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DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)

 DDIT3_HUMAN             Reviewed;         169 AA.
P35638; F8VS99;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
29-SEP-2021, entry version 207.
RecName: Full=DNA damage-inducible transcript 3 protein;
Short=DDIT-3;
AltName: Full=C/EBP zeta;
AltName: Full=C/EBP-homologous protein;
Short=CHOP;
AltName: Full=C/EBP-homologous protein 10;
Short=CHOP-10;
AltName: Full=CCAAT/enhancer-binding protein homologous protein;
AltName: Full=Growth arrest and DNA damage-inducible protein GADD153;
Name=DDIT3; Synonyms=CHOP, CHOP10, GADD153;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=1339368; DOI=10.1016/0378-1119(92)90523-r;
Park J.S., Luethy J.D., Wang M.G., Fargnoli J., Fornace A.J. Jr.,
McBride O.W., Holbrook N.J.;
"Isolation, characterization and chromosomal localization of the human
GADD153 gene.";
Gene 116:259-267(1992).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=8510758; DOI=10.1038/363640a0;
Crozat A., Aman P., Mandahl N., Ron D.;
"Fusion of CHOP to a novel RNA-binding protein in human myxoid
liposarcoma.";
Nature 363:640-644(1993).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INVOLVEMENT IN MXLIPO, AND
CHROMOSOMAL TRANSLOCATION WITH FUS.
PubMed=7503811; DOI=10.1038/ng0693-175;
Rabbitts T.H., Forster A., Larson R., Nathan P.;
"Fusion of the dominant negative transcription regulator CHOP with a novel
gene FUS by translocation t(12;16) in malignant liposarcoma.";
Nat. Genet. 4:175-180(1993).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Li X., Xie Y., Mao Y.;
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
NIEHS SNPs program;
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16541075; DOI=10.1038/nature04569;
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
Gibbs R.A.;
"The finished DNA sequence of human chromosome 12.";
Nature 440:346-351(2006).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Muscle;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[8]
REVIEW.
PubMed=14685163; DOI=10.1038/sj.cdd.4401373;
Oyadomari S., Mori M.;
"Roles of CHOP/GADD153 in endoplasmic reticulum stress.";
Cell Death Differ. 11:381-389(2004).
[9]
FUNCTION.
PubMed=15322075; DOI=10.1074/jbc.m406933200;
Yamaguchi H., Wang H.G.;
"CHOP is involved in endoplasmic reticulum stress-induced apoptosis by
enhancing DR5 expression in human carcinoma cells.";
J. Biol. Chem. 279:45495-45502(2004).
[10]
FUNCTION, AND INTERACTION WITH TRIB3.
PubMed=15775988; DOI=10.1038/sj.emboj.7600596;
Ohoka N., Yoshii S., Hattori T., Onozaki K., Hayashi H.;
"TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway
and is involved in cell death.";
EMBO J. 24:1243-1255(2005).
[11]
FUNCTION, AND INTERACTION WITH TCF7L2.
PubMed=16434966; DOI=10.1038/sj.onc.1209380;
Horndasch M., Lienkamp S., Springer E., Schmitt A., Pavenstaedt H.,
Walz G., Gloy J.;
"The C/EBP homologous protein CHOP (GADD153) is an inhibitor of Wnt/TCF
signals.";
Oncogene 25:3397-3407(2006).
[12]
N-TERMINAL REGION, SUBCELLULAR LOCATION, INTERACTION WITH TRIB3; EP300;
HDAC1; HDAC5 AND HDAC6, UBIQUITINATION, AND PROTEASOMAL DEGRADATION.
PubMed=17872950; DOI=10.1074/jbc.m703735200;
Ohoka N., Hattori T., Kitagawa M., Onozaki K., Hayashi H.;
"Critical and functional regulation of CHOP (C/EBP homologous protein)
through the N-terminal portion.";
J. Biol. Chem. 282:35687-35694(2007).
[13]
FUNCTION.
PubMed=17709599; DOI=10.1165/rcmb.2007-0197oc;
Vij N., Amoako M.O., Mazur S., Zeitlin P.L.;
"CHOP transcription factor mediates IL-8 signaling in cystic fibrosis
bronchial epithelial cells.";
Am. J. Respir. Cell Mol. Biol. 38:176-184(2008).
[14]
FUNCTION, AND INTERACTION WITH ATF4.
PubMed=18940792; DOI=10.1074/jbc.m806874200;
Su N., Kilberg M.S.;
"C/EBP homology protein (CHOP) interacts with activating transcription
factor 4 (ATF4) and negatively regulates the stress-dependent induction of
the asparagine synthetase gene.";
J. Biol. Chem. 283:35106-35117(2008).
[15]
INDUCTION.
PubMed=19855386; DOI=10.1038/ncb1996;
Woo C.W., Cui D., Arellano J., Dorweiler B., Harding H., Fitzgerald K.A.,
Ron D., Tabas I.;
"Adaptive suppression of the ATF4-CHOP branch of the unfolded protein
response by toll-like receptor signalling.";
Nat. Cell Biol. 11:1473-1480(2009).
[16]
FUNCTION.
PubMed=19672300; DOI=10.1371/journal.pone.0006618;
Oliveira S.J., Pinto J.P., Picarote G., Costa V.M., Carvalho F., Rangel M.,
de Sousa M., de Almeida S.F.;
"ER stress-inducible factor CHOP affects the expression of hepcidin by
modulating C/EBPalpha activity.";
PLoS ONE 4:E6618-E6618(2009).
[17]
FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH CEBPB, AND INDUCTION.
PubMed=20829347; DOI=10.1074/jbc.m110.136259;
Park S.H., Choi H.J., Yang H., Do K.H., Kim J., Lee D.W., Moon Y.;
"Endoplasmic reticulum stress-activated C/EBP homologous protein enhances
nuclear factor-kappaB signals via repression of peroxisome proliferator-
activated receptor gamma.";
J. Biol. Chem. 285:35330-35339(2010).
[18]
FUNCTION.
PubMed=20876114; DOI=10.1073/pnas.1011736107;
Goodall J.C., Wu C., Zhang Y., McNeill L., Ellis L., Saudek V.,
Gaston J.S.;
"Endoplasmic reticulum stress-induced transcription factor, CHOP, is
crucial for dendritic cell IL-23 expression.";
Proc. Natl. Acad. Sci. U.S.A. 107:17698-17703(2010).
[19]
REVIEW.
PubMed=22210905; DOI=10.1093/jb/mvr143;
Nishitoh H.;
"CHOP is a multifunctional transcription factor in the ER stress
response.";
J. Biochem. 151:217-219(2012).
[20]
FUNCTION, INTERACTION WITH FOXO3, AND SUBCELLULAR LOCATION.
PubMed=22761832; DOI=10.1371/journal.pone.0039586;
Ghosh A.P., Klocke B.J., Ballestas M.E., Roth K.A.;
"CHOP potentially co-operates with FOXO3a in neuronal cells to regulate
PUMA and BIM expression in response to ER stress.";
PLoS ONE 7:E39586-E39586(2012).
[21]
SUBCELLULAR LOCATION, ALTERNATIVE INITIATION (ISOFORM ALTDDIT3), AND
SUBUNIT.
PubMed=29083303; DOI=10.7554/elife.27860;
Samandi S., Roy A.V., Delcourt V., Lucier J.F., Gagnon J., Beaudoin M.C.,
Vanderperre B., Breton M.A., Motard J., Jacques J.F., Brunelle M.,
Gagnon-Arsenault I., Fournier I., Ouangraoua A., Hunting D.J., Cohen A.A.,
Landry C.R., Scott M.S., Roucou X.;
"Deep transcriptome annotation enables the discovery and functional
characterization of cryptic small proteins.";
Elife 6:0-0(2017).
[22]
SUBCELLULAR LOCATION, AND INDUCTION BY ER STRESS.
PubMed=33384352; DOI=10.1126/science.abb6896;
You K., Wang L., Chou C.H., Liu K., Nakata T., Jaiswal A., Yao J.,
Lefkovith A., Omar A., Perrigoue J.G., Towne J.E., Regev A., Graham D.B.,
Xavier R.J.;
"QRICH1 dictates the outcome of ER stress through transcriptional control
of proteostasis.";
Science 371:0-0(2021).
[23]
VARIANT [LARGE SCALE ANALYSIS] VAL-115.
PubMed=16959974; DOI=10.1126/science.1133427;
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
Velculescu V.E.;
"The consensus coding sequences of human breast and colorectal cancers.";
Science 314:268-274(2006).
-!- FUNCTION: Multifunctional transcription factor in endoplasmic reticulum
(ER) stress response (PubMed:15322075, PubMed:15775988,
PubMed:19672300). Plays an essential role in the response to a wide
variety of cell stresses and induces cell cycle arrest and apoptosis in
response to ER stress (PubMed:15322075, PubMed:15775988). Plays a dual
role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP)
function and as an activator of other genes (By similarity). Acts as a
dominant-negative regulator of C/EBP-induced transcription: dimerizes
with members of the C/EBP family, impairs their association with C/EBP
binding sites in the promoter regions, and inhibits the expression of
C/EBP regulated genes (By similarity). Positively regulates the
transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34,
BBC3/PUMA, BCL2L11/BIM and ERO1L (PubMed:15775988, PubMed:17709599,
PubMed:22761832, PubMed:20876114). Negatively regulates; expression of
BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine
synthetase (ASNS), CEBPA-dependent transcriptional activation of
hepcidin (HAMP) and CEBPB-mediated expression of peroxisome
proliferator-activated receptor gamma (PPARG) (PubMed:18940792,
PubMed:19672300, PubMed:20829347). Together with ATF4, mediates ER-
mediated cell death by promoting expression of genes involved in
cellular amino acid metabolic processes, mRNA translation and the
unfolded protein response (UPR) in response to ER stress (By
similarity). Inhibits the canonical Wnt signaling pathway by binding to
TCF7L2/TCF4, impairing its DNA-binding properties and repressing its
transcriptional activity (PubMed:16434966). Plays a regulatory role in
the inflammatory response through the induction of caspase-11
(CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and
both these caspases increase the activation of pro-IL1B to mature IL1B
which is involved in the inflammatory response (By similarity). Acts as
a major regulator of postnatal neovascularization through regulation of
endothelial nitric oxide synthase (NOS3)-related signaling (By
similarity). {ECO:0000250|UniProtKB:P35639,
ECO:0000269|PubMed:15322075, ECO:0000269|PubMed:15775988,
ECO:0000269|PubMed:16434966, ECO:0000269|PubMed:17709599,
ECO:0000269|PubMed:18940792, ECO:0000269|PubMed:19672300,
ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:20876114,
ECO:0000269|PubMed:22761832}.
-!- SUBUNIT: Heterodimer (PubMed:29083303). Interacts with TCF7L2/TCF4,
EP300/P300, HDAC1, HDAC5 and HDAC6 (PubMed:17872950, PubMed:16434966).
Interacts with TRIB3 which blocks its association with EP300/P300
(PubMed:15775988, PubMed:17872950). Interacts with FOXO3, CEBPB and
ATF4 (PubMed:18940792, PubMed:20829347, PubMed:22761832).
{ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16434966,
ECO:0000269|PubMed:17872950, ECO:0000269|PubMed:18940792,
ECO:0000269|PubMed:20829347, ECO:0000269|PubMed:22761832,
ECO:0000269|PubMed:29083303}.
-!- SUBUNIT: [Isoform 1]: Interacts with isoform AltDDIT3 of DDIT3.
{ECO:0000269|PubMed:29083303}.
-!- INTERACTION:
P35638; P15336: ATF2; NbExp=2; IntAct=EBI-742651, EBI-1170906;
P35638; P18847: ATF3; NbExp=23; IntAct=EBI-742651, EBI-712767;
P35638; P18848: ATF4; NbExp=5; IntAct=EBI-742651, EBI-492498;
P35638; O14867: BACH1; NbExp=2; IntAct=EBI-742651, EBI-1263541;
P35638; Q16520: BATF; NbExp=8; IntAct=EBI-742651, EBI-749503;
P35638; Q8N1L9: BATF2; NbExp=2; IntAct=EBI-742651, EBI-742695;
P35638; Q9NR55: BATF3; NbExp=8; IntAct=EBI-742651, EBI-10312707;
P35638; P49715: CEBPA; NbExp=4; IntAct=EBI-742651, EBI-1172054;
P35638; P17676: CEBPB; NbExp=2; IntAct=EBI-742651, EBI-969696;
P35638; P49716: CEBPD; NbExp=2; IntAct=EBI-742651, EBI-7962058;
P35638; Q15744: CEBPE; NbExp=3; IntAct=EBI-742651, EBI-3907048;
P35638; P53567: CEBPG; NbExp=6; IntAct=EBI-742651, EBI-740209;
P35638; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-742651, EBI-739773;
P35638; O43889: CREB3; NbExp=2; IntAct=EBI-742651, EBI-625002;
P35638; O60519: CREBL2; NbExp=3; IntAct=EBI-742651, EBI-2872455;
P35638; Q10586: DBP; NbExp=4; IntAct=EBI-742651, EBI-3908088;
P35638; P35638: DDIT3; NbExp=2; IntAct=EBI-742651, EBI-742651;
P35638; Q7Z589-5: EMSY; NbExp=3; IntAct=EBI-742651, EBI-11989522;
P35638; P01100: FOS; NbExp=8; IntAct=EBI-742651, EBI-852851;
P35638; P15408: FOSL2; NbExp=6; IntAct=EBI-742651, EBI-3893419;
P35638; P14136: GFAP; NbExp=3; IntAct=EBI-742651, EBI-744302;
P35638; Q16534: HLF; NbExp=3; IntAct=EBI-742651, EBI-2798854;
P35638; Q9BPX1: HSD17B14; NbExp=6; IntAct=EBI-742651, EBI-742664;
P35638; Q8WYK2: JDP2; NbExp=3; IntAct=EBI-742651, EBI-1248415;
P35638; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-742651, EBI-1055254;
P35638; P17275: JUNB; NbExp=2; IntAct=EBI-742651, EBI-748062;
P35638; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-742651, EBI-739832;
P35638; Q9BTE3-2: MCMBP; NbExp=3; IntAct=EBI-742651, EBI-9384556;
P35638; Q16236: NFE2L2; NbExp=5; IntAct=EBI-742651, EBI-2007911;
P35638; Q16649: NFIL3; NbExp=2; IntAct=EBI-742651, EBI-3951858;
P35638; O43508: TNFSF12; NbExp=3; IntAct=EBI-742651, EBI-6932080;
P35638; Q99757: TXN2; NbExp=3; IntAct=EBI-742651, EBI-2932492;
P35638; Q86VQ3: TXNDC2; NbExp=3; IntAct=EBI-742651, EBI-1220595;
P35638; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-742651, EBI-2559305;
P35638-2; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-10173632, EBI-10187270;
P35638-2; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-10173632, EBI-1166928;
P35638-2; Q9NR55: BATF3; NbExp=3; IntAct=EBI-10173632, EBI-10312707;
P35638-2; Q494R4: CCDC153; NbExp=3; IntAct=EBI-10173632, EBI-10241443;
P35638-2; P53567: CEBPG; NbExp=3; IntAct=EBI-10173632, EBI-740209;
P35638-2; Q7Z589: EMSY; NbExp=3; IntAct=EBI-10173632, EBI-6598631;
P35638-2; P15408: FOSL2; NbExp=3; IntAct=EBI-10173632, EBI-3893419;
P35638-2; Q9BPX1: HSD17B14; NbExp=3; IntAct=EBI-10173632, EBI-742664;
P35638-2; P25791: LMO2; NbExp=3; IntAct=EBI-10173632, EBI-739696;
P35638-2; O75971: SNAPC5; NbExp=3; IntAct=EBI-10173632, EBI-749483;
P35638-2; Q4ACW9: TWEAK; NbExp=3; IntAct=EBI-10173632, EBI-10241785;
P35638-2; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-10173632, EBI-2559305;
P35638-2; P24278: ZBTB25; NbExp=3; IntAct=EBI-10173632, EBI-739899;
P35638-2; Q6PJT7: ZC3H14; NbExp=3; IntAct=EBI-10173632, EBI-740660;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29083303}. Nucleus
{ECO:0000269|PubMed:29083303, ECO:0000269|PubMed:33384352}.
Note=Present in the cytoplasm under non-stressed conditions and ER
stress leads to its nuclear accumulation.
{ECO:0000269|PubMed:29083303}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing, Alternative initiation; Named isoforms=3;
Name=1;
IsoId=P35638-1; Sequence=Displayed;
Name=2;
IsoId=P35638-2; Sequence=VSP_047277;
Name=AltDDIT3;
IsoId=P0DPQ6-1; Sequence=External;
-!- INDUCTION: Up-regulated by oxidative stress, amino-acid deprivation,
hypoxia and endoplasmic reticulum stress (PubMed:33384352). During ER
stress, induced by a EIF2AK3/ATF4 pathway and/or ERN1/ATF6 pathway.
Expression is suppressed by TLR-TRIF signaling pathway during prolonged
ER stress. {ECO:0000269|PubMed:19855386, ECO:0000269|PubMed:20829347,
ECO:0000269|PubMed:33384352}.
-!- DOMAIN: The N-terminal region is necessary for its proteasomal
degradation, transcriptional activity and interaction with EP300/P300.
-!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
{ECO:0000269|PubMed:17872950}.
-!- PTM: Phosphorylation at serine residues by MAPK14 enhances its
transcriptional activation activity while phosphorylation at serine
residues by CK2 inhibits its transcriptional activation activity.
{ECO:0000250}.
-!- DISEASE: Myxoid liposarcoma (MXLIPO) [MIM:613488]: A soft tissue tumor
that tends to occur in the limbs (especially the thigh) of patients
ranging in age from 35 to 55 years. It is defined by the presence of a
hypocellular spindle cell proliferation set in a myxoid background,
often with mucin pooling. Lipoblasts tend to be small and often
monovacuolated and to cluster around vessels or at the periphery of the
lesion. {ECO:0000269|PubMed:7503811}. Note=The gene represented in this
entry may be involved in disease pathogenesis. A chromosomal aberration
involving DDIT3 has been found in a patient with malignant myxoid
liposarcoma. Translocation t(12;16)(q13;p11) with FUS (PubMed:7503811).
{ECO:0000269|PubMed:7503811}.
-!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAB27103.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
Haematology;
URL="http://atlasgeneticsoncology.org/Genes/DDIT3ID80.html";
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/ddit3/";
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; S40706; AAB22646.1; -; mRNA.
EMBL; S62138; AAB27103.1; ALT_SEQ; mRNA.
EMBL; AY461580; -; NOT_ANNOTATED_CDS; mRNA.
EMBL; AY880949; AAW56077.1; -; Genomic_DNA.
EMBL; AC022506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC003637; AAH03637.1; -; mRNA.
CCDS; CCDS55838.1; -. [P35638-2]
CCDS; CCDS8943.1; -. [P35638-1]
PIR; JC1169; JC1169.
PIR; S33798; S33798.
RefSeq; NP_001181982.1; NM_001195053.1. [P35638-2]
RefSeq; NP_001181983.1; NM_001195054.1. [P35638-2]
RefSeq; NP_001181984.1; NM_001195055.1. [P35638-2]
RefSeq; NP_001181986.1; NM_001195057.1. [P35638-1]
RefSeq; NP_004074.2; NM_004083.5. [P35638-1]
SMR; P35638; -.
BioGRID; 108016; 107.
ComplexPortal; CPX-6415; bZIP transcription factor complex, ATF2-DDIT3.
ComplexPortal; CPX-6473; bZIP transcription factor complex, ATF3-DDIT3.
ComplexPortal; CPX-6543; bZIP transcription factor complex, ATF4-DDIT3.
ComplexPortal; CPX-69; bZIP transcription factor complex, CEBPA-DDIT3.
ComplexPortal; CPX-70; bZIP transcription factor complex, CEBPB-DDIT3.
CORUM; P35638; -.
DIP; DIP-41589N; -.
IntAct; P35638; 67.
MINT; P35638; -.
STRING; 9606.ENSP00000448665; -.
ChEMBL; CHEMBL3351207; -.
GlyGen; P35638; 1 site, 1 O-linked glycan (1 site).
iPTMnet; P35638; -.
PhosphoSitePlus; P35638; -.
BioMuta; DDIT3; -.
DMDM; 544022; -.
jPOST; P35638; -.
MassIVE; P35638; -.
PaxDb; P35638; -.
PeptideAtlas; P35638; -.
PRIDE; P35638; -.
ProteomicsDB; 28566; -.
ProteomicsDB; 55121; -. [P35638-1]
Antibodypedia; 4408; 1019 antibodies.
CPTC; P35638; 3 antibodies.
DNASU; 1649; -.
Ensembl; ENST00000346473; ENSP00000340671; ENSG00000175197. [P35638-1]
Ensembl; ENST00000547303; ENSP00000447188; ENSG00000175197. [P35638-1]
Ensembl; ENST00000551116; ENSP00000448665; ENSG00000175197. [P35638-2]
Ensembl; ENST00000552740; ENSP00000447803; ENSG00000175197. [P35638-2]
Ensembl; ENST00000623876; ENSP00000494844; ENSG00000175197. [P35638-1]
GeneID; 1649; -.
KEGG; hsa:1649; -.
UCSC; uc009zps.4; human. [P35638-1]
CTD; 1649; -.
DisGeNET; 1649; -.
GeneCards; DDIT3; -.
HGNC; HGNC:2726; DDIT3.
HPA; ENSG00000175197; Low tissue specificity.
MalaCards; DDIT3; -.
MIM; 126337; gene.
MIM; 613488; phenotype.
neXtProt; NX_P35638; -.
OpenTargets; ENSG00000175197; -.
Orphanet; 99967; Myxoid/round cell liposarcoma.
PharmGKB; PA27193; -.
VEuPathDB; HostDB:ENSG00000175197; -.
eggNOG; KOG3119; Eukaryota.
GeneTree; ENSGT00390000006305; -.
HOGENOM; CLU_135108_0_0_1; -.
InParanoid; P35638; -.
OMA; QCPARAG; -.
OrthoDB; 1338770at2759; -.
PhylomeDB; P35638; -.
TreeFam; TF105006; -.
PathwayCommons; P35638; -.
Reactome; R-HSA-380994; ATF4 activates genes in response to endoplasmic reticulum stress.
Reactome; R-HSA-381183; ATF6 (ATF6-alpha) activates chaperone genes.
Reactome; R-HSA-9614657; FOXO-mediated transcription of cell death genes.
Reactome; R-HSA-9633012; Response of EIF2AK4 (GCN2) to amino acid deficiency.
Reactome; R-HSA-9648895; Response of EIF2AK1 (HRI) to heme deficiency.
SignaLink; P35638; -.
SIGNOR; P35638; -.
BioGRID-ORCS; 1649; 26 hits in 1036 CRISPR screens.
ChiTaRS; DDIT3; human.
GeneWiki; DNA_damage-inducible_transcript_3; -.
GenomeRNAi; 1649; -.
Pharos; P35638; Tchem.
PRO; PR:P35638; -.
Proteomes; UP000005640; Chromosome 12.
RNAct; P35638; protein.
Bgee; ENSG00000175197; Expressed in hypothalamus and 225 other tissues.
ExpressionAtlas; P35638; baseline and differential.
Genevisible; P35638; HS.
GO; GO:1990622; C:CHOP-ATF3 complex; IDA:ParkinsonsUK-UCL.
GO; GO:1990617; C:CHOP-ATF4 complex; IDA:ParkinsonsUK-UCL.
GO; GO:0036488; C:CHOP-C/EBP complex; ISS:ParkinsonsUK-UCL.
GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; TAS:ParkinsonsUK-UCL.
GO; GO:0005770; C:late endosome; IEA:Ensembl.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0032993; C:protein-DNA complex; IDA:ParkinsonsUK-UCL.
GO; GO:0005667; C:transcription regulator complex; NAS:ParkinsonsUK-UCL.
GO; GO:0008140; F:cAMP response element binding protein binding; IPI:ParkinsonsUK-UCL.
GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
GO; GO:0003700; F:DNA-binding transcription factor activity; IGI:ParkinsonsUK-UCL.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0043522; F:leucine zipper domain binding; IDA:ParkinsonsUK-UCL.
GO; GO:0046982; F:protein heterodimerization activity; IPI:ParkinsonsUK-UCL.
GO; GO:0042803; F:protein homodimerization activity; IDA:CAFA.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:ParkinsonsUK-UCL.
GO; GO:0008134; F:transcription factor binding; IPI:BHF-UCL.
GO; GO:0140416; F:transcription regulator inhibitor activity; ISS:ARUK-UCL.
GO; GO:0009948; P:anterior/posterior axis specification; ISS:BHF-UCL.
GO; GO:0036500; P:ATF6-mediated unfolded protein response; TAS:ParkinsonsUK-UCL.
GO; GO:0001955; P:blood vessel maturation; IEA:Ensembl.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0045454; P:cell redox homeostasis; IDA:MGI.
GO; GO:0006974; P:cellular response to DNA damage stimulus; TAS:ProtInc.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; ISS:UniProtKB.
GO; GO:0006983; P:ER overload response; IBA:GO_Central.
GO; GO:0072655; P:establishment of protein localization to mitochondrion; IEA:Ensembl.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IDA:UniProtKB.
GO; GO:1990442; P:intrinsic apoptotic signaling pathway in response to nitrosative stress; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:BHF-UCL.
GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; ISS:YuBioLab.
GO; GO:0032792; P:negative regulation of CREB transcription factor activity; IDA:ParkinsonsUK-UCL.
GO; GO:2000016; P:negative regulation of determination of dorsal identity; IDA:BHF-UCL.
GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; IDA:BHF-UCL.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IEA:Ensembl.
GO; GO:0032689; P:negative regulation of interferon-gamma production; IMP:ARUK-UCL.
GO; GO:0032700; P:negative regulation of interleukin-17 production; IMP:ARUK-UCL.
GO; GO:0032713; P:negative regulation of interleukin-4 production; IMP:ARUK-UCL.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:ARUK-UCL.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; IMP:ParkinsonsUK-UCL.
GO; GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IDA:ParkinsonsUK-UCL.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:ParkinsonsUK-UCL.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0036499; P:PERK-mediated unfolded protein response; TAS:ParkinsonsUK-UCL.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IMP:CAFA.
GO; GO:1902237; P:positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IC:ParkinsonsUK-UCL.
GO; GO:0032757; P:positive regulation of interleukin-8 production; IMP:UniProtKB.
GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; IDA:ParkinsonsUK-UCL.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
GO; GO:0010506; P:regulation of autophagy; ISS:UniProtKB.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IDA:MGI.
GO; GO:0043618; P:regulation of transcription from RNA polymerase II promoter in response to stress; TAS:BHF-UCL.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
GO; GO:0034976; P:response to endoplasmic reticulum stress; IDA:UniProtKB.
GO; GO:0042594; P:response to starvation; IEA:Ensembl.
GO; GO:0006986; P:response to unfolded protein; IDA:UniProtKB.
GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DisProt; DP00624; -.
InterPro; IPR004827; bZIP.
InterPro; IPR016670; DNA_damage_induc_transcript_3.
PANTHER; PTHR16833; PTHR16833; 1.
PIRSF; PIRSF016571; C/EBPzeta_CHOP_DDIT3; 1.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
1: Evidence at protein level;
Activator; Alternative initiation; Alternative splicing; Apoptosis;
Cell cycle; Chromosomal rearrangement; Cytoplasm; DNA-binding;
Growth arrest; Nucleus; Phosphoprotein; Proto-oncogene; Reference proteome;
Repressor; Stress response; Transcription; Transcription regulation;
Ubl conjugation; Unfolded protein response; Wnt signaling pathway.
CHAIN 1..169
/note="DNA damage-inducible transcript 3 protein"
/id="PRO_0000076642"
DOMAIN 99..162
/note="bZIP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
REGION 10..26
/note="N-terminal"
REGION 10..18
/note="Interaction with TRIB3"
REGION 32..139
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 101..130
/note="Basic motif"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
REGION 134..148
/note="Leucine-zipper"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
COMPBIAS 70..89
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 115..139
/note="Basic and acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOD_RES 14
/note="Phosphoserine; by CK2"
/evidence="ECO:0000250|UniProtKB:P35639"
MOD_RES 15
/note="Phosphoserine; by CK2"
/evidence="ECO:0000250|UniProtKB:P35639"
MOD_RES 30
/note="Phosphoserine; by CK2"
/evidence="ECO:0000250|UniProtKB:P35639"
MOD_RES 31
/note="Phosphoserine; by CK2"
/evidence="ECO:0000250|UniProtKB:P35639"
MOD_RES 79
/note="Phosphoserine; by MAPK14"
/evidence="ECO:0000250|UniProtKB:P35639"
MOD_RES 82
/note="Phosphoserine; by MAPK14"
/evidence="ECO:0000250|UniProtKB:P35639"
VAR_SEQ 1
/note="M -> MELVPATPHYPADVLFQTDPTAEM (in isoform 2)"
/evidence="ECO:0000303|Ref.4"
/id="VSP_047277"
VARIANT 115
/note="A -> V (in a colorectal cancer sample; somatic
mutation)"
/evidence="ECO:0000269|PubMed:16959974"
/id="VAR_036000"
CONFLICT 10..14
/note="FGTLS -> SDTV (in Ref. 1; AAB22646)"
/evidence="ECO:0000305"
SEQUENCE 169 AA; 19175 MW; 31905293FB1FBBE2 CRC64;
MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL
AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM
KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA


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Pathways :
WP1663: Homologous recombination
WP1676: Non-homologous end-joining
WP1531: Vitamin D synthesis
WP2292: Chemokine signaling pathway
WP1616: ABC transporters
WP731: Sterol regulatory element binding protein related
WP210: Cytoplasmic Ribosomal Proteins
WP1673: Naphthalene and anthracene degradation
WP2203: TSLP Signaling Pathway
WP2272: Pathogenic Escherichia coli infection
WP1613: 1,4-Dichlorobenzene degradation
WP73: G Protein Signaling Pathways
WP1678: Nucleotide excision repair
WP1371: G Protein Signaling Pathways
WP1690: Propanoate metabolism
WP2324: AGE/RAGE pathway
WP1625: Base excision repair
WP1654: gamma-Hexachlorocyclohexane degradation
WP1939: Unfolded Protein Response
WP1694: Pyrimidine metabolism
WP1502: Mitochondrial biogenesis
WP1714: Tyrosine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1672: Mismatch repair
WP2199: Seed Development

Related Genes :
[DDIT3 CHOP CHOP10 GADD153] DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)
[Ddit3 Chop Chop10 Gadd153] DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)
[Cebpb] CCAAT/enhancer-binding protein beta (C/EBP beta) (AGP/EBP) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched transcriptional activator) (LAP)
[Cebpa Cebp] CCAAT/enhancer-binding protein alpha (C/EBP alpha)
[CEBPB TCF5 PP9092] CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)
[Cebpb Crp2 Nf-il6 Sfb] CCAAT/enhancer-binding protein beta (C/EBP beta) (C/EBP-related protein 2) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched inhibitory protein) (LIP) (Liver-enriched transcriptional activator) (LAP) (Silencer factor B) (SF-B)
[Atf4 Creb2] Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (C/EBP-related ATF) (C/ATF) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2)
[Cebpa] CCAAT/enhancer-binding protein alpha (C/EBP alpha)
[Ddit4 Dig2 Redd1 Rtp801] DNA damage-inducible transcript 4 protein (Dexamethasone-induced gene 2 protein) (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)
[CEBPA CEBP] CCAAT/enhancer-binding protein alpha (C/EBP alpha)
[DDIT4L REDD2 RTP801L] DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)
[CEBPB] CCAAT/enhancer-binding protein beta (C/EBP beta)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[hchA A8C65_13880 A8X68_003796 ABT96_003721 ACW72_003908 ADS93_004744 AMK64_004563 AO169_004024 AT845_003071 AW086_18955 B2D52_004166 B5N24_004414 B6L15_004262 B9T59_01945 BF481_000399 BG944_002806 BJJ90_15205 BK272_05030 BKD45_004813 BM922_003014 BMC34_002412 BMT49_12710 BMT50_21300 BON65_01250 BON66_15955 BON86_06490 BON93_14110 BON95_14610 BOY03_000482 BUE81_10670 BvCmsKKP005_03878 BvCmsKKP057_02347 BvCmsKKP061_00566 BvCmsKSP067_02879 BvCmsSIP082_02402 BZL69_29425 C2U48_24800 C3F40_00665 C5715_19445 C5N07_21380 C5Y87_06915 C9Z43_06360 CBT22_003417 CCZ91_004170 CDC27_10055 CDL37_00765 CG831_003889 CLG78_003595 COD50_20045 CQP61_17160 CS116_003991 CY655_12940 D9D43_06110 D9D77_14400 D9H13_22385 DEN89_24995 DLW88_16170 DTL43_21780 DU321_04440 DXB10_02555 DXT73_20690 E2135_17195 E3N34_18700 E4K54_18520 E5S34_18005 E5S62_15980 EAX79_27320 EBP16_01985 EC95NR1_00961 ED648_25045 EH88_000903 EHD79_18540 ELV08_24970 ELX69_01215 ERS085386_05041 ETECE1373_01878 ExPECSC038_01920 EYX55_12230 F2N27_00930 F2N28_13090 F7F11_20115 F9407_21070 F9S83_26095 F9V07_22865 FDM60_13375 FHR00_11090 FOI11_003080 FOI11_16965 FQE77_07620 FWK02_18105 FZN26_21485 G3813_000471 G5696_13480 GFZ60_00075 GKZ24_21140 GQE64_12165 GQE87_19550 GQM04_17335 GQM10_10435 GQW80_12220 GRW05_22880 GRW57_10520 GTP88_06910 GUB08_10670 GUC01_04925 GXU05_000820 GXV26_000768 H0O72_18450 HH795_003783 HHH44_001696 HI055_003004 HIF90_003862 HIT56_001988 HJO75_002854 HJQ60_001626 HKA49_000011 HLU56_00030 HLZ50_02125 HMV95_17840 HNC52_06820 HND24_14805 HNO08_12550 HNV65_13940 HNY50_00190 HNY54_00190 HVV53_06790 HVW11_20930 HVW43_01085 HVX16_09450 HVY77_10520 HVZ33_09830 HZ71_003355 I6H02_04490 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC10974_02300 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13216_04667 NCTC8985_00529 NCTC9048_02115 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472056_01268 SAMEA3472080_04213 SAMEA3472112_00448 SAMEA3472117_00397 SAMEA3472120_00418 UN91_23615 WP4S18E07_18560 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[RNR3 DIN1 YIL066C] Ribonucleoside-diphosphate reductase large chain 2 (EC 1.17.4.1) (Ribonucleotide reductase DNA damage-inducible regulatory subunit 2) (Ribonucleotide reductase R1 subunit 2) (Ribonucleotide reductase large subunit 2)
[ligD Rv0938 MTCY08D9.01c MTCY10D7.36c] Multifunctional non-homologous end joining DNA repair protein LigD (NHEJ DNA repair protein D) (Mt-Lig) (NHEJ DNA polymerase) [Includes: DNA repair polymerase (Pol) (Polymerase/primase); 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase) (PE); DNA ligase (Lig) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])]
[TRIB3 C20orf97 NIPK SKIP3 TRB3] Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[CEBPA] CCAAT/enhancer-binding protein alpha (C/EBP alpha)
[ATF4 CREB2 TXREB] Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)
[EIF4EBP1] Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
[ligD PA2138] Multifunctional non-homologous end joining protein LigD (NHEJ DNA polymerase) [Includes: 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase); DNA ligase D (LigD) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]); DNA repair polymerase (Pol) (Polymerase/primase)]
[EP300 P300] Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
[yaiE ppnP yaiE_1 yaiE_2 A5U30_004171 A6519_004168 A6583_19230 A6592_08565 A8499_002689 A8C65_08910 A8W81_002402 A8X68_002957 A9819_01890 A9X72_19070 AAG43_001684 AAS29_000851 ABE90_005680 ABT96_001030 ACN002_0406 ACN68_10320 ACN81_25005 ACU57_12035 ACW72_000537 AM270_02350 AM340_00170 AM464_18935 AMK64_000048 AML23_18615 AO169_001228 APX88_10995 AT845_004245 AUQ29_12220 AW059_14025 AW086_04940 AW118_21925 AZZ83_000156 B2D52_001288 B5N24_001418 B6L15_000900 B6R12_004630 B6R15_004744 B6R17_001763 B6R27_001430 B6R48_001853 B6R87_002119 B7C15_002412 B9T59_05995 BANRA_00925 BANRA_01371 BANRA_02015 BANRA_03594 BB545_15535 BE963_16095 BER14_23410 BF271_000352 BFL24_02350 BG821_003456 BG944_000956 BH692_02565 BHF52_11910 BHS81_02405 BHS87_02130 BIQ87_02175 BIZ41_26355 BJI68_13875 BJJ90_20310 BK272_17750 BK292_14635 BK373_01320 BK375_26975 BKD45_000677 BMC34_003941 BMC79_001982 BMR21_14190 BMT50_02930 BMT91_05310 BN17_01951 BO068_001728 BOB65_000444 BOH76_16090 BON63_11530 BON65_18745 BON66_09075 BON70_06170 BON72_15085 BON73_05975 BON76_23825 BON83_20655 BON86_03800 BON87_15370 BON91_23895 BON92_15465 BON93_19270 BON94_14845 BON95_06500 BON96_22295 BON98_18895 BR158_003623 BR331_05500 BRV34_002179 BRV41_001603 BTQ06_17790 BUE81_15520 BUE82_18690 BvCms2454_01767 BvCmsC61A_02990 BvCmsHHP019_02594 BvCmsHHP019_02735 BvCmsHHP056_01410 BvCmsKKP005_02375 BvCmsKKP036_04281 BvCmsKKP057_03186 BvCmsKKP061_04019 BvCmsKSNP073_05624 BvCmsKSP011_04945 BvCmsKSP067_05191 BvCmsKSP076_04759 BvCmsNSNP036_04163 BvCmsSIP024_01003 BvCmsSIP082_02880 BVL39_00880 BWI89_12535 BXT93_00165 BZL69_16805 C2M16_02670 C2U48_08110 C3F40_10585 C4952_000933 C4M78_16865 C5542_003745 C5715_13595 C5F72_20070 C5N07_12740 C5Y87_03235 C6B22_00620 C6L19_003123 C6N50_002569 C7B02_04545 C9114_16640 C9160_00550 C9E67_23765 C9Z62_15540 C9Z68_20485 CA593_01185 CBT22_001283 CCS08_21635 CCZ91_001256 CD42_000819 CDC27_00860 CDL36_14165 CDL37_09465 CF32_001327 CG692_05055 CG831_000443 CIG67_05475 CLG78_001395 CN875_002288 CO706_24355 COD50_07875 CQP61_20925 CR539_06140 CS116_000640 CT143_00140 CV83915_01183 CWS33_22875 CXJ73_003963 CY655_02075 D0X26_07420 D1912_23295 D3822_22465 D3C88_28950 D3G36_08025 D3O91_15305 D3Y67_14350 D4U49_03050 D4V09_04715 D5H22_03840 D6T60_09300 D9D31_21970 D9D43_14830 D9D77_05600 D9E34_09525 D9E49_06955 D9H13_03415 D9H94_24405 D9J03_17400 D9J11_02150 D9J61_02635 D9K17_07345 DAH18_14975 DAH23_10455 DAH34_21345 DAH37_05240 DAH50_14800 DB282_04950 DD762_07680 DEN86_05080 DEN89_14495 DEN95_09255 DEO15_17360 DIV22_26285 DL654_17660 DLX40_16565 DM968_04210 DN627_04525 DNQ45_00335 DP258_05110 DRW19_06400 DS732_06920 DS966_18475 DTL43_07415 DTL90_10740 DTM10_06080 DTM45_10960 DU321_19460 DXB10_13805 DXT69_08115 DXT71_02970 DXT73_01860 E0I42_07410 E0N24_10860 E0P28_09655 E2119_01725 E2123_04610 E2127_09375 E2128_04435 E2129_13975 E2135_01410 E3N34_04125 E4K51_12070 E4K54_07340 E5P52_05895 E5S34_07545 E5S35_14895 E5S38_06765 E5S43_12135 E5S47_09895 E5S52_06115 E5S61_09810 E5S62_19990 EA239_15730 EA435_05820 EAI46_25725 EAI46_25840 EAN77_07940 EAX79_06830 EBP16_12520 EC1094V2_3464 EC3234A_4c00610 EC95NR1_04612 ECs0441 ED648_16775 EGC08_04505 EH88_002240 EHD79_03470 EHH55_15815 EI021_16245 EI041_08145 EIA13_09645 EIZ93_00830 EKI52_09170 EL79_3454 EL80_3408 ELT17_22260 ELT29_22585 ELT31_00280 ELT33_03015 ELT48_00735 ELT49_21480 ELT58_21305 ELT72_05540 ELU83_10395 ELU85_08960 ELU95_12465 ELV08_00785 ELV13_00555 ELV15_22680 ELV22_01630 ELV24_16525 ELV28_08410 ELX56_03900 ELX68_02065 ELX69_19550 ELX70_07125 ELX76_05850 ELX79_24270 ELX83_01445 ELX96_14305 ELY05_09885 ELY23_04665 ELY24_07180 ELY32_22740 ELY41_15435 ELY48_07355 ELY50_04295 EO241_13835 EPS76_10515 EQO00_19840 ERS085366_04179 ERS085386_01096 ERS085406_02227 ERS139208_01812 Esc0902E_04100 ETECE1373_03601 ETECE36_04584 ETECE925_03600 EVY14_00050 EWK56_10245 ExPECSC038_04895 EXX13_09665 EXX79_08270 EYX47_16280 EYX55_13650 EYY34_27625 F2N27_03375 F2N28_02020 F2N31_18495 F3N40_11580 F6U69_13610 F7F11_06850 F9386_04870 F9400_03995 F9407_08955 F9571_08760 F9B07_11235 F9S76_00660 F9S83_01525 F9V07_00950 F9V24_00540 F9X20_010625 F9X20_10705 FA849_16230 FA868_02660 FC554_02980 FDM60_01545 FEL34_02665 FFF58_18140 FGG80_03620 FGY90_08925 FHD44_10100 FHR00_04660 FJQ51_13145 FKO60_24460 FMP09_15400 FNJ67_20330 FOI11_011505 FOI11_08540 FPI65_02250 FPS82_09410 FQ021_04720 FQE77_10330 FQF29_11270 FTV90_10360 FTV92_11870 FTV93_12360 FV293_06120 FWK02_29295 FZC17_02065 FZN26_02330 FZN30_08825 FZN31_18905 G3565_02860 G3813_001670 G4A38_05410 G5696_10795 G6P89_19245 G6Z99_23355 G7635_000369 G9448_08700 GAJ26_09340 GBE29_07095 GF147_12390 GF646_06625 GF699_04160 GFY34_04590 GFY48_03475 GFZ60_05015 GIB53_01735 GJ11_02375 GKE84_19495 GKF52_17565 GKF86_04910 GKF89_04055 GKG12_02940 GKZ24_03305 GNO40_22710 GNZ05_01665 GOP20_09010 GP650_16700 GP662_13045 GP711_02810 GP946_18990 GP954_12950 GP979_17585 GQE42_04900 GQE64_07505 GQE87_15550 GQF58_00730 GQF59_00790 GQM04_16295 GQM06_17115 GQM09_10135 GQM10_05275 GQM13_16755 GQR15_01785 GQW07_10130 GQW68_15010 GQW76_11855 GQW80_20255 GRC73_12510 GRO95_09290 GRQ19_02985 GRW05_15575 GRW57_16360 GRW80_21245 GRW81_04110 GSY44_11760 GTP88_03425 GUB08_22335 GUB92_14995 GUC01_07480 GUI33_03675 GW978_01435 GXV26_001683 H0O53_01395 H0O72_08355 H4P47_18630 H4P50_19265 H4P51_19115 H5C78_05615 HCF72_000699 HH795_003019 HHH44_001374 HI055_001796 HIE44_000773 HIF90_002068 HIN64_001318 HIR12_001426 HIT56_001577 HJ942_001977 HJM92_003231 HJN04_001825 HJO75_000225 HJQ60_002362 HJS37_002167 HJS41_003943 HJU54_001570 HKA49_002910 HL563_20960 HLU10_04740 HLU56_09785 HLV18_07370 HLZ50_17655 HmCms169_03669 HmCms184_01874 HmCmsJML074_04353 HMS79_05370 HMT08_08320 HMT08_28135 HMU06_13895 HMU48_14510 HMV41_12865 HMV95_11570 HNC30_09785 HNC36_06780 HNC38_21355 HNC52_05780 HNC59_10160 HNC66_06600 HNC75_03340 HNC99_09055 HND24_23650 HNO08_21040 HNV65_12835 HNY50_21730 HNY54_14805 HPE39_05435 HV109_18115 HVV39_18775 HVV53_22620 HVW11_04845 HVW22_00965 HVW43_10265 HVX16_19490 HVY77_19945 HVZ33_18480 HVZ71_18990 HX136_19525 HZ71_000860 HZ72_001928 I6H02_19720 IA00_002609 JE86ST02C_04160 JE86ST05C_04220 MJ49_04490 MS7163_00387 NCTC10082_01078 NCTC10089_03910 NCTC10418_05682 NCTC10429_03762 NCTC10764_05371 NCTC10767_04209 NCTC10865_04787 NCTC11022_05137 NCTC11126_00022 NCTC11181_01145 NCTC11341_03896 NCTC12950_04180 NCTC13127_05156 NCTC13216_02895 NCTC7922_06246 NCTC7927_04270 NCTC8008_03382 NCTC8009_07014 NCTC8179_01642 NCTC8450_01367 NCTC8500_04283 NCTC8621_03984 NCTC8622_02997 NCTC8959_05017 NCTC8960_01314 NCTC8985_02798 NCTC9001_00537 NCTC9036_03840 NCTC9044_03501 NCTC9045_04434 NCTC9048_04159 NCTC9050_01764 NCTC9075_05103 NCTC9077_04792 NCTC9081_02496 NCTC9111_03977 NCTC9117_04804 NCTC9434_02812 NCTC9702_04480 NCTC9703_03222 NCTC9706_01114 NCTC9775_02088 NCTC9777_00174 NCTC9969_04032 ND22_001447 PGD_02920 PU06_02955 RG28_02910 SAMEA3472043_02682 SAMEA3472044_00466 SAMEA3472056_03633 SAMEA3472064_01205 SAMEA3472080_01810 SAMEA3472112_02965 SAMEA3472117_02973 SAMEA3472120_01236 SAMEA3472147_04902 SAMEA3484427_03543 SAMEA3484429_01888 SAMEA3485101_03989 SAMEA3485110_03675 SAMEA3751407_02141 SAMEA3752312_01369 SAMEA3752386_01995 SAMEA3752557_00215 SAMEA3753064_01236 SAMEA3753290_01725 SAMEA3753300_00458 SM09_01165 THOESC010_34040 TUM18780_32860 UN91_18725 WP2S18E08_35360 WP4S18E07_34480 WP4S18E08_34230 WQ89_01420 WR15_04360] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[MEC3 PIP3 PSO9 YLR288C L8003.15] DNA damage checkpoint control protein MEC3
[Hspa5 Grp78] Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
[TCF7L2 TCF4] Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
[EIF4E2 EIF4EL3] Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3)
[Tenm4 Doc4 Kiaa1302 Odz4 Tnm4] Teneurin-4 (Ten-4) (Downstream of CHOP4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4)

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