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Cytochrome b (Fragment)

 Q36560_THUTH            Unreviewed;       380 AA.
Q36560; Q36173;
01-NOV-1996, integrated into UniProtKB/TrEMBL.
01-NOV-1996, sequence version 1.
02-JUN-2021, entry version 118.
RecName: Full=Cytochrome b {ECO:0000256|RuleBase:RU362117};
Flags: Fragment;
Name=cyt b {ECO:0000313|EMBL:CAA57259.1};
Synonyms=Cyt b {ECO:0000313|EMBL:BAX09201.1},
CYTB {ECO:0000313|EMBL:AEI53237.1}, Cytb {ECO:0000313|EMBL:AAZ41994.1},
cytb {ECO:0000313|EMBL:ABF55617.1};
Thunnus thynnus (Atlantic bluefin tuna) (Scomber thynnus).
Mitochondrion {ECO:0000313|EMBL:CAA57259.1}.
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Pelagiaria; Scombriformes; Scombridae; Thunnus.
NCBI_TaxID=8237 {ECO:0000313|EMBL:CAA57259.1};
[1] {ECO:0000313|EMBL:CAA57259.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Liver {ECO:0000313|EMBL:CAA57259.1};
PubMed=7807548; DOI=10.1007/BF00160404;
Cantatore P, Roberti M, Pesole G, Ludovico A, Milella F, Gadaleta MNN,
Saccone C;
"Evolutionary analysis of cytochrome b sequences in some Perciformes:
evidence for a slower rate of evolution than in mammals.";
J. Mol. Evol. 39:589-597(1994).
[2] {ECO:0000313|EMBL:AAZ41994.1}
NUCLEOTIDE SEQUENCE.
STRAIN=ThuThy1CS {ECO:0000313|EMBL:AAZ41997.1},
ThuThy9m {ECO:0000313|EMBL:AAZ41998.1},
ThuThyMA2 {ECO:0000313|EMBL:AAZ41996.1},
ThuThyWM1 {ECO:0000313|EMBL:AAZ41994.1}, and
ThuThyWM2 {ECO:0000313|EMBL:AAZ41995.1};
Schonhuth S.I., Bautista J.M., Gonzalez J.A.;
"Molecular phylogeny of Scombridae inferred from nuclear and mitochondrial
sequences.";
Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|EMBL:ABF55617.1}
NUCLEOTIDE SEQUENCE.
STRAIN=TH1 {ECO:0000313|EMBL:ABF55617.1},
TH2 {ECO:0000313|EMBL:ABF55618.1}, TH3 {ECO:0000313|EMBL:ABF55619.1},
TH4 {ECO:0000313|EMBL:ABF55620.1}, and TH5 {ECO:0000313|EMBL:ABF55621.1};
Kuo C.-H., Jean C.-T.;
"Phylogenetic Relationships of Scombridae in Taiwan Inferred from mtDNA
Cytochrome b Gene Sequences.";
Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:ABO30961.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Muscle {ECO:0000313|EMBL:ABO30961.1};
FishTrace;
Gonzalez-Sevilla R., Perez-Benevente S., Gonzalez J.A., Jimenez S.,
Diez A., Bautista J.M.;
"FishTrace: Genetic Catalogue, Biological Reference Collections and Online
Database of European Marine Fishes (www.fishtrace.org).";
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
[5] {ECO:0000313|EMBL:ABO43156.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Muscle {ECO:0000313|EMBL:ABO43156.1};
Gonzalez-Sevilla R., Perez-Benavente S., Gonzalez J.A., Jimenez S.,
Diez A., Bautista J.M.;
"FishTrace: Genetic Catalogue, Biological Reference Collections and Online
Database of European Marine Fishes (www.fishtrace.org).";
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
[6] {ECO:0000313|EMBL:ABO43331.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Muscle {ECO:0000313|EMBL:ABO43331.1};
Gonzalez-Sevilla R., Perez-Benavente S., Biscoito M., Diez A.,
Bautista J.M.;
"FishTrace: Genetic Catalogue, Biological Reference Collections and Online
Database of European Marine Fishes (www.fishtrace.org).";
Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
[7] {ECO:0000313|EMBL:ABS85053.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Muscle {ECO:0000313|EMBL:ABS85053.1};
FishTrace;
Krey G., Favre-Krey L., Leontarakis P., Tsangridis A.;
"The sequence of the cytochrome b gene from 50 marine fish species of the
North Aegean Sea (Eastern Mediterranean).";
Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
[8] {ECO:0000313|EMBL:ABN47207.1}
NUCLEOTIDE SEQUENCE.
Lin W.-F., Hwang D.-F.;
"A multiplex PCR assay for species identification of raw and cooked
bonito.";
Food Control 19:879-885(2008).
[9] {ECO:0000313|EMBL:ADA69821.1}
NUCLEOTIDE SEQUENCE.
Martinez Ibarra C., Ishizaki S., Nagashima Y.;
"Development of a PCR-based method for differentiation of tuna and related
species in canned products.";
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
[10] {ECO:0000313|EMBL:AHH80754.1}
NUCLEOTIDE SEQUENCE.
PubMed=24438291;
Li Y., Chen C., Yu H., Peng S., Sun S., Wang L., Meng X., Huang Y.,
Kong X.;
"The complete mitochondrial genome of the juvenile Atlantic bluefin tuna
Thunnus thynnus (Perciformes, Scombridae).";
Mitochondrial DNA 0:0-0(2014).
[11] {ECO:0000313|EMBL:BAX09201.1}
NUCLEOTIDE SEQUENCE.
PubMed=27604148; DOI=10.1186/s12864-016-3054-y;
Satoh T.P., Miya M., Mabuchi K., Nishida M.;
"Structure and variation of the mitochondrial genome of fishes.";
BMC Genomics 17:719-719(2016).
[12] {ECO:0000313|EMBL:AXE43005.1}
NUCLEOTIDE SEQUENCE.
STRAIN=TH1 {ECO:0000313|EMBL:AXE43005.1};
Banno H., Chua N.-H.;
Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
[13] {ECO:0000313|EMBL:AXE43005.1}
NUCLEOTIDE SEQUENCE.
STRAIN=TH1 {ECO:0000313|EMBL:AXE43005.1};
Lee Y.-H., Yen T.-B., Chen C.-F., Tseng M.-C.;
"Variation in the Karyotype, Cytochrome b Gene, and 5S rDNA of Four Thunnus
(Perciformes, Scombridae) Tunas.";
Zool. Stud. 57:34-34(2018).
[14] {ECO:0000313|EMBL:QNM99596.1}
NUCLEOTIDE SEQUENCE.
STRAIN=DM353 {ECO:0000313|EMBL:QNM99596.1};
Margaryan A.;
"DNAmark Project.";
Submitted (APR-2020) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Component of the ubiquinol-cytochrome c reductase complex
(complex III or cytochrome b-c1 complex) that is part of the
mitochondrial respiratory chain. The b-c1 complex mediates electron
transfer from ubiquinol to cytochrome c. Contributes to the generation
of a proton gradient across the mitochondrial membrane that is then
used for ATP synthesis. {ECO:0000256|ARBA:ARBA00002566,
ECO:0000256|RuleBase:RU362117}.
-!- COFACTOR:
Name=heme; Xref=ChEBI:CHEBI:30413;
Evidence={ECO:0000256|ARBA:ARBA00001971};
-!- COFACTOR:
Name=heme; Xref=ChEBI:CHEBI:30413;
Evidence={ECO:0000256|PIRSR:PIRSR038885-2,
ECO:0000256|RuleBase:RU362117};
Note=Binds 2 heme groups non-covalently.
{ECO:0000256|PIRSR:PIRSR038885-2, ECO:0000256|RuleBase:RU362117};
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
inner membrane {ECO:0000256|ARBA:ARBA00004448,
ECO:0000256|RuleBase:RU362117}; Multi-pass membrane protein
{ECO:0000256|ARBA:ARBA00004448}.
-!- SIMILARITY: Belongs to the cytochrome b family.
{ECO:0000256|RuleBase:RU362117}.
---------------------------------------------------------------------------
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EMBL; DQ080266; AAZ41994.1; -; Genomic_DNA.
EMBL; DQ080267; AAZ41995.1; -; Genomic_DNA.
EMBL; DQ080268; AAZ41996.1; -; Genomic_DNA.
EMBL; DQ080269; AAZ41997.1; -; Genomic_DNA.
EMBL; DQ080270; AAZ41998.1; -; Genomic_DNA.
EMBL; DQ497905; ABF55617.1; -; Genomic_DNA.
EMBL; DQ497906; ABF55618.1; -; Genomic_DNA.
EMBL; DQ497907; ABF55619.1; -; Genomic_DNA.
EMBL; DQ497908; ABF55620.1; -; Genomic_DNA.
EMBL; DQ497909; ABF55621.1; -; Genomic_DNA.
EMBL; EF141185; ABN47207.1; -; Genomic_DNA.
EMBL; EF427611; ABO30961.1; -; Genomic_DNA.
EMBL; EF427612; ABO30962.1; -; Genomic_DNA.
EMBL; EF439608; ABO43156.1; -; Genomic_DNA.
EMBL; EF439609; ABO43157.1; -; Genomic_DNA.
EMBL; EF439242; ABO43331.1; -; Genomic_DNA.
EMBL; EF439243; ABO43332.1; -; Genomic_DNA.
EMBL; EU036522; ABS85053.1; -; Genomic_DNA.
EMBL; EU036523; ABS85054.1; -; Genomic_DNA.
EMBL; GU256522; ADA69821.1; -; Genomic_DNA.
EMBL; JN086149; AEI53237.1; -; Genomic_DNA.
EMBL; KF906720; AHH80754.1; -; Genomic_DNA.
EMBL; MG017705; AXE43005.1; -; Genomic_DNA.
EMBL; AP006034; BAX09201.1; -; Genomic_DNA.
EMBL; X81563; CAA57259.1; -; Genomic_DNA.
EMBL; MT410869; QNM99596.1; -; Genomic_DNA.
RefSeq; YP_003587407.1; NC_014052.1.
SMR; Q36560; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO; GO:0045275; C:respiratory chain complex III; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
GO; GO:0008121; F:ubiquinol-cytochrome-c reductase activity; IEA:InterPro.
GO; GO:0022904; P:respiratory electron transport chain; IEA:InterPro.
CDD; cd00290; cytochrome_b_C; 1.
CDD; cd00284; Cytochrome_b_N; 1.
Gene3D; 1.20.810.10; -; 1.
InterPro; IPR005798; Cyt_b/b6_C.
InterPro; IPR036150; Cyt_b/b6_C_sf.
InterPro; IPR005797; Cyt_b/b6_N.
InterPro; IPR027387; Cytb/b6-like_sf.
InterPro; IPR030689; Cytochrome_b.
InterPro; IPR016174; Di-haem_cyt_TM.
Pfam; PF00032; Cytochrom_B_C; 1.
Pfam; PF00033; Cytochrome_B; 1.
PIRSF; PIRSF038885; COB; 1.
SUPFAM; SSF81342; SSF81342; 1.
SUPFAM; SSF81648; SSF81648; 1.
PROSITE; PS51003; CYTB_CTER; 1.
PROSITE; PS51002; CYTB_NTER; 1.
3: Inferred from homology;
Electron transport {ECO:0000256|ARBA:ARBA00022660,
ECO:0000256|RuleBase:RU362117};
Heme {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR038885-2};
Iron {ECO:0000256|ARBA:ARBA00022617, ECO:0000256|PIRSR:PIRSR038885-2};
Membrane {ECO:0000256|ARBA:ARBA00022792, ECO:0000256|ARBA:ARBA00022989,
ECO:0000256|RuleBase:RU362117};
Metal-binding {ECO:0000256|ARBA:ARBA00022617,
ECO:0000256|PIRSR:PIRSR038885-2};
Mitochondrion {ECO:0000256|ARBA:ARBA00022792};
Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792};
Respiratory chain {ECO:0000256|ARBA:ARBA00022660,
ECO:0000256|RuleBase:RU362117};
Transmembrane {ECO:0000256|ARBA:ARBA00022989,
ECO:0000256|RuleBase:RU362117};
Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
ECO:0000256|RuleBase:RU362117};
Transport {ECO:0000256|ARBA:ARBA00022660, ECO:0000256|RuleBase:RU362117};
Ubiquinone {ECO:0000256|ARBA:ARBA00023075}.
TRANSMEM 30..56
/note="Helical"
/evidence="ECO:0000256|RuleBase:RU362117"
TRANSMEM 77..98
/note="Helical"
/evidence="ECO:0000256|RuleBase:RU362117"
TRANSMEM 113..133
/note="Helical"
/evidence="ECO:0000256|RuleBase:RU362117"
TRANSMEM 145..166
/note="Helical"
/evidence="ECO:0000256|RuleBase:RU362117"
TRANSMEM 178..200
/note="Helical"
/evidence="ECO:0000256|RuleBase:RU362117"
TRANSMEM 229..250
/note="Helical"
/evidence="ECO:0000256|RuleBase:RU362117"
TRANSMEM 288..308
/note="Helical"
/evidence="ECO:0000256|RuleBase:RU362117"
TRANSMEM 320..341
/note="Helical"
/evidence="ECO:0000256|RuleBase:RU362117"
TRANSMEM 347..372
/note="Helical"
/evidence="ECO:0000256|RuleBase:RU362117"
DOMAIN 1..209
/note="CYTB_NTER"
/evidence="ECO:0000259|PROSITE:PS51002"
DOMAIN 210..380
/note="CYTB_CTER"
/evidence="ECO:0000259|PROSITE:PS51003"
METAL 83
/note="Iron 1 (heme b562 axial ligand)"
/evidence="ECO:0000256|PIRSR:PIRSR038885-2"
METAL 97
/note="Iron 2 (heme b566 axial ligand)"
/evidence="ECO:0000256|PIRSR:PIRSR038885-2"
METAL 182
/note="Iron 1 (heme b562 axial ligand)"
/evidence="ECO:0000256|PIRSR:PIRSR038885-2"
METAL 196
/note="Iron 2 (heme b566 axial ligand)"
/evidence="ECO:0000256|PIRSR:PIRSR038885-2"
BINDING 201
/note="Ubiquinone"
/evidence="ECO:0000256|PIRSR:PIRSR038885-1"
NON_TER 380
/evidence="ECO:0000313|EMBL:CAA57259.1"
SEQUENCE 380 AA; 42446 MW; 6DAA7728D07BC488 CRC64;
MASLRKTHPL LKIANDALVD LPTPSNISAW WNFGSLLGLC LISQILTGLF LAMHYTPDVE
SAFASVAHIC RDVNFGWLIR NLHANGASFF FICIYFHIGR GLYYGSYLYK ETWNIGVVLL
LLVMMTAFVG YVLPWGQMSF WGATVITNLL SAVPYVGTTL VEWIWGGFSV DNATLTRFFA
FHFLFPFVIA AMTILHLLFL HETGSNNPIG LNSNADKISF HPYFSYKDLL GFVILLVALA
SLALFSPNLL GDPDNFTPAN PMVTPPHIKP EWYFLFAYAI LRSIPNKLGG VLALLASILV
LMVVPFLHTS KQRTLTFRPV SQFLFWTLIA DVAILTWIGG MPAEQPFIII GQVASVLYFS
LFLVFFPLAG WAENKILGWS


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[CYB5R4 NCB5OR] Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R)
[APP A4 AD1] Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
[App] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (APP-C99) (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (APP-C59) (Amyloid intracellular domain 59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (APP-C57) (Amyloid intracellular domain 57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AID(50)) (Gamma-CTF(50)); C31]
[Cyb5r4 Ncb5or] Cytochrome b5 reductase 4 (EC 1.6.2.2) (Flavohemoprotein b5/b5R) (b5+b5R) (N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein) (cb5/cb5R)
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF) (CTF-beta); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF) (CTF-alpha); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[APP] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[App] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) (Amyloidogenic glycoprotein) (AG) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[APP QccE-15949] Amyloid-beta A4 protein (ABPP) (APP) (Alzheimer disease amyloid A4 protein homolog) (Amyloid precursor protein) (Amyloid-beta precursor protein) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Gamma-CTF(50)); C31]
[C3 CPAMD1] Complement C3 (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[C3] Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc) (Neutrophil chemotactic factor-2) (ENCF-2); Complement C3 alpha chain; C3a anaphylatoxin (Neutrophil chemotactic factor-1) (ENCF-1); Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[C3] Complement C3 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; C3-beta-c (C3bc); Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[C3] Complement C3 (HSE-MSF) [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[c3] Complement C3 [Cleaved into: Complement C3 beta chain; Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2] (Fragment)
[C3] Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[C3] Complement C3 [Cleaved into: Complement C3 beta chain; C3-beta-c (C3bc); Complement C3 alpha chain; C3a anaphylatoxin; Acylation stimulating protein (ASP) (C3adesArg); Complement C3b alpha' chain; Complement C3c alpha' chain fragment 1; Complement C3dg fragment; Complement C3g fragment; Complement C3d fragment; Complement C3f fragment; Complement C3c alpha' chain fragment 2]
[MYOC GLC1A TIGR] Myocilin (Myocilin 55 kDa subunit) (Trabecular meshwork-induced glucocorticoid response protein) [Cleaved into: Myocilin, N-terminal fragment (Myocilin 20 kDa N-terminal fragment); Myocilin, C-terminal fragment (Myocilin 35 kDa N-terminal fragment)]
[ADGRG1 GPR56 TM7LN4 TM7XN1 UNQ540/PRO1083] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Protein TM7XN1) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[Adgrg1 Cyt28 Gpr56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) (Serpentine receptor cyt28) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1-CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[Adgrg1 Gpr56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]
[ADGRG1 GPR56] Adhesion G-protein coupled receptor G1 (G-protein coupled receptor 56) [Cleaved into: ADGRG1 N-terminal fragment (ADGRG1 NT) (GPR56 N-terminal fragment) (GPR56 NT) (GPR56(N)) (GPR56 extracellular subunit) (GPR56 subunit alpha); ADGRG1 C-terminal fragment (ADGRG1 CT) (GPR56 C-terminal fragment) (GPR56 CT) (GPR56(C)) (GPR56 seven-transmembrane subunit) (GPR56 7TM) (GPR56 subunit beta)]

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