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Cytotoxin-like basic protein (CLBP) (Less-cytotoxic basic polypeptide) (LCBP)

 3SOFL_NAJNA             Reviewed;          62 AA.
P62377; P14554;
05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
05-JUL-2004, sequence version 1.
05-JUN-2019, entry version 57.
RecName: Full=Cytotoxin-like basic protein {ECO:0000303|PubMed:2311757, ECO:0000303|PubMed:2583280};
Short=CLBP {ECO:0000303|PubMed:2311757, ECO:0000303|PubMed:2583280};
AltName: Full=Less-cytotoxic basic polypeptide {ECO:0000303|PubMed:3566773};
Short=LCBP {ECO:0000303|PubMed:3566773};
Naja naja (Indian cobra).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Naja.
NCBI_TaxID=35670;
[1]
PROTEIN SEQUENCE.
TISSUE=Venom;
PubMed=2583280; DOI=10.1016/0014-5793(89)81561-3;
Inoue S., Okumura K., Tsujino M., Ohkura K., Ikeda K., Takechi M.,
Tanaka Y., Hayashi K.;
"Amino acid sequences of cytotoxin-like basic proteins derived from
cobra venoms.";
FEBS Lett. 257:319-323(1989).
[2]
PROTEIN SEQUENCE.
TISSUE=Venom;
PubMed=2311757; DOI=10.1016/0014-5793(90)80563-X;
Shafqat J., Zaidi Z.H., Joernvall H.;
"Characterization of a cytotoxin-like basic protein from the cobra
(Naja naja naja) venom.";
FEBS Lett. 261:245-246(1990).
[3]
PRELIMINARY PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
TISSUE=Venom;
PubMed=3566773;
Takechi M., Tanaka Y., Hayashi K.;
"Amino acid sequence of a less-cytotoxic basic polypeptide (LCBP)
isolated from the venom of the Indian cobra (Naja naja).";
Biochem. Int. 14:145-152(1987).
-!- FUNCTION: Has low cytotoxic activity.
{ECO:0000250|UniProtKB:P14541}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3566773}.
Target cell membrane {ECO:0000250|UniProtKB:P62375}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
-!- TOXIC DOSE: LD(50) is 60 mg/kg by subcutaneous injection.
-!- MISCELLANEOUS: Is classified as a P-type cytotoxin, since a
proline residue stands at position 31 (Pro-31 in standard
classification). {ECO:0000305}.
-!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-
chain subfamily. Orphan group XV sub-subfamily. {ECO:0000305}.
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PIR; S06674; S06674.
SMR; P62377; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0044179; P:hemolysis in other organism; IEA:UniProtKB-KW.
CDD; cd00206; snake_toxin; 1.
InterPro; IPR003572; Cytotoxin_Cobra.
InterPro; IPR003571; Snake_3FTx.
InterPro; IPR018354; Snake_toxin_con_site.
InterPro; IPR035076; Toxin/TOLIP.
Pfam; PF00087; Toxin_TOLIP; 1.
PRINTS; PR00282; CYTOTOXIN.
PROSITE; PS00272; SNAKE_TOXIN; 1.
1: Evidence at protein level;
Cytolysis; Direct protein sequencing; Disulfide bond; Hemolysis;
Membrane; Secreted; Target cell membrane; Target membrane; Toxin.
CHAIN 1 62 Cytotoxin-like basic protein.
{ECO:0000269|PubMed:2311757,
ECO:0000269|PubMed:2583280}.
/FTId=PRO_0000093525.
DISULFID 3 22 {ECO:0000250|UniProtKB:P60301}.
DISULFID 15 40 {ECO:0000250|UniProtKB:P60301}.
DISULFID 44 55 {ECO:0000250|UniProtKB:P60301}.
DISULFID 56 61 {ECO:0000250|UniProtKB:P60301}.
SEQUENCE 62 AA; 7014 MW; 0E88D09AEFA7FBA5 CRC64;
LKCHNTQLPF IYKTCPEGKN LCFKATLKKF PLKFPVKRGC ADNCPKNSAL LKYVCCSTDK
CN


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Bibliography :