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Cytochrome P450 7A1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cholesterol 7-alpha-monooxygenase) (EC 1.14.14.23)

 CP7A1_RABIT             Reviewed;         501 AA.
P51542;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
01-OCT-1996, sequence version 1.
11-DEC-2019, entry version 113.
RecName: Full=Cytochrome P450 7A1 {ECO:0000250|UniProtKB:P22680};
AltName: Full=24-hydroxycholesterol 7-alpha-hydroxylase {ECO:0000250|UniProtKB:P22680};
EC=1.14.14.26 {ECO:0000250|UniProtKB:P22680};
AltName: Full=CYPVII;
AltName: Full=Cholesterol 7-alpha-hydroxylase {ECO:0000303|PubMed:7751825};
AltName: Full=Cholesterol 7-alpha-monooxygenase;
EC=1.14.14.23 {ECO:0000269|PubMed:7751825};
Name=CYP7A1; Synonyms=CYP7;
Oryctolagus cuniculus (Rabbit).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
NCBI_TaxID=9986;
[1]
NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, AND TISSUE SPECIFICITY.
STRAIN=New Zealand white; TISSUE=Liver;
PubMed=7751825;
Kai M., Eto T., Kondo K., Setoguchi Y., Higashi S., Maeda Y., Setoguchi T.;
"Synchronous circadian rhythms of mRNA levels and activities of cholesterol
7 alpha-hydroxylase in the rabbit and rat.";
J. Lipid Res. 36:367-374(1995).
-!- FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of
endogenous cholesterol and its oxygenated derivatives (oxysterols) (By
similarity). Mechanistically, uses molecular oxygen inserting one
oxygen atom into a substrate, and reducing the second into a water
molecule, with two electrons provided by NADPH via cytochrome P450
reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity).
Functions as a critical regulatory enzyme of bile acid biosynthesis and
cholesterol homeostasis (Probable). Catalyzes the hydroxylation of
carbon hydrogen bond at 7-alpha position of cholesterol, a rate-
limiting step in cholesterol catabolism and bile acid biosynthesis
(Probable). 7-alpha hydroxylates several oxysterols, including 4beta-
hydroxycholesterol and 24-hydroxycholesterol (By similarity). Catalyzes
the oxidation of the 7,8 double bond of 7-dehydrocholesterol and
lathosterol with direct and predominant formation of the 7-keto
derivatives (By similarity). {ECO:0000250|UniProtKB:P22680,
ECO:0000305|PubMed:7751825}.
-!- CATALYTIC ACTIVITY:
Reaction=cholesterol + O2 + reduced [NADPH--hemoprotein reductase] =
7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein
reductase]; Xref=Rhea:RHEA:21812, Rhea:RHEA-COMP:11964, Rhea:RHEA-
COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
ChEBI:CHEBI:16113, ChEBI:CHEBI:17500, ChEBI:CHEBI:57618,
ChEBI:CHEBI:58210; EC=1.14.14.23;
Evidence={ECO:0000305|PubMed:7751825};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21813;
Evidence={ECO:0000305|PubMed:7751825};
-!- CATALYTIC ACTIVITY:
Reaction=4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein
reductase] = 4beta,7alpha-dihydroxycholesterol + H(+) + H2O +
oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46120,
Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618,
ChEBI:CHEBI:58210, ChEBI:CHEBI:85778, ChEBI:CHEBI:85779;
Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46121;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--
hemoprotein reductase] = 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-
ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase];
Xref=Rhea:RHEA:53256, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965,
ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
ChEBI:CHEBI:17168, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
ChEBI:CHEBI:137063; Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53257;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--
hemoprotein reductase] = 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O
+ oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53252,
Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17168,
ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137062;
Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53253;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein
reductase] = 3beta-hydroxycholest-5-en-7-one + H(+) + H2O + oxidized
[NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53248, Rhea:RHEA-
COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17759,
ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:64294;
Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53249;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein
reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O +
oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46124,
Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:34310,
ChEBI:CHEBI:37640, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210;
EC=1.14.14.26; Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46125;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein
reductase] = (24R)-7alpha-dihydroxycholesterol + H(+) + H2O +
oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:16093,
Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:50516,
ChEBI:CHEBI:50518, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210;
Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16094;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- COFACTOR:
Name=heme; Xref=ChEBI:CHEBI:30413;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- PATHWAY: Lipid metabolism; bile acid biosynthesis.
{ECO:0000305|PubMed:7751825}.
-!- PATHWAY: Steroid metabolism; cholesterol degradation.
{ECO:0000305|PubMed:7751825}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:P22680}; Single-pass membrane protein
{ECO:0000250|UniProtKB:P22680}. Microsome membrane
{ECO:0000250|UniProtKB:P22680}; Single-pass membrane protein
{ECO:0000250|UniProtKB:P22680}.
-!- TISSUE SPECIFICITY: Detected in liver. {ECO:0000269|PubMed:7751825}.
-!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; L10754; AAA74382.1; -; mRNA.
PIR; I46701; I46701.
RefSeq; NP_001164400.1; NM_001170929.1.
SMR; P51542; -.
STRING; 9986.ENSOCUP00000010572; -.
GeneID; 100328551; -.
KEGG; ocu:100328551; -.
CTD; 1581; -.
eggNOG; KOG0684; Eukaryota.
eggNOG; COG2124; LUCA.
HOGENOM; HOG000231026; -.
InParanoid; P51542; -.
KO; K00489; -.
OrthoDB; 864748at2759; -.
UniPathway; UPA00221; -.
UniPathway; UPA01058; -.
Proteomes; UP000001811; Unplaced.
GO; GO:0005623; C:cell; IEA:GOC.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO; GO:0008123; F:cholesterol 7-alpha-monooxygenase activity; ISS:UniProtKB.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0006699; P:bile acid biosynthetic process; ISS:UniProtKB.
GO; GO:0071397; P:cellular response to cholesterol; ISS:UniProtKB.
GO; GO:0071333; P:cellular response to glucose stimulus; ISS:UniProtKB.
GO; GO:0006707; P:cholesterol catabolic process; ISS:UniProtKB.
GO; GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
GO; GO:0070857; P:regulation of bile acid biosynthetic process; ISS:UniProtKB.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR030681; Cholesterol_7a_monooxygenase.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR024204; Cyt_P450_CYP7A1-type.
InterPro; IPR002403; Cyt_P450_E_grp-IV.
InterPro; IPR036396; Cyt_P450_sf.
PANTHER; PTHR24304:SF1; PTHR24304:SF1; 1.
Pfam; PF00067; p450; 1.
PIRSF; PIRSF500625; Cytochrome_CYP7A1; 1.
PIRSF; PIRSF000047; Cytochrome_CYPVIIA1; 1.
PRINTS; PR00465; EP450IV.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
1: Evidence at protein level;
Cholesterol metabolism; Endoplasmic reticulum; Heme; Iron;
Lipid metabolism; Membrane; Metal-binding; Microsome; Monooxygenase;
Oxidoreductase; Reference proteome; Steroid metabolism; Sterol metabolism;
Transmembrane; Transmembrane helix.
CHAIN 1..501
/note="Cytochrome P450 7A1"
/id="PRO_0000051904"
TRANSMEM 4..24
/note="Helical"
/evidence="ECO:0000255"
METAL 441
/note="Iron (heme axial ligand)"
/evidence="ECO:0000250|UniProtKB:P22680"
SEQUENCE 501 AA; 58090 MW; FEF1247B151AA6B1 CRC64;
MITIFWIWGI CLSVCCCLWL ILGLRRRRMG EPPLEKGWIP YLGCALQFGA NPLDFLRANQ
RKYGHVFTCK LMGKYVHFIT NSLSYHKVLC HGKYFDWKKF HFTTSAKAFG HRSIDPRDGN
TTENINNTFN KTLQGDALIS LTDAMMENLQ LTLRRPEPKS RAWVTEGMYS FCYRVMFEAG
YLTLFGRELT RQDAQRAFIL NSLEDFKQFD KVFPALVAGL PIHIFMTAHN AREKLAEGLK
HDNLRTRDHI SELIRLRMFL NDTLSTFDAM EKAKTHLAIL WASQANTIPA TFWSLFHMMR
SSEALKAATE EVNKALEDAD QQINFEGKPI HLNQTQLNDM PVLDSIIKES LRLSSASLNI
RTAKEDFTLH LEDGSYNIRK DDIIALYPQL MHLDPEIYPD PMTFKYDRYL DENRKTKTTF
YSKGLKLKYY YMPFGSGATI CPGRLFAIQE IKQFLILMLS YFELEFVDSH VKCPPLDQSR
AGLGILPPLN DIEFKYKFKH L


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Catalog number Product name Quantity
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E1053p ELISA kit Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,CYP7,CYP7A1,CYPVII,Cytochrome P450 7A1,Pig,Sus scrofa 96T
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E1053m ELISA Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,Cyp7,Cyp7a1,CYPVII,Cytochrome P450 7A1,Mouse,Mus musculus 96T
E1053m ELISA kit Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,Cyp7,Cyp7a1,CYPVII,Cytochrome P450 7A1,Mouse,Mus musculus 96T
U1053r CLIA Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,Cyp7,Cyp7a1,CYPVII,Cytochrome P450 7A1,Rat,Rattus norvegicus 96T
U1053m CLIA Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,Cyp7,Cyp7a1,CYPVII,Cytochrome P450 7A1,Mouse,Mus musculus 96T
E1053h ELISA Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,CYP7,CYP7A1,CYPVII,Cytochrome P450 7A1,Homo sapiens,Human 96T
U1053Rb CLIA Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,CYP7,CYP7A1,CYPVII,Cytochrome P450 7A1,Oryctolagus cuniculus,Rabbit 96T
E1053Rb ELISA kit Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,CYP7,CYP7A1,CYPVII,Cytochrome P450 7A1,Oryctolagus cuniculus,Rabbit 96T
E1053Rb ELISA Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,CYP7,CYP7A1,CYPVII,Cytochrome P450 7A1,Oryctolagus cuniculus,Rabbit 96T
U1053h CLIA Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,CYP7,CYP7A1,CYPVII,Cytochrome P450 7A1,Homo sapiens,Human 96T
E1053h ELISA kit Cholesterol 7-alpha-hydroxylase,Cholesterol 7-alpha-monooxygenase,CYP7,CYP7A1,CYPVII,Cytochrome P450 7A1,Homo sapiens,Human 96T
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Pathways :
WP1614: 1- and 2-Methylnaphthalene degradation
WP1003: Ovarian Infertility Genes
WP1434: Osteopontin Signaling
WP215: noncanonical wnt pathway
WP1655: Geraniol degradation
WP34: Ovarian Infertility Genes
WP1224: EBV LMP1 signaling
WP433: tRNA Synthetases
WP1531: Vitamin D synthesis
WP885: Ovarian Infertility Genes
WP1772: Apoptosis Modulation and Signaling
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP566: canonical wnt - zebrafish
WP244: Alpha 6 Beta 4 signaling pathway
WP1633: Bisphenol A degradation
WP263: Ovarian Infertility Genes
WP1163: TNF-alpha NF-kB Signaling Pathway
WP2100: AhR pathway
WP1209: EBV LMP1 signaling
WP32: Translation Factors
WP2199: Seed Development
WP231: TNF alpha Signaling Pathway
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1571: EBV LMP1 signaling
WP1120: Ovarian Infertility Genes

Related Genes :
[CYP7B1] Cytochrome P450 7B1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (25/26-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.29) (3-hydroxysteroid 7-alpha hydroxylase) (Oxysterol 7-alpha-hydroxylase)
[Cyp7b1] Cytochrome P450 7B1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (25/26-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.29) (3-hydroxysteroid 7-alpha hydroxylase) (Hippocampal transcript 1 protein) (HCT-1) (Oxysterol 7-alpha-hydroxylase)
[CYP2C9 CYP2C10] Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase)
[CYP27A1 CYP27] Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)
[CYP2D6 CYP2DL1] Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase)
[CYP1A2] Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
[Cyp1a2 Cyp1a-2] Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P450-P2) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
[Cyp1a2 Cyp1a-2] Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P-448) (Cytochrome P-450d) (Cytochrome P450-D) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
[CYP2D6] Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase)
[CYP17A1 CYP17 S17AH] Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)
[Cyp2a1 Cyp2a-1] Cytochrome P450 2A1 (EC 1.14.14.1) (CYPIIA1) (Cytochrome P450-UT-F) (Steroid hormones 7-alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase)
[CYP2C19] Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase)
[CYP4F2] Cytochrome P450 4F2 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94) (Phylloquinone omega-hydroxylase CYP4F2) (EC 1.14.14.78)
[CYP2D6] Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase)
[CYP2A6 CYP2A3] Cytochrome P450 2A6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I))
[Cyp2a4 Cyp2a-4] Cytochrome P450 2A4 (EC 1.14.14.1) (CYPIIA4) (Cytochrome P450-15-alpha) (Cytochrome P450-IIA3.1) (Testosterone 15-alpha-hydroxylase)
[CYP11B2] Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase)
[CYP11A1] Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc))
[Cyp24a1 Cyp24] 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24)
[Cyp2e1 Cyp2e Cyp2e-1] Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) (Cytochrome P450RLM6)
[CYP4F11] Cytochrome P450 4F11 (CYPIVF11) (EC 1.14.14.1) (3-hydroxy fatty acids omega-hydroxylase CYP4F11) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) (Phylloquinone omega-hydroxylase CYP4F11) (EC 1.14.14.78)
[Cyp2a12] Cytochrome P450 2A12 (EC 1.14.14.1) (CYPIIA12) (Steroid hormones 7-alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase)
[CYP2E1 CYP2E] Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J)
[Cyp2e1 Cyp2e Cyp2e-1] Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-ALC) (Cytochrome P450-J)
[CYP2E1 CYP2E] Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P-450-J) (Cytochrome P450-J)
[Cyp11b2 Cyp11b-2] Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase)
[Cyp6g1 CYP6-like DDT-R Rst(2)DDT CG8453] Cytochrome P450 6g1 (EC 1.14.-.-) (CYPVIG1) (Cyp6-like protein)
[Cyp2b10 Cyp2b-10 Cyp2b20] Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (CYPIIB20) (Cytochrome P450 2B20) (Cytochrome P450 clone PF3/46) (Cytochrome P450-16-alpha) (P24) (Testosterone 16-alpha hydroxylase)
[CYP2E1 CYP2E] Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1)
[CYP11A1 CYP11A] Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc))

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