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Cytotoxin 4 (CTX M3) (Cardiotoxin V(II)4)

 3SA4_NAJMO              Reviewed;          60 AA.
P01452;
21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
21-JUL-1986, sequence version 1.
05-JUN-2019, entry version 97.
RecName: Full=Cytotoxin 4;
AltName: Full=CTX M3 {ECO:0000303|PubMed:8182052};
AltName: Full=Cardiotoxin V(II)4;
Naja mossambica (Mozambique spitting cobra).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
NCBI_TaxID=8644;
[1]
PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
TISSUE=Venom;
PubMed=4834686; DOI=10.1016/S0006-291X(74)80246-9;
Louw A.I.;
"Snake venom toxins. The complete amino acid sequence of cytotoxin
VII4 from the venom of Naja mossambica mossambica.";
Biochem. Biophys. Res. Commun. 58:1022-1029(1974).
[2]
FUNCTION, AND APPARTENANCE TO S-TYPE CYTOTOXIN GROUP.
PubMed=8182052;
Chien K.-Y., Chiang C.-M., Hseu Y.-C., Vyas A.A., Rule G.S., Wu W.-G.;
"Two distinct types of cardiotoxin as revealed by the structure and
activity relationship of their interaction with zwitterionic
phospholipid dispersions.";
J. Biol. Chem. 269:14473-14483(1994).
[3]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), AND DISULFIDE BONDS.
PubMed=2370666; DOI=10.1016/0022-2836(90)90161-E;
Rees B., Bilwes A., Samama J.-P., Moras D.;
"Cardiotoxin VII4 from Naja mossambica mossambica. The refined crystal
structure.";
J. Mol. Biol. 214:281-297(1990).
-!- FUNCTION: Shows cytolytic activity on many different cells by
forming pore in lipid membranes. In vivo, increases heart rate or
kills the animal by cardiac arrest. In addition, it binds to
heparin with high affinity, interacts with Kv channel-interacting
protein 1 (KCNIP1) in a calcium-independent manner, and binds to
integrin alpha-V/beta-3 (ITGAV/ITGB3) with moderate affinity.
{ECO:0000250|UniProtKB:P60301, ECO:0000250|UniProtKB:P60304,
ECO:0000269|PubMed:8182052}.
-!- SUBUNIT: Monomer in solution; Homodimer and oligomer in the
presence of negatively charged lipids forming a pore with a size
ranging between 20 and 30 Angstroms.
{ECO:0000250|UniProtKB:P60301}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:4834686}.
Target cell membrane {ECO:0000250|UniProtKB:P60301}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- TOXIC DOSE: LD(50) is 1.97 mg/kg by intravenous injection.
-!- MISCELLANEOUS: Is classified as a S-type cytotoxin, since a serine
residue stands at position 28 (Ser-29 in standard classification).
{ECO:0000305|PubMed:8182052}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-
chain subfamily. Type IA cytotoxin sub-subfamily. {ECO:0000305}.
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PIR; A01717; H3NJ4M.
PDB; 1CDT; X-ray; 2.50 A; A/B=1-60.
PDBsum; 1CDT; -.
SMR; P01452; -.
EvolutionaryTrace; P01452; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003572; Cytotoxin_Cobra.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR018354; Snake_toxin_con_site.
InterPro; IPR035076; Toxin/TOLIP.
Pfam; PF00087; Toxin_TOLIP; 1.
PRINTS; PR00282; CYTOTOXIN.
PROSITE; PS00272; SNAKE_TOXIN; 1.
1: Evidence at protein level;
3D-structure; Cardiotoxin; Cytolysis; Direct protein sequencing;
Disulfide bond; Membrane; Secreted; Target cell membrane;
Target membrane; Toxin.
CHAIN 1 60 Cytotoxin 4.
{ECO:0000269|PubMed:4834686}.
/FTId=PRO_0000093508.
DISULFID 3 21 {ECO:0000269|PubMed:2370666,
ECO:0000312|PDB:1CDT}.
DISULFID 14 38 {ECO:0000269|PubMed:2370666,
ECO:0000312|PDB:1CDT}.
DISULFID 42 53 {ECO:0000269|PubMed:2370666,
ECO:0000312|PDB:1CDT}.
DISULFID 54 59 {ECO:0000269|PubMed:2370666,
ECO:0000312|PDB:1CDT}.
STRAND 2 4 {ECO:0000244|PDB:1CDT}.
STRAND 11 13 {ECO:0000244|PDB:1CDT}.
STRAND 20 26 {ECO:0000244|PDB:1CDT}.
TURN 27 30 {ECO:0000244|PDB:1CDT}.
STRAND 32 41 {ECO:0000244|PDB:1CDT}.
STRAND 47 54 {ECO:0000244|PDB:1CDT}.
SEQUENCE 60 AA; 6715 MW; F37CCB912A6EA48A CRC64;
LKCNKLIPIA YKTCPEGKNL CYKMMLASKK MVPVKRGCIN VCPKNSALVK YVCCSTDRCN


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Pathways :
No related Items

Related Genes :
[] Cytotoxin 1 (CTX1) (CX1) (Cardiotoxin F8) (Cardiotoxin-I) (CTX-I) (Toxin CM-6)
[] Cytotoxin 4 (CTX M3) (Cardiotoxin V(II)4)
[Pre C,C C core E PC pre-C pre-C/C PreC preC PreC/C preC/C precore-core HBVgp4] Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[] Cytotoxin 1 (CTX M1) (Cardiotoxin IIB) (CTX-IIB) (Cytotoxin V(II)1)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[] Long-sarafotoxin (L-SRTX) [Cleaved into: Sarafotoxin-m (SRTX-m); Sarafotoxin-m1 (SRTX-m1); Sarafotoxin-m2 (SRTX-m2); Sarafotoxin-m3 (SRTX-m3); Sarafotoxin-m4 (SRTX-m4); Sarafotoxin-m5 (SRTX-m5)] (Fragment)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[] Cytotoxin 2 (CTX M2) (Cardiotoxin IIA) (CTX IIA) (Cytotoxin V(II)2)
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[tat] Protein Tat (Transactivating regulatory protein)
[tat] Protein Tat (Transactivating regulatory protein)
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[atnM ANIA_07873] Fatty acid synthase beta subunit aflB (EC 2.3.1.86) (Aspercryptin biosynthesis cluster protein M) [Includes: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase (EC 4.2.1.59); Enoyl-[acyl-carrier-protein] reductase [NADH] (EC 1.3.1.9); [Acyl-carrier-protein] acetyltransferase (EC 2.3.1.38); [Acyl-carrier-protein] malonyltransferase (EC 2.3.1.39); S-acyl fatty acid synthase thioesterase (EC 3.1.2.14)]
[tat] Protein Tat (Transactivating regulatory protein)
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[NTH2 At1g05900 T20M3.18] Endonuclease III homolog 2, chloroplastic (AtNTH2) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 2) (DNA glycosylase/AP lyase 2)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[C c core preC HBVgp4] Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[pyrG HOT0M-3E5_0002] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)
[] Cytotoxin 4b (Cardiotoxin-4b) (CTX-4b) (Ctx4b)

Bibliography :