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Cytochrome P450 family 24 subfamily A member 1

 F6YIY6_HORSE            Unreviewed;       514 AA.
F6YIY6;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
10-APR-2019, sequence version 2.
26-FEB-2020, entry version 50.
SubName: Full=Cytochrome P450 family 24 subfamily A member 1 {ECO:0000313|Ensembl:ENSECAP00000014163};
Name=CYP24A1 {ECO:0000313|Ensembl:ENSECAP00000014163,
ECO:0000313|VGNC:VGNC:50560};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000014163, ECO:0000313|Proteomes:UP000002281};
[1] {ECO:0000313|Ensembl:ENSECAP00000014163, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014163,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|Ensembl:ENSECAP00000014163}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000014163};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- SIMILARITY: Belongs to the cytochrome P450 family.
{ECO:0000256|RuleBase:RU000461}.
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PaxDb; F6YIY6; -.
Ensembl; ENSECAT00000017433; ENSECAP00000014163; ENSECAG00000016322.
VGNC; VGNC:50560; CYP24A1.
eggNOG; KOG0159; Eukaryota.
eggNOG; COG2124; LUCA.
GeneTree; ENSGT00950000182905; -.
HOGENOM; CLU_001570_28_1_1; -.
InParanoid; F6YIY6; -.
OrthoDB; 1273535at2759; -.
TreeFam; TF105094; -.
Proteomes; UP000002281; Chromosome 22.
Bgee; ENSECAG00000016322; Expressed in adult mammalian kidney.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0030342; F:1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity; IEA:Ensembl.
GO; GO:0008403; F:25-hydroxycholecalciferol-24-hydroxylase activity; IEA:Ensembl.
GO; GO:0020037; F:heme binding; IEA:InterPro.
GO; GO:0005506; F:iron ion binding; IEA:InterPro.
GO; GO:0070643; F:vitamin D 25-hydroxylase activity; IEA:Ensembl.
GO; GO:0001649; P:osteoblast differentiation; IEA:Ensembl.
GO; GO:0033280; P:response to vitamin D; IEA:Ensembl.
GO; GO:0042369; P:vitamin D catabolic process; IEA:Ensembl.
Gene3D; 1.10.630.10; -; 1.
InterPro; IPR001128; Cyt_P450.
InterPro; IPR017972; Cyt_P450_CS.
InterPro; IPR002401; Cyt_P450_E_grp-I.
InterPro; IPR036396; Cyt_P450_sf.
Pfam; PF00067; p450; 1.
PRINTS; PR00463; EP450I.
PRINTS; PR00385; P450.
SUPFAM; SSF48264; SSF48264; 1.
PROSITE; PS00086; CYTOCHROME_P450; 1.
3: Inferred from homology;
Heme {ECO:0000256|RuleBase:RU000461}; Iron {ECO:0000256|RuleBase:RU000461};
Metal-binding {ECO:0000256|RuleBase:RU000461};
Monooxygenase {ECO:0000256|RuleBase:RU000461};
Oxidoreductase {ECO:0000256|RuleBase:RU000461};
Reference proteome {ECO:0000313|Proteomes:UP000002281}.
SEQUENCE 514 AA; 58918 MW; A3F3B0EFEBAFD651 CRC64;
MTSPISKSRS LAAFLQQLRS LGQPPRAVTS RACAPAQPRE VPLCPLMERG EAQNAADLPG
PTKWPLLGSL LEILWKGGLK KQHDTLAEYH KKYGKIFRMK LGSFDSVHLG SPCLLEALYR
TESAHPQRLE IKPWKAYRDY RKEGYGLLIL EGEDWQRVRS AFQKKLMKPV EIMKLDNKIN
EVLADFVGRI DELCDERGHI EDLYSELNKW SFESICLVLY EKRFGLLQQN AGADALNFIA
AIKTMMSTFG RMMVTPVELH RTLNTRVWQA HTQAWDTIFK SVKSCVNNRL EKYSEQPSVD
FLCDIYHHNQ LSKKELYAAV TELQLAAVET TANSLMWLLY NLSRNPHVQQ KLLKEIQSVL
PENQIPQAED LRNMPYLKAC LKESMRLTPS VPFTTRTLDK AIVLGEYALP KGTVLMLNTQ
VLGSNEENFE NSSEFRPERW LQEKKKINAF AHLPFGVGKR MCIGRRLAEL QLHLAVCWII
RKYDIVATDN EPVEMLHLGI LVPSRELPIA FCQR


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Bibliography :
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[31287590] On the relationship between VDR, RORα and RORγ receptors expression and HIF1-α levels in human melanomas.
[30387187] miR-30a promoter variation contributes to the increased risk of colorectal cancer in an Iranian population.
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[29574006] A rapid screening of a recurrent CYP24A1 pathogenic variant opens the way to molecular testing for Idiopathic Infantile Hypercalcemia (IIH).
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