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Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b)

 CDN2B_RAT               Reviewed;         130 AA.
P55272;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
12-AUG-2020, entry version 138.
RecName: Full=Cyclin-dependent kinase 4 inhibitor B;
AltName: Full=p14-INK4b;
AltName: Full=p15-INK4b;
Name=Cdkn2b; Synonyms=Ink4;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=7546221; DOI=10.1002/mc.2940140106;
Hino O., Kobayashi E., Hirayama Y., Kobayashi T., Kubo Y., Tsuchiya H.,
Kikuchi Y., Mitani H.;
"Molecular genetic basis of renal carcinogenesis in the Eker rat model of
tuberous sclerosis (Tsc2).";
Mol. Carcinog. 14:23-27(1995).
[2]
NUCLEOTIDE SEQUENCE.
STRAIN=ACI/SegHsd, and COP; TISSUE=Lung;
Buckles L.K., Shull J.D.;
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-86.
PubMed=7712460;
Knapek D.F., Serrano M., Beach D., Trono D., Walker C.L.;
"Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney
epithelial cell lines but not primary renal tumors.";
Cancer Res. 55:1607-1612(1995).
-!- FUNCTION: Interacts strongly with CDK4 and CDK6. Potent inhibitor.
Potential effector of TGF-beta induced cell cycle arrest (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Heterodimer of CDKN2B with CDK4 or CDK6.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative initiation; Named isoforms=2;
Name=Long;
IsoId=P55272-1; Sequence=Displayed;
Name=Short;
IsoId=P55272-2; Sequence=VSP_018702;
-!- TISSUE SPECIFICITY: Expression abundant in lung, less abundant in
testis, barely detectable in liver, and not detectable in neonatal
kidney, adult kidney, brain, heart, or spleen.
-!- SIMILARITY: Belongs to the CDKN2 cyclin-dependent kinase inhibitor
family. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; S79760; AAB35360.1; -; mRNA.
EMBL; AF474978; AAL76340.1; -; mRNA.
EMBL; AF474979; AAL76341.1; -; mRNA.
EMBL; S77734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; NP_570825.1; NM_130812.3. [P55272-1]
STRING; 10116.ENSRNOP00000008898; -.
PaxDb; P55272; -.
PRIDE; P55272; -.
GeneID; 25164; -.
KEGG; rno:25164; -.
UCSC; RGD:2324; rat. [P55272-1]
CTD; 1030; -.
RGD; 2324; Cdkn2b.
eggNOG; KOG0504; Eukaryota.
InParanoid; P55272; -.
KO; K04685; -.
OrthoDB; 1435166at2759; -.
PhylomeDB; P55272; -.
TreeFam; TF352389; -.
PRO; PR:P55272; -.
Proteomes; UP000002494; Unplaced.
Genevisible; P55272; RN.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0004861; F:cyclin-dependent protein serine/threonine kinase inhibitor activity; ISO:RGD.
GO; GO:0019901; F:protein kinase binding; ISO:RGD.
GO; GO:0007568; P:aging; IEP:RGD.
GO; GO:0007050; P:cell cycle arrest; ISO:RGD.
GO; GO:0031668; P:cellular response to extracellular stimulus; ISO:RGD.
GO; GO:0031670; P:cellular response to nutrient; ISO:RGD.
GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD.
GO; GO:0090398; P:cellular senescence; ISO:RGD.
GO; GO:0000086; P:G2/M transition of mitotic cell cycle; ISO:RGD.
GO; GO:0001889; P:liver development; IEP:RGD.
GO; GO:0030219; P:megakaryocyte differentiation; ISO:RGD.
GO; GO:0007093; P:mitotic cell cycle checkpoint; ISO:RGD.
GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IMP:RGD.
GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:RGD.
GO; GO:0050680; P:negative regulation of epithelial cell proliferation; ISO:RGD.
GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISO:RGD.
GO; GO:0060253; P:negative regulation of glial cell proliferation; IMP:RGD.
GO; GO:0042326; P:negative regulation of phosphorylation; ISO:RGD.
GO; GO:0030858; P:positive regulation of epithelial cell differentiation; IEP:RGD.
GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; ISO:RGD.
GO; GO:0034097; P:response to cytokine; IEP:RGD.
GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
GO; GO:0048536; P:spleen development; ISO:RGD.
Gene3D; 1.25.40.20; -; 1.
InterPro; IPR002110; Ankyrin_rpt.
InterPro; IPR020683; Ankyrin_rpt-contain_dom.
InterPro; IPR036770; Ankyrin_rpt-contain_sf.
Pfam; PF12796; Ank_2; 1.
SMART; SM00248; ANK; 3.
SUPFAM; SSF48403; SSF48403; 1.
PROSITE; PS50297; ANK_REP_REGION; 1.
PROSITE; PS50088; ANK_REPEAT; 1.
2: Evidence at transcript level;
Alternative initiation; ANK repeat; Cell cycle; Phosphoprotein;
Reference proteome; Repeat; Tumor suppressor.
CHAIN 1..130
/note="Cyclin-dependent kinase 4 inhibitor B"
/id="PRO_0000004808"
REPEAT 5..34
/note="ANK 1"
REPEAT 38..66
/note="ANK 2"
REPEAT 71..100
/note="ANK 3"
REPEAT 104..130
/note="ANK 4"
MOD_RES 12
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P55271"
VAR_SEQ 1..45
/note="Missing (in isoform Short)"
/evidence="ECO:0000305"
/id="VSP_018702"
SEQUENCE 130 AA; 13749 MW; AC45B21FA69FAD92 CRC64;
MLGGGSDAGL ATAAARGQVE TVRQLLEAGA DPNAVNRFGR RPIQVMMMGS AQVAELLLLH
GAEPNCADPA TLTRPVHDAA REGFLDTLMV LHKAGARLDV CDAWGRLPVD LAEEQGHRDI
ARYLHAATGD


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Pathways :
WP1493: Carbon assimilation C4 pathway
WP1619: Amino sugar and nucleotide sugar metabolism
WP1033: ACE Inhibitor Pathway
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WP215: noncanonical wnt pathway
WP2344: vitamin B6 (pyridoxine, pyridoxal, pyridoxamine) biosynthesis and salvage pathway
WP1625: Base excision repair
WP253: Glycolysis
WP468: ACE Inhibitor Pathway
WP1676: Non-homologous end-joining
WP1701: Starch and sucrose metabolism
WP654: ATM
WP710: DNA damage response (only ATM dependent)
WP1946: Cori Cycle
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1403: AMPK signaling
WP2361: Gastric cancer network 1
WP396: ACE Inhibitor Pathway
WP1672: Mismatch repair
WP1681: Pantothenate and CoA biosynthesis
WP557: ACE Inhibitor Pathway
WP656: p53 signal pathway
WP1844: MAP kinase cascade
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1151: ACE Inhibitor Pathway

Related Genes :
[CDKN2B MTS2] Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B)
[Cdkn2b Ink4] Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b)
[Cdkn2b] Cyclin-dependent kinase 4 inhibitor B (p14-INK4b) (p15-INK4b)
[Cdkn2a P16ink4a] Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (p16-INK4a) (p16-INK4)
[CDKN2A CDKN2 MTS1] Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A)
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10 (NC-pol); Protease p14 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p80 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[CDKN2B] Cyclin-dependent kinase 4 inhibitor B (p14-INK4b)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10 (NC-pol); Protease p14 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p80 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10 (NC-pol); Protease p14 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p80 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein [Cleaved into: Matrix protein p10 (MA); p20; Capsid protein p25 (CA); Nucleocapsid protein p14 (NC-pol); Protease p15 (PR) (EC 3.4.23.-); Reverse transcriptase/ribonuclease H p90 (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase p46 (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein (Pr180gag-pol) [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12 (pp12); Capsid protein p30 (CA); Nucleocapsid protein p10-Pol (NC-pol); Protease (PR) (EC 3.4.23.-) (p14); Reverse transcriptase/ribonuclease H (RT) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4) (p80); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (p46)]
[CDKN2A CDKN2 MLM] Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[ZBTB17 MIZ1 ZNF151 ZNF60] Zinc finger and BTB domain-containing protein 17 (Myc-interacting zinc finger protein 1) (Miz-1) (Zinc finger protein 151) (Zinc finger protein 60)
[HCFC1 HCF1 HFC1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[Cdkn2a] Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p19ARF)
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[Hcfc1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[HCFC1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[SP1 TSFP1] Transcription factor Sp1
[C c core PreC preC] Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
[gag-pol] Gag-Pol polyprotein [Cleaved into: Matrix protein p19; p2A; p2B; p10; Capsid protein p27, alternate cleaved 1; Capsid protein p27, alternate cleaved 2; p3; Nucleocapsid protein p12; Protease p15 (EC 3.4.23.-); Reverse transcriptase beta-subunit (RT-beta); Reverse transcriptase alpha-subunit (RT-alpha) (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.4); Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-) (pp32); p4]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]

Bibliography :