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Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)

 CDN2B_HUMAN             Reviewed;         138 AA.
P42772; O15125; Q6FI09;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
12-AUG-2020, entry version 181.
RecName: Full=Cyclin-dependent kinase 4 inhibitor B;
AltName: Full=Multiple tumor suppressor 2;
Short=MTS-2;
AltName: Full=p14-INK4b;
AltName: Full=p15-INK4b;
Short=p15INK4B;
Name=CDKN2B; Synonyms=MTS2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=8001816; DOI=10.1101/gad.8.24.2939;
Guan K.-L., Jenkins C.W., Li Y., Nichols M.A., Wu X., O'Keefe C.L.,
Matera G.A., Xiong Y.;
"Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6
inhibitor, correlates with wild-type pRb function.";
Genes Dev. 8:2939-2952(1994).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=8078588; DOI=10.1038/371257a0;
Hannon G.J., Beach D.;
"p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.";
Nature 371:257-261(1994).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SUBCELLULAR LOCATION, AND TISSUE
SPECIFICITY.
PubMed=9230210;
Tsubari M., Tiihonen E., Laiho M.;
"Cloning and characterization of p10, an alternatively spliced form of p15
cyclin-dependent kinase inhibitor.";
Cancer Res. 57:2966-2973(1997).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P.,
Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y.,
LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry
vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NIEHS SNPs program;
Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164053; DOI=10.1038/nature02465;
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
Dunham I.;
"DNA sequence and analysis of human chromosome 9.";
Nature 429:369-374(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Skin;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 53-138.
PubMed=8153634; DOI=10.1126/science.8153634;
Kamb A., Gruis N.A., Weaver-Feldhaus J., Liu Q., Harshman K.,
Tavtigian S.V., Stockert E., Day R.S. III, Johnson B.E., Skolnick M.H.;
"A cell cycle regulator potentially involved in genesis of many tumor
types.";
Science 264:436-440(1994).
[9]
STRUCTURE BY NMR.
PubMed=10892805; DOI=10.1110/ps.9.6.1120;
Yuan C., Selby T.L., Li J., Byeon I.J., Tsai M.D.;
"Tumor suppressor INK4: refinement of p16INK4A structure and determination
of p15INK4B structure by comparative modeling and NMR data.";
Protein Sci. 9:1120-1128(2000).
[10]
VARIANTS LUNG ADENOCARCINOMA GLU-47 AND VAL-50.
PubMed=7882351;
Okamoto A., Hussain S.P., Hagiwara K., Spillare E.A., Rusin M.R.,
Demetrick D.J., Serrano M., Hannon G.J., Shiseki M., Zariwala M., Xiong Y.,
Beach D.H., Yokota J., Harris C.C.;
"Mutations in the p16INK4/MTS1/CDKN2, p15INK4B/MTS2, and p18 genes in
primary and metastatic lung cancer.";
Cancer Res. 55:1448-1451(1995).
-!- FUNCTION: Interacts strongly with CDK4 and CDK6. Potent inhibitor.
Potential effector of TGF-beta induced cell cycle arrest.
-!- SUBUNIT: Heterodimer of CDKN2B with CDK4 or CDK6. Isoform 2 does not
interact with CDK4 nor CDK6.
-!- INTERACTION:
P42772; Q9UI12: ATP6V1H; NbExp=3; IntAct=EBI-711280, EBI-724719;
P42772; P24863: CCNC; NbExp=3; IntAct=EBI-711280, EBI-395261;
P42772; Q00537: CDK17; NbExp=3; IntAct=EBI-711280, EBI-624648;
P42772; P11802: CDK4; NbExp=18; IntAct=EBI-711280, EBI-295644;
P42772; Q00534: CDK6; NbExp=15; IntAct=EBI-711280, EBI-295663;
P42772; Q6P9H4: CNKSR3; NbExp=3; IntAct=EBI-711280, EBI-10253274;
P42772; Q0VD86: INCA1; NbExp=3; IntAct=EBI-711280, EBI-6509505;
P42772; P43364: MAGEA11; NbExp=4; IntAct=EBI-711280, EBI-739552;
P42772; Q9GZT8: NIF3L1; NbExp=3; IntAct=EBI-711280, EBI-740897;
P42772; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-711280, EBI-79165;
P42772; Q53H96: PYCR3; NbExp=3; IntAct=EBI-711280, EBI-2959680;
P42772; A6ZKI3: RTL8C; NbExp=3; IntAct=EBI-711280, EBI-10174072;
P42772; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-711280, EBI-6257312;
P42772; Q9NZD8: SPG21; NbExp=6; IntAct=EBI-711280, EBI-742688;
P42772; Q13077: TRAF1; NbExp=7; IntAct=EBI-711280, EBI-359224;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9230210}. Note=Also
found in the nucleus.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=p15;
IsoId=P42772-1; Sequence=Displayed;
Name=2; Synonyms=p10;
IsoId=P42772-2; Sequence=VSP_043898;
-!- TISSUE SPECIFICITY: Isoform 2 is expressed in normal (keratinocytes,
fibroblasts) and tumor cell lines. {ECO:0000269|PubMed:9230210}.
-!- SIMILARITY: Belongs to the CDKN2 cyclin-dependent kinase inhibitor
family. {ECO:0000305}.
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/cdkn2b/";
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
Haematology;
URL="http://atlasgeneticsoncology.org/Genes/CDKN2BID187ch9p21.html";
---------------------------------------------------------------------------
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EMBL; U17075; AAC50075.1; -; mRNA.
EMBL; L36844; AAA50282.1; -; mRNA.
EMBL; AF004819; AAB69989.1; -; mRNA.
EMBL; CR536529; CAG38766.1; -; mRNA.
EMBL; AF513858; AAM44859.1; -; Genomic_DNA.
EMBL; AL449423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC014469; AAH14469.1; -; mRNA.
EMBL; S69805; AAD14049.1; -; Genomic_DNA.
CCDS; CCDS6512.1; -. [P42772-1]
CCDS; CCDS6513.1; -. [P42772-2]
PIR; B55479; B55479.
RefSeq; NP_004927.2; NM_004936.3. [P42772-1]
RefSeq; NP_511042.1; NM_078487.2. [P42772-2]
SMR; P42772; -.
BioGRID; 107464; 56.
IntAct; P42772; 23.
MINT; P42772; -.
STRING; 9606.ENSP00000276925; -.
iPTMnet; P42772; -.
PhosphoSitePlus; P42772; -.
BioMuta; CDKN2B; -.
DMDM; 1168869; -.
jPOST; P42772; -.
MassIVE; P42772; -.
MaxQB; P42772; -.
PaxDb; P42772; -.
PeptideAtlas; P42772; -.
PRIDE; P42772; -.
ProteomicsDB; 55555; -. [P42772-1]
ProteomicsDB; 55556; -. [P42772-2]
Antibodypedia; 3605; 600 antibodies.
DNASU; 1030; -.
Ensembl; ENST00000276925; ENSP00000276925; ENSG00000147883. [P42772-1]
Ensembl; ENST00000380142; ENSP00000369487; ENSG00000147883. [P42772-2]
GeneID; 1030; -.
KEGG; hsa:1030; -.
UCSC; uc003zpn.4; human. [P42772-1]
CTD; 1030; -.
DisGeNET; 1030; -.
EuPathDB; HostDB:ENSG00000147883.10; -.
GeneCards; CDKN2B; -.
HGNC; HGNC:1788; CDKN2B.
HPA; ENSG00000147883; Tissue enhanced (intestine).
MalaCards; CDKN2B; -.
MIM; 600431; gene.
neXtProt; NX_P42772; -.
OpenTargets; ENSG00000147883; -.
Orphanet; 618; Familial melanoma.
Orphanet; 652; Multiple endocrine neoplasia type 1.
PharmGKB; PA26321; -.
eggNOG; KOG0504; Eukaryota.
GeneTree; ENSGT00940000162423; -.
HOGENOM; CLU_000134_37_1_1; -.
InParanoid; P42772; -.
KO; K04685; -.
OMA; QQGHHQV; -.
OrthoDB; 962484at2759; -.
PhylomeDB; P42772; -.
TreeFam; TF352389; -.
PathwayCommons; P42772; -.
Reactome; R-HSA-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
Reactome; R-HSA-2559580; Oxidative Stress Induced Senescence.
Reactome; R-HSA-2559582; Senescence-Associated Secretory Phenotype (SASP).
Reactome; R-HSA-2559585; Oncogene Induced Senescence.
Reactome; R-HSA-69231; Cyclin D associated events in G1.
SIGNOR; P42772; -.
BioGRID-ORCS; 1030; 6 hits in 880 CRISPR screens.
GeneWiki; CDKN2B; -.
GenomeRNAi; 1030; -.
Pharos; P42772; Tbio.
PRO; PR:P42772; -.
Proteomes; UP000005640; Chromosome 9.
RNAct; P42772; protein.
Bgee; ENSG00000147883; Expressed in vagina and 167 other tissues.
ExpressionAtlas; P42772; baseline and differential.
Genevisible; P42772; HS.
GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; IDA:BHF-UCL.
GO; GO:0019901; F:protein kinase binding; IPI:BHF-UCL.
GO; GO:0007050; P:cell cycle arrest; IMP:BHF-UCL.
GO; GO:0031668; P:cellular response to extracellular stimulus; IMP:BHF-UCL.
GO; GO:0031670; P:cellular response to nutrient; IMP:BHF-UCL.
GO; GO:0090398; P:cellular senescence; IMP:BHF-UCL.
GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:BHF-UCL.
GO; GO:0030219; P:megakaryocyte differentiation; IEP:UniProtKB.
GO; GO:0007093; P:mitotic cell cycle checkpoint; IMP:BHF-UCL.
GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:BHF-UCL.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:BHF-UCL.
GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; TAS:Reactome.
GO; GO:0042326; P:negative regulation of phosphorylation; IDA:BHF-UCL.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; TAS:Reactome.
GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IMP:BHF-UCL.
GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IDA:BHF-UCL.
GO; GO:0048536; P:spleen development; IEA:Ensembl.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
SUPFAM; SSF48403; SSF48403; 1.
PROSITE; PS50297; ANK_REP_REGION; 1.
1: Evidence at protein level;
Alternative splicing; ANK repeat; Cell cycle; Cytoplasm; Polymorphism;
Reference proteome; Repeat; Tumor suppressor.
CHAIN 1..138
/note="Cyclin-dependent kinase 4 inhibitor B"
/id="PRO_0000144184"
REPEAT 13..39
/note="ANK 1; truncated"
REPEAT 46..74
/note="ANK 2"
REPEAT 79..108
/note="ANK 3"
REPEAT 112..138
/note="ANK 4"
VAR_SEQ 54..138
/note="MMMGSARVAELLLLHGAEPNCADPATLTRPVHDAAREGFLDTLVVLHRAGAR
LDVRDAWGRLPVDLAEERGHRDVAGYLRTATGD -> AGAPGPRRQGARERGARPRRIG
AGT (in isoform 2)"
/evidence="ECO:0000303|PubMed:9230210"
/id="VSP_043898"
VARIANT 47
/note="G -> E (in lung adenocarcinoma)"
/evidence="ECO:0000269|PubMed:7882351"
/id="VAR_001488"
VARIANT 50
/note="A -> V (in lung adenocarcinoma; dbSNP:rs1423790481)"
/evidence="ECO:0000269|PubMed:7882351"
/id="VAR_001489"
CONFLICT 20..22
/note="SAA -> TP (in Ref. 2; AAA50282)"
/evidence="ECO:0000305"
CONFLICT 32..34
/note="QLL -> HSW (in Ref. 2; AAA50282)"
/evidence="ECO:0000305"
SEQUENCE 138 AA; 14722 MW; 0D6FFBDFA6FEAD21 CRC64;
MREENKGMPS GGGSDEGLAS AAARGLVEKV RQLLEAGADP NGVNRFGRRA IQVMMMGSAR
VAELLLLHGA EPNCADPATL TRPVHDAARE GFLDTLVVLH RAGARLDVRD AWGRLPVDLA
EERGHRDVAG YLRTATGD


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Related Genes :
[CDKN2B MTS2] Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)
[Cdkn2b Ink4] Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b)
[Cdkn2b] Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b)
[CDKN2A CDKN2 MTS1] Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
[Cdkn2a P16ink4a] Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4a) (p16-INK4)
[CDKN2A CDKN2 MLM] Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF)
[Cdkn2a] Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p19ARF)
[SP1 TSFP1] Transcription factor Sp1
[CDKN2B] Cyclin-dependent kinase 4 inhibitor B (p14-INK4b)
[ZBTB17 MIZ1 ZNF151 ZNF60] Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60)
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10 (NC-pol); Protease p14 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p80 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[HCFC1 HCF1 HFC1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10 (NC-pol); Protease p14 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p80 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10 (NC-pol); Protease p14 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p80 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10-Pol (NC-pol); Protease (PR) (EC 3.4.23.-) (p14); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p80); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p46)]
[gag-pol] Gag-Pol polyprotein [Cleaved into: Matrix protein p10 (MA); p20; Capsid protein p25 (CA); Nucleocapsid protein p14 (NC-pol); Protease p15 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p90 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[Hcfc1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[HCFC1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[SNAI1 SNAH] Zinc finger protein SNAI1 (Protein snail homolog 1) (Protein sna)
[EGR1 KROX24 ZNF225] Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24)
[Cdkn2a] Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p19ARF)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[Cdkn2a P16ink4a] Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4a) (p16) (p16-INK4)

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