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Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)

 IL2RG_HUMAN             Reviewed;         369 AA.
P31785; Q5FC12;
01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
01-JUL-1993, sequence version 1.
12-AUG-2020, entry version 224.
RecName: Full=Cytokine receptor common subunit gamma;
AltName: Full=Interleukin-2 receptor subunit gamma;
Short=IL-2 receptor subunit gamma;
Short=IL-2R subunit gamma;
Short=IL-2RG;
AltName: Full=gammaC;
AltName: Full=p64;
AltName: CD_antigen=CD132;
Flags: Precursor;
Name=IL2RG;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND PARTIAL PROTEIN SEQUENCE.
PubMed=1631559; DOI=10.1126/science.1631559;
Takeshita T., Asao H., Ohtani K., Ishii N., Kumaki S., Tanaka N.,
Munakata H., Nakamura M., Sugamura K.;
"Cloning of the gamma chain of the human IL-2 receptor.";
Science 257:379-382(1992).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Liver;
PubMed=8514792;
Noguchi M., Adelstein S., Cao X., Leonard W.J.;
"Characterization of the human interleukin-2 receptor gamma chain gene.";
J. Biol. Chem. 268:13601-13608(1993).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS XSCID ASP-114 AND ASN-153.
PubMed=8401490; DOI=10.1093/hmg/2.8.1099;
Puck J.M., Deschenes S.M., Porter J.C., Dutra A.S., Brown C.J., Willard H.,
Henthorn P.S.;
"The interleukin-2 receptor gamma chain maps to Xq13.1 and is mutated in X-
linked severe combined immunodeficiency, SCIDX1.";
Hum. Mol. Genet. 2:1099-1104(1993).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Hayashi A., Sameshima E., Tabata Y., Iida K., Mitsuyama M., Kanai S.,
Furuya T., Saito T.;
"IL2RG mRNA, nirs splice variant 2.";
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT LYS-109.
SeattleSNPs variation discovery resource;
Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15772651; DOI=10.1038/nature03440;
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D.,
Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L.,
Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.,
Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A.,
Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P.,
Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D.,
Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D.,
Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L.,
Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P.,
Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G.,
Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J.,
Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D.,
Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L.,
Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z.,
Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S.,
Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S.,
Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O.,
Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H.,
Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T.,
Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L.,
Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R.,
Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y.,
Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K.,
Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J.,
Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L.,
Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S.,
Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A.,
Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L.,
Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D.,
Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H.,
McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S.,
Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C.,
Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S.,
Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V.,
Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K.,
Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K.,
Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D.,
Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R.,
Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B.,
Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C.,
d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q.,
Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N.,
Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A.,
Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J.,
Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A.,
Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F.,
Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L.,
Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S.,
Rogers J., Bentley D.R.;
"The DNA sequence of the human X chromosome.";
Nature 434:325-337(2005).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=B-cell;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
IDENTIFICATION AS A IL4R SUBUNIT.
PubMed=8266076; DOI=10.1126/science.8266076;
Kondo M., Takeshita T., Ishii N., Nakamura M., Watanabe S., Arai K.,
Sugamura K.;
"Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors
for IL-2 and IL-4.";
Science 262:1874-1877(1993).
[9]
IDENTIFICATION AS A IL4R SUBUNIT.
PubMed=8266078; DOI=10.1126/science.8266078;
Russell S.M., Kkegan A.D., Harada N., Nakamura Y., Noguchi M., Leland P.,
Friedmann M.C., Miyajima A., Puri R.K., Paul W.E., Leonard W.J.;
"Interleukin-2 receptor gamma chain: a functional component of the
interleukin-4 receptor.";
Science 262:1880-1883(1993).
[10]
IDENTIFICATION AS A IL7R SUBUNIT.
PubMed=8266077; DOI=10.1126/science.8266077;
Noguchi M., Nakamura Y., Russell S.M., Ziegler S.F., Tsang M., Cao X.,
Leonard W.J.;
"Interleukin-2 receptor gamma chain: a functional component of the
interleukin-7 receptor.";
Science 262:1877-1880(1993).
[11]
INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I (MICROBIAL INFECTION).
PubMed=8648694;
Mulloy J.C., Crownley R.W., Fullen J., Leonard W.J., Franchini G.;
"The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the
interleukin-2 receptor beta and gammac chains and affects their expression
on the cell surface.";
J. Virol. 70:3599-3605(1996).
[12]
INTERACTION WITH SHB.
PubMed=12200137; DOI=10.1016/s0006-291x(02)02016-8;
Lindholm C.K.;
"IL-2 receptor signaling through the Shb adapter protein in T and NK
cells.";
Biochem. Biophys. Res. Commun. 296:929-936(2002).
[13]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=15123770; DOI=10.1189/jlb.0605298;
Ratthe C., Girard D.;
"Interleukin-15 enhances human neutrophil phagocytosis by a Syk-dependent
mechanism: importance of the IL-15Ralpha chain.";
J. Leukoc. Biol. 76:162-168(2004).
[14]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-292, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Leukemic T-cell;
PubMed=19690332; DOI=10.1126/scisignal.2000007;
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
Rodionov V., Han D.K.;
"Quantitative phosphoproteomic analysis of T cell receptor signaling
reveals system-wide modulation of protein-protein interactions.";
Sci. Signal. 2:RA46-RA46(2009).
[15]
3D-STRUCTURE MODELING OF 57-248.
PubMed=7529123; DOI=10.1016/s0969-2126(94)00085-9;
Bamborough P., Hedgecock C.J., Richards W.G.;
"The interleukin-2 and interleukin-4 receptors studied by molecular
modelling.";
Structure 2:839-851(1994).
[16]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 56-254 IN COMPLEX WITH IL2; IL2RA
AND IL2RB, DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-71; ASN-84 AND
ASN-159.
PubMed=16293754; DOI=10.1126/science.1117893;
Wang X., Rickert M., Garcia K.C.;
"Structure of the quaternary complex of interleukin-2 with its alpha, beta,
and gammac receptors.";
Science 310:1159-1163(2005).
[17]
X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 23-255 IN COMPLEX WITH IL2; IL2RA
AND IL2RB, DISULFIDE BONDS, AND GLYCOSYLATION AT ASN-71; ASN-84 AND
ASN-159.
PubMed=16477002; DOI=10.1073/pnas.0511161103;
Stauber D.J., Debler E.W., Horton P.A., Smith K.A., Wilson I.A.;
"Crystal structure of the IL-2 signaling complex: paradigm for a
heterotrimeric cytokine receptor.";
Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793(2006).
[18]
VARIANTS XSCID PHE-115; CYS-240 AND ILE-241.
PubMed=8299698; DOI=10.1002/eji.1830240232;
Disanto J.P., Dautry-Varsat A., Certain S., Fischer A., de Saint Basile G.;
"Interleukin-2 (IL-2) receptor gamma chain mutations in X-linked severe
combined immunodeficiency disease result in the loss of high-affinity IL-2
receptor binding.";
Eur. J. Immunol. 24:475-479(1994).
[19]
VARIANT XSCID LYS-68.
PubMed=8088810; DOI=10.1006/geno.1994.1265;
Markiewicz S., Subtil A., Dautry-Varsat A., Fischer A., de Saint Basile G.;
"Detection of three nonsense mutations and one missense mutation in the
interleukin-2 receptor gamma chain gene in SCIDX1 that differently affect
the mRNA processing.";
Genomics 21:291-293(1994).
[20]
VARIANT XSCID HIS-162.
PubMed=8027558;
Ishii N., Asao H., Kimura Y., Takeshita T., Nakamura M., Tsuchiya S.,
Konno T., Maeda M., Uchiyama T., Sugamura K.;
"Impairment of ligand binding and growth signaling of mutant IL-2 receptor
gamma-chains in patients with X-linked severe combined immunodeficiency.";
J. Immunol. 153:1310-1317(1994).
[21]
VARIANT XSCID ASN-39.
PubMed=7937790; DOI=10.1073/pnas.91.20.9466;
Disanto J.P., Rieux-Laucat F., Dautry-Varsat A., Fischer A.,
de Saint Basile G.;
"Defective human interleukin 2 receptor gamma chain in an atypical X
chromosome-linked severe combined immunodeficiency with peripheral T
cells.";
Proc. Natl. Acad. Sci. U.S.A. 91:9466-9470(1994).
[22]
VARIANTS XSCID CYS-226 AND HIS-226.
PubMed=7668284;
Pepper A.E., Buckley R.H., Small T.N., Puck J.M.;
"Two mutational hotspots in the interleukin-2 receptor gamma chain gene
causing human X-linked severe combined immunodeficiency.";
Am. J. Hum. Genet. 57:564-571(1995).
[23]
VARIANT XSCID SER-183.
PubMed=7557965; DOI=10.1007/bf00191801;
Clark P.A., Lester T., Genet S., Jones A.M., Hendriks R., Levinsky R.L.,
Kinnon C.;
"Screening for mutations causing X-linked severe combined immunodeficiency
in the IL-2R gamma chain gene by single-strand conformation polymorphism
analysis.";
Hum. Genet. 96:427-432(1995).
[24]
VARIANT XSCID GLN-HIS-TRP-237 INS.
PubMed=7860773; DOI=10.1172/jci117740;
Puck J.M., Pepper A.E., Bedard P.-M., Laframboise R.;
"Female germ line mosaicism as the origin of a unique IL-2 receptor gamma-
chain mutation causing X-linked severe combined immunodeficiency.";
J. Clin. Invest. 95:895-899(1995).
[25]
VARIANT XCID GLN-293.
PubMed=7883965; DOI=10.1172/jci117765;
Schmalstieg F.C., Leonard W.J., Noguchi M., Berg M., Rudloff H.E.,
Denney R.M., Dave S.K., Brooks E.G., Goldman A.S.;
"Missense mutation in exon 7 of the common gamma chain gene causes a
moderate form of X-linked combined immunodeficiency.";
J. Clin. Invest. 95:1169-1173(1995).
[26]
VARIANT XSCID ARG-115.
PubMed=8900089; DOI=10.1056/nejm199611213352104;
Stephan V., Wahn V., Le Deist F., Dirksen U., Broeker B.,
Mueller-Fleckenstein I., Horneff G., Schroten H., Fischer A.,
de Saint Basile G.;
"Atypical X-linked severe combined immunodeficiency due to possible
spontaneous reversion of the genetic defect in T cells.";
N. Engl. J. Med. 335:1563-1567(1996).
[27]
VARIANT XSCID GLN-285.
PubMed=9150740; DOI=10.1007/s004390050428;
Jones A.M., Clark P.A., Katz F., Genet S., McMahon C., Alterman L.,
Cant A., Kinnon C.;
"B-cell-negative severe combined immunodeficiency associated with a common
gamma chain mutation.";
Hum. Genet. 99:677-680(1997).
[28]
VARIANT XSCID TRP-224.
PubMed=9049783; DOI=10.1023/a:1027332327827;
O'Marcaigh A.S., Puck J.M., Pepper A.E., De Santes K., Cowan M.J.;
"Maternal mosaicism for a novel interleukin-2 receptor gamma-chain mutation
causing X-linked severe combined immunodeficiency in a Navajo kindred.";
J. Clin. Immunol. 17:29-33(1997).
[29]
VARIANT XCID CYS-222.
PubMed=9399950; DOI=10.1172/jci119858;
Sharfe N., Shahar M., Roifman C.M.;
"An interleukin-2 receptor gamma chain mutation with normal thymus
morphology.";
J. Clin. Invest. 100:3036-3043(1997).
-!- FUNCTION: Common subunit for the receptors for a variety of
interleukins. Probably in association with IL15RA, involved in the
stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770).
{ECO:0000269|PubMed:15123770}.
-!- SUBUNIT: The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21
and probably also the IL13 receptors. Interacts with SHB upon
interleukin stimulation. {ECO:0000269|PubMed:12200137,
ECO:0000269|PubMed:16293754, ECO:0000269|PubMed:16477002}.
-!- SUBUNIT: (Microbial infection) Interacts with HTLV-1 accessory protein
p12I. {ECO:0000269|PubMed:8648694}.
-!- INTERACTION:
P31785; P13232: IL7; NbExp=2; IntAct=EBI-80475, EBI-80516;
P31785; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-80475, EBI-10171774;
P31785; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-80475, EBI-11987425;
P31785; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-80475, EBI-945833;
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15123770};
Single-pass type I membrane protein {ECO:0000255}. Cell surface
{ECO:0000269|PubMed:15123770}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=P31785-1; Sequence=Displayed;
Name=2;
IsoId=P31785-2; Sequence=VSP_047581, VSP_047582;
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-surface
receptor binding.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation.
-!- DISEASE: Severe combined immunodeficiency X-linked T-cell-negative/B-
cell-positive/NK-cell-negative (XSCID) [MIM:300400]: A form of severe
combined immunodeficiency (SCID), a genetically and clinically
heterogeneous group of rare congenital disorders characterized by
impairment of both humoral and cell-mediated immunity, leukopenia, and
low or absent antibody levels. Patients present in infancy recurrent,
persistent infections by opportunistic organisms. The common
characteristic of all types of SCID is absence of T-cell-mediated
cellular immunity due to a defect in T-cell development.
{ECO:0000269|PubMed:7557965, ECO:0000269|PubMed:7668284,
ECO:0000269|PubMed:7860773, ECO:0000269|PubMed:7937790,
ECO:0000269|PubMed:8027558, ECO:0000269|PubMed:8088810,
ECO:0000269|PubMed:8299698, ECO:0000269|PubMed:8401490,
ECO:0000269|PubMed:8900089, ECO:0000269|PubMed:9049783,
ECO:0000269|PubMed:9150740}. Note=The disease is caused by mutations
affecting the gene represented in this entry.
-!- DISEASE: X-linked combined immunodeficiency (XCID) [MIM:312863]: Less
severe form of X-linked immunodeficiency with a less severe degree of
deficiency in cellular and humoral immunity than that seen in XSCID.
{ECO:0000269|PubMed:7883965, ECO:0000269|PubMed:9399950}. Note=The
disease is caused by mutations affecting the gene represented in this
entry.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
subfamily. {ECO:0000305}.
-!- WEB RESOURCE: Name=IL2RGbase; Note=X-linked SCID mutation database;
URL="http://research.nhgri.nih.gov/scid/";
-!- WEB RESOURCE: Name=SeattleSNPs;
URL="http://pga.gs.washington.edu/data/il2rg/";
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EMBL; D11086; BAA01857.1; -; mRNA.
EMBL; L12183; AAA59145.1; -; Genomic_DNA.
EMBL; L12178; AAA59145.1; JOINED; Genomic_DNA.
EMBL; L12176; AAA59145.1; JOINED; Genomic_DNA.
EMBL; L12177; AAA59145.1; JOINED; Genomic_DNA.
EMBL; L12179; AAA59145.1; JOINED; Genomic_DNA.
EMBL; L12180; AAA59145.1; JOINED; Genomic_DNA.
EMBL; L12181; AAA59145.1; JOINED; Genomic_DNA.
EMBL; L12182; AAA59145.1; JOINED; Genomic_DNA.
EMBL; L19546; AAC37524.1; -; Genomic_DNA.
EMBL; AB102794; BAD89385.1; -; mRNA.
EMBL; AY692262; AAT85803.1; -; Genomic_DNA.
EMBL; AL590764; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC014972; AAH14972.1; -; mRNA.
CCDS; CCDS14406.1; -. [P31785-1]
PIR; A42565; A42565.
RefSeq; NP_000197.1; NM_000206.2. [P31785-1]
PDB; 1ILL; Model; -; G=57-248.
PDB; 1ILM; Model; -; G=57-248.
PDB; 1ILN; Model; -; G=57-248.
PDB; 1ITE; Model; -; B=23-254.
PDB; 2B5I; X-ray; 2.30 A; C=56-254.
PDB; 2ERJ; X-ray; 3.00 A; C/G=23-255.
PDB; 3BPL; X-ray; 2.93 A; C=56-254.
PDB; 3QAZ; X-ray; 3.80 A; C/F/I/L/O/R/U/X/a/d/g/j=56-254.
PDB; 3QB7; X-ray; 3.24 A; C/D=55-254.
PDB; 4GS7; X-ray; 2.35 A; C=55-254.
PDB; 5M5E; X-ray; 2.30 A; C=23-262.
PDB; 6OEL; X-ray; 3.10 A; C=61-249.
PDBsum; 1ILL; -.
PDBsum; 1ILM; -.
PDBsum; 1ILN; -.
PDBsum; 1ITE; -.
PDBsum; 2B5I; -.
PDBsum; 2ERJ; -.
PDBsum; 3BPL; -.
PDBsum; 3QAZ; -.
PDBsum; 3QB7; -.
PDBsum; 4GS7; -.
PDBsum; 5M5E; -.
PDBsum; 6OEL; -.
SMR; P31785; -.
BioGRID; 109776; 24.
CORUM; P31785; -.
DIP; DIP-173N; -.
IntAct; P31785; 18.
STRING; 9606.ENSP00000363318; -.
ChEMBL; CHEMBL2364167; -.
DrugBank; DB00041; Aldesleukin.
DrugBank; DB00004; Denileukin diftitox.
DrugBank; DB05943; Resatorvid.
DrugCentral; P31785; -.
GuidetoPHARMACOLOGY; 2303; -.
GlyGen; P31785; 8 sites.
iPTMnet; P31785; -.
PhosphoSitePlus; P31785; -.
BioMuta; IL2RG; -.
DMDM; 400048; -.
EPD; P31785; -.
MassIVE; P31785; -.
MaxQB; P31785; -.
PaxDb; P31785; -.
PeptideAtlas; P31785; -.
PRIDE; P31785; -.
ProteomicsDB; 54802; -. [P31785-1]
ProteomicsDB; 62802; -.
ABCD; P31785; 1 sequenced antibody.
Antibodypedia; 27479; 586 antibodies.
DNASU; 3561; -.
Ensembl; ENST00000374202; ENSP00000363318; ENSG00000147168. [P31785-1]
Ensembl; ENST00000456850; ENSP00000388967; ENSG00000147168. [P31785-2]
GeneID; 3561; -.
KEGG; hsa:3561; -.
UCSC; uc004dyw.4; human. [P31785-1]
CTD; 3561; -.
DisGeNET; 3561; -.
EuPathDB; HostDB:ENSG00000147168.12; -.
GeneCards; IL2RG; -.
GeneReviews; IL2RG; -.
HGNC; HGNC:6010; IL2RG.
HPA; ENSG00000147168; Group enriched (blood, lymphoid tissue).
MalaCards; IL2RG; -.
MIM; 300400; phenotype.
MIM; 308380; gene.
MIM; 312863; phenotype.
neXtProt; NX_P31785; -.
OpenTargets; ENSG00000147168; -.
Orphanet; 39041; Omenn syndrome.
Orphanet; 276; T-B+ severe combined immunodeficiency due to gamma chain deficiency.
PharmGKB; PA196; -.
eggNOG; ENOG502S289; Eukaryota.
GeneTree; ENSGT00510000048979; -.
HOGENOM; CLU_060544_1_0_1; -.
InParanoid; P31785; -.
KO; K05070; -.
OMA; MPRIPNP; -.
OrthoDB; 753404at2759; -.
PhylomeDB; P31785; -.
TreeFam; TF333657; -.
PathwayCommons; P31785; -.
Reactome; R-HSA-1266695; Interleukin-7 signaling.
Reactome; R-HSA-5673001; RAF/MAP kinase cascade.
Reactome; R-HSA-6785807; Interleukin-4 and Interleukin-13 signaling.
Reactome; R-HSA-8983432; Interleukin-15 signaling.
Reactome; R-HSA-8985947; Interleukin-9 signaling.
Reactome; R-HSA-9020558; Interleukin-2 signaling.
Reactome; R-HSA-9020958; Interleukin-21 signaling.
Reactome; R-HSA-912526; Interleukin receptor SHC signaling.
SignaLink; P31785; -.
SIGNOR; P31785; -.
BioGRID-ORCS; 3561; 6 hits in 501 CRISPR screens.
ChiTaRS; IL2RG; human.
EvolutionaryTrace; P31785; -.
GeneWiki; Common_gamma_chain; -.
GenomeRNAi; 3561; -.
Pharos; P31785; Tclin.
PRO; PR:P31785; -.
Proteomes; UP000005640; Chromosome X.
RNAct; P31785; protein.
Bgee; ENSG00000147168; Expressed in granulocyte and 188 other tissues.
ExpressionAtlas; P31785; baseline and differential.
Genevisible; P31785; HS.
GO; GO:0009986; C:cell surface; IDA:UniProtKB.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0005768; C:endosome; TAS:Reactome.
GO; GO:0009897; C:external side of plasma membrane; ISS:UniProtKB.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
GO; GO:0042010; F:interleukin-15 receptor activity; IDA:UniProtKB.
GO; GO:0019976; F:interleukin-2 binding; ISS:UniProtKB.
GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
GO; GO:0006955; P:immune response; TAS:ProtInc.
GO; GO:0035723; P:interleukin-15-mediated signaling pathway; IMP:UniProtKB.
GO; GO:0038110; P:interleukin-2-mediated signaling pathway; TAS:Reactome.
GO; GO:0038114; P:interleukin-21-mediated signaling pathway; TAS:Reactome.
GO; GO:0035771; P:interleukin-4-mediated signaling pathway; IEA:GOC.
GO; GO:0038111; P:interleukin-7-mediated signaling pathway; TAS:Reactome.
GO; GO:0038113; P:interleukin-9-mediated signaling pathway; TAS:Reactome.
GO; GO:0000165; P:MAPK cascade; TAS:Reactome.
GO; GO:0050766; P:positive regulation of phagocytosis; IMP:UniProtKB.
GO; GO:0007165; P:signal transduction; NAS:ProtInc.
GO; GO:0016032; P:viral process; IEA:UniProtKB-KW.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR015321; TypeI_recpt_CBD.
Pfam; PF09240; IL6Ra-bind; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 1.
PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
1: Evidence at protein level;
3D-structure; Alternative splicing; Cell membrane;
Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein;
Host-virus interaction; Membrane; Phosphoprotein; Polymorphism; Receptor;
Reference proteome; SCID; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1..22
CHAIN 23..369
/note="Cytokine receptor common subunit gamma"
/id="PRO_0000010866"
TOPO_DOM 23..262
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 263..283
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 284..369
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 156..253
/note="Fibronectin type-III"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
MOTIF 237..241
/note="WSXWS motif"
MOTIF 286..294
/note="Box 1 motif"
MOD_RES 292
/note="Phosphothreonine"
/evidence="ECO:0000244|PubMed:19690332"
CARBOHYD 24
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 71
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:16293754,
ECO:0000269|PubMed:16477002"
CARBOHYD 75
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 84
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:16293754,
ECO:0000269|PubMed:16477002"
CARBOHYD 159
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000269|PubMed:16293754,
ECO:0000269|PubMed:16477002"
CARBOHYD 249
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 62..72
DISULFID 102..115
DISULFID 182..231
VAR_SEQ 1..8
/note="MLKPSLPF -> MGMKTPQL (in isoform 2)"
/evidence="ECO:0000303|Ref.4"
/id="VSP_047581"
VAR_SEQ 9..198
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|Ref.4"
/id="VSP_047582"
VARIANT 39
/note="D -> N (in XSCID)"
/evidence="ECO:0000269|PubMed:7937790"
/id="VAR_002668"
VARIANT 44
/note="T -> S (in dbSNP:rs7885041)"
/id="VAR_059301"
VARIANT 62
/note="C -> G (in XSCID)"
/id="VAR_002669"
VARIANT 68
/note="E -> G (in XSCID)"
/id="VAR_002670"
VARIANT 68
/note="E -> K (in XSCID; dbSNP:rs1057520644)"
/evidence="ECO:0000269|PubMed:8088810"
/id="VAR_002671"
VARIANT 84
/note="N -> K (in XSCID)"
/id="VAR_002672"
VARIANT 89
/note="Y -> C (in XSCID)"
/id="VAR_002673"
VARIANT 105
/note="Y -> C (in XSCID; dbSNP:rs193922347)"
/id="VAR_002674"
VARIANT 109
/note="E -> K (in dbSNP:rs17875899)"
/evidence="ECO:0000269|Ref.5"
/id="VAR_020611"
VARIANT 114
/note="G -> D (in XSCID; dbSNP:rs111033620)"
/evidence="ECO:0000269|PubMed:8401490"
/id="VAR_002675"
VARIANT 115
/note="C -> F (in XSCID)"
/evidence="ECO:0000269|PubMed:8299698"
/id="VAR_002676"
VARIANT 115
/note="C -> R (in XSCID; atypical; dbSNP:rs111033622)"
/evidence="ECO:0000269|PubMed:8900089"
/id="VAR_002677"
VARIANT 123
/note="H -> P (in XSCID)"
/id="VAR_002678"
VARIANT 125
/note="Y -> N (in XSCID)"
/id="VAR_002679"
VARIANT 144
/note="Q -> P (in XSCID)"
/id="VAR_002680"
VARIANT 153
/note="I -> N (in XSCID; dbSNP:rs111033621)"
/evidence="ECO:0000269|PubMed:8401490"
/id="VAR_002681"
VARIANT 156
/note="A -> V (in XSCID; dbSNP:rs1057521062)"
/id="VAR_002682"
VARIANT 162
/note="L -> H (in XSCID)"
/evidence="ECO:0000269|PubMed:8027558"
/id="VAR_002683"
VARIANT 172
/note="L -> P (in XSCID)"
/id="VAR_002684"
VARIANT 172
/note="L -> Q (in XSCID)"
/id="VAR_002685"
VARIANT 182
/note="C -> R (in XSCID)"
/id="VAR_002686"
VARIANT 183
/note="L -> S (in XSCID)"
/evidence="ECO:0000269|PubMed:7557965"
/id="VAR_002687"
VARIANT 222
/note="R -> C (in XCID; dbSNP:rs111033618)"
/evidence="ECO:0000269|PubMed:9399950"
/id="VAR_002688"
VARIANT 224
/note="R -> W (in XSCID; dbSNP:rs869320658)"
/evidence="ECO:0000269|PubMed:9049783"
/id="VAR_002689"
VARIANT 226
/note="R -> C (in XSCID; dbSNP:rs869320659)"
/evidence="ECO:0000269|PubMed:7668284"
/id="VAR_002690"
VARIANT 226
/note="R -> H (in XSCID; dbSNP:rs869320660)"
/evidence="ECO:0000269|PubMed:7668284"
/id="VAR_002691"
VARIANT 227
/note="F -> C (in XSCID)"
/id="VAR_002692"
VARIANT 230
/note="L -> P (in XSCID)"
/id="VAR_002693"
VARIANT 231
/note="C -> Y (in XSCID)"
/id="VAR_002694"
VARIANT 232
/note="G -> R (in XSCID)"
/id="VAR_002695"
VARIANT 237
/note="W -> WQHW (in XSCID)"
/evidence="ECO:0000269|PubMed:7860773"
/id="VAR_002696"
VARIANT 240
/note="W -> C (in XSCID)"
/evidence="ECO:0000269|PubMed:8299698"
/id="VAR_002697"
VARIANT 241
/note="S -> I (in XSCID)"
/evidence="ECO:0000269|PubMed:8299698"
/id="VAR_002698"
VARIANT 270
/note="M -> R (in XSCID)"
/id="VAR_002699"
VARIANT 285
/note="R -> Q (in XSCID; dbSNP:rs111033617)"
/evidence="ECO:0000269|PubMed:9150740"
/id="VAR_002701"
VARIANT 293
/note="L -> Q (in XCID; dbSNP:rs137852510)"
/evidence="ECO:0000269|PubMed:7883965"
/id="VAR_002702"
STRAND 61..65
/evidence="ECO:0000244|PDB:2B5I"
TURN 66..68
/evidence="ECO:0000244|PDB:2B5I"
STRAND 69..73
/evidence="ECO:0000244|PDB:2B5I"
STRAND 78..81
/evidence="ECO:0000244|PDB:2B5I"
STRAND 86..91
/evidence="ECO:0000244|PDB:2B5I"
STRAND 94..96
/evidence="ECO:0000244|PDB:2B5I"
STRAND 99..101
/evidence="ECO:0000244|PDB:4GS7"
STRAND 103..108
/evidence="ECO:0000244|PDB:2B5I"
STRAND 111..118
/evidence="ECO:0000244|PDB:2B5I"
HELIX 119..121
/evidence="ECO:0000244|PDB:2B5I"
STRAND 124..126
/evidence="ECO:0000244|PDB:3BPL"
STRAND 128..133
/evidence="ECO:0000244|PDB:2B5I"
STRAND 135..137
/evidence="ECO:0000244|PDB:4GS7"
STRAND 141..146
/evidence="ECO:0000244|PDB:2B5I"
HELIX 148..150
/evidence="ECO:0000244|PDB:2B5I"
STRAND 151..153
/evidence="ECO:0000244|PDB:2B5I"
STRAND 158..166
/evidence="ECO:0000244|PDB:2B5I"
STRAND 169..175
/evidence="ECO:0000244|PDB:2B5I"
HELIX 180..182
/evidence="ECO:0000244|PDB:5M5E"
STRAND 184..191
/evidence="ECO:0000244|PDB:2B5I"
STRAND 198..202
/evidence="ECO:0000244|PDB:2B5I"
STRAND 207..210
/evidence="ECO:0000244|PDB:2B5I"
STRAND 215..217
/evidence="ECO:0000244|PDB:3QB7"
STRAND 219..226
/evidence="ECO:0000244|PDB:2B5I"
STRAND 229..231
/evidence="ECO:0000244|PDB:2B5I"
STRAND 244..246
/evidence="ECO:0000244|PDB:2B5I"
SEQUENCE 369 AA; 42287 MW; 3B6215246D610215 CRC64;
MLKPSLPFTS LLFLQLPLLG VGLNTTILTP NGNEDTTADF FLTTMPTDSL SVSTLPLPEV
QCFVFNVEYM NCTWNSSSEP QPTNLTLHYW YKNSDNDKVQ KCSHYLFSEE ITSGCQLQKK
EIHLYQTFVV QLQDPREPRR QATQMLKLQN LVIPWAPENL TLHKLSESQL ELNWNNRFLN
HCLEHLVQYR TDWDHSWTEQ SVDYRHKFSL PSVDGQKRYT FRVRSRFNPL CGSAQHWSEW
SHPIHWGSNT SKENPFLFAL EAVVISVGSM GLIISLLCVY FWLERTMPRI PTLKNLEDLV
TEYHGNFSAW SGVSKGLAES LQPDYSERLC LVSEIPPKGG ALGEGPGASP CNQHSPYWAP
PCYTLKPET


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Related Genes :
[IL2RG] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[Il2rg] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[IL2RG] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[IL2RG] Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
[IL2RB IL15RB] Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (Interleukin-15 receptor subunit beta) (p70-75) (p75) (CD antigen CD122)
[IL4R IL4RA 582J2.1] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124) [Cleaved into: Soluble interleukin-4 receptor subunit alpha (Soluble IL-4 receptor subunit alpha) (Soluble IL-4R-alpha) (sIL4Ralpha/prot) (IL-4-binding protein) (IL4-BP)]
[IL13RA1 IL13R IL13RA] Interleukin-13 receptor subunit alpha-1 (IL-13 receptor subunit alpha-1) (IL-13R subunit alpha-1) (IL-13R-alpha-1) (IL-13RA1) (Cancer/testis antigen 19) (CT19) (CD antigen CD213a1)
[Csf2rb Aic2b Csf2rb1 Il3rb1] Cytokine receptor common subunit beta (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
[CSF2RB IL3RB IL5RB] Cytokine receptor common subunit beta (CDw131) (GM-CSF/IL-3/IL-5 receptor common beta subunit) (CD antigen CD131)
[IL31RA CRL3 GPL UNQ6368/PRO21073/PRO21384] Interleukin-31 receptor subunit alpha (IL-31 receptor subunit alpha) (IL-31R subunit alpha) (IL-31R-alpha) (IL-31RA) (Cytokine receptor-like 3) (GLM-R) (hGLM-R) (Gp130-like monocyte receptor) (Gp130-like receptor) (ZcytoR17)
[IL10RB CRFB4 D21S58 D21S66] Interleukin-10 receptor subunit beta (IL-10 receptor subunit beta) (IL-10R subunit beta) (IL-10RB) (Cytokine receptor class-II member 4) (Cytokine receptor family 2 member 4) (CRF2-4) (Interleukin-10 receptor subunit 2) (IL-10R subunit 2) (IL-10R2) (CD antigen CDw210b)
[IL27RA CRL1 TCCR WSX1 UNQ296/PRO336] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Cytokine receptor WSX-1) (Cytokine receptor-like 1) (Type I T-cell cytokine receptor) (TCCR) (ZcytoR1)
[IFNLR1 IL28RA LICR2] Interferon lambda receptor 1 (IFN-lambda receptor 1) (IFN-lambda-R1) (Cytokine receptor class-II member 12) (Cytokine receptor family 2 member 12) (CRF2-12) (Interleukin-28 receptor subunit alpha) (IL-28 receptor subunit alpha) (IL-28R-alpha) (IL-28RA) (Likely interleukin or cytokine receptor 2) (LICR2)
[Il6st] Interleukin-6 receptor subunit beta (IL-6 receptor subunit beta) (IL-6R subunit beta) (IL-6R-beta) (IL-6RB) (Interleukin-6 signal transducer) (Membrane glycoprotein 130) (gp130) (Oncostatin-M receptor subunit alpha) (CD antigen CD130)
[Il2rb] Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (p70-75) (CD antigen CD122)
[IL12RB1 IL12R IL12RB] Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12RB1) (IL-12 receptor beta component) (CD antigen CD212)
[Il2rb] Interleukin-2 receptor subunit beta (IL-2 receptor subunit beta) (IL-2R subunit beta) (IL-2RB) (High affinity IL-2 receptor subunit beta) (p70-75) (CD antigen CD122)
[IL1R1 IL1R IL1RA IL1RT1] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL18RAP IL1R7] Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (EC 3.2.2.6) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)
[Il27ra Tccr Wsx1] Interleukin-27 receptor subunit alpha (IL-27 receptor subunit alpha) (IL-27R subunit alpha) (IL-27R-alpha) (IL-27RA) (Type I T-cell cytokine receptor) (TCCR) (WSX-1)
[Il7r] Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CD antigen CD127)
[Il12rb1 Il12rb] Interleukin-12 receptor subunit beta-1 (IL-12 receptor subunit beta-1) (IL-12R subunit beta-1) (IL-12R-beta-1) (IL-12 receptor beta component) (CD antigen CD212)
[Il4r Il4ra] Interleukin-4 receptor subunit alpha (IL-4 receptor subunit alpha) (IL-4R subunit alpha) (IL-4R-alpha) (IL-4RA) (CD antigen CD124)
[Il11ra1 Etl2 Il11ra] Interleukin-11 receptor subunit alpha-1 (IL-11 receptor subunit alpha-1) (IL-11R subunit alpha-1) (IL-11R-alpha-1) (IL-11RA1) (Enhancer trap locus homolog 2) (Etl-2) (Novel cytokine receptor 1) (NR-1) (NR1) [Cleaved into: Soluble interleukin-11 receptor subunit alpha (sIL-11R) (sIL-11RA) (sIL11RA)]
[IL18R1 IL1RRP] Interleukin-18 receptor 1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218 antigen-like family member A) (CDw218a) (IL1 receptor-related protein) (IL-1Rrp) (IL1R-rp) (Interleukin-18 receptor alpha) (IL-18R-alpha) (IL-18Ralpha) (CD antigen CD218a)
[Il1r1 Il-1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[Il12rb2] Interleukin-12 receptor subunit beta-2 (IL-12 receptor subunit beta-2) (IL-12R subunit beta-2) (IL-12R-beta-2) (IL-12RB2)
[Il1r1 Il1ra] Interleukin-1 receptor type 1 (IL-1R-1) (IL-1RT-1) (IL-1RT1) (EC 3.2.2.6) (CD121 antigen-like family member A) (Interleukin-1 receptor alpha) (IL-1R-alpha) (Interleukin-1 receptor type I) (p80) (CD antigen CD121a) [Cleaved into: Interleukin-1 receptor type 1, membrane form (mIL-1R1) (mIL-1RI); Interleukin-1 receptor type 1, soluble form (sIL-1R1) (sIL-1RI)]
[IL7R] Interleukin-7 receptor subunit alpha (IL-7 receptor subunit alpha) (IL-7R subunit alpha) (IL-7R-alpha) (IL-7RA) (CDw127) (CD antigen CD127)

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