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Cytochrome P450 family 24 subfamily A member 1

 A0A2K6RJI6_RHIRO        Unreviewed;       514 AA.
A0A2K6RJI6;
28-MAR-2018, integrated into UniProtKB/TrEMBL.
28-MAR-2018, sequence version 1.
26-FEB-2020, entry version 14.
SubName: Full=Cytochrome P450 family 24 subfamily A member 1 {ECO:0000313|Ensembl:ENSRROP00000041165};
Name=CYP24A1 {ECO:0000313|Ensembl:ENSRROP00000041165};
Rhinopithecus roxellana (Golden snub-nosed monkey) (Pygathrix roxellana).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
Cercopithecidae; Colobinae; Rhinopithecus.
NCBI_TaxID=61622 {ECO:0000313|Ensembl:ENSRROP00000041165, ECO:0000313|Proteomes:UP000233200};
[1] {ECO:0000313|Ensembl:ENSRROP00000041165, ECO:0000313|Proteomes:UP000233200}
NUCLEOTIDE SEQUENCE.
PubMed=25362486;
Zhou X., Wang B., Pan Q., Zhang J., Kumar S., Sun X., Liu Z., Pan H.,
Lin Y., Liu G., Zhan W., Li M., Ren B., Ma X., Ruan H., Cheng C., Wang D.,
Shi F., Hui Y., Tao Y., Zhang C., Zhu P., Xiang Z., Jiang W., Chang J.,
Wang H., Cao Z., Jiang Z., Li B., Yang G., Roos C., Garber P.A.,
Bruford M.W., Li R., Li M.;
"Whole-genome sequencing of the snub-nosed monkey provides insights into
folivory and evolutionary history.";
Nat. Genet. 46:1303-1310(2014).
[2] {ECO:0000313|Ensembl:ENSRROP00000041165}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
-!- SIMILARITY: Belongs to the cytochrome P450 family.
{ECO:0000256|RuleBase:RU000461}.
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RefSeq; XP_010361660.1; XM_010363358.1.
Ensembl; ENSRROT00000065661; ENSRROP00000041165; ENSRROG00000043791.
Ensembl; ENSRROT00000065666; ENSRROP00000041170; ENSRROG00000043791.
GeneID; 104662355; -.
KEGG; rro:104662355; -.
GeneTree; ENSGT00950000182905; -.
KO; K07436; -.
OMA; HIGAPCL; -.
OrthoDB; 1273535at2759; -.
Proteomes; UP000233200; Whole Genome Shotgun Assembly.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0030342; F:1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; IEA:Ensembl.
GO; GO:0008403; F:25-hydroxycholecalciferol-24-hydroxylase activity; IEA:Ensembl.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0070643; F:vitamin D 25-hydroxylase activity; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0033280; P:response to vitamin D; IEA:Ensembl.
GO; GO:0042369; P:vitamin D catabolic process; IEA:Ensembl.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR002401; Cyt_P450_E_grp-I.
InterPro; IPR036396; Cyt_P450_sf.
Pfam; PF00067; p450; 1.
PRINTS; PR00463; EP450I.
PRINTS; PR00385; P450.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
3: Inferred from homology;
Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
Metal-binding {ECO:0000256|RuleBase:RU000461};
Monooxygenase {ECO:0000256|RuleBase:RU000461};
Oxidoreductase {ECO:0000256|RuleBase:RU000461};
Reference proteome {ECO:0000313|Proteomes:UP000233200}.
REGION 16..40
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 16..36
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 514 AA; 59035 MW; BF08C486057152D8 CRC64;
MSSSISKSRS LAAFLQQLRS PRQPPRPVTS TAYKSPQPRE VPVCPLTAGG ETQNAAALPG
PTSWPLLGSL LQILWKGGLK KQPDTLVEYH KKYGKIFRMK LGSFESVHLG SPCLLEALYR
TESAYPQRLE IKPWKAYRDY RKEGYGLLIL EGEDWQRVRS AFQKKLMKPV EVMKLDNKIN
EVLADFMGRI DELCDERGHI EDLYSELNKW SFESICLVLY EKRFGLLQKN AGDEAVNFIM
AIKTMMSTFG RMMVTPVELH KSLNTKVWQD HTLAWDTIFK SVKSCVDNRL EKYSQQPSAD
FLCDIYQQNR LSKKELYGAV TELQLAAVET TANSLMWILY NLSRNPKVQQ KLFKEIQSVL
PENQVPRAED LRNMPYLKAC LKESMRLTPS IPFTTRTLDK ATVLGEYALP KGTVLMLNTH
VLGSDEDNFE DSSQFRPERW LQEKEKINPF AHLPFGIGKR MCIGRRLAEL QLHLALCWIV
RKYDIQATDN EPVEMLHSGT LVPNRELPIV FIQR


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Bibliography :
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[31287590] On the relationship between VDR, RORα and RORγ receptors expression and HIF1-α levels in human melanomas.
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