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Cytochrome c oxidase subunit 8A, mitochondrial (Cytochrome c oxidase polypeptide VIII-liver/heart) (Cytochrome c oxidase subunit 8-2)

 COX8A_SAISC             Reviewed;          69 AA.
Q863G5;
16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
25-OCT-2017, entry version 58.
RecName: Full=Cytochrome c oxidase subunit 8A, mitochondrial;
AltName: Full=Cytochrome c oxidase polypeptide VIII-liver/heart;
AltName: Full=Cytochrome c oxidase subunit 8-2;
Flags: Precursor;
Name=COX8A; Synonyms=COX8, COX8L;
Saimiri sciureus (Common squirrel monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Platyrrhini; Cebidae; Saimiriinae; Saimiri.
NCBI_TaxID=9521;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=12716970; DOI=10.1073/pnas.0931463100;
Goldberg A., Wildman D.E., Schmidt T.R., Huttemann M., Goodman M.,
Weiss M.L., Grossman L.I.;
"Adaptive evolution of cytochrome c oxidase subunit VIII in anthropoid
primates.";
Proc. Natl. Acad. Sci. U.S.A. 100:5873-5878(2003).
-!- FUNCTION: This protein is one of the nuclear-coded polypeptide
chains of cytochrome c oxidase, the terminal oxidase in
mitochondrial electron transport.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane.
-!- SIMILARITY: Belongs to the cytochrome c oxidase VIII family.
{ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; AY254821; AAP32252.1; -; mRNA.
ProteinModelPortal; Q863G5; -.
SMR; Q863G5; -.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
GO; GO:0004129; F:cytochrome-c oxidase activity; IEA:InterPro.
Gene3D; 4.10.81.10; -; 1.
InterPro; IPR003205; Cyt_c_oxidase_su8.
InterPro; IPR036548; Cyt_c_oxidase_su8_sf.
PANTHER; PTHR16717; PTHR16717; 1.
Pfam; PF02285; COX8; 1.
SUPFAM; SSF81431; SSF81431; 1.
3: Inferred from homology;
Membrane; Mitochondrion; Mitochondrion inner membrane;
Transit peptide; Transmembrane; Transmembrane helix.
TRANSIT 1 25 Mitochondrion. {ECO:0000250}.
CHAIN 26 69 Cytochrome c oxidase subunit 8A,
mitochondrial.
/FTId=PRO_0000006196.
TOPO_DOM 26 36 Mitochondrial matrix. {ECO:0000250}.
TRANSMEM 37 60 Helical. {ECO:0000250}.
TOPO_DOM 61 69 Mitochondrial intermembrane.
{ECO:0000250}.
SEQUENCE 69 AA; 7539 MW; EBE9775D463C9E41 CRC64;
MSVLTPLLLR GLTGSARRLP VPRAQVHSMP PEQKLGVLEL AIGFTSCLVT FLLPAGWILS
HLDSYKKRG


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EIAAB08787 Cox8b,Cox8h,Cytochrome c oxidase polypeptide VIII-heart,Cytochrome c oxidase subunit 8-1,Cytochrome c oxidase subunit 8B, mitochondrial,Cytochrome c oxidase subunit 8H,Mouse,Mus musculus
EIAAB08788 Cox8b,Cox8h,Cytochrome c oxidase polypeptide VIII-heart,Cytochrome c oxidase subunit 8-1,Cytochrome c oxidase subunit 8B, mitochondrial,Cytochrome c oxidase subunit 8H,Rat,Rattus norvegicus
EIAAB08789 COX8B,COX8H,Cytochrome c oxidase polypeptide VIII-liver_heart,Cytochrome c oxidase subunit 8-1,Cytochrome c oxidase subunit 8B, mitochondrial,Cytochrome c oxidase subunit 8H,Oryctolagus cuniculus,Rabb
EIAAB08782 Bos taurus,Bovine,COX8,COX8A,COX8L,Cytochrome c oxidase polypeptide VIII-liver,Cytochrome c oxidase subunit 8-2,Cytochrome c oxidase subunit 8A, mitochondrial,IX
EIAAB08783 Cox8,Cox8a,Cox8l,Cytochrome c oxidase polypeptide VIII-liver,Cytochrome c oxidase subunit 8-2,Cytochrome c oxidase subunit 8A, mitochondrial,Rat,Rattus norvegicus
EIAAB08784 Cox8,Cox8a,Cox8l,Cytochrome c oxidase polypeptide VIII-liver,Cytochrome c oxidase subunit 8-2,Cytochrome c oxidase subunit 8A, mitochondrial,Mouse,Mus musculus
EIAAB08786 Canis familiaris,Canis lupus familiaris,COX8B,COX8H,Cytochrome c oxidase polypeptide VIII-heart,Cytochrome c oxidase subunit 8-1,Cytochrome c oxidase subunit 8B, mitochondrial,Cytochrome c oxidase sub
EIAAB08781 COX8,COX8A,COX8L,Cytochrome c oxidase polypeptide VIII-liver_heart,Cytochrome c oxidase subunit 8-2,Cytochrome c oxidase subunit 8A, mitochondrial,Homo sapiens,Human
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EIAAB08791 COX VIII-3,COX8C,Cytochrome c oxidase polypeptide 8 isoform 3,Cytochrome c oxidase polypeptide VIII isoform 3,Cytochrome c oxidase subunit 8-3,Cytochrome c oxidase subunit 8C, mitochondrial,Homo sapie
EIAAB10082 COX VIa-L,COX6A1,COX6AL,Cytochrome c oxidase polypeptide VIa-liver,Cytochrome c oxidase subunit 6A1, mitochondrial,Cytochrome c oxidase subunit VIA-liver,Homo sapiens,Human
EIAAB10080 Bos taurus,Bovine,COX6A1,Cytochrome c oxidase polypeptide VIa-liver,Cytochrome c oxidase subunit 6A1, mitochondrial,Cytochrome c oxidase subunit SSG
EIAAB10087 Bos taurus,Bovine,COX6A,COX6A2,COXVIAH,Cytochrome c oxidase polypeptide VIa-heart,Cytochrome c oxidase polypeptide VIb,Cytochrome c oxidase subunit 6A2, mitochondrial
EIAAB08780 Canis familiaris,Canis lupus familiaris,COX8A,Cytochrome c oxidase polypeptide VIII-liver,Cytochrome c oxidase subunit 8-2,Cytochrome c oxidase subunit 8A, mitochondrial,Dog
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EIAAB08792 COX VIII-3,Cox8c,Cytochrome c oxidase polypeptide 8 isoform 3,Cytochrome c oxidase polypeptide VIII isoform 3,Cytochrome c oxidase subunit 8-3,Cytochrome c oxidase subunit 8C, mitochondrial,Mouse,Mus
EIAAB10099 Bos taurus,Bovine,COX7A,COX7A1,COX7AH,Cytochrome c oxidase subunit 7A1, mitochondrial,Cytochrome c oxidase subunit VIIa-H,Cytochrome c oxidase subunit VIIa-heart,Cytochrome c oxidase subunit VIIa-M,Cy
EIAAB10102 Cox7a,Cox7a1,Cox7ah,Cytochrome c oxidase subunit 7A1, mitochondrial,Cytochrome c oxidase subunit VIIa-H,Cytochrome c oxidase subunit VIIa-heart,Cytochrome c oxidase subunit VIIa-M,Cytochrome c oxidase
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EIAAB10105 COX7A2,COX7AL,Cytochrome c oxidase subunit 7A2, mitochondrial,Cytochrome c oxidase subunit VIIaL,Cytochrome c oxidase subunit VIIa-L,Cytochrome c oxidase subunit VIIa-liver_heart,Homo sapiens,Human
EIAAB10091 Bos taurus,Bovine,COX VIb-1,COX6B,COX6B1,Cytochrome c oxidase polypeptide VII,Cytochrome c oxidase subunit 6B1,Cytochrome c oxidase subunit AED,Cytochrome c oxidase subunit VIb isoform 1
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EIAAB08759 Cox5b,Cytochrome c oxidase polypeptide Vb,Cytochrome c oxidase subunit 5B, mitochondrial,Cytochrome c oxidase subunit VIA*,Rat,Rattus norvegicus

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Pathways :
WP1502: Mitochondrial biogenesis
WP1077: cytochrome P450
WP1194: cytochrome P450
WP1219: cytochrome P450
WP1274: cytochrome P450
WP1390: cytochrome P450
WP2316: PPAR signaling pathway
WP2430: Quercetin metabolism
WP43: cytochrome P450
WP617: Ureide biosynthesis
WP626: Abscisic Acid Biosynthesis
WP677: Momilactone biosynthesis
WP696: Benzo(a)pyrene metabolism
WP958: cytochrome P450
WP1566: Citrate cycle (TCA cycle)
WP1614: 1- and 2-Methylnaphthalene degradation
WP1626: Benzoate degradation via CoA ligation
WP1634: Butanoate metabolism
WP1644: DNA replication
WP1655: Geraniol degradation
WP1663: Homologous recombination
WP1671: Methane metabolism
WP1672: Mismatch repair
WP1680: Oxidative phosphorylation
WP1693: Purine metabolism

Related Genes :
[COX8A COX8 COX8L] Cytochrome c oxidase subunit 8A, mitochondrial (Cytochrome c oxidase polypeptide VIII-liver) (Cytochrome c oxidase subunit 8-2) (IX)
[COQ8A ADCK3 CABC1 PP265] Atypical kinase COQ8A, mitochondrial (EC 2.7.-.-) (Chaperone activity of bc1 complex-like) (Chaperone-ABC1-like) (Coenzyme Q protein 8A) (aarF domain-containing protein kinase 3)
[LRRC8A KIAA1437 LRRC8 SWELL1 UNQ221/PRO247] Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A) (Swelling protein 1)
[RBM8A RBM8 HSPC114 MDS014] RNA-binding protein 8A (Binder of OVCA1-1) (BOV-1) (RNA-binding motif protein 8A) (RNA-binding protein Y14) (Ribonucleoprotein RBM8A)
[ST8SIA1 SIAT8 SIAT8A] Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.99.8) (Alpha-2,8-sialyltransferase 8A) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Sialyltransferase 8A) (SIAT8-A) (Sialyltransferase St8Sia I) (ST8SiaI)
[ATP8A2 ATPIB] Phospholipid-transporting ATPase IB (EC 7.6.2.1) (ATPase class I type 8A member 2) (ML-1) (P4-ATPase flippase complex alpha subunit ATP8A2)
[st8sia1 siat8a] Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.99.8) (Alpha-2,8-sialyltransferase 8A) (Ganglioside GD3 synthase) (XlGD3 synthase) (Sialyltransferase 8A) (SIAT8-A) (Sialyltransferase St8Sia I) (ST8SiaI)
[Lrrc8a Lrrc8] Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A)
[St8sia1 Siat8 Siat8a] Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (EC 2.4.99.8) (Alpha-2,8-sialyltransferase 8A) (Ganglioside GD3 synthase) (Ganglioside GT3 synthase) (Sialyltransferase 8A) (SIAT8-A) (Sialyltransferase St8Sia I) (ST8SiaI)
[Pde8a Pde8] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (MmPDE8) (EC 3.1.4.53)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[Lrrc8a Lrrc8] Volume-regulated anion channel subunit LRRC8A (Leucine-rich repeat-containing protein 8A)
[PDE8A] High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (EC 3.1.4.53)
[PRP8A EMB14 EMB177 EMB33 SOF81 SUS2 At1g80070 F18B13.15] Pre-mRNA-processing-splicing factor 8A (PRP8 homolog A) (AtPRP8A) (Protein ABNORMAL SUSPENSOR 2) (Protein EMBRYO DEFECTIVE 14) (Protein EMBRYO DEFECTIVE 177) (Protein EMBRYO DEFECTIVE 33) (Protein SUPPRESSOR OF OVEREXPRESSED FCA 81)
[COX8B COX8H] Cytochrome c oxidase subunit 8B, mitochondrial (Cytochrome c oxidase polypeptide VIII-heart) (Cytochrome c oxidase subunit 8-1) (Cytochrome c oxidase subunit 8H) (IX) (VIIIb)
[Rab8a Mel Rab8] Ras-related protein Rab-8A (Oncogene c-mel)
[RAB8A MEL RAB8] Ras-related protein Rab-8A (Oncogene c-mel)
[Rbm8a Rbm8] RNA-binding protein 8A (RNA-binding motif protein 8A) (Ribonucleoprotein RBM8A)
[CD8A MAL] T-cell surface glycoprotein CD8 alpha chain (T-lymphocyte differentiation antigen T8/Leu-2) (CD antigen CD8a)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[Cd8a Lyt-2 Lyt2] T-cell surface glycoprotein CD8 alpha chain (T-cell surface glycoprotein Lyt-2) (CD antigen CD8a)
[Rab8a Rab8] Ras-related protein Rab-8A
[RAB8A MEL RAB8] Ras-related protein Rab-8A (Oncogene c-mel)
[cox-2 cox2 oxi1 NCM018 NCU16028] Cytochrome c oxidase subunit 2 (EC 1.9.3.1) (Cytochrome c oxidase polypeptide II)
[Scn8a Nbna1] Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)
[SCN8A MED] Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)
[COX4 YGL187C G1362] Cytochrome c oxidase subunit 4, mitochondrial (EC 1.9.3.1) (Cytochrome c oxidase polypeptide IV)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]

Bibliography :
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