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Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase)

 CP2C8_HUMAN             Reviewed;         490 AA.
P10632; A8K9N8; B0AZN2; B7Z1F6; Q5VX93; Q8WWB1; Q9UCZ9;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-NOV-1990, sequence version 2.
13-FEB-2019, entry version 206.
RecName: Full=Cytochrome P450 2C8;
EC=1.14.14.1 {ECO:0000269|PubMed:7574697};
AltName: Full=CYPIIC8;
AltName: Full=Cytochrome P450 IIC2;
AltName: Full=Cytochrome P450 MP-12;
AltName: Full=Cytochrome P450 MP-20;
AltName: Full=Cytochrome P450 form 1;
AltName: Full=S-mephenytoin 4-hydroxylase;
Name=CYP2C8;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT MET-264.
TISSUE=Liver;
PubMed=3500169;
Okino S.T., Quattrochi L.C., Pendurthi U.R., McBride O.W., Tukey R.H.;
"Characterization of multiple human cytochrome P-450 1 cDNAs. The
chromosomal localization of the gene and evidence for alternate RNA
splicing.";
J. Biol. Chem. 262:16072-16079(1987).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Liver;
PubMed=3697070; DOI=10.1093/nar/15.23.10053;
Kimura S., Pastewka J., Gelboin H.V., Gonzalez F.J.;
"cDNA and amino acid sequences of two members of the human P450IIC
gene subfamily.";
Nucleic Acids Res. 15:10053-10054(1987).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT MET-264.
PubMed=2009263; DOI=10.1021/bi00227a012;
Romkes M., Faletto M.B., Blaisdell J.A., Raucy J.L., Goldstein J.A.;
"Cloning and expression of complementary DNAs for multiple members of
the human cytochrome P450IIC subfamily.";
Biochemistry 30:3247-3255(1991).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND
VARIANTS LYS-139 AND ARG-399.
TISSUE=Liver, and Mammary gland;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LYS-139; VAL-244;
MET-264; PHE-269 AND ARG-399.
NIEHS SNPs program;
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15164054; DOI=10.1038/nature02462;
Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J.,
Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D.,
Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L.,
Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S.,
Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L.,
Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J.,
Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M.,
Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S.,
Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M.,
Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A.,
Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T.,
Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T.,
Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W.,
Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H.,
Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L.,
Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K.,
Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T.,
Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 10.";
Nature 429:375-381(2004).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[9]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
TISSUE=Blood;
PubMed=1707679; DOI=10.1016/0167-4781(91)90138-C;
Ged C., Beaune P.;
"Isolation of the human cytochrome P-450 IIC8 gene: multiple
glucocorticoid responsive elements in the 5' region.";
Biochim. Biophys. Acta 1088:433-435(1991).
[10]
PROTEIN SEQUENCE OF 2-15, NUCLEOTIDE SEQUENCE [MRNA] OF 6-490,
FUNCTION, CATALYTIC ACTIVITY, AND VARIANT LEU-411.
TISSUE=Kidney;
PubMed=7574697; DOI=10.1006/abbi.1995.1438;
Zeldin D.C., DuBois R.N., Falck J.R., Capdevila J.H.;
"Molecular cloning, expression and characterization of an endogenous
human cytochrome P450 arachidonic acid epoxygenase isoform.";
Arch. Biochem. Biophys. 322:76-86(1995).
[11]
NUCLEOTIDE SEQUENCE [MRNA] OF 11-490 (ISOFORM 1), AND VARIANTS
ASP-154; LYS-193; ARG-249 AND LEU-411.
TISSUE=Liver;
PubMed=3196692; DOI=10.1021/bi00418a039;
Ged C., Umbenhauer D.R., Bellew T.M., Bork R.W., Srivastava P.K.,
Shinriki N., Lloyd R.S., Guengerich F.P.;
"Characterization of cDNAs, mRNAs, and proteins related to human liver
microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase.";
Biochemistry 27:6929-6940(1988).
[12]
NUCLEOTIDE SEQUENCE [MRNA] OF 34-382 (ISOFORM 1), AND VARIANT LYS-139.
PubMed=2729895; DOI=10.1111/j.1469-1809.1989.tb01119.x;
Shephard E.A., Phillips I.R., Santisteban I., Palmer C.N., Povey S.;
"Cloning, expression and chromosomal localization of a member of the
human cytochrome P450IIC gene sub-family.";
Ann. Hum. Genet. 53:23-31(1989).
[13]
NUCLEOTIDE SEQUENCE [MRNA] OF 281-490 (ISOFORM 1), AND VARIANT
ARG-399.
PubMed=2216732; DOI=10.1093/nar/18.18.5550;
Kolyada A.Y.;
"Sequence of a human liver cytochrome P-450 cDNA clone.";
Nucleic Acids Res. 18:5550-5550(1990).
[14]
POLYMORPHISM.
PubMed=15365880; DOI=10.1007/s10038-004-0188-6;
Ishikawa C., Ozaki H., Nakajima T., Ishii T., Kanai S., Anjo S.,
Shirai K., Inoue I.;
"A frameshift variant of CYP2C8 was identified in a patient who
suffered from rhabdomyolysis after administration of cerivastatin.";
J. Hum. Genet. 49:582-585(2004).
[15]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D.,
Wang L., Ye M., Zou H.;
"An enzyme assisted RP-RPLC approach for in-depth analysis of human
liver phosphoproteome.";
J. Proteomics 96:253-262(2014).
[16]
X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 28-490.
PubMed=14676196; DOI=10.1074/jbc.M312516200;
Schoch G.A., Yano J.K., Wester M.R., Griffin K.J., Stout C.D.,
Johnson E.F.;
"Structure of human microsomal cytochrome P450 2C8. Evidence for a
peripheral fatty acid binding site.";
J. Biol. Chem. 279:9497-9503(2004).
[17]
X-RAY CRYSTALLOGRAPHY (2.28 ANGSTROMS) OF 28-490 IN COMPLEX WITH
INHIBITORS, AND SUBSTRATE-BINDING SITES.
PubMed=18413310; DOI=10.1074/jbc.M802180200;
Schoch G.A., Yano J.K., Sansen S., Dansette P.M., Stout C.D.,
Johnson E.F.;
"Determinants of cytochrome P450 2C8 substrate binding: structures of
complexes with montelukast, troglitazone, felodipine, and 9-cis-
retinoic acid.";
J. Biol. Chem. 283:17227-17237(2008).
[18]
VARIANTS LYS-139; PHE-269 AND ARG-399.
PubMed=11668219; DOI=10.1097/00008571-200110000-00006;
Dai D., Zeldin D.C., Blaisdell J.A., Chanas B., Coulter S.J.,
Ghanayem B.I., Goldstein J.A.;
"Polymorphisms in human CYP2C8 decrease metabolism of the anticancer
drug paclitaxel and arachidonic acid.";
Pharmacogenetics 11:597-607(2001).
[19]
VARIANTS LYS-139; MET-264; PHE-269; SER-390 AND ARG-399.
PubMed=12429347; DOI=10.1016/S0006-2952(02)01354-0;
Bahadur N., Leathart J.B., Mutch E., Steimel-Crespi D., Dunn S.A.,
Gilissen R., Houdt J.V., Hendrickx J., Mannens G., Bohets H.,
Williams F.M., Armstrong M., Crespi C.L., Daly A.K.;
"CYP2C8 polymorphisms in Caucasians and their relationship with
paclitaxel 6alpha-hydroxylase activity in human liver microsomes.";
Biochem. Pharmacol. 64:1579-1589(2002).
[20]
VARIANTS LYS-139; MET-264; PHE-269 AND ARG-399.
PubMed=15469410; DOI=10.1517/14622416.5.7.895;
Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q.,
McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.;
"Genetic variation in eleven phase I drug metabolism genes in an
ethnically diverse population.";
Pharmacogenomics 5:895-931(2004).
[21]
CHARACTERIZATION OF VARIANTS LYS-139; SER-171; GLY-186; MET-223;
PRO-238; ARG-247; MET-264; PHE-269; ASN-383; ARG-399 AND VAL-461 DEL,
FUNCTION, BIOPHYSICOCHEMICAL PROPERTIES, AND POLYMORPHISM.
PubMed=26427316; DOI=10.1016/j.dmpk.2015.07.003;
Tsukada C., Saito T., Maekawa M., Mano N., Oda A., Hirasawa N.,
Hiratsuka M.;
"Functional characterization of 12 allelic variants of CYP2C8 by
assessment of paclitaxel 6alpha-hydroxylation and amodiaquine N-
deethylation.";
Drug Metab. Pharmacokinet. 30:366-373(2015).
-!- FUNCTION: Cytochromes P450 are a group of heme-thiolate
monooxygenases. In liver microsomes, this enzyme is involved in an
NADPH-dependent electron transport pathway. It oxidizes a variety
of structurally unrelated compounds, including steroids, fatty
acids, and xenobiotics. In the epoxidation of arachidonic acid it
generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It
is the principal enzyme responsible for the metabolism the anti-
cancer drug paclitaxel (taxol). {ECO:0000269|PubMed:26427316,
ECO:0000269|PubMed:7574697}.
-!- CATALYTIC ACTIVITY:
Reaction=an alkane + O2 + reduced [NADPH--hemoprotein reductase] =
a primary alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964,
Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
ChEBI:CHEBI:15379, ChEBI:CHEBI:15734, ChEBI:CHEBI:18310,
ChEBI:CHEBI:57618, ChEBI:CHEBI:58210; EC=1.14.14.1;
Evidence={ECO:0000269|PubMed:7574697};
-!- COFACTOR:
Name=heme; Xref=ChEBI:CHEBI:30413;
-!- BIOPHYSICOCHEMICAL PROPERTIES:
Kinetic parameters:
KM=7.18 uM for paclitaxel {ECO:0000269|PubMed:26427316};
KM=1.35 uM for amodiaquine {ECO:0000269|PubMed:26427316};
Vmax=2.18 pmol/min/pmol enzyme with paclitaxel as substrate
{ECO:0000269|PubMed:26427316};
Vmax=11.30 pmol/min/pmol enzyme with amodiaquine as substrate
{ECO:0000269|PubMed:26427316};
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
membrane protein. Microsome membrane; Peripheral membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P10632-1; Sequence=Displayed;
Name=2;
IsoId=P10632-2; Sequence=VSP_043306, VSP_043307;
Note=No experimental confirmation available.;
-!- INDUCTION: By phenobarbital.
-!- POLYMORPHISM: Several alleles are found in the human population,
contributing to interindividual variations in the therapeutic
efficacy and toxicity of a myriad of drugs such as paclitaxel or
amodiaquine. The allele shown here is CYP2C8*1 (PubMed:26427316).
CYP2C8 genetic variations are associated with altered drug
metabolism and adverse drug effects including acute rhabdomyolysis
after cerivastatin use [MIM:618018]. {ECO:0000269|PubMed:15365880,
ECO:0000269|PubMed:26427316}.
-!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
-!- CAUTION: Alternative splicing has been shown to occur but the
shorter forms are believed to be non-functional. {ECO:0000305}.
-!- WEB RESOURCE: Name=Cytochrome P450 Allele Nomenclature Committee;
Note=CYP2C8 alleles;
URL="http://www.cypalleles.ki.se/cyp2c8.htm";
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/cyp2c8/";
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EMBL; M17397; AAA35739.1; -; mRNA.
EMBL; M17398; AAA35740.1; -; mRNA.
EMBL; Y00498; CAA68550.1; -; mRNA.
EMBL; AK292753; BAF85442.1; -; mRNA.
EMBL; AK293328; BAH11492.1; -; mRNA.
EMBL; AK315823; BAF98714.1; -; mRNA.
EMBL; AY514490; AAR89907.1; -; Genomic_DNA.
EMBL; AL359672; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471066; EAW50018.1; -; Genomic_DNA.
EMBL; BC020596; AAH20596.1; -; mRNA.
EMBL; X54807; CAA38578.1; -; Genomic_DNA.
EMBL; M21941; AAA52160.1; -; mRNA.
EMBL; M21942; AAA52161.1; -; mRNA.
EMBL; X51535; CAA35915.1; -; mRNA.
CCDS; CCDS55721.1; -. [P10632-2]
CCDS; CCDS7438.1; -. [P10632-1]
PIR; A29782; A29782.
RefSeq; NP_000761.3; NM_000770.3. [P10632-1]
RefSeq; NP_001185782.1; NM_001198853.1.
RefSeq; NP_001185783.1; NM_001198854.1. [P10632-2]
RefSeq; NP_001185784.1; NM_001198855.1.
UniGene; Hs.709188; -.
PDB; 1PQ2; X-ray; 2.70 A; A/B=19-490.
PDB; 2NNH; X-ray; 2.60 A; A/B=28-490.
PDB; 2NNI; X-ray; 2.80 A; A=28-490.
PDB; 2NNJ; X-ray; 2.28 A; A=28-490.
PDB; 2VN0; X-ray; 2.70 A; A=28-490.
PDBsum; 1PQ2; -.
PDBsum; 2NNH; -.
PDBsum; 2NNI; -.
PDBsum; 2NNJ; -.
PDBsum; 2VN0; -.
ProteinModelPortal; P10632; -.
SMR; P10632; -.
BioGrid; 107936; 15.
IntAct; P10632; 10.
STRING; 9606.ENSP00000360317; -.
BindingDB; P10632; -.
ChEMBL; CHEMBL3721; -.
DrugBank; DB05812; Abiraterone.
DrugBank; DB00316; Acetaminophen.
DrugBank; DB00945; Acetylsalicylic acid.
DrugBank; DB00918; Almotriptan.
DrugBank; DB01424; Aminophenazone.
DrugBank; DB01118; Amiodarone.
DrugBank; DB00321; Amitriptyline.
DrugBank; DB00381; Amlodipine.
DrugBank; DB00613; Amodiaquine.
DrugBank; DB00701; Amprenavir.
DrugBank; DB01435; Antipyrine.
DrugBank; DB06605; Apixaban.
DrugBank; DB01076; Atorvastatin.
DrugBank; DB00972; Azelastine.
DrugBank; DB06770; Benzyl alcohol.
DrugBank; DB05229; Beraprost.
DrugBank; DB01393; Bezafibrate.
DrugBank; DB00835; Brompheniramine.
DrugBank; DB00921; Buprenorphine.
DrugBank; DB01156; Bupropion.
DrugBank; DB06772; Cabazitaxel.
DrugBank; DB00201; Caffeine.
DrugBank; DB00796; Candesartan.
DrugBank; DB00564; Carbamazepine.
DrugBank; DB00748; Carbinoxamine.
DrugBank; DB00482; Celecoxib.
DrugBank; DB00439; Cerivastatin.
DrugBank; DB00446; Chloramphenicol.
DrugBank; DB00608; Chloroquine.
DrugBank; DB00169; Cholecalciferol.
DrugBank; DB00501; Cimetidine.
DrugBank; DB00604; Cisapride.
DrugBank; DB00758; Clopidogrel.
DrugBank; DB00257; Clotrimazole.
DrugBank; DB00363; Clozapine.
DrugBank; DB00907; Cocaine.
DrugBank; DB01394; Colchicine.
DrugBank; DB05219; Crisaborole.
DrugBank; DB00531; Cyclophosphamide.
DrugBank; DB00091; Cyclosporine.
DrugBank; DB08912; Dabrafenib.
DrugBank; DB00250; Dapsone.
DrugBank; DB09183; Dasabuvir.
DrugBank; DB00705; Delavirdine.
DrugBank; DB01234; Dexamethasone.
DrugBank; DB00514; Dextromethorphan.
DrugBank; DB00647; Dextropropoxyphene.
DrugBank; DB00829; Diazepam.
DrugBank; DB00586; Diclofenac.
DrugBank; DB00255; Diethylstilbestrol.
DrugBank; DB00343; Diltiazem.
DrugBank; DB01184; Domperidone.
DrugBank; DB00625; Efavirenz.
DrugBank; DB06210; Eltrombopag.
DrugBank; DB08899; Enzalutamide.
DrugBank; DB00530; Erlotinib.
DrugBank; DB00783; Estradiol.
DrugBank; DB00402; Eszopiclone.
DrugBank; DB00977; Ethinyl Estradiol.
DrugBank; DB00773; Etoposide.
DrugBank; DB01023; Felodipine.
DrugBank; DB01039; Fenofibrate.
DrugBank; DB00544; Fluorouracil.
DrugBank; DB01095; Fluvastatin.
DrugBank; DB01320; Fosphenytoin.
DrugBank; DB01241; Gemfibrozil.
DrugBank; DB01218; Halofantrine.
DrugBank; DB00741; Hydrocortisone.
DrugBank; DB01050; Ibuprofen.
DrugBank; DB09054; Idelalisib.
DrugBank; DB01181; Ifosfamide.
DrugBank; DB01029; Irbesartan.
DrugBank; DB00951; Isoniazid.
DrugBank; DB09570; Ixazomib.
DrugBank; DB01221; Ketamine.
DrugBank; DB06738; Ketobemidone.
DrugBank; DB01026; Ketoconazole.
DrugBank; DB01009; Ketoprofen.
DrugBank; DB00448; Lansoprazole.
DrugBank; DB01259; Lapatinib.
DrugBank; DB08918; Levomilnacipran.
DrugBank; DB00451; Levothyroxine.
DrugBank; DB04725; Licofelone.
DrugBank; DB00281; Lidocaine.
DrugBank; DB01583; Liotrix.
DrugBank; DB00836; Loperamide.
DrugBank; DB01601; Lopinavir.
DrugBank; DB00455; Loratadine.
DrugBank; DB00678; Losartan.
DrugBank; DB00227; Lovastatin.
DrugBank; DB09280; Lumacaftor.
DrugBank; DB00603; Medroxyprogesterone acetate.
DrugBank; DB00784; Mefenamic acid.
DrugBank; DB00814; Meloxicam.
DrugBank; DB00532; Mephenytoin.
DrugBank; DB00333; Methadone.
DrugBank; DB00916; Metronidazole.
DrugBank; DB00370; Mirtazapine.
DrugBank; DB00764; Mometasone.
DrugBank; DB00471; Montelukast.
DrugBank; DB00295; Morphine.
DrugBank; DB00688; Mycophenolate mofetil.
DrugBank; DB01183; Naloxone.
DrugBank; DB00788; Naproxen.
DrugBank; DB00622; Nicardipine.
DrugBank; DB00184; Nicotine.
DrugBank; DB01115; Nifedipine.
DrugBank; DB04868; Nilotinib.
DrugBank; DB00665; Nilutamide.
DrugBank; DB06712; Nilvadipine.
DrugBank; DB09080; Olodaterol.
DrugBank; DB09296; Ombitasvir.
DrugBank; DB00338; Omeprazole.
DrugBank; DB01062; Oxybutynin.
DrugBank; DB01229; Paclitaxel.
DrugBank; DB03796; Palmitic Acid.
DrugBank; DB00617; Paramethadione.
DrugBank; DB00715; Paroxetine.
DrugBank; DB06589; Pazopanib.
DrugBank; DB00738; Pentamidine.
DrugBank; DB00850; Perphenazine.
DrugBank; DB00780; Phenelzine.
DrugBank; DB01174; Phenobarbital.
DrugBank; DB00946; Phenprocoumon.
DrugBank; DB00252; Phenytoin.
DrugBank; DB01132; Pioglitazone.
DrugBank; DB00554; Piroxicam.
DrugBank; DB08860; Pitavastatin.
DrugBank; DB08901; Ponatinib.
DrugBank; DB00175; Pravastatin.
DrugBank; DB00794; Primidone.
DrugBank; DB01032; Probenecid.
DrugBank; DB00396; Progesterone.
DrugBank; DB01182; Propafenone.
DrugBank; DB00818; Propofol.
DrugBank; DB09396; Propoxyphene napsylate.
DrugBank; DB00205; Pyrimethamine.
DrugBank; DB04216; Quercetin.
DrugBank; DB00908; Quinidine.
DrugBank; DB00468; Quinine.
DrugBank; DB01129; Rabeprazole.
DrugBank; DB00481; Raloxifene.
DrugBank; DB08896; Regorafenib.
DrugBank; DB00912; Repaglinide.
DrugBank; DB01045; Rifampicin.
DrugBank; DB01201; Rifapentine.
DrugBank; DB08931; Riociguat.
DrugBank; DB00503; Ritonavir.
DrugBank; DB00533; Rofecoxib.
DrugBank; DB00412; Rosiglitazone.
DrugBank; DB01698; Rutin.
DrugBank; DB00938; Salmeterol.
DrugBank; DB01232; Saquinavir.
DrugBank; DB00418; Secobarbital.
DrugBank; DB01037; Selegiline.
DrugBank; DB11362; Selexipag.
DrugBank; DB00641; Simvastatin.
DrugBank; DB01261; Sitagliptin.
DrugBank; DB00398; Sorafenib.
DrugBank; DB00421; Spironolactone.
DrugBank; DB09118; Stiripentol.
DrugBank; DB00359; Sulfadiazine.
DrugBank; DB01015; Sulfamethoxazole.
DrugBank; DB06729; Sulfaphenazole.
DrugBank; DB01138; Sulfinpyrazone.
DrugBank; DB00675; Tamoxifen.
DrugBank; DB00799; Tazarotene.
DrugBank; DB01079; Tegaserod.
DrugBank; DB00231; Temazepam.
DrugBank; DB00857; Terbinafine.
DrugBank; DB00342; Terfenadine.
DrugBank; DB08880; Teriflunomide.
DrugBank; DB00624; Testosterone.
DrugBank; DB00277; Theophylline.
DrugBank; DB00679; Thioridazine.
DrugBank; DB00208; Ticlopidine.
DrugBank; DB01007; Tioconazole.
DrugBank; DB01124; Tolbutamide.
DrugBank; DB00214; Torasemide.
DrugBank; DB08911; Trametinib.
DrugBank; DB00755; Tretinoin.
DrugBank; DB00897; Triazolam.
DrugBank; DB00347; Trimethadione.
DrugBank; DB00440; Trimethoprim.
DrugBank; DB00197; Troglitazone.
DrugBank; DB01361; Troleandomycin.
DrugBank; DB00313; Valproic Acid.
DrugBank; DB00661; Verapamil.
DrugBank; DB08828; Vismodegib.
DrugBank; DB09068; Vortioxetine.
DrugBank; DB00682; Warfarin.
DrugBank; DB00549; Zafirlukast.
DrugBank; DB00495; Zidovudine.
DrugBank; DB01198; Zopiclone.
GuidetoPHARMACOLOGY; 1325; -.
SwissLipids; SLP:000001548; -.
SwissLipids; SLP:000001616; -. [P10632-1]
iPTMnet; P10632; -.
PhosphoSitePlus; P10632; -.
BioMuta; CYP2C8; -.
DMDM; 117225; -.
PaxDb; P10632; -.
PeptideAtlas; P10632; -.
PRIDE; P10632; -.
ProteomicsDB; 52621; -.
ProteomicsDB; 52622; -. [P10632-2]
DNASU; 1558; -.
Ensembl; ENST00000371270; ENSP00000360317; ENSG00000138115. [P10632-1]
Ensembl; ENST00000535898; ENSP00000445062; ENSG00000138115. [P10632-2]
GeneID; 1558; -.
KEGG; hsa:1558; -.
UCSC; uc001kkb.4; human. [P10632-1]
CTD; 1558; -.
DisGeNET; 1558; -.
EuPathDB; HostDB:ENSG00000138115.13; -.
GeneCards; CYP2C8; -.
HGNC; HGNC:2622; CYP2C8.
HPA; HPA013547; -.
HPA; HPA013970; -.
HPA; HPA015066; -.
MIM; 601129; gene.
MIM; 618018; phenotype.
neXtProt; NX_P10632; -.
OpenTargets; ENSG00000138115; -.
PharmGKB; PA125; -.
eggNOG; KOG0156; Eukaryota.
eggNOG; COG2124; LUCA.
GeneTree; ENSGT00940000163696; -.
HOGENOM; HOG000036992; -.
HOVERGEN; HBG015789; -.
InParanoid; P10632; -.
KO; K17718; -.
OMA; AEDCKVN; -.
OrthoDB; 702827at2759; -.
PhylomeDB; P10632; -.
TreeFam; TF352043; -.
BRENDA; 1.14.14.1; 2681.
Reactome; R-HSA-211981; Xenobiotics.
Reactome; R-HSA-211999; CYP2E1 reactions.
Reactome; R-HSA-2142670; Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET).
Reactome; R-HSA-2142816; Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE).
Reactome; R-HSA-9027307; Biosynthesis of maresin-like SPMs.
SABIO-RK; P10632; -.
ChiTaRS; CYP2C8; human.
EvolutionaryTrace; P10632; -.
GeneWiki; CYP2C8; -.
GenomeRNAi; 1558; -.
PRO; PR:P10632; -.
Proteomes; UP000005640; Chromosome 10.
Bgee; ENSG00000138115; Expressed in 117 organ(s), highest expression level in liver.
ExpressionAtlas; P10632; baseline and differential.
Genevisible; P10632; HS.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
GO; GO:0031090; C:organelle membrane; IEA:UniProtKB-SubCell.
GO; GO:0008392; F:arachidonic acid epoxygenase activity; IBA:GO_Central.
GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
GO; GO:0034875; F:caffeine oxidase activity; IDA:BHF-UCL.
GO; GO:0101020; F:estrogen 16-alpha-hydroxylase activity; IDA:BHF-UCL.
GO; GO:0020037; F:heme binding; IBA:GO_Central.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0004497; F:monooxygenase activity; IDA:BHF-UCL.
GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IBA:GO_Central.
GO; GO:0008395; F:steroid hydroxylase activity; IBA:GO_Central.
GO; GO:0017144; P:drug metabolic process; IDA:BHF-UCL.
GO; GO:0019373; P:epoxygenase P450 pathway; IBA:GO_Central.
GO; GO:0042738; P:exogenous drug catabolic process; IDA:BHF-UCL.
GO; GO:0002933; P:lipid hydroxylation; IDA:BHF-UCL.
GO; GO:0042759; P:long-chain fatty acid biosynthetic process; TAS:Reactome.
GO; GO:0097267; P:omega-hydroxylase P450 pathway; TAS:Reactome.
GO; GO:0006082; P:organic acid metabolic process; IDA:BHF-UCL.
GO; GO:0055114; P:oxidation-reduction process; IDA:BHF-UCL.
GO; GO:0070989; P:oxidative demethylation; IDA:BHF-UCL.
GO; GO:0008202; P:steroid metabolic process; IDA:BHF-UCL.
GO; GO:0006805; P:xenobiotic metabolic process; IBA:GO_Central.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR002401; Cyt_P450_E_grp-I.
InterPro; IPR036396; Cyt_P450_sf.
Pfam; PF00067; p450; 1.
PRINTS; PR00463; EP450I.
PRINTS; PR00385; P450.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Complete proteome;
Direct protein sequencing; Endoplasmic reticulum; Heme; Iron;
Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase;
Phosphoprotein; Polymorphism; Reference proteome.
CHAIN 1 490 Cytochrome P450 2C8.
/FTId=PRO_0000051699.
METAL 435 435 Iron (heme axial ligand).
BINDING 100 100 Substrate.
BINDING 204 204 Substrate.
BINDING 241 241 Substrate.
MOD_RES 100 100 Phosphoserine.
{ECO:0000244|PubMed:24275569}.
VAR_SEQ 1 8 MEPFVVLV -> MFLQPIAK (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_043306.
VAR_SEQ 9 110 Missing (in isoform 2).
{ECO:0000303|PubMed:14702039}.
/FTId=VSP_043307.
VARIANT 139 139 R -> K (in allele CYP2C8*3; reduces
enzymatic activity with paclitaxel as
substrate; decreases intrinsic clearance
of paclitaxel; reduces enzymatic activity
with amodiaquine as substrate;
dbSNP:rs11572080).
{ECO:0000269|PubMed:11668219,
ECO:0000269|PubMed:12429347,
ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15469410,
ECO:0000269|PubMed:26427316,
ECO:0000269|PubMed:2729895,
ECO:0000269|Ref.5}.
/FTId=VAR_012238.
VARIANT 154 154 E -> D. {ECO:0000269|PubMed:3196692}.
/FTId=VAR_001250.
VARIANT 171 171 G -> S (in allele CYP2C8*6; no effect on
affinity or enzymatic activity with
paclitaxel as substrate; decreases
affinity for amodiaquine; reduces
enzymatic activity with amodiaquine as
substrate; decreases intrinsic clearance
of amodiaquine; dbSNP:rs142886225).
{ECO:0000269|PubMed:26427316}.
/FTId=VAR_075541.
VARIANT 186 186 R -> G (in allele CYP2C8*8; increases
affinity for paclitaxel; reduces
enzymatic activity with paclitaxel as
substrate; decreases intrinsic clearance
of paclitaxel; reduces enzymatic activity
with amodiaquine as substrate; decreases
intrinsic clearance of amodiaquine;
dbSNP:rs72558195).
{ECO:0000269|PubMed:26427316}.
/FTId=VAR_075542.
VARIANT 193 193 N -> K. {ECO:0000269|PubMed:3196692}.
/FTId=VAR_001251.
VARIANT 223 223 I -> M (in allele CYP2C8*13; reduces
enzymatic activity with paclitaxel as
substrate; decreases intrinsic clearance
of paclitaxel; reduces enzymatic activity
with amodiaquine as substrate; decreases
intrinsic clearance of amodiaquine).
{ECO:0000269|PubMed:26427316}.
/FTId=VAR_075543.
VARIANT 238 238 A -> P (in allele CYP2C8*14; reduces
enzymatic activity with paclitaxel as
substrate; decreases intrinsic clearance
of paclitaxel; dbSNP:rs188934928).
{ECO:0000269|PubMed:26427316}.
/FTId=VAR_075544.
VARIANT 244 244 I -> V (in dbSNP:rs11572102).
{ECO:0000269|Ref.5}.
/FTId=VAR_018958.
VARIANT 247 247 K -> R (in allele CYP2C8*9; increases
enzymatic activity with paclitaxel as
substrate; reduces enzymatic activity
with amodiaquine as substrate; decreases
intrinsic clearance of amodiaquine;
dbSNP:rs769460274).
{ECO:0000269|PubMed:26427316}.
/FTId=VAR_075545.
VARIANT 249 249 K -> R. {ECO:0000269|PubMed:3196692}.
/FTId=VAR_001252.
VARIANT 264 264 I -> M (in allele CYP2C8*4; reduces
enzymatic activity with paclitaxel as
substrate; decreases affinity for
amodiaquine; dbSNP:rs1058930).
{ECO:0000269|PubMed:12429347,
ECO:0000269|PubMed:15469410,
ECO:0000269|PubMed:2009263,
ECO:0000269|PubMed:26427316,
ECO:0000269|PubMed:3500169,
ECO:0000269|Ref.5}.
/FTId=VAR_011754.
VARIANT 269 269 I -> F (in allele CYP2C8*2; only found in
African-Americans; increases intrinsic
clearance of paclitaxel; decreases
affinity for amodiaquine; increases
enzymatic activity with amodiaquine as
substrate; dbSNP:rs11572103).
{ECO:0000269|PubMed:11668219,
ECO:0000269|PubMed:12429347,
ECO:0000269|PubMed:15469410,
ECO:0000269|PubMed:26427316,
ECO:0000269|Ref.5}.
/FTId=VAR_012239.
VARIANT 383 383 K -> N (in allele CYP2C8*10; reduces
enzymatic activity with paclitaxel as
substrate; reduces enzymatic activity
with amodiaquine as substrate; decreases
intrinsic clearance of amodiaquine).
{ECO:0000269|PubMed:26427316}.
/FTId=VAR_075546.
VARIANT 390 390 L -> S (in dbSNP:rs72558194).
{ECO:0000269|PubMed:12429347}.
/FTId=VAR_016947.
VARIANT 399 399 K -> R (in allele CYP2C8*3; reduces
enzymatic activity with paclitaxel as
substrate; decreases intrinsic clearance
of paclitaxel; reduces enzymatic activity
with amodiaquine as substrate;
dbSNP:rs10509681).
{ECO:0000269|PubMed:11668219,
ECO:0000269|PubMed:12429347,
ECO:0000269|PubMed:14702039,
ECO:0000269|PubMed:15469410,
ECO:0000269|PubMed:2216732,
ECO:0000269|PubMed:26427316,
ECO:0000269|Ref.5}.
/FTId=VAR_012240.
VARIANT 411 411 H -> L. {ECO:0000269|PubMed:3196692,
ECO:0000269|PubMed:7574697}.
/FTId=VAR_001253.
VARIANT 461 461 Missing (in allele CYP2C8*12; increases
enzymatic activity with paclitaxel as
substrate; reduces enzymatic activity
with amodiaquine as substrate; decreases
intrinsic clearance of amodiaquine).
{ECO:0000269|PubMed:26427316}.
/FTId=VAR_075547.
CONFLICT 54 54 F -> L (in Ref. 12; no nucleotide entry).
{ECO:0000305}.
CONFLICT 67 67 V -> L (in Ref. 12; no nucleotide entry).
{ECO:0000305}.
CONFLICT 76 76 V -> C (in Ref. 12; no nucleotide entry).
{ECO:0000305}.
CONFLICT 82 82 A -> S (in Ref. 8; AAH20596).
{ECO:0000305}.
CONFLICT 130 130 T -> N (in Ref. 1; AAA35739/AAA35740 and
3; no nucleotide entry). {ECO:0000305}.
CONFLICT 209 209 N -> S (in Ref. 12; no nucleotide entry).
{ECO:0000305}.
CONFLICT 384 393 GTTIMALLTS -> SFDNKIMLAA (in Ref. 1;
AAA35740). {ECO:0000305}.
CONFLICT 386 386 T -> A (in Ref. 4; BAF85442).
{ECO:0000305}.
TURN 37 39 {ECO:0000244|PDB:2NNJ}.
HELIX 42 44 {ECO:0000244|PDB:2NNJ}.
STRAND 47 49 {ECO:0000244|PDB:1PQ2}.
HELIX 50 61 {ECO:0000244|PDB:2NNJ}.
STRAND 63 69 {ECO:0000244|PDB:2NNJ}.
STRAND 72 77 {ECO:0000244|PDB:2NNJ}.
HELIX 80 87 {ECO:0000244|PDB:2NNJ}.
TURN 88 94 {ECO:0000244|PDB:2NNJ}.
HELIX 101 107 {ECO:0000244|PDB:2NNJ}.
TURN 111 113 {ECO:0000244|PDB:2NNJ}.
HELIX 117 130 {ECO:0000244|PDB:2NNJ}.
TURN 133 136 {ECO:0000244|PDB:2NNJ}.
STRAND 137 139 {ECO:0000244|PDB:2NNJ}.
HELIX 141 157 {ECO:0000244|PDB:2NNJ}.
TURN 158 161 {ECO:0000244|PDB:2NNJ}.
HELIX 167 182 {ECO:0000244|PDB:2NNJ}.
STRAND 183 185 {ECO:0000244|PDB:2NNJ}.
HELIX 192 208 {ECO:0000244|PDB:2NNJ}.
HELIX 212 218 {ECO:0000244|PDB:2NNJ}.
HELIX 220 225 {ECO:0000244|PDB:2NNJ}.
HELIX 227 252 {ECO:0000244|PDB:2NNJ}.
HELIX 263 273 {ECO:0000244|PDB:2NNJ}.
HELIX 284 298 {ECO:0000244|PDB:2NNJ}.
HELIX 300 315 {ECO:0000244|PDB:2NNJ}.
HELIX 317 330 {ECO:0000244|PDB:2NNJ}.
STRAND 333 335 {ECO:0000244|PDB:2NNJ}.
HELIX 339 344 {ECO:0000244|PDB:2NNJ}.
HELIX 346 359 {ECO:0000244|PDB:2NNJ}.
STRAND 374 376 {ECO:0000244|PDB:2NNJ}.
STRAND 379 381 {ECO:0000244|PDB:2NNJ}.
STRAND 386 389 {ECO:0000244|PDB:2NNJ}.
HELIX 391 395 {ECO:0000244|PDB:2NNJ}.
TURN 398 400 {ECO:0000244|PDB:2NNJ}.
STRAND 401 403 {ECO:0000244|PDB:2NNJ}.
HELIX 409 412 {ECO:0000244|PDB:2NNJ}.
HELIX 431 433 {ECO:0000244|PDB:2NNJ}.
HELIX 438 455 {ECO:0000244|PDB:2NNJ}.
STRAND 456 459 {ECO:0000244|PDB:2NNJ}.
HELIX 464 466 {ECO:0000244|PDB:2NNJ}.
STRAND 472 479 {ECO:0000244|PDB:2NNJ}.
STRAND 485 489 {ECO:0000244|PDB:2NNJ}.
SEQUENCE 490 AA; 55825 MW; E920EB2084F477E1 CRC64;
MEPFVVLVLC LSFMLLFSLW RQSCRRRKLP PGPTPLPIIG NMLQIDVKDI CKSFTNFSKV
YGPVFTVYFG MNPIVVFHGY EAVKEALIDN GEEFSGRGNS PISQRITKGL GIISSNGKRW
KEIRRFSLTT LRNFGMGKRS IEDRVQEEAH CLVEELRKTK ASPCDPTFIL GCAPCNVICS
VVFQKRFDYK DQNFLTLMKR FNENFRILNS PWIQVCNNFP LLIDCFPGTH NKVLKNVALT
RSYIREKVKE HQASLDVNNP RDFIDCFLIK MEQEKDNQKS EFNIENLVGT VADLFVAGTE
TTSTTLRYGL LLLLKHPEVT AKVQEEIDHV IGRHRSPCMQ DRSHMPYTDA VVHEIQRYSD
LVPTGVPHAV TTDTKFRNYL IPKGTTIMAL LTSVLHDDKE FPNPNIFDPG HFLDKNGNFK
KSDYFMPFSA GKRICAGEGL ARMELFLFLT TILQNFNLKS VDDLKNLNTT AVTKGIVSLP
PSYQICFIPV


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U1557b CLIA 21-OHase,Bos taurus,Bovine,CYP21,CYP21A1,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Steroid 21-hydroxylase 96T
E1557r ELISA 21-OHase,Cyp21,Cyp21a1,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Rat,Rattus norvegicus,Steroid 21-hydroxylase 96T
E1557r ELISA kit 21-OHase,Cyp21,Cyp21a1,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Rat,Rattus norvegicus,Steroid 21-hydroxylase 96T
E1557p ELISA kit 21-OHase,CYP21,CYP21A1,CYP21A3,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Pig,Steroid 21-hydroxylase,Sus scrofa 96T
E1557p ELISA 21-OHase,CYP21,CYP21A1,CYP21A3,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Pig,Steroid 21-hydroxylase,Sus scrofa 96T
U1557p CLIA 21-OHase,CYP21,CYP21A1,CYP21A3,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Pig,Steroid 21-hydroxylase,Sus scrofa 96T
E1557b ELISA 21-OHase,Bos taurus,Bovine,CYP21,CYP21A1,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Steroid 21-hydroxylase 96T
E1557b ELISA kit 21-OHase,Bos taurus,Bovine,CYP21,CYP21A1,Cytochrome P450 21,Cytochrome P450 XXI,Cytochrome P-450c21,Cytochrome P450-C21,Steroid 21-hydroxylase 96T

Kits Elisa; taq POLYMERASE

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Gentaur; yes we can

Pathways :
WP1077: cytochrome P450
WP1194: cytochrome P450
WP1219: cytochrome P450
WP1274: cytochrome P450
WP1390: cytochrome P450
WP2316: PPAR signaling pathway
WP43: cytochrome P450
WP677: Momilactone biosynthesis
WP696: Benzo(a)pyrene metabolism
WP958: cytochrome P450
WP1021: Phase I, non P450
WP1140: Phase I, non P450
WP1213: Phase I, non P450
WP1255: Phase I, non P450
WP1291: Phase I, non P450
WP136: Phase I, non P450
WP1502: Mitochondrial biogenesis
WP1573: Phase I, non P450
WP2430: Quercetin metabolism
WP791: Phase I, non P450
WP904: Phase I, non P450
WP1024: Steroid Biosynthesis
WP1143: Steroid Biosynthesis
WP2248: anthocyanin biosynthesis
WP2263: Prostate Cancer

Related Genes :
[CYP2C8] Cytochrome P450 2C8 (EC 1.14.14.1) (CYPIIC8) (Cytochrome P450 IIC2) (Cytochrome P450 MP-12) (Cytochrome P450 MP-20) (Cytochrome P450 form 1) (S-mephenytoin 4-hydroxylase)
[CYP2C9 CYP2C10] Cytochrome P450 2C9 (EC 1.14.14.-) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (EC 1.14.14.-) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase)
[CYP2C19] Cytochrome P450 2C19 (EC 1.14.14.-) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase)
[CYP3A4 CYP3A3] Cytochrome P450 3A4 (EC 1.14.14.-) (1,8-cineole 2-exo-monooxygenase) (EC 1.14.14.56) (Albendazole monooxygenase (sulfoxide-forming)) (EC 1.14.14.73) (Albendazole sulfoxidase) (CYPIIIA3) (CYPIIIA4) (Cholesterol 25-hydroxylase) (EC 1.14.14.-) (Cytochrome P450 3A3) (Cytochrome P450 HLp) (Cytochrome P450 NF-25) (Cytochrome P450-PCN1) (Nifedipine oxidase) (Quinine 3-monooxygenase) (EC 1.14.14.55) (Taurochenodeoxycholate 6-alpha-hydroxylase) (EC 1.14.14.-)
[cyp102A1 cyp102 BG04_163] Bifunctional cytochrome P450/NADPH--P450 reductase (Cytochrome P450(BM-3)) (Cytochrome P450BM-3) (Fatty acid monooxygenase) (Flavocytochrome P450 BM3) [Includes: Cytochrome P450 102A1 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)]
[cypB cyp102A3 yrhJ BSU27160] Bifunctional cytochrome P450/NADPH--P450 reductase 2 (CYP102A3) (Fatty acid hydroxylase CypB) (Flavocytochrome P450 102A3) [Includes: Cytochrome P450 102A3 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)]
[cypD cyp102A2 yetO yfnJ BSU07250] Bifunctional cytochrome P450/NADPH--P450 reductase 1 (CYP102A2) (Fatty acid hydroxylase CypD) (Flavocytochrome P450 102A2) [Includes: Cytochrome P450 102A2 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)]
[CYP505] Bifunctional cytochrome P450/NADPH--P450 reductase (Cytochrome P450foxy) (Fatty acid omega-hydroxylase) (P450foxy) [Includes: Cytochrome P450 505 (EC 1.14.14.1); NADPH--cytochrome P450 reductase (EC 1.6.2.4)]
[Cyp2d4 Cyp2d-18 Cyp2d-4 Cyp2d18] Cytochrome P450 2D4 (EC 1.14.14.1) (CYPIID18) (CYPIID4) (Cytochrome P450 2D-29) (Cytochrome P450 2D-35) (Cytochrome P450 2D18) (Cytochrome P450-CMF3) (Cytochrome P450-DB4) (Debrisoquine 4-hydroxylase)
[CYP21A2 CYP21 CYP21B] Steroid 21-hydroxylase (EC 1.14.14.16) (21-OHase) (Cytochrome P-450c21) (Cytochrome P450 21) (Cytochrome P450 XXI) (Cytochrome P450-C21) (Cytochrome P450-C21B)
[Cyp2b10 Cyp2b-10 Cyp2b20] Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (CYPIIB20) (Cytochrome P450 2B20) (Cytochrome P450 clone PF3/46) (Cytochrome P450-16-alpha) (P24) (Testosterone 16-alpha hydroxylase)
[CYP1A2] Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3)
[CYP2A6 CYP2A3] Cytochrome P450 2A6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I))
[Cyp2b1 Cyp2b-1] Cytochrome P450 2B1 (EC 1.14.14.1) (CYPIIB1) (Cytochrome P450-B) (Cytochrome P450b) (Cytochrome P450-LM2) (Cytochrome P450-PB1) (Cytochrome P450-PB2)
[CYP26B1 CYP26A2 P450RAI2] Cytochrome P450 26B1 (EC 1.14.13.-) (Cytochrome P450 26A2) (Cytochrome P450 retinoic acid-inactivating 2) (Cytochrome P450RAI-2) (Retinoic acid-metabolizing cytochrome)
[CYP17A1 CYP17 S17AH] Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)
[Cyp1a1 Cyp1a-1] Cytochrome P450 1A1 (CYP1A1) (EC 1.14.14.1) (CYPIA1) (Cytochrome P450-C) (Cytochrome P450MT2) [Cleaved into: Cytochrome P450MT2A; Cytochrome P450MT2B]
[Cyp2c11 Cyp2c Cyp2c-11] Cytochrome P450 2C11 (EC 1.14.14.1) (CYPIIC11) (Cytochrome P-450(M-1)) (Cytochrome P450-UT-2) (Cytochrome P450-UT-A) (Cytochrome P450H)
[CYP4F2] Phylloquinone omega-hydroxylase CYP4F2 (EC 1.14.14.78) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.14.-) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450 4F2) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94)
[CYP26A1 CYP26 P450RAI1] Cytochrome P450 26A1 (EC 1.14.13.-) (Cytochrome P450 retinoic acid-inactivating 1) (Cytochrome P450RAI) (hP450RAI) (Retinoic acid 4-hydroxylase) (Retinoic acid-metabolizing cytochrome)
[Cyp2d1 Cyp2d-1 Cyp2d9] Cytochrome P450 2D1 (EC 1.14.14.1) (CYPIID1) (Cytochrome P450-CMF1A) (Cytochrome P450-DB1) (Cytochrome P450-UT-7) (Debrisoquine 4-hydroxylase)
[CYP4F3 LTB4H] Docosahexaenoic acid omega-hydroxylase CYP4F3 (EC 1.14.14.79) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (EC 1.14.14.-) (CYPIVF3) (Cytochrome P450 4F3) (Cytochrome P450-LTB-omega) (Leukotriene-B(4) 20-monooxygenase 2) (Leukotriene-B(4) omega-hydroxylase 2) (EC 1.14.14.94)
[Cyp2b2 Cyp2b-2] Cytochrome P450 2B2 (EC 1.14.14.1) (CYPIIB2) (Cytochrome P450 PB4) (Cytochrome P450E)
[Cyp2e1 Cyp2e Cyp2e-1] Cytochrome P450 2E1 (EC 1.14.13.-) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) (Cytochrome P450RLM6)
[CYP11B1 S11BH] Cytochrome P450 11B1, mitochondrial (CYPXIB1) (Cytochrome P-450c11) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase) (EC 1.14.15.4)
[Cyp2c13 Cyp2c-13] Cytochrome P450 2C13, male-specific (EC 1.14.14.1) (CYPIIC13) (Cytochrome P-450g) (Cytochrome P450-G) (Cytochrome P450-UT-5)
[pikC picK] Cytochrome P450 monooxygenase PikC (EC 1.14.15.33) (Cytochrome P450 monooxygenase PicK) (Narbomycin C-12 hydroxylase) (Pikromycin synthase CYP107L1)
[CYP11B2] Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (EC 1.14.15.4) (EC 1.14.15.5) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 18-hydroxylase)
[Cyp2e1 Cyp2e Cyp2e-1] Cytochrome P450 2E1 (EC 1.14.13.-) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-ALC) (Cytochrome P450-J)
[Cyp2a4 Cyp2a-4] Cytochrome P450 2A4 (EC 1.14.14.1) (CYPIIA4) (Cytochrome P450-15-alpha) (Cytochrome P450-IIA3.1) (Testosterone 15-alpha-hydroxylase)

Bibliography :
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