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Cytochrome P450 7A1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (CYPVII) (Cholesterol 7-alpha-hydroxylase) (Cholesterol 7-alpha-monooxygenase) (EC 1.14.14.23)

 CP7A1_MOUSE             Reviewed;         503 AA.
Q64505; Q8BFR7;
15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
12-AUG-2020, entry version 148.
RecName: Full=Cytochrome P450 7A1 {ECO:0000250|UniProtKB:P22680};
AltName: Full=24-hydroxycholesterol 7-alpha-hydroxylase {ECO:0000250|UniProtKB:P22680};
EC=1.14.14.26 {ECO:0000250|UniProtKB:P22680};
AltName: Full=CYPVII;
AltName: Full=Cholesterol 7-alpha-hydroxylase {ECO:0000303|PubMed:8088795};
AltName: Full=Cholesterol 7-alpha-monooxygenase;
EC=1.14.14.23 {ECO:0000250|UniProtKB:P18125};
Name=Cyp7a1 {ECO:0000303|PubMed:14522988, ECO:0000312|MGI:MGI:106091};
Synonyms=Cyp7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8088795; DOI=10.1006/geno.1994.1250;
Tzung K.W., Ishimura-Oka K., Kihara S., Oka K., Chan L.;
"Structure of the mouse cholesterol 7 alpha-hydroxylase gene.";
Genomics 21:244-247(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Liver;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=C57BL/6J;
PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
Eichler E.E., Ponting C.P.;
"Lineage-specific biology revealed by a finished genome assembly of the
mouse.";
PLoS Biol. 7:E1000112-E1000112(2009).
[4]
FUNCTION, INDUCTION BY FASTING, AND PATHWAY.
PubMed=14522988; DOI=10.1074/jbc.m309736200;
Shin D.J., Campos J.A., Gil G., Osborne T.F.;
"PGC-1alpha activates CYP7A1 and bile acid biosynthesis.";
J. Biol. Chem. 278:50047-50052(2003).
[5]
INDUCTION BY FASTING.
PubMed=17636037; DOI=10.1210/me.2007-0196;
Ponugoti B., Fang S., Kemper J.K.;
"Functional interaction of hepatic nuclear factor-4 and peroxisome
proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1
regulation is inhibited by a key lipogenic activator, sterol regulatory
element-binding protein-1c.";
Mol. Endocrinol. 21:2698-2712(2007).
-!- FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of
endogenous cholesterol and its oxygenated derivatives (oxysterols) (By
similarity). Mechanistically, uses molecular oxygen inserting one
oxygen atom into a substrate, and reducing the second into a water
molecule, with two electrons provided by NADPH via cytochrome P450
reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity).
Functions as a critical regulatory enzyme of bile acid biosynthesis and
cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen
bond at 7-alpha position of cholesterol, a rate-limiting step in
cholesterol catabolism and bile acid biosynthesis (Probable). 7-alpha
hydroxylates several oxysterols, including 4beta-hydroxycholesterol and
24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond
of 7-dehydrocholesterol and lathosterol with direct and predominant
formation of the 7-keto derivatives (By similarity).
{ECO:0000250|UniProtKB:P22680, ECO:0000305|PubMed:14522988}.
-!- CATALYTIC ACTIVITY:
Reaction=cholesterol + O2 + reduced [NADPH--hemoprotein reductase] =
7alpha-hydroxycholesterol + H(+) + H2O + oxidized [NADPH--hemoprotein
reductase]; Xref=Rhea:RHEA:21812, Rhea:RHEA-COMP:11964, Rhea:RHEA-
COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
ChEBI:CHEBI:16113, ChEBI:CHEBI:17500, ChEBI:CHEBI:57618,
ChEBI:CHEBI:58210; EC=1.14.14.23;
Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:21813;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=4beta-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein
reductase] = 4beta,7alpha-dihydroxycholesterol + H(+) + H2O +
oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46120,
Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:57618,
ChEBI:CHEBI:58210, ChEBI:CHEBI:85778, ChEBI:CHEBI:85779;
Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46121;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--
hemoprotein reductase] = 7alpha,8alpha-epoxy-5alpha-cholestan-3beta-
ol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase];
Xref=Rhea:RHEA:53256, Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965,
ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
ChEBI:CHEBI:17168, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
ChEBI:CHEBI:137063; Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53257;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=5alpha-cholest-7-en-3beta-ol + O2 + reduced [NADPH--
hemoprotein reductase] = 5alpha-cholestan-7-oxo-3beta-ol + H(+) + H2O
+ oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53252,
Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17168,
ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:137062;
Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53253;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=cholesta-5,7-dien-3beta-ol + O2 + reduced [NADPH--hemoprotein
reductase] = 3beta-hydroxycholest-5-en-7-one + H(+) + H2O + oxidized
[NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:53248, Rhea:RHEA-
COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:17759,
ChEBI:CHEBI:57618, ChEBI:CHEBI:58210, ChEBI:CHEBI:64294;
Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:53249;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=(24S)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein
reductase] = (24S)-7alpha-dihydroxycholesterol + H(+) + H2O +
oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:46124,
Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:34310,
ChEBI:CHEBI:37640, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210;
EC=1.14.14.26; Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:46125;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- CATALYTIC ACTIVITY:
Reaction=(24R)-hydroxycholesterol + O2 + reduced [NADPH--hemoprotein
reductase] = (24R)-7alpha-dihydroxycholesterol + H(+) + H2O +
oxidized [NADPH--hemoprotein reductase]; Xref=Rhea:RHEA:16093,
Rhea:RHEA-COMP:11964, Rhea:RHEA-COMP:11965, ChEBI:CHEBI:15377,
ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:50516,
ChEBI:CHEBI:50518, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210;
Evidence={ECO:0000250|UniProtKB:P22680};
PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16094;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- COFACTOR:
Name=heme; Xref=ChEBI:CHEBI:30413;
Evidence={ECO:0000250|UniProtKB:P22680};
-!- PATHWAY: Lipid metabolism; bile acid biosynthesis.
{ECO:0000269|PubMed:14522988}.
-!- PATHWAY: Steroid metabolism; cholesterol degradation.
{ECO:0000250|UniProtKB:P22680}.
-!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
{ECO:0000250|UniProtKB:P22680}; Single-pass membrane protein
{ECO:0000250|UniProtKB:P22680}. Microsome membrane
{ECO:0000250|UniProtKB:P22680}; Single-pass membrane protein
{ECO:0000250|UniProtKB:P22680}.
-!- INDUCTION: Up-regulated by fasting, returns to ground state upon
feeding. Up-regulated by experimentally induced diabetes. Down-
regulated by insulin treatment. {ECO:0000269|PubMed:14522988,
ECO:0000269|PubMed:17636037}.
-!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; L23754; AAA68867.1; -; Genomic_DNA.
EMBL; AK050020; BAC34033.1; -; mRNA.
EMBL; AK050210; BAC34123.1; -; mRNA.
EMBL; AK050220; BAC34131.1; -; mRNA.
EMBL; AK050260; BAC34150.1; -; mRNA.
EMBL; AL772306; -; NOT_ANNOTATED_CDS; Genomic_DNA.
CCDS; CCDS17950.1; -.
PIR; A54779; A54779.
RefSeq; NP_031850.2; NM_007824.2.
RefSeq; XP_006537666.1; XM_006537603.1.
SMR; Q64505; -.
STRING; 10090.ENSMUSP00000029905; -.
ChEMBL; CHEMBL2212; -.
iPTMnet; Q64505; -.
PhosphoSitePlus; Q64505; -.
jPOST; Q64505; -.
MaxQB; Q64505; -.
PaxDb; Q64505; -.
PRIDE; Q64505; -.
Antibodypedia; 2602; 148 antibodies.
Ensembl; ENSMUST00000029905; ENSMUSP00000029905; ENSMUSG00000028240.
GeneID; 13122; -.
KEGG; mmu:13122; -.
UCSC; uc008rxk.1; mouse.
CTD; 1581; -.
MGI; MGI:106091; Cyp7a1.
eggNOG; KOG0684; Eukaryota.
GeneTree; ENSGT00940000153141; -.
HOGENOM; CLU_018012_1_3_1; -.
InParanoid; Q64505; -.
KO; K00489; -.
OMA; VCCCLWL; -.
OrthoDB; 864748at2759; -.
TreeFam; TF105090; -.
BRENDA; 1.14.13.17; 3474.
Reactome; R-MMU-192105; Synthesis of bile acids and bile salts.
Reactome; R-MMU-193368; Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.
Reactome; R-MMU-193807; Synthesis of bile acids and bile salts via 27-hydroxycholesterol.
Reactome; R-MMU-211976; Endogenous sterols.
UniPathway; UPA00221; -.
UniPathway; UPA01058; -.
BioGRID-ORCS; 13122; 0 hits in 18 CRISPR screens.
ChiTaRS; Cyp7a1; mouse.
PRO; PR:Q64505; -.
Proteomes; UP000000589; Chromosome 4.
RNAct; Q64505; protein.
Bgee; ENSMUSG00000028240; Expressed in liver and 35 other tissues.
Genevisible; Q64505; MM.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
GO; GO:0008123; F:cholesterol 7-alpha-monooxygenase activity; IDA:MGI.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0008395; F:steroid hydroxylase activity; IBA:GO_Central.
GO; GO:0006699; P:bile acid biosynthetic process; ISS:UniProtKB.
GO; GO:0071397; P:cellular response to cholesterol; ISS:UniProtKB.
GO; GO:0071333; P:cellular response to glucose stimulus; ISS:UniProtKB.
GO; GO:0006707; P:cholesterol catabolic process; IDA:MGI.
GO; GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.
GO; GO:0032966; P:negative regulation of collagen biosynthetic process; ISO:MGI.
GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; ISO:MGI.
GO; GO:0070859; P:positive regulation of bile acid biosynthetic process; TAS:BHF-UCL.
GO; GO:0045542; P:positive regulation of cholesterol biosynthetic process; ISO:MGI.
GO; GO:0070857; P:regulation of bile acid biosynthetic process; ISS:UniProtKB.
GO; GO:0010468; P:regulation of gene expression; ISO:MGI.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR030681; Cholesterol_7a_monooxygenase.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR024204; Cyt_P450_CYP7A1-type.
InterPro; IPR002403; Cyt_P450_E_grp-IV.
InterPro; IPR036396; Cyt_P450_sf.
PANTHER; PTHR24304:SF1; PTHR24304:SF1; 1.
Pfam; PF00067; p450; 1.
PIRSF; PIRSF500625; Cytochrome_CYP7A1; 1.
PIRSF; PIRSF000047; Cytochrome_CYPVIIA1; 1.
PRINTS; PR00465; EP450IV.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
2: Evidence at transcript level;
Cholesterol metabolism; Endoplasmic reticulum; Heme; Iron;
Lipid metabolism; Membrane; Metal-binding; Microsome; Monooxygenase;
Oxidoreductase; Reference proteome; Steroid metabolism; Sterol metabolism;
Transmembrane; Transmembrane helix.
CHAIN 1..503
/note="Cytochrome P450 7A1"
/id="PRO_0000051902"
TRANSMEM 4..24
/note="Helical"
/evidence="ECO:0000255"
METAL 444
/note="Iron (heme axial ligand)"
/evidence="ECO:0000250|UniProtKB:P22680"
CONFLICT 197
/note="S -> T (in Ref. 1; AAA68867)"
/evidence="ECO:0000305"
CONFLICT 228
/note="F -> L (in Ref. 1; AAA68867)"
/evidence="ECO:0000305"
CONFLICT 318
/note="A -> S (in Ref. 1; AAA68867)"
/evidence="ECO:0000305"
SEQUENCE 503 AA; 57262 MW; F7F8BC2CDD2C43D1 CRC64;
MMSISLIWGI AVVVSCCIWF IIGIRRRKVG EPPLDNGLIP YLGCALKFGS NPLEFLRAKQ
RKHGHVFTCK LMGKYVHFIT NSLSYHKVLC HGKYFDWKKF HYTTSAKAFG HRSIDPSDGN
TTENINKTFN KTLQGDALCS LSEAMMQNLQ SVMRPPGLPK SKSAVWVTEG MYAFCYRVMF
EAGYLTLFGK DISKTDSQRA FIQNNLDSFK QFDQVFPALV AGVPIHLFKT AHKARERLAE
SLKHKNLYMR DQVSELIRLR MFLNDTLSTF DDMEKAKTHL VILWASQANT IPATFWSLFQ
MIRSPEAMKA ASEEVNGALQ SAGQELSSGG NAIYLDQEQL NNLPVLDSII KEALRLSSAS
LNIRTAKEDF TLHLEDGSYN IRKDDIIALY PQLMHLDPEI YPDPLTFKYD RYLDESGKAK
TTFYRNGNKL KYFYMPFGSG ATICPGRLFA VQEIKQFLIL MLSYFELELV ESHTKCPPLD
QSRAGLGILP PLNDIEFKYK LKH


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EIAAB09035 25-hydroxycholesterol 7-alpha-hydroxylase,Cyp7b1,Cytochrome P450 7B1,HCT-1,Hippocampal transcript 1 protein,Oxysterol 7-alpha-hydroxylase,Rat,Rattus norvegicus
EIAAB08889 25-hydroxyvitamin D(3) 1-alpha-hydroxylase,25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial,25-OHD-1 alpha-hydroxylase,Calcidiol 1-monooxygenase,Cyp27b,Cyp27b1,Cytochrome p450 27B1,Cytochrome P4
EIAAB08887 25-hydroxyvitamin D(3) 1-alpha-hydroxylase,25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial,25-OHD-1 alpha-hydroxylase,Calcidiol 1-monooxygenase,Cyp27b,Cyp27b1,Cyp40,Cytochrome p450 27B1,Cytochr
EIAAB08888 25-hydroxyvitamin D(3) 1-alpha-hydroxylase,25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial,25-OHD-1 alpha-hydroxylase,Calcidiol 1-monooxygenase,CYP1ALPHA,CYP27B,CYP27B1,Cytochrome p450 27B1,Cyt
EIAAB09037 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase,7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase,CYP12,CYP8B1,CYPVIIIB1,Cytochrome P450 8B1,Homo sapiens,Human,Sterol 12-alpha-hydroxylase
EIAAB09038 7-alpha-hydroxy-4-cholesten-3-one 12-alpha-hydroxylase,7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase,Cyp12,Cyp8b1,CYPVIIIB1,Cytochrome P450 8B1,Mouse,Mus musculus,Sterol 12-alpha-hydroxylase
Pathways :
WP1614: 1- and 2-Methylnaphthalene degradation
WP1655: Geraniol degradation
WP34: Ovarian Infertility Genes
WP1003: Ovarian Infertility Genes
WP1434: Osteopontin Signaling
WP215: noncanonical wnt pathway
WP1224: EBV LMP1 signaling
WP433: tRNA Synthetases
WP1531: Vitamin D synthesis
WP885: Ovarian Infertility Genes
WP1772: Apoptosis Modulation and Signaling
WP1904: RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
WP566: canonical wnt - zebrafish
WP244: Alpha 6 Beta 4 signaling pathway
WP1163: TNF-alpha NF-kB Signaling Pathway
WP1633: Bisphenol A degradation
WP263: Ovarian Infertility Genes
WP2100: AhR pathway
WP1209: EBV LMP1 signaling
WP32: Translation Factors
WP2199: Seed Development
WP1047: TNF-alpha NF-kB Signaling Pathway
WP1571: EBV LMP1 signaling
WP231: TNF alpha Signaling Pathway
WP1835: Interferon alpha/beta signaling

Related Genes :
[CYP7B1] Cytochrome P450 7B1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (25/26-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.29) (3-hydroxysteroid 7-alpha hydroxylase) (Oxysterol 7-alpha-hydroxylase)
[Cyp7b1] Cytochrome P450 7B1 (24-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.26) (25/26-hydroxycholesterol 7-alpha-hydroxylase) (EC 1.14.14.29) (3-hydroxysteroid 7-alpha hydroxylase) (Hippocampal transcript 1 protein) (HCT-1) (Oxysterol 7-alpha-hydroxylase)
[CYP2C9 CYP2C10] Cytochrome P450 2C9 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC9) (Cholesterol 25-hydroxylase) (Cytochrome P-450MP) (Cytochrome P450 MP-4) (Cytochrome P450 MP-8) (Cytochrome P450 PB-1) (S-mephenytoin 4-hydroxylase)
[CYP27A1 CYP27] Sterol 26-hydroxylase, mitochondrial (EC 1.14.15.15) (5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase) (Cytochrome P-450C27/25) (Cytochrome P450 27) (Sterol 27-hydroxylase) (Vitamin D(3) 25-hydroxylase)
[CYP1A2] Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P(3)450) (Cytochrome P450 4) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
[CYP2D6 CYP2DL1] Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase)
[Cyp1a2 Cyp1a-2] Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P450-P2) (Cytochrome P450-P3) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
[Cyp1a2 Cyp1a-2] Cytochrome P450 1A2 (EC 1.14.14.1) (CYPIA2) (Cholesterol 25-hydroxylase) (Cytochrome P-448) (Cytochrome P-450d) (Cytochrome P450-D) (Hydroperoxy icosatetraenoate dehydratase) (EC 4.2.1.152)
[CYP2D6] Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase)
[CYP17A1 CYP17 S17AH] Steroid 17-alpha-hydroxylase/17,20 lyase (EC 1.14.14.19) (17-alpha-hydroxyprogesterone aldolase) (EC 1.14.14.32) (CYPXVII) (Cytochrome P450 17A1) (Cytochrome P450-C17) (Cytochrome P450c17) (Steroid 17-alpha-monooxygenase)
[Cyp2a1 Cyp2a-1] Cytochrome P450 2A1 (EC 1.14.14.1) (CYPIIA1) (Cytochrome P450-UT-F) (Steroid hormones 7-alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase)
[CYP2C19] Cytochrome P450 2C19 (EC 1.14.14.1) ((R)-limonene 6-monooxygenase) (EC 1.14.14.53) ((S)-limonene 6-monooxygenase) (EC 1.14.14.51) ((S)-limonene 7-monooxygenase) (EC 1.14.14.52) (CYPIIC17) (CYPIIC19) (Cytochrome P450-11A) (Cytochrome P450-254C) (Fenbendazole monooxygenase (4'-hydroxylating)) (EC 1.14.14.75) (Mephenytoin 4-hydroxylase)
[CYP2D6] Cytochrome P450 2D6 (EC 1.14.14.-) (CYPIID6) (Cholesterol 25-hydroxylase) (Cytochrome P450-DB1) (Debrisoquine 4-hydroxylase)
[CYP4F2] Cytochrome P450 4F2 (EC 1.14.14.1) (20-hydroxyeicosatetraenoic acid synthase) (20-HETE synthase) (Arachidonic acid omega-hydroxylase) (CYPIVF2) (Cytochrome P450-LTB-omega) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Leukotriene-B(4) 20-monooxygenase 1) (Leukotriene-B(4) omega-hydroxylase 1) (EC 1.14.14.94) (Phylloquinone omega-hydroxylase CYP4F2) (EC 1.14.14.78)
[CYP2A6 CYP2A3] Cytochrome P450 2A6 (EC 1.14.13.-) (1,4-cineole 2-exo-monooxygenase) (CYPIIA6) (Coumarin 7-hydroxylase) (Cytochrome P450 IIA3) (Cytochrome P450(I))
[Cyp2b10 Cyp2b-10 Cyp2b20] Cytochrome P450 2B10 (EC 1.14.14.1) (CYPIIB10) (CYPIIB20) (Cytochrome P450 2B20) (Cytochrome P450 clone PF3/46) (Cytochrome P450-16-alpha) (P24) (Testosterone 16-alpha hydroxylase)
[Cyp2a4 Cyp2a-4] Cytochrome P450 2A4 (EC 1.14.14.1) (CYPIIA4) (Cytochrome P450-15-alpha) (Cytochrome P450-IIA3.1) (Testosterone 15-alpha-hydroxylase)
[CYP11B2] Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase)
[hchA hchA_1 AM465_15370 AWF59_019055 AZZ83_004235 B9N33_26475 BFD68_20845 C7B02_06890 C9Z28_17130 CCZ14_26645 CCZ17_22700 CRJUMX01_1140054 CRT43_11430 CUB99_23505 D3C88_02905 D3P02_16265 D9D33_15385 D9D94_15735 D9E49_19020 D9I20_10460 D9J46_03345 DJ487_18960 DJ492_13470 DL251_00505 DL979_00380 DMC44_18755 DMZ50_24495 DNR41_00375 DS966_16070 DU333_03260 DW236_02290 E0L04_20335 EA159_21345 EA167_21075 EA189_00370 EA191_21560 EA198_02280 EA200_00370 EA203_21510 EA222_02305 EA232_20265 EA233_11705 EA242_17410 EA245_13290 EA429_05770 EA435_21775 EA834_21700 ECTO124_02024 EGT48_04930 ELT22_00120 ELT23_21030 ELT33_08025 ELU82_24705 ELU96_05025 ELV13_26065 ELV22_24670 ELX56_18060 ELX70_18575 ELX79_15035 ELX83_25640 ELY23_20490 ELY24_19085 ELY50_24510 EPS76_06485 EPS91_17475 EPS94_00505 ERS085406_02591 EWK56_00075 ExPECSC065_02714 EYX99_25670 FNJ67_10775 FV295_16190 GFU40_00360 GFU45_09680 GFU47_04835 GJ638_18410 GKE92_23545 GKF28_00040 GKF34_00055 GKF47_00040 GKG08_13460 GKG09_11990 GKG11_12245 GKG22_12830 GKG29_13740 GQE47_24120 GQN33_12435 GQS26_09145 HmCmsJML236_01281 NCTC10766_03778 NCTC7928_05955 NCTC8450_02317 NCTC9007_02951 NCTC9075_02834 SY51_11150 U12A_02105 U14A_02105] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[CYP11A1] Cholesterol side-chain cleavage enzyme, mitochondrial (EC 1.14.15.6) (CYPXIA1) (Cholesterol desmolase) (Cytochrome P450 11A1) (Cytochrome P450(scc))
[Cyp24a1 Cyp24] 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (24-OHase) (Vitamin D(3) 24-hydroxylase) (EC 1.14.15.16) (Cytochrome P450 24A1) (Cytochrome P450-CC24)
[CYP4F11] Cytochrome P450 4F11 (CYPIVF11) (EC 1.14.14.1) (3-hydroxy fatty acids omega-hydroxylase CYP4F11) (Docosahexaenoic acid omega-hydroxylase) (EC 1.14.14.79) (Long-chain fatty acid omega-monooxygenase) (EC 1.14.14.80) (Phylloquinone omega-hydroxylase CYP4F11) (EC 1.14.14.78)
[Cyp2e1 Cyp2e Cyp2e-1] Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J) (Cytochrome P450RLM6)
[Cyp2a12] Cytochrome P450 2A12 (EC 1.14.14.1) (CYPIIA12) (Steroid hormones 7-alpha-hydroxylase) (Testosterone 7-alpha-hydroxylase)
[CYP2E1 CYP2E] Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-J)
[Cyp2e1 Cyp2e Cyp2e-1] Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P450-ALC) (Cytochrome P450-J)
[gpt gpt_1 gpt_2 A6581_24735 A6592_07875 A6V01_15140 A8C65_11920 A9819_01270 A9P13_20710 AC067_13025 ACN68_09550 ACN81_04985 ACU57_05530 ACU90_21540 AM270_24435 AM446_22285 AM464_18035 AMK83_11675 AML07_18865 AML35_26760 APT94_26465 APZ14_03320 ARC77_20695 AU473_25460 AUQ13_19175 AUS26_00725 AW059_23210 AW106_16590 AWB10_20405 AWG90_003065 AWP75_23700 B7C53_21605 B9M99_20010 B9T59_06965 BANRA_00643 BANRA_00738 BANRA_02177 BANRA_03434 BB545_01610 BE963_15335 BEN53_03430 BER14_12690 BHF03_17015 BHF46_16390 BHJ80_04935 BHS81_01365 BHS87_01210 BIU72_04015 BIZ41_25355 BK248_22765 BK292_26975 BK296_11955 BK334_06615 BK375_21430 BK383_27375 BMA87_21655 BMA87_28570 BMT91_15840 BOH76_06515 BON63_03345 BON65_03985 BON69_12250 BON71_19305 BON83_19950 BON86_17080 BON87_16065 BON92_10240 BON95_07500 BON96_23095 BTQ04_20965 BTQ06_22075 BUE81_28385 BvCms12BK_03956 BvCms2454_04711 BvCms28BK_00811 BvCms35BK_03961 BvCmsC61A_02864 BvCmsHHP001_04975 BvCmsHHP056_02076 BvCmsKKP036_04089 BvCmsKKP061_04508 BvCmsKSNP073_03786 BvCmsKSNP081_01254 BvCmsKSNP120_01648 BvCmsKSP011_04056 BvCmsKSP024_01910 BvCmsKSP026_01630 BvCmsKSP045_00796 BvCmsKSP058_02901 BvCmsKSP067_02218 BvCmsKSP076_02633 BvCmsNSNP036_03992 BvCmsNSP006_02398 BvCmsNSP007_02005 BvCmsNSP047_03995 BvCmsNSP072_02750 BvCmsOUP014_00416 BvCmsSINP011_02987 BvCmsSINP022_01835 BvCmsSIP019_03456 BvCmsSIP044_02857 BVL39_01690 BW690_21415 BWP17_22815 BXT93_00225 BZL69_23795 C2M16_01965 C2U48_09075 C4M78_16185 C5715_22025 C5N07_13760 C5P01_21980 C5P44_21315 C6669_03760 C6B13_09340 C7235_19745 C7B02_25470 C7B08_00095 C7B18_22295 C9098_03130 C9114_26985 C9141_09755 C9160_01185 C9201_03165 C9306_10875 C9E25_22805 C9E67_24700 C9Z03_26210 C9Z23_22300 C9Z28_26570 C9Z29_22335 C9Z37_27125 C9Z39_22150 C9Z68_09975 C9Z69_27145 C9Z70_25050 C9Z78_07770 C9Z89_15250 CA593_02395 CDC27_25030 CDL37_13510 CF006_20670 CG692_23500 CI641_017195 CI693_17170 CI694_08655 CIG45_12330 CJU63_01405 CJU64_01420 CO706_23540 COD30_18335 COD46_17250 CQB02_19385 CQP61_21535 CR539_05390 CRD98_23120 CRE06_24510 CRM83_14605 CRX46_01755 CSB64_26950 CVH05_19670 CWM24_22145 CWS33_23735 D0X26_15070 D2185_25105 D2188_25000 D3821_16100 D3822_06565 D3P01_25990 D3Y67_06595 D4011_23175 D4011_28855 D4023_13325 D4023_28745 D4074_23775 D4074_28125 D4628_24155 D4628_28600 D4636_05010 D4636_29605 D4638_18395 D4638_26940 D4660_23335 D4660_28165 D4718_12915 D4718_26095 D4L91_24085 D4L91_28845 D4M06_25275 D4M06_29470 D4U85_23525 D4U85_29025 D4V08_08355 D4V08_27555 D5H35_23985 D5H35_30060 D5I97_23775 D5I97_29105 D6004_15800 D6004_29060 D6C36_24035 D6C36_28485 D6D43_24420 D6D43_29410 D6T60_07325 D6T98_09315 D6T98_29095 D6W00_22375 D6W00_27760 D6X36_25220 D6X36_27940 D6X63_19690 D6X63_30750 D6X76_25805 D6X76_29570 D7K63_22005 D7K63_29015 D7K66_24115 D7K66_28550 D7W70_23150 D7W70_28285 D8Y65_22575 D9610_13520 D9610_28220 D9C99_19800 D9C99_28275 D9D20_20050 D9D20_27320 D9D31_21340 D9D31_29190 D9D43_12910 D9D43_30910 D9D44_18550 D9D44_26290 D9E19_12450 D9E19_25065 D9E34_23825 D9E34_29905 D9E35_23540 D9E35_26575 D9E73_22940 D9E73_26685 D9G11_18645 D9G29_15190 D9G29_23545 D9G42_22480 D9G42_26240 D9G48_16265 D9G48_29215 D9G69_08570 D9G69_26570 D9H36_06175 D9H36_25670 D9H53_23915 D9H53_26745 D9H68_19500 D9H68_25150 D9H70_13915 D9H70_27810 D9H94_21005 D9H94_27450 D9I18_13670 D9I18_25405 D9I87_19245 D9I87_28290 D9I88_08305 D9I88_28725 D9I97_17060 D9I97_27320 D9J03_14485 D9J03_27980 D9J11_18255 D9J11_27180 D9J44_21820 D9J44_27170 D9J52_18195 D9J52_25855 D9J58_23055 D9J58_24365 D9J60_25310 D9J60_27465 D9J63_02850 D9J63_23790 D9J78_22620 D9J78_26485 D9K48_18335 D9K54_02155 D9L89_23375 D9L89_29740 D9S45_15760 D9S45_27600 D9X77_22165 D9X77_27305 D9X97_24085 D9X97_28835 D9Z28_10520 D9Z28_27455 DAH18_18315 DAH26_21060 DAH30_18735 DAH32_06350 DAH34_23765 DAH37_16845 DAH43_23055 DB359_23260 DBQ99_20880 DD762_24820 DEN86_05755 DEN97_24850 DEO04_03875 DEO19_23880 DEO20_15015 DIV22_00630 DJ492_11165 DJ503_22095 DK132_21260 DK132_27085 DL257_09335 DL257_26160 DL292_23280 DL292_26935 DL326_18855 DL326_27365 DL455_23505 DL455_30205 DL530_05345 DL530_29040 DL705_23200 DL705_29885 DL800_03175 DLT82_22145 DLT82_28135 DLU50_23620 DLU50_27500 DLU67_21040 DLU67_28755 DLU82_21760 DLU82_28810 DLW60_14310 DLW60_30375 DLX40_09740 DLX40_30010 DLY41_13185 DLY41_27720 DLY44_15600 DLY44_25650 DM102_12030 DM129_06785 DM129_27415 DM155_18895 DM155_29495 DM267_19615 DM267_28325 DM280_12915 DM280_26030 DM296_20930 DM296_26640 DM382_21300 DM382_27965 DM820_05140 DM820_29140 DM962_23610 DM973_24980 DM973_29180 DMI04_23535 DMI04_28235 DMI53_23945 DMI53_30115 DMO02_23120 DMO02_29500 DMY83_13725 DMY83_25955 DN627_09465 DN627_29990 DN660_05015 DN660_29840 DN700_23800 DN700_28885 DN703_24875 DN703_30875 DN808_04490 DN808_28870 DNB37_23165 DNB37_28300 DNC98_21945 DNC98_29725 DND16_19405 DND16_27515 DND79_03435 DND79_29510 DNI21_13010 DNI21_28935 DNJ62_24055 DNJ62_29265 DNK12_23120 DNK12_28235 DNQ45_25580 DNR35_21910 DNR35_28385 DNW42_07305 DNW42_26635 DNX19_11455 DNX19_29500 DNX30_04115 DNX30_29635 DOE35_24530 DOE35_31355 DOS18_23750 DOS18_28080 DOT81_23125 DOT81_29525 DOU81_23770 DOU81_28595 DOY22_22905 DOY22_29925 DOY56_23865 DOY56_28365 DOY61_01370 DOY61_29265 DOY67_05900 DOY67_30380 DP258_20540 DP258_29895 DP265_24490 DP265_28410 DP277_14380 DP277_29835 DQE91_08395 DQE91_28260 DQF36_21740 DQF36_26790 DQF71_16435 DQF71_31365 DQF72_23835 DQF72_28435 DQG35_19245 DQG35_28775 DQO13_04865 DQO13_29630 DQP61_09080 DQP61_29705 DRP48_23310 DRP48_28310 DRW19_21750 DRW19_30500 DS143_15935 DS143_31085 DS721_23580 DS721_28425 DT034_17525 DT034_27975 DTL43_23520 DTL90_09990 DTM45_23885 DTZ20_18435 DTZ20_30380 DU309_04460 DU321_20225 DVB38_15835 DVB38_28395 DWB25_19960 DXT69_13235 DXT71_24310 DXT73_18220 DXX80_017640 E0I42_20560 E0L12_22475 E2112_12685 E2114_14475 E2115_07010 E2119_20065 E2127_12735 E2128_13600 E2129_02525 E2134_00765 E2135_19800 E2148_09760 E2855_00301 E2863_00298 E4K55_14840 E4K60_19540 E4K61_16065 E5P22_16425 E5P28_19185 E5P37_20610 E5S42_17300 E5S46_09610 E5S47_10460 E5S56_05750 E5S58_22690 E5S61_10425 EA213_21795 EA214_13115 EA218_22575 EA225_23465 EA233_19695 EAI42_20865 EAI46_21030 EAI52_15405 EAM59_04145 EAM59_29595 EAN70_18670 EAN70_29725 EAN77_22945 EAN77_30680 EAX79_20060 EAX79_30825 EB476_17090 EB476_22680 EB509_20890 EB509_27800 EB510_18030 EB510_28315 EB515_23745 EB515_27880 EBA46_22205 EBA46_26395 EBA84_23430 EBA84_28170 EBJ06_23935 EBJ06_28545 EBM08_17745 EBM08_28280 EC1094V2_3589 EC3234A_186c00200 EC3426_01015 EC382_20120 EC382_27180 EC95NR1_04490 ECONIH1_01360 ECs0265 ECTO6_03818 ED225_23470 ED225_27940 ED307_05870 ED307_22700 ED600_12330 ED600_29810 ED607_19340 ED607_28020 ED611_24270 ED611_27810 ED648_18230 ED648_28315 ED903_19880 ED903_27815 ED944_23820 ED944_28290 EEA45_22330 EEA45_28065 EEP23_17860 EEP23_26875 EF082_19475 EF082_28120 EF173_22210 EF173_28140 EG075_16745 EG075_25400 EG599_14780 EG599_28925 EG796_21370 EG796_27615 EG808_20920 EG808_28375 EGC26_19180 EGC26_27180 EGU87_21300 EGU87_26855 EH186_14160 EH186_27945 EH412_06165 EH412_29675 EHD45_23575 EHD45_25935 EHD63_22900 EHD63_27715 EHD79_02905 EHD79_28125 EHH55_16495 EHJ36_16400 EHJ36_31060 EHJ66_23500 EHJ66_27500 EHV81_20960 EHV81_28820 EHV90_23810 EHV90_28430 EHW09_22310 EHW09_29050 EHX09_23125 EHX09_28420 EI021_14935 EI028_13710 EI032_16170 EI041_20535 EIA08_18435 EIA21_13445 EIZ93_22985 EJC75_23220 EKI52_09795 EL75_3518 EL79_3619 EL80_3521 ELT17_18520 ELT20_16230 ELT49_13100 ELT58_17560 ELU85_08285 ELV15_03520 ELV28_09060 ELX76_23175 ELY41_11455 ELY48_07995 EO241_22520 EPS91_24430 EPT01_14645 EPU41_01385 EQ820_00105 EQ823_20985 EQ825_21365 EQ830_24960 ERL57_20515 ERS085365_04413 ERS085366_02764 ERS085374_02249 ERS085379_04652 ERS085383_04165 ERS085386_03030 ERS085404_04643 ERS085416_04477 ERS139211_04430 ERS150873_03530 ERS150876_03636 EST51_19640 EVY14_16635 EXM29_23430 ExPECSC019_02478 ExPECSC038_02153 EXX06_21375 EXX13_14735 EXX23_23120 EXX24_20845 EXX53_17670 EXX55_21830 EXX71_22590 EXX78_22900 EXX87_21610 EYD11_18080 EYY27_14995 EYY34_21905 F1E13_21100 F1E19_22925 F7F00_06690 F7F18_01705 F7F23_17330 F7F26_17430 F7F29_14405 F7G01_17995 F7G03_23955 F9059_11055 F9Z74_17445 FAF34_024940 FE846_18930 FKO60_20295 FNJ69_22830 FNJ83_03065 FORC82_3792 FQ022_18270 FQ915_01480 FQR64_18230 FQZ46_18180 FRV13_03065 FV293_09695 FV295_11685 FV438_21145 FVB16_19925 FY127_14205 FZ043_04515 GHR40_00230 GII67_08135 GII91_21680 GIY13_22240 GIY19_23890 GJ11_01580 GJD97_22500 GKE15_16855 GKE22_18265 GKE24_17015 GKE26_18245 GKE29_15295 GKE31_17560 GKE39_18225 GKE46_16970 GKE58_14855 GKE60_15570 GKE64_15995 GKE77_15355 GKE87_15250 GKE93_18450 GKF00_04030 GKF03_04170 GKF74_21850 GKF86_21170 GKF89_17245 GKG08_09615 GKG09_09865 GKG11_10070 GKG12_19080 GKG22_09875 GKG29_09915 GN312_14520 GNZ00_20595 GNZ02_22410 GNZ03_23045 GP654_24520 GP661_12300 GP664_16685 GP689_21100 GP700_22210 GP712_22580 GP720_18440 GP727_21535 GP912_22305 GP946_21975 GQE22_13250 GQE30_20040 GQE34_15240 GQE42_16370 GQE51_19490 GQE64_16650 GQE68_11955 GQE88_11005 GQE93_04600 GQL64_16980 GQM06_14655 GQM09_17995 GQM13_21780 GQM17_10910 GQN16_22060 GRW42_08140 GRW80_22225 HmCms184_00518 HmCmsJML074_02688 HmCmsJML079_04239 HmCmsJML236_03821 HMPREF3040_05403 HW43_05000 MS6198_02780 NCTC10082_01255 NCTC10090_02014 NCTC10418_05865 NCTC10429_04036 NCTC10764_05531 NCTC10865_04958 NCTC10963_03998 NCTC10974_04512 NCTC11112_03566 NCTC11126_03770 NCTC11341_03813 NCTC12650_00242 NCTC12950_04321 NCTC13127_05339 NCTC13216_02789 NCTC13846_03809 NCTC7922_06425 NCTC7927_04385 NCTC7928_04751 NCTC8009_07187 NCTC8179_01495 NCTC8450_01242 NCTC8622_02801 NCTC8960_01426 NCTC8985_02965 NCTC9036_03941 NCTC9044_03359 NCTC9050_01892 NCTC9058_02906 NCTC9062_04335 NCTC9073_03237 NCTC9077_04973 NCTC9111_04170 NCTC9119_04172 NCTC9701_04276 NCTC9702_04610 NCTC9703_03337 NCTC9706_01196 NCTC9777_00306 NCTC9777_03689 NCTC9962_07295 NCTC9969_04170 PGD_03028 PU06_00100 RG28_03440 RK56_027385 SAMEA3472043_03024 SAMEA3472044_03219 SAMEA3472047_03118 SAMEA3472055_05115 SAMEA3472056_02836 SAMEA3472070_01939 SAMEA3472080_03519 SAMEA3472108_04671 SAMEA3472110_01888 SAMEA3472112_03297 SAMEA3472147_04102 SAMEA3484434_04071 SAMEA3485101_01928 SAMEA3752372_03315 SAMEA3752553_04691 SAMEA3752557_00102 SAMEA3752559_04613 SAMEA3753097_03779 SAMEA3753300_00352 SK85_00269 UC41_02310 UN86_24680 UN91_25330 WQ89_22485 WR15_21355 YDC107_3487] Xanthine-guanine phosphoribosyltransferase (XGPRT) (EC 2.4.2.22) (Xanthine phosphoribosyltransferase)
[Cyp11b2 Cyp11b-2] Cytochrome P450 11B2, mitochondrial (Aldosterone synthase) (ALDOS) (Aldosterone-synthesizing enzyme) (CYPXIB2) (Corticosterone 18-monooxygenase, CYP11B2) (EC 1.14.15.5) (Cytochrome P-450Aldo) (Cytochrome P-450C18) (Cytochrome P450C11) (Steroid 11-beta-hydroxylase, CYP11B2) (EC 1.14.15.4) (Steroid 18-hydroxylase)
[CYP2E1 CYP2E] Cytochrome P450 2E1 (EC 1.14.14.1) (4-nitrophenol 2-hydroxylase) (EC 1.14.13.n7) (CYPIIE1) (Cytochrome P-450-J) (Cytochrome P450-J)
[pyrG A6592_02570 A6V01_01290 A9P13_05400 A9R57_06965 A9X72_05250 AC067_22330 AC789_1c31020 ACN002_2797 ACN68_00955 ACN81_20385 ACU57_24415 ACU90_23015 AJ318_22735 AM270_00945 AM446_06950 AM464_05605 AM465_10605 AML07_12460 AML35_05300 APT94_17890 APU18_18535 APZ14_09290 ARC77_10140 AU473_08010 AUQ13_17535 AUS26_15660 AW059_10675 AW106_00665 AWB10_05845 AWE53_025360 AWF59_014510 AWG78_018325 AWG90_017920 AWP75_20610 AZZ83_003241 B6V57_15035 B7C53_10055 B9M99_21725 B9N33_09475 B9T59_19685 BANRA_01301 BANRA_03509 BANRA_03630 BANRA_04324 BB545_13920 BE963_03670 BEN53_16995 BFD68_17190 BHF03_06455 BHF46_05050 BHJ80_19590 BHS81_16640 BHS87_15735 BIQ87_15835 BIU72_09520 BIZ41_16885 BJJ90_05265 BK248_12970 BK292_23205 BK296_17745 BK334_11935 BK373_15870 BK375_10085 BK383_11680 BMA87_05450 BMT49_17330 BMT91_11105 BN17_26661 BOH76_24715 BON63_19880 BON65_10470 BON66_19055 BON69_14990 BON71_18475 BON75_14060 BON76_10430 BON83_26590 BON86_03420 BON87_20865 BON91_20235 BON92_09140 BON96_25385 BTQ04_11510 BTQ06_23845 BUE81_06975 BvCms12BK_05148 BvCms2454_02052 BvCms35BK_01272 BvCmsC61A_01055 BvCmsHHP001_01156 BvCmsHHP019_01127 BvCmsHHP056_01979 BvCmsKKP036_03980 BvCmsKKP061_04391 BvCmsKSNP073_04203 BvCmsKSNP081_03790 BvCmsKSNP120_03969 BvCmsKSP011_02434 BvCmsKSP024_03358 BvCmsKSP026_00102 BvCmsKSP045_02208 BvCmsKSP058_00862 BvCmsKSP067_03640 BvCmsKSP076_05173 BvCmsNSNP036_03047 BvCmsNSP007_01096 BvCmsNSP047_01557 BvCmsNSP072_00181 BvCmsOUP014_01917 BvCmsSINP011_00512 BvCmsSINP022_00781 BvCmsSIP019_01766 BvCmsSIP044_01614 BVL39_12970 BW690_04975 BWI89_25410 BWP17_05185 BXT93_24405 BZL31_00820 BZL69_02125 C2M16_17770 C2U48_20025 C4K41_05275 C4M78_00835 C5715_23540 C5N07_06155 C5P01_05005 C5P44_09340 C6669_14670 C6B13_03370 C7235_05745 C7B02_19400 C7B06_11630 C7B07_14530 C7B08_01430 C7B18_14945 C9098_13720 C9114_10610 C9141_08815 C9160_11785 C9162_15350 C9201_02025 C9306_10515 C9E25_03325 C9E67_05815 C9Z03_03520 C9Z23_09225 C9Z37_12455 C9Z39_03205 C9Z43_07790 C9Z69_03200 C9Z70_05405 C9Z78_15545 C9Z89_02595 CA593_12975 CCZ14_04445 CCZ17_10850 CDC27_14650 CDL37_13440 CF006_02945 CG692_07005 CI641_006865 CI693_01450 CI694_13655 CIG45_04935 CJU63_16170 CJU64_16425 CMR93_10525 CO706_11780 COD30_01795 COD46_07095 CQP61_06810 CR538_05495 CR539_18815 CRE06_03485 CRJUMX01_160005 CRM83_26360 CRT43_16405 CRX46_18850 CSB64_15850 CT146_00680 CUB99_19065 CV83915_03339 CVH05_06295 CWM24_00790 CWS33_03125 D0X26_06660 D2184_01135 D2185_02785 D2188_08435 D3821_11140 D3M98_14175 D3O91_13425 D3P01_10795 D3P02_18650 D3Y67_06430 D4011_20680 D4023_03535 D4074_08165 D4636_12345 D4638_15660 D4660_07760 D4718_06700 D4L91_10970 D4M06_10805 D4U49_02065 D4U85_13910 D4V08_11640 D5H35_06960 D5I97_07085 D6004_06600 D6C36_08560 D6D43_15090 D6T60_21710 D6W00_05605 D6X63_06250 D6X76_00665 D7K33_11370 D7K63_03745 D7K66_09735 D7W70_08720 D7Y10_03025 D7Z75_00480 D8Y65_06395 D9610_06925 D9C99_02870 D9D20_04450 D9D33_19300 D9D43_17525 D9D44_11660 D9D94_19995 D9E13_19660 D9E19_06295 D9E35_20180 D9E73_07150 D9F17_11720 D9F32_18535 D9F87_14880 D9G11_05335 D9G29_07695 D9G42_05640 D9G48_11875 D9G69_15675 D9G95_24305 D9H36_19535 D9H53_12755 D9H68_17340 D9H70_12195 D9H94_16855 D9I18_10690 D9I20_00375 D9I87_07250 D9I88_14405 D9I97_09750 D9J03_22055 D9J11_17735 D9J44_16360 D9J46_14445 D9J52_13520 D9J58_10595 D9J60_10045 D9J63_04880 D9J78_14800 D9K02_13530 D9K48_23835 D9K54_13555 D9L89_10810 D9L99_02095 D9S45_05925 D9X77_06065 D9X97_06540 D9Z28_07585 DAH18_08260 DAH26_03580 DAH30_04675 DAH32_02015 DAH34_11000 DAH37_01335 DAH43_05325 DB359_08835 DBQ99_06250 DD762_13665 DEN89_06185 DEN97_03935 DEO04_02940 DEO19_03715 DEO20_03950 DIV22_29760 DJ487_00440 DJ492_07250 DJ503_09945 DL251_04515 DL257_11915 DL292_16405 DL326_19010 DL455_11645 DL479_12200 DL530_03985 DL545_05995 DL800_20505 DL979_18970 DLT82_09290 DLU67_11100 DLU82_08170 DLW60_06590 DLW88_08740 DLX38_01400 DLX40_17180 DLY41_21435 DLY44_20595 DM102_10625 DM129_10705 DM155_07315 DM267_14905 DM272_03810 DM280_20210 DM382_13710 DM820_02080 DM962_00445 DM973_18825 DMI04_14240 DMI53_07435 DMO02_14990 DMY83_10765 DMZ50_15435 DN627_17365 DN660_13250 DN700_02075 DN703_12685 DN808_12120 DNB37_12630 DNC98_03960 DND16_10185 DND79_12465 DNI21_05695 DNJ62_04410 DNK12_06795 DNR35_10760 DNR41_08670 DNX19_04715 DNX30_08935 DOE35_02030 DOM23_03020 DOS18_12055 DOT81_13135 DOU81_11955 DOY22_19570 DOY56_02000 DOY61_03145 DOY67_13090 DP258_16075 DP265_17025 DP277_11440 DQE91_10495 DQF36_14860 DQF71_04970 DQF72_16505 DQG35_07980 DQO13_13250 DRP48_13490 DRW19_11765 DS143_05250 DS721_02825 DS732_20695 DS966_06010 DT034_02885 DTL43_09355 DTL90_02675 DTM10_03745 DTM45_13530 DTZ20_19385 DU309_08860 DU321_06150 DU333_12515 DVB38_02710 DW236_13020 DWB25_05920 DXT69_20555 DXT71_17355 DXT73_08070 DXX80_007370 E0I42_10500 E0K84_20120 E0L04_10915 E0L12_01040 E2112_20720 E2114_10485 E2115_08690 E2119_13595 E2127_11355 E2128_06395 E2129_11320 E2134_08140 E2135_07675 E2148_10650 E2855_03617 E2863_03463 E4K55_04550 E4K60_10640 E4K61_15140 E5P22_15685 E5P28_02240 E5P37_16160 E5S42_03270 E5S46_13510 E5S47_04995 E5S56_08680 E5S58_00660 E5S61_16625 EA159_15255 EA167_16290 EA189_08455 EA191_15960 EA198_05390 EA200_09530 EA203_16215 EA213_04170 EA214_11185 EA218_13120 EA223_08230 EA225_01145 EA231_20080 EA232_13255 EA233_00965 EA242_06320 EA245_06985 EA250_17410 EA410_00760 EA429_04715 EA434_00760 EA435_11325 EA834_09100 EAI42_07155 EAI46_14335 EAI52_12500 EAM59_05115 EAN70_01890 EB476_14050 EB509_19080 EB510_16355 EB515_03490 EBA46_07975 EBA84_02290 EBJ06_02570 EBM08_02305 EC1094V2_904 EC3234A_48c00890 EC3426_03921 EC382_15705 EC95NR1_02021 ECONIH1_15890 ECs3640 ECTO124_01152 ECTO6_01068 ED225_00710 ED307_10820 ED600_14885 ED607_09825 ED611_00710 ED648_01520 ED903_09700 ED944_03505 EEA45_12675 EEP23_14050 EF082_18470 EF173_03685 EG075_13145 EG599_01830 EG808_06220 EGC26_11055 EGT48_09620 EGU87_12650 EH186_13570 EH412_03190 EHD45_02185 EHD63_08185 EHD79_13870 EHH55_20810 EHJ36_03270 EHJ66_02550 EHV81_04065 EHV90_01500 EHW09_03455 EHX09_18045 EI021_14555 EI028_04155 EI032_03990 EI041_16020 EIA08_07275 EIA21_04795 EIZ93_11190 EJ366_03305 EJC75_12775 EKI52_20580 EL75_0914 EL79_0915 EL80_0918 ELT17_10180 ELT20_14390 ELT22_13655 ELT23_08310 ELT33_11340 ELT48_15890 ELT49_03005 ELT58_07520 ELU82_04890 ELU85_05750 ELU96_10810 ELV08_21905 ELV13_07545 ELV15_07575 ELV22_07685 ELV24_11300 ELV28_16420 ELX56_07655 ELX70_21165 ELX76_02410 ELX79_10280 ELX83_17325 ELY05_07495 ELY23_11490 ELY24_07925 ELY41_05035 ELY48_16065 ELY50_05380 EO241_20205 EPS91_16285 EPS94_11415 EPT01_17055 EPU41_15765 EQ820_17285 EQ823_14605 EQ825_07980 EQ830_01100 ERL57_14345 ERS085365_02427 ERS085366_03042 ERS085374_03279 ERS085386_03410 ERS085416_02898 ERS139211_02072 ERS150873_02003 ERS150876_01467 EST51_05505 EVY14_17325 EWK56_05345 ExPECSC019_02242 ExPECSC038_01963 ExPECSC065_01289 EXX06_06960 EXX13_05855 EXX23_03700 EXX24_19085 EXX53_03685 EXX55_06445 EXX71_16235 EXX78_11575 EXX87_15385 EYD11_05205 EYX82_06265 EYX99_17285 EYY27_21685 EYY34_09650 EYY78_11015 F1E13_12850 F1E19_13585 F7F00_02940 F7F11_01115 F7F23_00665 F7F26_03065 F7G01_03890 F7G03_02700 F9059_06090 F9Z74_18200 FAF34_010195 FE846_02780 FKO60_03565 FNJ67_06370 FNJ69_12285 FNJ83_17875 FORC82_1067 FQ022_17605 FQR64_05280 FQU83_07080 FQZ46_00480 FRV13_23300 FTV93_23860 FV293_15850 FV295_08510 FV438_15285 FY127_14515 FZ043_19260 GFU40_06320 GFU47_11920 GHR40_09615 GII67_05930 GII91_14310 GIY13_16875 GJ11_18025 GJ638_02750 GJD97_05060 GKE15_03135 GKE22_09005 GKE24_03125 GKE26_03130 GKE29_04180 GKE31_03095 GKE39_03150 GKE46_11750 GKE58_03040 GKE60_03095 GKE64_07540 GKE77_03100 GKE87_04995 GKE92_01660 GKE93_03620 GKF03_04460 GKF28_13940 GKF34_13235 GKF47_13220 GKF74_07795 GKF86_09815 GKF89_09790 GKG08_07710 GKG09_07960 GKG11_08165 GKG12_00975 GKG22_07970 GKG29_08010 GN312_04475 GNZ00_00805 GNZ02_06270 GNZ03_13180 GP654_05220 GP661_15475 GP664_04220 GP666_07425 GP689_01920 GP700_13945 GP712_05420 GP720_12915 GP727_17550 GP912_17995 GP935_06995 GP946_10500 GP950_03155 GQE22_17855 GQE30_14975 GQE34_06655 GQE42_09295 GQE47_08060 GQE51_07155 GQE58_08185 GQE64_12560 GQE68_19320 GQE88_19580 GQE93_00635 GQL64_00935 GQM06_06780 GQM09_04835 GQM13_07125 GQM17_05020 GQN16_02715 GQN33_06080 GQS26_09385 GRW42_02075 GRW80_15480 HmCms169_01730 HmCms184_04776 HmCmsJML074_04422 HmCmsJML079_03779 HmCmsJML146_01816 HmCmsJML204_00525 HmCmsJML236_00834 HMPREF3040_01161 HW43_18180 MJ49_17095 MS6198_30910 MS8345_02965 NCTC10082_03473 NCTC10090_04050 NCTC10418_01701 NCTC10764_00296 NCTC10766_00690 NCTC10767_02309 NCTC10963_01055 NCTC10974_01288 NCTC11022_02860 NCTC11112_00121 NCTC11181_03277 NCTC12650_01316 NCTC12950_01251 NCTC13127_01436 NCTC13216_00824 NCTC13846_01212 NCTC7927_01209 NCTC8500_01090 NCTC8960_03783 NCTC9007_03892 NCTC9036_01135 NCTC9044_00576 NCTC9045_01221 NCTC9050_04166 NCTC9058_00847 NCTC9062_02131 NCTC9075_01630 NCTC9077_01409 NCTC9081_05851 NCTC9117_01609 NCTC9119_01271 NCTC9434_01004 NCTC9702_01298 NCTC9706_03296 NCTC9777_02704 NCTC9969_01292 PGD_04325 PU06_02080 RG28_07675 RK56_023165 SAMEA3472043_01265 SAMEA3472044_02272 SAMEA3472047_00339 SAMEA3472056_05455 SAMEA3472070_01673 SAMEA3472080_03155 SAMEA3472090_00131 SAMEA3472108_00527 SAMEA3472110_03462 SAMEA3472112_03722 SAMEA3472114_02432 SAMEA3472147_03296 SAMEA3484427_03298 SAMEA3484429_03415 SAMEA3484434_01581 SAMEA3485101_02257 SAMEA3752372_03639 SAMEA3752553_01510 SAMEA3752557_03040 SAMEA3752559_02995 SAMEA3752620_01282 SAMEA3753064_02287 SAMEA3753097_02219 SAMEA3753164_01192 SAMEA3753290_02847 SAMEA3753300_01107 SK85_03024 SY51_15605 U12A_02895 U14A_02898 UC41_20365 UN91_03645 WQ89_10170 WR15_06090 YDC107_1339] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)

Bibliography :