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Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (CPEB-3)

 CPEB3_XENTR             Reviewed;         632 AA.
Q28CH2;
12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
04-APR-2006, sequence version 1.
08-MAY-2019, entry version 68.
RecName: Full=Cytoplasmic polyadenylation element-binding protein 3;
Short=CPE-BP3;
Short=CPE-binding protein 3;
Short=CPEB-3;
Name=cpeb3; ORFNames=TGas021m22.1;
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Silurana.
NCBI_TaxID=8364;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Gastrula;
Sanger Xenopus tropicalis EST/cDNA project;
Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
[2]
FUNCTION, AND TISSUE SPECIFICITY.
PubMed=18472403; DOI=10.1016/j.mod.2008.03.001;
Kyuno J., Masse K., Jones E.A.;
"A functional screen for genes involved in Xenopus pronephros
development.";
Mech. Dev. 125:571-586(2008).
-!- FUNCTION: Sequence-specific RNA-binding protein which acts as a
translational repressor in the basal unstimulated state but,
following neuronal stimulation, acts as a translational activator
(By similarity). Does not bind to the cytoplasmic polyadenylation
element (CPE), a uridine-rich sequence element within the mRNA 3'-
UTR, but binds to a U-rich loop within a stem-loop structure (By
similarity). Required for the consolidation and maintenance of
hippocampal-based long term memory (By similarity). Inhibits
differentiation of intermediate mesoderm from an early stage to
inhibit pronephric differentiation but induce neural
differentiation (PubMed:18472403). {ECO:0000250|UniProtKB:Q7TN99,
ECO:0000269|PubMed:18472403}.
-!- SUBUNIT: Following synaptic activity, forms amyloid-like oligomers
(By similarity). Aggregation requires an intact actin cytoskeleton
(By similarity). {ECO:0000250|UniProtKB:Q7TN99}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7TN99}.
Nucleus {ECO:0000250|UniProtKB:Q7TN99}. Cell junction, synapse
{ECO:0000250|UniProtKB:Q7TN99}. Cell projection, dendrite
{ECO:0000250|UniProtKB:Q7TN99}. Cell junction, synapse,
postsynaptic cell membrane, postsynaptic density
{ECO:0000250|UniProtKB:Q7TN99}. Note=Predominantly cytoplasmic in
unstimulated neurons but translocates to the nucleus following
neuronal stimulation. {ECO:0000250|UniProtKB:Q7TN99}.
-!- TISSUE SPECIFICITY: In embryos, expressed in the central nervous
system, and intermediate and distal pronephric tubule segments of
the embryonic kidney. {ECO:0000269|PubMed:18472403}.
-!- DOMAIN: The N-terminal Gln-rich region is required for the
formation of amyloid-like oligomers and for the stability of long-
term potentiation and spatial memory.
{ECO:0000250|UniProtKB:Q7TN99}.
-!- SIMILARITY: Belongs to the RRM CPEB family. {ECO:0000305}.
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EMBL; CR926390; CAJ82507.1; -; mRNA.
RefSeq; NP_001015925.1; NM_001015925.2.
SMR; Q28CH2; -.
STRING; 8364.ENSXETP00000026614; -.
PaxDb; Q28CH2; -.
GeneID; 548679; -.
KEGG; xtr:548679; -.
CTD; 22849; -.
Xenbase; XB-GENE-5716009; cpeb3.
eggNOG; KOG0129; Eukaryota.
eggNOG; ENOG410Y1XZ; LUCA.
HOGENOM; HOG000290660; -.
InParanoid; Q28CH2; -.
KO; K02602; -.
OrthoDB; 1075356at2759; -.
Proteomes; UP000008143; Unassembled WGS sequence.
GO; GO:0097440; C:apical dendrite; ISS:UniProtKB.
GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0030425; C:dendrite; ISS:UniProtKB.
GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
GO; GO:0043005; C:neuron projection; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-KW.
GO; GO:0045202; C:synapse; ISS:UniProtKB.
GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; ISS:UniProtKB.
GO; GO:0003730; F:mRNA 3'-UTR binding; ISS:UniProtKB.
GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
GO; GO:0003723; F:RNA binding; ISS:UniProtKB.
GO; GO:0035613; F:RNA stem-loop binding; ISS:UniProtKB.
GO; GO:0008135; F:translation factor activity, RNA binding; ISS:UniProtKB.
GO; GO:0000900; F:translation repressor activity, mRNA regulatory element binding; ISS:UniProtKB.
GO; GO:0061158; P:3'-UTR-mediated mRNA destabilization; ISS:UniProtKB.
GO; GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB.
GO; GO:0007616; P:long-term memory; ISS:UniProtKB.
GO; GO:2000766; P:negative regulation of cytoplasmic translation; IBA:GO_Central.
GO; GO:1900248; P:negative regulation of cytoplasmic translational elongation; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0017148; P:negative regulation of translation; ISS:UniProtKB.
GO; GO:0060999; P:positive regulation of dendritic spine development; ISS:UniProtKB.
GO; GO:1900365; P:positive regulation of mRNA polyadenylation; ISS:UniProtKB.
GO; GO:1900153; P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; ISS:UniProtKB.
GO; GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; ISS:UniProtKB.
GO; GO:0045727; P:positive regulation of translation; ISS:UniProtKB.
GO; GO:0048793; P:pronephros development; IMP:UniProtKB.
GO; GO:0060998; P:regulation of dendritic spine development; ISS:UniProtKB.
GO; GO:0048167; P:regulation of synaptic plasticity; ISS:UniProtKB.
Gene3D; 3.30.40.130; -; 1.
Gene3D; 3.30.70.330; -; 2.
InterPro; IPR032296; CEBP_ZZ.
InterPro; IPR038446; CEBP_ZZ_sf.
InterPro; IPR034819; CPEB.
InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
InterPro; IPR035979; RBD_domain_sf.
InterPro; IPR000504; RRM_dom.
PANTHER; PTHR12566; PTHR12566; 1.
Pfam; PF16366; CEBP_ZZ; 1.
Pfam; PF16367; RRM_7; 1.
SMART; SM00360; RRM; 2.
SUPFAM; SSF54928; SSF54928; 1.
PROSITE; PS50102; RRM; 2.
2: Evidence at transcript level;
Activator; Cell junction; Cell membrane; Cell projection;
Complete proteome; Cytoplasm; Developmental protein; Differentiation;
Membrane; Nucleus; Postsynaptic cell membrane; Reference proteome;
Repeat; Repressor; RNA-binding; Synapse.
CHAIN 1 632 Cytoplasmic polyadenylation element-
binding protein 3.
/FTId=PRO_0000269263.
DOMAIN 375 466 RRM 1. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
DOMAIN 483 565 RRM 2. {ECO:0000255|PROSITE-
ProRule:PRU00176}.
COMPBIAS 13 30 Gln-rich.
SEQUENCE 632 AA; 70211 MW; F15B94347560ED82 CRC64;
MQDDLLMDKS KAQQRQQPQQ PPSSQTQQQQ KEAASVAEPP SSRESSPPTH KDKMQMESPL
LPGLSFQQEP PTTPSLSPSF GSTWSTGGSN SAVDDSFFPG ITPVNGTMLF QNFPHHHHVN
PVFGGTFSPQ MGLAHQTQQQ QRRSPASPNN HTAYTQRNAY SHQPILTNKP SSSPNSSSPS
PSNWNNQQNA AWNTPSNPWG AMQPGRDPRR AVGVGVGVGV GVPSPLNPIS PLKKTFSSNV
IAPPKFSRAS PLTPKSWVED NAFRTDNGNT LLPLQDRNRP YDSFNLHTLE NSLMDMIRTD
HEPLKARMGL NFHHPGTDNI MALNTRSYGR RRGRSSLFPF EDGFLGDGHG DQSLSSGLSS
PTHCQNGERI ERYSRKVFVG GLPPDIDEDE ITASFRRFGP LVVDWPHKAE SKSYFPPKGY
AFLLFQEESS VQALIDACLE EDGKLYLCVS SPTIKDKPVQ IRPWNLSDSD FVMDGSQPLD
PRKTIFVGGV PRPLRAVELA MIMDRLYGGV CYAGIDTDPE LKYPKGAGRV AFSNQQSYIA
AISARFVQLQ HNDIDKRVEV KPYVLDDQMC DECQGTRCGG KFAPFFCANV TCLQYYCEYC
WASIHSRAGR EFHKPLVKEG GDRPRHVPFH WS


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Pathways :
WP731: Sterol regulatory element binding protein related
WP1531: Vitamin D synthesis
WP1616: ABC transporters
WP2292: Chemokine signaling pathway
WP210: Cytoplasmic Ribosomal Proteins
WP1825: GPCR ligand binding
WP813: G Protein Signaling Pathways
WP1665: Limonene and pinene degradation
WP2272: Pathogenic Escherichia coli infection
WP1493: Carbon assimilation C4 pathway
WP2324: AGE/RAGE pathway
WP1566: Citrate cycle (TCA cycle)
WP1892: Protein folding
WP1675: Nitrogen metabolism
WP1685: Peptidoglycan biosynthesis
WP1624: Bacterial secretion system
WP1939: Unfolded Protein Response
WP35: G Protein Signaling Pathways
WP1644: DNA replication
WP1049: G Protein Signaling Pathways
WP1692: Protein export
WP1700: Selenoamino acid metabolism
WP1657: Glycerolipid metabolism
WP1663: Homologous recombination
WP2218: sGC

Related Genes :
[CPEB3 KIAA0940] Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (hCPEB-3)
[Cpeb3 Kiaa0940] Cytoplasmic polyadenylation element-binding protein 3 (CPE-BP3) (CPE-binding protein 3) (mCPEB-3)
[cpeb1-a cpeb] Cytoplasmic polyadenylation element-binding protein 1-A (CPE-BP1-A) (CPE-binding protein 1-A) (CPEB-1-A) (58 kDa CPE-binding protein)
[CPEB1 CPEB] Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (h-CPEB) (hCPEB-1)
[Cpeb1] Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (CPEB) (CPEB-1)
[Cpeb1 Cpeb] Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (mCPEB) (mCPEB-1)
[Cpeb4 Kiaa1673] Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (mCPEB-4)
[CPEB4 KIAA1673] Cytoplasmic polyadenylation element-binding protein 4 (CPE-BP4) (CPE-binding protein 4) (hCPEB-4)
[] Cytoplasmic polyadenylation element-binding protein (CPE-binding protein) (CPEB)
[CPEB1] Cytoplasmic polyadenylation element-binding protein 1 (CPE-BP1) (CPE-binding protein 1) (CPEB-1)
[igf2bp3-a vera-a vickz3-a] Insulin-like growth factor 2 mRNA-binding protein 3-A (IGF2 mRNA-binding protein 3-A) (IMP-3-A) (69 kDa RNA-binding protein A) (IGF-II mRNA-binding protein 3-A) (KH domain-containing transcription factor B3-A) (RNA-binding protein Vera-A) (Trans-acting factor B3-A) (VICKZ family member 3-A) (VLE-binding protein A) (Vg1 RNA-binding protein A) (Vg1 RBP-A) (Vg1 localization element binding protein A) (VgLE-binding and ER association protein A)
[cpeb1-b] Cytoplasmic polyadenylation element-binding protein 1-B (CPE-BP1-B) (CPE-binding protein 1-B) (CPEB-1-B)
[igf2bp3-b vickz3-b] Insulin-like growth factor 2 mRNA-binding protein 3-B (IGF2 mRNA-binding protein 3-B) (IMP-3-B) (69 kDa RNA-binding protein B) (B3.65 protein B) (IGF-II mRNA-binding protein 3-B) (KH domain-containing transcription factor B3-B) (RNA-binding protein Vera-B) (Trans-acting factor B3-B) (VICKZ family member 3-B) (VLE-binding protein B) (Vg1 RNA-binding protein B) (Vg1 RBP-B) (Vg1 localization element binding protein B) (VgLE-binding and ER association protein B)
[IGF2BP3 IMP3 KOC1 VICKZ3] Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (IGF-II mRNA-binding protein 3) (KH domain-containing protein overexpressed in cancer) (hKOC) (VICKZ family member 3)
[SH3KBP1 CIN85] SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
[elavl1-a elavl1 elrA] ELAV-like protein 1-A (36 kDa embryonic-type cytoplasmic polyadenylation element-binding protein) (36 kDa eCPE-binding protein) (36 kDa eCPEB) (p36) (Protein ElrA-A) (ElrA)
[NMRK2 ITGB1BP3 NRK2] Nicotinamide riboside kinase 2 (NRK 2) (NmR-K 2) (EC 2.7.1.22) (Integrin beta-1-binding protein 3) (Muscle integrin-binding protein) (MIBP) (Nicotinic acid riboside kinase 2) (EC 2.7.1.173) (Ribosylnicotinamide kinase 2) (RNK 2) (Ribosylnicotinic acid kinase 2)
[Cpe] Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase)
[Cpe] Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase)
[CPE] Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase)
[Nmrk2 Itgb1bp3 Nrk2] Nicotinamide riboside kinase 2 (NRK 2) (NmR-K 2) (EC 2.7.1.22) (Integrin beta-1-binding protein 3) (Muscle integrin-binding protein) (MIBP) (Nicotinic acid riboside kinase 2) (EC 2.7.1.173) (Ribosylnicotinamide kinase 2) (RNK 2) (Ribosylnicotinic acid kinase 2)
[plc cpa CPE0036] Phospholipase C (PLC) (EC 3.1.4.3) (Alpha-toxin) (Hemolysin) (Lecithinase) (Phosphatidylcholine cholinephosphohydrolase)
[CPE] Carboxypeptidase E (CPE) (EC 3.4.17.10) (Carboxypeptidase H) (CPH) (Enkephalin convertase) (Prohormone-processing carboxypeptidase)
[FGFBP3 C10orf13 PSEC0101] Fibroblast growth factor-binding protein 3 (FGF-BP3) (FGF-binding protein 3) (FGFBP-3)
[igf2bp3 dvr1rbp vickz3] Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (Decapentaplegic and Vg-related 1 RNA-binding protein) (IGF-II mRNA-binding protein 3) (VICKZ family member 3) (Vg1 RNA-binding protein) (Vg1-RBP)
[Znf106 H3a Sh3bp3 Sirm Zfp106 Znf474] Zinc finger protein 106 (Zfp-106) (H3a minor histocompatibility antigen) (Son of insulin receptor mutant) (Zinc finger protein 474)
[Igf2bp3 Vickz3] Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2 mRNA-binding protein 3) (IMP-3) (mIMP-3) (IGF-II mRNA-binding protein 3) (VICKZ family member 3)
[ACO1 IREB1] Cytoplasmic aconitate hydratase (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase) (Ferritin repressor protein) (Iron regulatory protein 1) (IRP1) (Iron-responsive element-binding protein 1) (IRE-BP 1)
[CREB3L3 CREBH HYST1481] Cyclic AMP-responsive element-binding protein 3-like protein 3 (cAMP-responsive element-binding protein 3-like protein 3) (Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]
[CREB3 LZIP] Cyclic AMP-responsive element-binding protein 3 (CREB-3) (cAMP-responsive element-binding protein 3) (Leucine zipper protein) (Luman) (Transcription factor LZIP-alpha) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3 (N-terminal Luman) (Transcriptionally active form)]

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