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Cytochrome P450 26A1 (EC 1 14 13 -) (Retinoic acid-degrading enzyme CYP26)

 CP26A_CHICK             Reviewed;         492 AA.
Q9PUB4; Q9PUG2;
23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
16-JAN-2019, entry version 106.
RecName: Full=Cytochrome P450 26A1;
EC=1.14.13.- {ECO:0000269|PubMed:10588879};
AltName: Full=Retinoic acid-degrading enzyme CYP26;
Name=CYP26A1; Synonyms=CYP26;
Gallus gallus (Chicken).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes;
Phasianidae; Phasianinae; Gallus.
NCBI_TaxID=9031;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, CATALYTIC ACTIVITY, INDUCTION,
AND DEVELOPMENTAL STAGE.
TISSUE=Embryonic spinal cord;
PubMed=10588879; DOI=10.1006/dbio.1999.9487;
Swindell E.C., Thaller C., Sockanathan S., Petkovich M., Jessell T.M.,
Eichele G.;
"Complementary domains of retinoic acid production and degradation in
the early chick embryo.";
Dev. Biol. 216:282-296(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 368-474.
Martinez-Ceballos E., Burdsal C.A.;
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Plays a key role in retinoic acid metabolism. Appears to
be involved in the specific inactivation of all-trans-retinoic
acid (RA). Responsible for generation of several hydroxylated
forms of RA, including 4-OH-RA, 4-oxo-RA, and 18-OH-RA.
{ECO:0000269|PubMed:10588879}.
-!- COFACTOR:
Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
membrane protein. Microsome membrane; Peripheral membrane protein.
-!- DEVELOPMENTAL STAGE: Expressed at stage 4 in the ectoderm, stage
5-7 in the nascent notochord and at stage 7 its expression
decreases in the anterior part of the embryo. From stage 7-10 its
expression is restricted to the dorsal folds of the neural tube
and to rhombomere 2. At stage 10, it is expressed in the lateral
plate endoderm and in the tail bud and by stage 11/12 it
disappears in the neural tube, followed by a confined expression
at stage 12 to dorsal neural tube and at stage 15 an increasing
expression in the ectoderm. {ECO:0000269|PubMed:10588879}.
-!- INDUCTION: By retinoic acid. {ECO:0000269|PubMed:10588879}.
-!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF199462; AAF09250.1; -; mRNA.
EMBL; AF185266; AAD56546.1; -; mRNA.
RefSeq; NP_001001129.1; NM_001001129.1.
UniGene; Gga.331; -.
ProteinModelPortal; Q9PUB4; -.
SMR; Q9PUB4; -.
STRING; 9031.ENSGALP00000010871; -.
PaxDb; Q9PUB4; -.
GeneID; 408183; -.
KEGG; gga:408183; -.
CTD; 1592; -.
eggNOG; KOG0157; Eukaryota.
eggNOG; COG2124; LUCA.
HOGENOM; HOG000220829; -.
HOVERGEN; HBG051099; -.
InParanoid; Q9PUB4; -.
KO; K07437; -.
OrthoDB; 871849at2759; -.
PhylomeDB; Q9PUB4; -.
PRO; PR:Q9PUB4; -.
Proteomes; UP000000539; Unplaced.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0008401; F:retinoic acid 4-hydroxylase activity; IDA:UniProtKB.
GO; GO:0055114; P:oxidation-reduction process; IBA:GO_Central.
GO; GO:0034653; P:retinoic acid catabolic process; IDA:MGI.
GO; GO:0016125; P:sterol metabolic process; IBA:GO_Central.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR002403; Cyt_P450_E_grp-IV.
InterPro; IPR036396; Cyt_P450_sf.
Pfam; PF00067; p450; 1.
PRINTS; PR00465; EP450IV.
PRINTS; PR00385; P450.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
1: Evidence at protein level;
Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane;
Metal-binding; Microsome; Monooxygenase; Oxidoreductase;
Reference proteome.
CHAIN 1 492 Cytochrome P450 26A1.
/FTId=PRO_0000051982.
METAL 437 437 Iron (heme axial ligand). {ECO:0000255}.
CONFLICT 371 371 I -> V (in Ref. 2; AAD56546).
{ECO:0000305}.
CONFLICT 472 474 GPI -> SPT (in Ref. 2; AAD56546).
{ECO:0000305}.
SEQUENCE 492 AA; 55265 MW; 7F28B72E75C232FB CRC64;
MGFSALVASA LCTFLLPLLL FLAAVRLWDL YCASGRDPSC PLPLPPGTMG LPFFGETLQM
VLQRRKFLQM KRRKYGFIYK THLFGRPTVR VMGAENVRHI LLGEHRLVSV QWPASVRTIL
GSGCLSNLHN GQHKHRKKVI MQAFSRDALQ HYVPVIQEEV SACLAQWLGA GPCLLVYPEV
KRLMFRIAMR ILLGFQPRQA SPDGEQQLVE AFEEMIRNLF SLPIDVPFSG LYRGLRARNI
IHAKIEENIR AKMARKEPEG GYKDALQLLM EHTQGNGEQL NMQELKESAT ELLFGGHETT
ASAATSLIAF LGLHHDVLQK VRKELQLKGL LSGPNQEKQL NMEFLEQLKY TGCVIKETLR
LSPPVPGGFR IALKTLELNG YQIPKGWNVI YSICDTHDVA DLFTDKDEFN PDRFMSPSPE
DSSRFSFIPF GGGLRSCVGK EFAKVLLKIF TVELARSCDW QLLNGPPTMK TGPIVYPVDN
LPAKFIGFSG QI


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Pathways :
WP2316: PPAR signaling pathway
WP1077: cytochrome P450
WP1194: cytochrome P450
WP1219: cytochrome P450
WP1274: cytochrome P450
WP1390: cytochrome P450
WP1498: Dopminergic Neurogenesis
WP43: cytochrome P450
WP626: Abscisic Acid Biosynthesis
WP677: Momilactone biosynthesis
WP696: Benzo(a)pyrene metabolism
WP958: cytochrome P450
WP1008: amino acid conjugation of benzoic acid
WP1020: Fatty Acid Biosynthesis
WP1021: Phase I, non P450
WP105: Fatty Acid Beta Oxidation 2
WP1061: Fatty Acid Beta Oxidation
WP1075: Folic Acid Network
WP1107: Mitochondrial LC-Fatty Acid Beta-Oxidation
WP1127: amino acid conjugation of benzoic acid
WP1139: Fatty Acid Biosynthesis
WP1140: Phase I, non P450
WP1177: Fatty Acid Beta Oxidation
WP1192: Folic Acid Network
WP1207: Fatty Acid Beta Oxidation

Related Genes :
[CYP26A1 CYP26 P450RAI1] Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
[Cyp26a1 Cyp26 P450ra] Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
[cyp26a1 cyp26] Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
[CYP26B1 CYP26A2 P450RAI2] Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 26A2) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2) (Retinoic acid-metabolizing cytochrome)
[Cyp26b1] Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2)
[cyp26b1] Cytochrome P450 26B1 (Cyp26B1) (EC 1.14.13.-) (Retinoic acid-metabolizing cytochrome)
[CYP26A1 CYP26] Cytochrome P450 26A1 (EC 1.14.13.-) (Retinoic acid-degrading enzyme CYP26)
[CYP26C1] Cytochrome P450 26C1 (EC 1.14.-.-)
[Cyp26b1] Cytochrome P450 26B1 (EC 1.14.13.-)
[cyp26a1 cyp26] Cytochrome P450 26A1 (EC 1.14.13.-) (Retinoic acid-converting enzyme) (RACE) (Retinoic acid-degrading enzyme CYP26) (xCYP26)
[cyp102A1 cyp102 BG04_163] Bifunctional cytochrome P450/NADPH--P450 reductase (Cytochrome P450(BM-3)) (Cytochrome P450BM-3) (Fatty acid monooxygenase) (Flavocytochrome P450 BM3) [Includes: Cytochrome P450 102A1 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)]
[CYP26B1] Cytochrome P450 26B1 (EC 1.14.13.-)
[cypD cyp102A2 yetO yfnJ BSU07250] Bifunctional cytochrome P450/NADPH--P450 reductase 1 (CYP102A2) (Fatty acid hydroxylase CypD) (Flavocytochrome P450 102A2) [Includes: Cytochrome P450 102A2 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)]
[CYP2C8] Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase)
[cypB cyp102A3 yrhJ BSU27160] Bifunctional cytochrome P450/NADPH--P450 reductase 2 (CYP102A3) (Fatty acid hydroxylase CypB) (Flavocytochrome P450 102A3) [Includes: Cytochrome P450 102A3 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)]
[CYP4F2] Phylloquinone omega-hydroxylase CYP4F2 (EC 1.14.14.78) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.14.-) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450 4F2) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94)
[CYP3A4 CYP3A3] Cytochrome P450 3A4 (EC 1.14.14.-) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (EC 1.14.14.-) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) (Taurochenodeoxycholate 6-alpha-hydroxylase) (EC 1.14.14.-)
[CYP2C9 CYP2C10] Cytochrome P450 2C9 (EC 1.14.14.-) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (EC 1.14.14.-) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase)
[CYP505] Bifunctional cytochrome P450/NADPH--P450 reductase (Cytochrome P450foxy) (Fatty acid omega-hydroxylase) (P450foxy) [Includes: Cytochrome P450 505 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)]
[Cyp2e1 Cyp2e Cyp2e-1] Cytochrome P450 2E1 (EC 1.14.13.-) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) (Cytochrome P450RLM6)
[CYP2A6 CYP2A3] Cytochrome P450 2A6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I))
[Cyp2c13 Cyp2c-13] Cytochrome P450 2C13, male-specific (EC 1.14.14.1) (CYPIIC13) (Cytochrome P-450g) (Cytochrome P450-G) (Cytochrome P450-UT-5)
[CYP2C19] Cytochrome P450 2C19 (EC 1.14.14.-) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase)
[Cyp2e1 Cyp2e Cyp2e-1] Cytochrome P450 2E1 (EC 1.14.13.-) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-ALC) (Cytochrome P450-J)
[Cyp1a1 Cyp1a-1] Cytochrome P450 1A1 (CYP1A1) (EC 1.14.14.1) (CYPIA1) (Cytochrome P450-C) (Cytochrome P450MT2) [Cleaved into: Cytochrome P450MT2A; Cytochrome P450MT2B]
[CYP2E1 CYP2E] Cytochrome P450 2E1 (EC 1.14.13.-) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J)
[CYP21A2 CYP21 CYP21B] Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (Cytochrome P450-C21B)
[CYP1A2] Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3)
[CYP2B6] Cytochrome P450 2B6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIB6) (Cytochrome P450 IIB1)
[CYP4F3 LTB4H] Docosahexaenoic acid omega-hydroxylase CYP4F3 (EC 1.14.14.79) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.14.-) (CYPIVF3) (Cytochrome P450 4F3) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 2) (Leukotriene-B(4) omega-hydroxylase 2) (EC 1.14.14.94)

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