBI-717634;
O95273; Q9UK11: ZNF223; NbExp=3; IntAct=EBI-748961, EBI-10322867;
O95273; Q9UIE0: ZNF230; NbExp=3; IntAct=EBI-748961, EBI-1105361;
O95273; Q9HCZ1: ZNF334; NbExp=4; IntAct=EBI-748961, EBI-748965;
O95273; Q53GI3: ZNF394; NbExp=3; IntAct=EBI-748961, EBI-10211248;
O95273; Q8TAU3: ZNF417; NbExp=4; IntAct=EBI-748961, EBI-740727;
O95273; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-748961, EBI-747580;
O95273; Q8WV37: ZNF480; NbExp=3; IntAct=EBI-748961, EBI-8490675;
O95273; Q9ULM2: ZNF490; NbExp=3; IntAct=EBI-748961, EBI-1105370;
O95273; Q9H707: ZNF552; NbExp=3; IntAct=EBI-748961, EBI-2555731;
O95273; Q8NEP9: ZNF555; NbExp=4; IntAct=EBI-748961, EBI-10270752;
O95273; Q8N988-2: ZNF557; NbExp=3; IntAct=EBI-748961, EBI-10699005;
O95273; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-748961, EBI-10273713;
O95273; Q96N58: ZNF578; NbExp=3; IntAct=EBI-748961, EBI-11955189;
O95273; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-748961, EBI-745520;
O95273; Q7L945: ZNF627; NbExp=4; IntAct=EBI-748961, EBI-2797561;
O95273; Q9BS34: ZNF670; NbExp=6; IntAct=EBI-748961, EBI-745276;
O95273; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-748961, EBI-11090299;
O95273; Q8N508: ZNF697; NbExp=3; IntAct=EBI-748961, EBI-10265733;
O95273; Q96C28: ZNF707; NbExp=7; IntAct=EBI-748961, EBI-748111;
O95273; A8K8V0: ZNF785; NbExp=3; IntAct=EBI-748961, EBI-3925400;
O95273; Q8N393: ZNF786; NbExp=3; IntAct=EBI-748961, EBI-10265203;
O95273; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-748961, EBI-5667516;
O95273; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-748961, EBI-11962574;
O95273; Q16670: ZSCAN26; NbExp=3; IntAct=EBI-748961, EBI-3920053;
O95273; B0FTY2; NbExp=3; IntAct=EBI-748961, EBI-10175366;
O95273; B2R4U6; NbExp=3; IntAct=EBI-748961, EBI-10175477;
O95273; F4ZW62; NbExp=3; IntAct=EBI-748961, EBI-10177680;
O95273; Q5XG85; NbExp=3; IntAct=EBI-748961, EBI-10248413;
O95273; Q8N9J2; NbExp=3; IntAct=EBI-748961, EBI-10268244;
O95273; Q96BA2; NbExp=3; IntAct=EBI-748961, EBI-10282278;
O95273; Q60867: Neurod1; Xeno; NbExp=4; IntAct=EBI-748961, EBI-309315;
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=4;
Name=1;
IsoId=O95273-1; Sequence=Displayed;
Name=2;
IsoId=O95273-2; Sequence=VSP_032014, VSP_032015;
Name=3;
IsoId=O95273-3; Sequence=VSP_032012;
Name=4;
IsoId=O95273-4; Sequence=VSP_032012, VSP_032013, VSP_032016;
-!- TISSUE SPECIFICITY: Ubiquitously expressed. Expression is down-
regulated in a variety of tumor types including breast, colon, prostate
and rectal tumors, and is up-regulated in certain hepatic carcinomas.
{ECO:0000269|PubMed:10801854, ECO:0000269|PubMed:10854051,
ECO:0000269|PubMed:10915743, ECO:0000269|PubMed:15887118,
ECO:0000269|PubMed:17131381}.
-!- DEVELOPMENTAL STAGE: Expression may increase during differentiation.
{ECO:0000269|PubMed:10854051}.
-!- INDUCTION: Expression is induced by sodium butyrate, an inhibitor of
colon cancer cell proliferation. {ECO:0000269|PubMed:17131381}.
-!- PTM: Phosphorylated. {ECO:0000269|PubMed:10854051}.
-!- SIMILARITY: Belongs to the CCNDBP1 family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAD11777.1; Type=Frameshift; Evidence={ECO:0000305};
Sequence=AAP97163.1; Type=Frameshift; Evidence={ECO:0000305};
---------------------------------------------------------------------------
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EMBL; AF082569; AAD11777.1; ALT_FRAME; mRNA.
EMBL; AF132034; AAF77613.1; -; mRNA.
EMBL; AF246144; AAF67182.1; -; mRNA.
EMBL; AF087852; AAP97163.1; ALT_FRAME; mRNA.
EMBL; AF113535; AAF14872.1; -; mRNA.
EMBL; CR450331; CAG29327.1; -; mRNA.
EMBL; AK075296; BAC11530.1; -; mRNA.
EMBL; AK128849; BAC87645.1; -; mRNA.
EMBL; AK290665; BAF83354.1; -; mRNA.
EMBL; AK290707; BAF83396.1; -; mRNA.
EMBL; AK075146; BAC11433.1; -; mRNA.
EMBL; CH471125; EAW92588.1; -; Genomic_DNA.
EMBL; CH471125; EAW92590.1; -; Genomic_DNA.
EMBL; BC009689; AAH09689.1; -; mRNA.
CCDS; CCDS10092.1; -. [O95273-1]
RefSeq; NP_036274.3; NM_012142.4. [O95273-1]
PDB; 3AY5; X-ray; 2.50 A; A=1-360.
PDBsum; 3AY5; -.
SMR; O95273; -.
BioGRID; 117117; 109.
IntAct; O95273; 143.
MINT; O95273; -.
STRING; 9606.ENSP00000300213; -.
iPTMnet; O95273; -.
MetOSite; O95273; -.
PhosphoSitePlus; O95273; -.
BioMuta; CCNDBP1; -.
EPD; O95273; -.
jPOST; O95273; -.
MassIVE; O95273; -.
MaxQB; O95273; -.
PaxDb; O95273; -.
PeptideAtlas; O95273; -.
PRIDE; O95273; -.
ProteomicsDB; 50774; -. [O95273-1]
ProteomicsDB; 50775; -. [O95273-2]
ProteomicsDB; 50776; -. [O95273-3]
ProteomicsDB; 50777; -. [O95273-4]
Antibodypedia; 23815; 242 antibodies.
DNASU; 23582; -.
Ensembl; ENST00000300213; ENSP00000300213; ENSG00000166946. [O95273-1]
Ensembl; ENST00000565296; ENSP00000455419; ENSG00000166946. [O95273-2]
Ensembl; ENST00000566515; ENSP00000456797; ENSG00000166946. [O95273-2]
GeneID; 23582; -.
KEGG; hsa:23582; -.
UCSC; uc001zqv.4; human. [O95273-1]
CTD; 23582; -.
DisGeNET; 23582; -.
EuPathDB; HostDB:ENSG00000166946.13; -.
GeneCards; CCNDBP1; -.
HGNC; HGNC:1587; CCNDBP1.
HPA; ENSG00000166946; Tissue enhanced (bone).
MIM; 607089; gene.
neXtProt; NX_O95273; -.
OpenTargets; ENSG00000166946; -.
PharmGKB; PA26154; -.
eggNOG; ENOG410II9T; Eukaryota.
eggNOG; ENOG410ZPHZ; LUCA.
GeneTree; ENSGT00390000018016; -.
HOGENOM; CLU_067580_0_0_1; -.
InParanoid; O95273; -.
KO; K21626; -.
OMA; GVWSACD; -.
OrthoDB; 1249310at2759; -.
PhylomeDB; O95273; -.
TreeFam; TF336444; -.
BioGRID-ORCS; 23582; 7 hits in 791 CRISPR screens.
ChiTaRS; CCNDBP1; human.
GeneWiki; CCNDBP1; -.
GenomeRNAi; 23582; -.
Pharos; O95273; Tbio.
PRO; PR:O95273; -.
Proteomes; UP000005640; Chromosome 15.
RNAct; O95273; protein.
Bgee; ENSG00000166946; Expressed in bone marrow and 199 other tissues.
ExpressionAtlas; O95273; baseline and differential.
Genevisible; O95273; HS.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0016604; C:nuclear body; IDA:HPA.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0051726; P:regulation of cell cycle; IEA:InterPro.
InterPro; IPR026907; CCNDBP1.
PANTHER; PTHR15492; PTHR15492; 1.
1: Evidence at protein level;
3D-structure; Acetylation; Alternative splicing; Cell cycle; Cytoplasm;
Nucleus; Phosphoprotein; Reference proteome.
INIT_MET 1
/note="Removed"
/evidence="ECO:0000244|PubMed:22814378"
CHAIN 2..360
/note="Cyclin-D1-binding protein 1"
/id="PRO_0000323372"
REGION 2..208
/note="Required for interaction with CCND1"
REGION 2..190
/note="Interaction with RPLP0"
/evidence="ECO:0000269|PubMed:17621266"
REGION 2..184
/note="Interaction with TCF3"
/evidence="ECO:0000269|PubMed:10915743"
REGION 150..360
/note="Interaction with TCF3"
/evidence="ECO:0000269|PubMed:10915743"
REGION 240..360
/note="Interaction with RPLP0"
/evidence="ECO:0000269|PubMed:17621266"
MOD_RES 2
/note="N-acetylalanine"
/evidence="ECO:0000244|PubMed:22814378"
VAR_SEQ 1..128
/note="Missing (in isoform 3 and isoform 4)"
/evidence="ECO:0000303|PubMed:10931946,
ECO:0000303|PubMed:14702039"
/id="VSP_032012"
VAR_SEQ 308..333
/note="SAKLVSVLKKALEITKASHVTPQPED -> VSTGFEGIATEQMGRISLITSI
SCK (in isoform 4)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_032013"
VAR_SEQ 308..309
/note="SA -> EP (in isoform 2)"
/evidence="ECO:0000303|PubMed:16303743"
/id="VSP_032014"
VAR_SEQ 310..360
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|PubMed:16303743"
/id="VSP_032015"
VAR_SEQ 334..360
/note="Missing (in isoform 4)"
/evidence="ECO:0000303|PubMed:14702039"
/id="VSP_032016"
CONFLICT 40
/note="A -> D (in Ref. 1; AAD11777)"
/evidence="ECO:0000305"
CONFLICT 41
/note="Q -> R (in Ref. 4; AAP97163)"
/evidence="ECO:0000305"
CONFLICT 74
/note="F -> S (in Ref. 8; BAC11433)"
/evidence="ECO:0000305"
CONFLICT 211
/note="N -> S (in Ref. 8; BAC11433)"
/evidence="ECO:0000305"
CONFLICT 235
/note="E -> G (in Ref. 7; BAF83396)"
/evidence="ECO:0000305"
CONFLICT 267
/note="K -> R (in Ref. 7; BAC87645)"
/evidence="ECO:0000305"
CONFLICT 274
/note="L -> M (in Ref. 1; AAD11777 and 3; AAF67182)"
/evidence="ECO:0000305"
CONFLICT 310
/note="K -> R (in Ref. 7; BAC11530)"
/evidence="ECO:0000305"
CONFLICT 334
/note="S -> I (in Ref. 7; BAF83354)"
/evidence="ECO:0000305"
HELIX 17..29
/evidence="ECO:0000244|PDB:3AY5"
HELIX 31..36
/evidence="ECO:0000244|PDB:3AY5"
HELIX 49..73
/evidence="ECO:0000244|PDB:3AY5"
STRAND 76..78
/evidence="ECO:0000244|PDB:3AY5"
HELIX 82..103
/evidence="ECO:0000244|PDB:3AY5"
HELIX 108..110
/evidence="ECO:0000244|PDB:3AY5"
HELIX 112..137
/evidence="ECO:0000244|PDB:3AY5"
HELIX 154..160
/evidence="ECO:0000244|PDB:3AY5"
TURN 161..164
/evidence="ECO:0000244|PDB:3AY5"
HELIX 169..197
/evidence="ECO:0000244|PDB:3AY5"
HELIX 235..265
/evidence="ECO:0000244|PDB:3AY5"
HELIX 271..295
/evidence="ECO:0000244|PDB:3AY5"
STRAND 296..298
/evidence="ECO:0000244|PDB:3AY5"
HELIX 301..324
/evidence="ECO:0000244|PDB:3AY5"
HELIX 335..352
/evidence="ECO:0000244|PDB:3AY5"
HELIX 353..358
/evidence="ECO:0000244|PDB:3AY5"
SEQUENCE 360 AA; 40262 MW; 40C7C3686632F6A7 CRC64;
MASATAPAAA VPTLASPLEQ LRHLAEELRL LLPRVRVGEA QETTEEFNRE MFWRRLNEAA
VTVSREATTL TIVFSQLPLP SPQETQKFCE QVHAAIKAFI AVYYLLPKDQ GITLRKLVRG
ATLDIVDGMA QLMEVLSVTP TQSPENNDLI SYNSVWVACQ QMPQIPRDNK AAALLMLTKN
VDFVKDAHEE MEQAVEECDP YSGLLNDTEE NNSDNHNHED DVLGFPSNQD LYWSEDDQEL
IIPCLALVRA SKACLKKIRM LVAENGKKDQ VAQLDDIVDI SDEISPSVDD LALSIYPPMC
HLTVRINSAK LVSVLKKALE ITKASHVTPQ PEDSWIPLLI NAIDHCMNRI KELTQSELEL


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