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Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)

 IL2RG_BOVIN             Reviewed;         379 AA.
Q95118; A7YW94;
01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
01-FEB-1997, sequence version 1.
26-FEB-2020, entry version 144.
RecName: Full=Cytokine receptor common subunit gamma;
AltName: Full=Interleukin-2 receptor subunit gamma;
Short=IL-2 receptor subunit gamma;
Short=IL-2R subunit gamma;
Short=IL-2RG;
AltName: Full=gammaC;
AltName: Full=p64;
AltName: CD_antigen=CD132;
Flags: Precursor;
Name=IL2RG;
Bos taurus (Bovine).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
Bovinae; Bos.
NCBI_TaxID=9913;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8672241; DOI=10.1089/dna.1996.15.453;
Yoo J., Stone R.T., Solinas-Toldo S., Fries R., Beattie C.W.;
"Cloning and chromosomal mapping of bovine interleukin-2 receptor gamma
gene.";
DNA Cell Biol. 15:453-459(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Hereford; TISSUE=Thymus;
NIH - Mammalian Gene Collection (MGC) project;
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Common subunit for the receptors for a variety of
interleukins. Probably in association with IL15RA, involved in the
stimulation of neutrophil phagocytosis by IL15 (By similarity).
{ECO:0000250|UniProtKB:P31785}.
-!- SUBUNIT: The gamma subunit is common to the IL2, IL4, IL7, IL15, IL21
and probably also the IL13 receptors. Interacts with SHB upon
interleukin stimulation (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P31785};
Single-pass type I membrane protein {ECO:0000255}. Cell surface
{ECO:0000250|UniProtKB:P31785}.
-!- DOMAIN: The WSXWS motif appears to be necessary for proper protein
folding and thereby efficient intracellular transport and cell-surface
receptor binding.
-!- DOMAIN: The box 1 motif is required for JAK interaction and/or
activation.
-!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 5
subfamily. {ECO:0000305}.
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EMBL; U33748; AAB07812.1; -; Genomic_DNA.
EMBL; BC134467; AAI34468.1; -; mRNA.
RefSeq; NP_776784.1; NM_174359.1.
SMR; Q95118; -.
STRING; 9913.ENSBTAP00000010033; -.
PaxDb; Q95118; -.
PRIDE; Q95118; -.
Ensembl; ENSBTAT00000010033; ENSBTAP00000010033; ENSBTAG00000007626.
GeneID; 281862; -.
KEGG; bta:281862; -.
CTD; 3561; -.
VGNC; VGNC:30153; IL2RG.
eggNOG; ENOG410IGNI; Eukaryota.
eggNOG; ENOG4111N9N; LUCA.
GeneTree; ENSGT00510000048979; -.
HOGENOM; CLU_060544_1_0_1; -.
InParanoid; Q95118; -.
KO; K05070; -.
OMA; PLPKVQC; -.
OrthoDB; 753404at2759; -.
TreeFam; TF333657; -.
Reactome; R-BTA-1266695; Interleukin-7 signaling.
Reactome; R-BTA-5673001; RAF/MAP kinase cascade.
Reactome; R-BTA-6785807; Interleukin-4 and Interleukin-13 signaling.
Reactome; R-BTA-8983432; Interleukin-15 signaling.
Reactome; R-BTA-8985947; Interleukin-9 signaling.
Reactome; R-BTA-9020558; Interleukin-2 signaling.
Reactome; R-BTA-9020958; Interleukin-21 signaling.
Reactome; R-BTA-912526; Interleukin receptor SHC signaling.
Proteomes; UP000009136; Chromosome X.
Bgee; ENSBTAG00000007626; Expressed in spleen and 9 other tissues.
ExpressionAtlas; Q95118; baseline and differential.
GO; GO:0009986; C:cell surface; ISS:UniProtKB.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0043235; C:receptor complex; IBA:GO_Central.
GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
GO; GO:0004896; F:cytokine receptor activity; IBA:GO_Central.
GO; GO:0042010; F:interleukin-15 receptor activity; ISS:UniProtKB.
GO; GO:0019976; F:interleukin-2 binding; IBA:GO_Central.
GO; GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0050766; P:positive regulation of phagocytosis; ISS:UniProtKB.
CDD; cd00063; FN3; 1.
Gene3D; 2.60.40.10; -; 2.
InterPro; IPR003961; FN3_dom.
InterPro; IPR036116; FN3_sf.
InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
InterPro; IPR013783; Ig-like_fold.
InterPro; IPR015321; TypeI_recpt_CBD.
Pfam; PF00041; fn3; 1.
Pfam; PF09240; IL6Ra-bind; 1.
SMART; SM00060; FN3; 1.
SUPFAM; SSF49265; SSF49265; 2.
PROSITE; PS50853; FN3; 1.
PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
2: Evidence at transcript level;
Cell membrane; Disulfide bond; Glycoprotein; Membrane; Phosphoprotein;
Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix.
SIGNAL 1..22
/evidence="ECO:0000255"
CHAIN 23..379
/note="Cytokine receptor common subunit gamma"
/id="PRO_0000010864"
TOPO_DOM 23..269
/note="Extracellular"
/evidence="ECO:0000255"
TRANSMEM 270..290
/note="Helical"
/evidence="ECO:0000255"
TOPO_DOM 291..379
/note="Cytoplasmic"
/evidence="ECO:0000255"
DOMAIN 163..260
/note="Fibronectin type-III"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
MOTIF 244..248
/note="WSXWS motif"
MOTIF 299..307
/note="Box 1 motif"
MOD_RES 305
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P31785"
CARBOHYD 77
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 81
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 90
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 166
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
CARBOHYD 171
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 68..78
/evidence="ECO:0000255"
DISULFID 109..122
/evidence="ECO:0000255"
SEQUENCE 379 AA; 43038 MW; 33CFAD9C9B032178 CRC64;
MLKPPLPLRS LLFLQLPLLG VGLNPKFLTP SGNEDIGGKP GTGGDFFLTS TPAGTLDVST
LPLPKVQCFV FNVEYMNCTW NSSSEPQPNN LTLHYGYRNF NGDDKLQECG HYLFSEGITS
GCWFGKKEIR LYETFVVQLQ DPREHRKQPK QMLKLQDLVI PWAPENLTLR NLSEFQLELS
WSNRYLDHCL EHLVQYRSDR DRSWTEQSVD HRHSFSLPSV DAQKLYTFRV RSRYNPLCGS
AQHWSDWSYP IHWGSNTSKE NIENPENPSL FALEAVLIPL GSMGLIVSLI CVYCWLERTM
PRIPTLKNLE DLVTEYQGNF SAWSGVSKGL AESLQPDYSE RLCHVSEIPP KGGEGPGGSP
CSQHSPYWAP PCYTLKPEP


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