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DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)

 DDIT3_MOUSE             Reviewed;         168 AA.
P35639; Q91YW9;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
29-SEP-2021, entry version 168.
RecName: Full=DNA damage-inducible transcript 3 protein;
Short=DDIT-3;
AltName: Full=C/EBP zeta;
AltName: Full=C/EBP-homologous protein {ECO:0000303|PubMed:21285359};
Short=CHOP {ECO:0000303|PubMed:21285359};
AltName: Full=C/EBP-homologous protein 10;
Short=CHOP-10;
AltName: Full=CCAAT/enhancer-binding protein homologous protein;
AltName: Full=Growth arrest and DNA-damage-inducible protein GADD153;
Name=Ddit3; Synonyms=Chop {ECO:0000303|PubMed:21285359}, Chop10, Gadd153;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
STRAIN=SWR/J;
PubMed=1547942; DOI=10.1101/gad.6.3.439;
Ron D., Habener J.F.;
"CHOP, a novel developmentally regulated nuclear protein that dimerizes
with transcription factors C/EBP and LAP and functions as a dominant-
negative inhibitor of gene transcription.";
Genes Dev. 6:439-453(1992).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=Czech II; TISSUE=Mammary tumor;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PHOSPHORYLATION AT SER-78 AND SER-81.
PubMed=8650547; DOI=10.1126/science.272.5266.1347;
Wang X.Z., Ron D.;
"Stress-induced phosphorylation and activation of the transcription factor
CHOP (GADD153) by p38 MAP Kinase.";
Science 272:1347-1349(1996).
[4]
FUNCTION.
PubMed=12706815; DOI=10.1016/s0014-5793(03)00283-7;
Hattori T., Ohoka N., Hayashi H., Onozaki K.;
"C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by
trapping negative regulating NF-IL6 isoform.";
FEBS Lett. 541:33-39(2003).
[5]
PHOSPHORYLATION AT SER-14; SER-15; SER-30 AND SER-31, AND MUTAGENESIS OF
SER-14; SER-15; SER-30 AND SER-31.
PubMed=12876286; DOI=10.1074/jbc.m306404200;
Ubeda M., Habener J.F.;
"CHOP transcription factor phosphorylation by casein kinase 2 inhibits
transcriptional activation.";
J. Biol. Chem. 278:40514-40520(2003).
[6]
FUNCTION.
PubMed=14684614; DOI=10.1210/en.2003-0868;
Pereira R.C., Delany A.M., Canalis E.;
"CCAAT/enhancer binding protein homologous protein (DDIT3) induces
osteoblastic cell differentiation.";
Endocrinology 145:1952-1960(2004).
[7]
FUNCTION.
PubMed=15601821; DOI=10.1101/gad.1250704;
Marciniak S.J., Yun C.Y., Oyadomari S., Novoa I., Zhang Y., Jungreis R.,
Nagata K., Harding H.P., Ron D.;
"CHOP induces death by promoting protein synthesis and oxidation in the
stressed endoplasmic reticulum.";
Genes Dev. 18:3066-3077(2004).
[8]
FUNCTION.
PubMed=15775988; DOI=10.1038/sj.emboj.7600596;
Ohoka N., Yoshii S., Hattori T., Onozaki K., Hayashi H.;
"TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway
and is involved in cell death.";
EMBO J. 24:1243-1255(2005).
[9]
FUNCTION, AND INDUCTION.
PubMed=16670335; DOI=10.4049/jimmunol.176.10.6245;
Endo M., Mori M., Akira S., Gotoh T.;
"C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11
and the pathogenesis of lipopolysaccharide-induced inflammation.";
J. Immunol. 176:6245-6253(2006).
[10]
FUNCTION, AND INDUCTION.
PubMed=19752026; DOI=10.1083/jcb.200904060;
Li G., Mongillo M., Chin K.T., Harding H., Ron D., Marks A.R., Tabas I.;
"Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate
receptor activity in endoplasmic reticulum stress-induced apoptosis.";
J. Cell Biol. 186:783-792(2009).
[11]
INDUCTION.
PubMed=19855386; DOI=10.1038/ncb1996;
Woo C.W., Cui D., Arellano J., Dorweiler B., Harding H., Fitzgerald K.A.,
Ron D., Tabas I.;
"Adaptive suppression of the ATF4-CHOP branch of the unfolded protein
response by toll-like receptor signalling.";
Nat. Cell Biol. 11:1473-1480(2009).
[12]
FUNCTION, AND INDUCTION.
PubMed=19919955; DOI=10.1093/jb/mvp189;
Nakayama Y., Endo M., Tsukano H., Mori M., Oike Y., Gotoh T.;
"Molecular mechanisms of the LPS-induced non-apoptotic ER stress-CHOP
pathway.";
J. Biochem. 147:471-483(2010).
[13]
FUNCTION, AND INDUCTION.
PubMed=21159964; DOI=10.1523/jneurosci.1598-10.2010;
Galehdar Z., Swan P., Fuerth B., Callaghan S.M., Park D.S., Cregan S.P.;
"Neuronal apoptosis induced by endoplasmic reticulum stress is regulated by
ATF4-CHOP-mediated induction of the Bcl-2 homology 3-only member PUMA.";
J. Neurosci. 30:16938-16948(2010).
[14]
INDUCTION.
PubMed=21285359; DOI=10.1074/jbc.m110.216093;
Palam L.R., Baird T.D., Wek R.C.;
"Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory
upstream ORF to enhance CHOP translation.";
J. Biol. Chem. 286:10939-10949(2011).
[15]
FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND INTERACTION WITH HDAC1.
PubMed=22242125; DOI=10.1371/journal.pone.0029498;
Alter J., Bengal E.;
"Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription
to delay myoblast differentiation.";
PLoS ONE 6:E29498-E29498(2011).
[16]
FUNCTION.
PubMed=22265908; DOI=10.1161/circulationaha.111.041830;
Loinard C., Zouggari Y., Rueda P., Ramkhelawon B., Cochain C., Vilar J.,
Recalde A., Richart A., Charue D., Duriez M., Mori M.,
Arenzana-Seisdedos F., Levy B.I., Heymes C., Silvestre J.S.;
"C/EBP homologous protein-10 (CHOP-10) limits postnatal neovascularization
through control of endothelial nitric oxide synthase gene expression.";
Circulation 125:1014-1026(2012).
[17]
FUNCTION, AND INTERACTION WITH ATF4.
PubMed=23624402; DOI=10.1038/ncb2738;
Han J., Back S.H., Hur J., Lin Y.H., Gildersleeve R., Shan J., Yuan C.L.,
Krokowski D., Wang S., Hatzoglou M., Kilberg M.S., Sartor M.A.,
Kaufman R.J.;
"ER-stress-induced transcriptional regulation increases protein synthesis
leading to cell death.";
Nat. Cell Biol. 15:481-490(2013).
-!- FUNCTION: Multifunctional transcription factor in endoplasmic reticulum
(ER) stress response (PubMed:15601821, PubMed:19752026). Plays an
essential role in the response to a wide variety of cell stresses and
induces cell cycle arrest and apoptosis in response to ER stress
(PubMed:15601821, PubMed:19752026). Plays a dual role both as an
inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an
activator of other genes (PubMed:1547942). Acts as a dominant-negative
regulator of C/EBP-induced transcription: dimerizes with members of the
C/EBP family, impairs their association with C/EBP binding sites in the
promoter regions, and inhibits the expression of C/EBP regulated genes
(PubMed:1547942). Positively regulates the transcription of TRIB3, IL6,
IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and
ERO1L (PubMed:12706815, PubMed:15775988, PubMed:21159964,
PubMed:14684614, PubMed:19919955). Negatively regulates; expression of
BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine
synthetase (ASNS), CEBPA-dependent transcriptional activation of
hepcidin (HAMP) and CEBPB-mediated expression of peroxisome
proliferator-activated receptor gamma (PPARG) (By similarity). Together
with ATF4, mediates ER-mediated cell death by promoting expression of
genes involved in cellular amino acid metabolic processes, mRNA
translation and the unfolded protein response (UPR) in response to ER
stress (PubMed:22242125, PubMed:23624402). Inhibits the canonical Wnt
signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding
properties and repressing its transcriptional activity (By similarity).
Plays a regulatory role in the inflammatory response through the
induction of caspase-11 (CASP4/CASP11) which induces the activation of
caspase-1 (CASP1) and both these caspases increase the activation of
pro-IL1B to mature IL1B which is involved in the inflammatory response
(PubMed:16670335). Acts as a major regulator of postnatal
neovascularization through regulation of endothelial nitric oxide
synthase (NOS3)-related signaling (PubMed:22265908).
{ECO:0000250|UniProtKB:P35638, ECO:0000269|PubMed:12706815,
ECO:0000269|PubMed:14684614, ECO:0000269|PubMed:1547942,
ECO:0000269|PubMed:15601821, ECO:0000269|PubMed:15775988,
ECO:0000269|PubMed:16670335, ECO:0000269|PubMed:19752026,
ECO:0000269|PubMed:19919955, ECO:0000269|PubMed:21159964,
ECO:0000269|PubMed:22242125, ECO:0000269|PubMed:22265908,
ECO:0000269|PubMed:23624402}.
-!- SUBUNIT: Heterodimer. Interacts with TCF7L2/TCF4, EP300/P300, HDAC5 and
HDAC6 (By similarity). Interacts with TRIB3 which blocks its
association with EP300/P300 (By similarity). Interacts with FOXO3, and
CEBPB (By similarity). Interacts with ATF4 (PubMed:23624402). Interacts
with HDAC1 (PubMed:22242125). {ECO:0000250|UniProtKB:P35638,
ECO:0000269|PubMed:22242125, ECO:0000269|PubMed:23624402}.
-!- SUBUNIT: [Isoform 1]: Interacts with isoform AltDDIT3 of DDIT3.
{ECO:0000250|UniProtKB:P35638}.
-!- INTERACTION:
P35639; Q06507: Atf4; NbExp=3; IntAct=EBI-10636142, EBI-77383;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1547942}. Nucleus
{ECO:0000269|PubMed:22242125}. Note=Present in the cytoplasm under non-
stressed conditions and ER stress leads to its nuclear accumulation.
{ECO:0000269|PubMed:22242125}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative initiation; Named isoforms=2;
Name=1;
IsoId=P35639-1; Sequence=Displayed;
Name=AltDDIT3;
IsoId=A0A2R8VHR8-1; Sequence=External;
-!- INDUCTION: [Isoform 1]: By various stress, such as oxidative stress,
amino-acid deprivation, hypoxia and ER stress (PubMed:16670335,
PubMed:19752026, PubMed:19855386, PubMed:19919955, PubMed:21159964,
PubMed:22242125). Specifically produced in response to stress: in
absence of stress, AltDDIT3, the upstream ORF of this bicistronic gene,
is translated, thereby preventing its translation (PubMed:21285359).
During ER stress, induced by a EIF2AK3/ATF4 pathway and/or ERN1/ATF6
pathway (PubMed:19855386, PubMed:21159964). Expression is suppressed by
TLR-TRIF signaling pathway during prolonged ER stress (PubMed:16670335,
PubMed:19752026, PubMed:19855386, PubMed:19919955, PubMed:21159964,
PubMed:22242125). {ECO:0000269|PubMed:16670335,
ECO:0000269|PubMed:19752026, ECO:0000269|PubMed:19855386,
ECO:0000269|PubMed:19919955, ECO:0000269|PubMed:21159964,
ECO:0000269|PubMed:21285359, ECO:0000269|PubMed:22242125}.
-!- DOMAIN: The N-terminal region is necessary for its proteasomal
degradation, transcriptional activity and interaction with EP300/P300.
{ECO:0000250}.
-!- PTM: Ubiquitinated, leading to its degradation by the proteasome.
{ECO:0000250}.
-!- PTM: Phosphorylation at serine residues by MAPK14 enhances its
transcriptional activation activity while phosphorylation at serine
residues by CK2 inhibits its transcriptional activation activity.
{ECO:0000269|PubMed:12876286, ECO:0000269|PubMed:8650547}.
-!- SIMILARITY: Belongs to the bZIP family. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; X67083; CAA47465.1; -; mRNA.
EMBL; BC013718; AAH13718.1; -; mRNA.
CCDS; CCDS24236.1; -. [P35639-1]
PIR; S26148; S26148.
RefSeq; NP_001277112.1; NM_001290183.1. [P35639-1]
RefSeq; NP_031863.3; NM_007837.4. [P35639-1]
RefSeq; XP_006513260.1; XM_006513197.3. [P35639-1]
SMR; P35639; -.
BioGRID; 199078; 4.
ComplexPortal; CPX-65; bZIP transcription factor complex, Cebpa-Ddit3.
ComplexPortal; CPX-66; bZIP transcription factor complex, Cebpb-Ddit3.
DIP; DIP-60705N; -.
IntAct; P35639; 3.
STRING; 10090.ENSMUSP00000026475; -.
BindingDB; P35639; -.
ChEMBL; CHEMBL2146304; -.
iPTMnet; P35639; -.
PhosphoSitePlus; P35639; -.
MaxQB; P35639; -.
PaxDb; P35639; -.
PRIDE; P35639; -.
ProteomicsDB; 279512; -. [P35639-1]
Antibodypedia; 4408; 1019 antibodies.
DNASU; 13198; -.
Ensembl; ENSMUST00000026475; ENSMUSP00000026475; ENSMUSG00000025408. [P35639-1]
GeneID; 13198; -.
KEGG; mmu:13198; -.
UCSC; uc007hiy.2; mouse. [P35639-1]
CTD; 1649; -.
MGI; MGI:109247; Ddit3.
VEuPathDB; HostDB:ENSMUSG00000025408; -.
eggNOG; KOG3119; Eukaryota.
GeneTree; ENSGT00390000006305; -.
InParanoid; P35639; -.
OMA; QCPARAG; -.
OrthoDB; 1338770at2759; -.
PhylomeDB; P35639; -.
TreeFam; TF105006; -.
BioGRID-ORCS; 13198; 4 hits in 63 CRISPR screens.
ChiTaRS; Ddit3; mouse.
PRO; PR:P35639; -.
Proteomes; UP000000589; Chromosome 10.
RNAct; P35639; protein.
Bgee; ENSMUSG00000025408; Expressed in islet of Langerhans and 307 other tissues.
Genevisible; P35639; MM.
GO; GO:1990622; C:CHOP-ATF3 complex; ISO:MGI.
GO; GO:1990617; C:CHOP-ATF4 complex; ISO:MGI.
GO; GO:0036488; C:CHOP-C/EBP complex; IPI:ParkinsonsUK-UCL.
GO; GO:0005737; C:cytoplasm; IDA:ParkinsonsUK-UCL.
GO; GO:0005770; C:late endosome; IDA:MGI.
GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0032993; C:protein-DNA complex; ISO:MGI.
GO; GO:0090575; C:RNA polymerase II transcription regulator complex; IPI:ParkinsonsUK-UCL.
GO; GO:0008140; F:cAMP response element binding protein binding; IDA:UniProtKB.
GO; GO:0003677; F:DNA binding; IDA:MGI.
GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0043522; F:leucine zipper domain binding; ISO:MGI.
GO; GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:ParkinsonsUK-UCL.
GO; GO:0008134; F:transcription factor binding; IPI:ParkinsonsUK-UCL.
GO; GO:0140416; F:transcription regulator inhibitor activity; IDA:ARUK-UCL.
GO; GO:0009948; P:anterior/posterior axis specification; IDA:BHF-UCL.
GO; GO:0006915; P:apoptotic process; IMP:UniProtKB.
GO; GO:0001955; P:blood vessel maturation; IMP:UniProtKB.
GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
GO; GO:0045454; P:cell redox homeostasis; ISO:MGI.
GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IDA:UniProtKB.
GO; GO:0006983; P:ER overload response; IMP:MGI.
GO; GO:0072655; P:establishment of protein localization to mitochondrion; IDA:ParkinsonsUK-UCL.
GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IDA:UniProtKB.
GO; GO:1990442; P:intrinsic apoptotic signaling pathway in response to nitrosative stress; IDA:ParkinsonsUK-UCL.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IDA:BHF-UCL.
GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IMP:YuBioLab.
GO; GO:0032792; P:negative regulation of CREB transcription factor activity; ISO:MGI.
GO; GO:2000016; P:negative regulation of determination of dorsal identity; IDA:BHF-UCL.
GO; GO:0043392; P:negative regulation of DNA binding; IGI:ParkinsonsUK-UCL.
GO; GO:0043433; P:negative regulation of DNA-binding transcription factor activity; ISO:MGI.
GO; GO:0045599; P:negative regulation of fat cell differentiation; IGI:MGI.
GO; GO:0032689; P:negative regulation of interferon-gamma production; ISO:MGI.
GO; GO:0032700; P:negative regulation of interleukin-17 production; ISO:MGI.
GO; GO:0032713; P:negative regulation of interleukin-4 production; ISO:MGI.
GO; GO:0045662; P:negative regulation of myoblast differentiation; IMP:UniProtKB.
GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISO:MGI.
GO; GO:0051898; P:negative regulation of protein kinase B signaling; ISO:MGI.
GO; GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; ISO:MGI.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0043065; P:positive regulation of apoptotic process; ISO:MGI.
GO; GO:0034263; P:positive regulation of autophagy in response to ER overload; ISO:MGI.
GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IDA:ParkinsonsUK-UCL.
GO; GO:0032757; P:positive regulation of interleukin-8 production; ISO:MGI.
GO; GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; ISS:UniProtKB.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:UniProtKB.
GO; GO:1901216; P:positive regulation of neuron death; IMP:ParkinsonsUK-UCL.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IGI:ParkinsonsUK-UCL.
GO; GO:1990440; P:positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; IMP:ParkinsonsUK-UCL.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; ISO:MGI.
GO; GO:0010506; P:regulation of autophagy; ISS:UniProtKB.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IMP:UniProtKB.
GO; GO:0034976; P:response to endoplasmic reticulum stress; IDA:UniProtKB.
GO; GO:0042594; P:response to starvation; IDA:UniProtKB.
GO; GO:0006986; P:response to unfolded protein; ISO:MGI.
GO; GO:0007605; P:sensory perception of sound; IGI:MGI.
GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
InterPro; IPR004827; bZIP.
InterPro; IPR016670; DNA_damage_induc_transcript_3.
PANTHER; PTHR16833; PTHR16833; 1.
PIRSF; PIRSF016571; C/EBPzeta_CHOP_DDIT3; 1.
SMART; SM00338; BRLZ; 1.
PROSITE; PS50217; BZIP; 1.
1: Evidence at protein level;
Activator; Alternative initiation; Apoptosis; Cell cycle; Cytoplasm;
DNA-binding; Growth arrest; Nucleus; Phosphoprotein; Reference proteome;
Repressor; Stress response; Transcription; Transcription regulation;
Ubl conjugation; Unfolded protein response; Wnt signaling pathway.
CHAIN 1..168
/note="DNA damage-inducible transcript 3 protein"
/id="PRO_0000076643"
DOMAIN 98..161
/note="bZIP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
REGION 10..26
/note="N-terminal"
/evidence="ECO:0000250"
REGION 10..18
/note="Interaction with TRIB3"
/evidence="ECO:0000250"
REGION 34..139
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 100..129
/note="Basic motif"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
REGION 133..147
/note="Leucine-zipper"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
COMPBIAS 34..58
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 69..88
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 115..139
/note="Basic and acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOD_RES 14
/note="Phosphoserine; by CK2"
/evidence="ECO:0000269|PubMed:12876286"
MOD_RES 15
/note="Phosphoserine; by CK2"
/evidence="ECO:0000269|PubMed:12876286"
MOD_RES 30
/note="Phosphoserine; by CK2"
/evidence="ECO:0000269|PubMed:12876286"
MOD_RES 31
/note="Phosphoserine; by CK2"
/evidence="ECO:0000269|PubMed:12876286"
MOD_RES 78
/note="Phosphoserine; by MAPK14"
/evidence="ECO:0000269|PubMed:8650547"
MOD_RES 81
/note="Phosphoserine; by MAPK14"
/evidence="ECO:0000269|PubMed:8650547"
MUTAGEN 14
/note="S->A: Loss of phosphorylation."
/evidence="ECO:0000269|PubMed:12876286"
MUTAGEN 15
/note="S->A: Loss of phosphorylation."
/evidence="ECO:0000269|PubMed:12876286"
MUTAGEN 30
/note="S->A: Loss of phosphorylation."
/evidence="ECO:0000269|PubMed:12876286"
MUTAGEN 31
/note="S->A: Loss of phosphorylation."
/evidence="ECO:0000269|PubMed:12876286"
CONFLICT 34
/note="I -> N (in Ref. 2; AAH13718)"
/evidence="ECO:0000305"
SEQUENCE 168 AA; 19189 MW; CA423B79512F33AB CRC64;
MAAESLPFTL ETVSSWELEA WYEDLQEVLS SDEIGGTYIS SPGNEEEESK TFTTLDPASL
AWLTEEPGPT EVTRTSQSPR SPDSSQSSMA QEEEEEEQGR TRKRKQSGQC PARPGKQRMK
EKEQENERKV AQLAEENERL KQEIERLTRE VETTRRALID RMVSLHQA


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EIAAB10727 Bos taurus,Bovine,C_EBP-homologous protein,C_EBP-homologous protein 10,CHOP,CHOP,CHOP10,CHOP-10,DDIT3,DDIT-3,DNA damage-inducible transcript 3 protein,GADD153,Growth arrest and DNA-damage-inducible pr
EIAAB10726 C_EBP-homologous protein,C_EBP-homologous protein 10,CHOP,Chop,Chop10,CHOP-10,Ddit3,DDIT-3,DNA damage-inducible transcript 3 protein,Gadd153,Growth arrest and DNA-damage-inducible protein GADD153,Mous
EIAAB10729 C_EBP-homologous protein,C_EBP-homologous protein 10,CHOP,CHOP,CHOP10,CHOP-10,DDIT3,DDIT-3,DNA damage-inducible transcript 3 protein,GADD153,Growth arrest and DNA damage-inducible protein GADD153,Homo
EIAAB10728 C_EBP-homologous protein,C_EBP-homologous protein 10,CHOP,Chop,Chop10,CHOP-10,Ddit3,DDIT-3,DNA damage-inducible transcript 3 protein,Gadd153,Growth arrest and DNA-damage-inducible protein GADD153,Rat,
20-272-190514 GADD153 - Mouse monoclonal [9C8] to GADD153; DDIT-3; Growth arrest and DNA-damage-inducible protein GADD153; C_EBP-homologous protein; CHOP Monoclonal 0.05 mg
18-272-195087 DDIT3 - Rabbit polyclonal to DDIT3; DDIT-3; Growth arrest and DNA-damage-inducible protein GADD153; C_EBP-homologous protein; CHOP Polyclonal 0.1 ml
EIAAB10733 Ddit4,Dexamethasone-induced gene 2 protein,Dig2,DNA damage-inducible transcript 4 protein,HIF-1 responsive protein RTP801,Mouse,Mus musculus,Protein regulated in development and DNA damage response 1,
EIAAB10743 DDIT4L,DNA damage-inducible transcript 4-like protein,HIF-1 responsive protein RTP801-like,Homo sapiens,Human,Protein regulated in development and DNA damage response 2,REDD2,REDD-2,RTP801L
bs-1361P Peptides: GADD153(Growth arrest and DNA damage-inducible 153) Protein Length:12-25 amino acids. 200ug lyophilized
EIAAB10730 Ddit4,DNA damage-inducible transcript 4 protein,HIF-1 responsive protein RTP801,Protein regulated in development and DNA damage response 1,Rat,Rattus norvegicus,Redd1,REDD-1,Rtp801
EIAAB10732 DDIT4,DNA damage-inducible transcript 4 protein,HIF-1 responsive protein RTP801,Homo sapiens,Human,Protein regulated in development and DNA damage response 1,REDD1,REDD-1,RTP801
10-288-22011F Growth arrest and DNA-damage-inducible protein GADD45 gamma - Cytokine-responsive protein CR6 0.05 mg
10-288-22011F Growth arrest and DNA-damage-inducible protein GADD45 gamma - Cytokine-responsive protein CR6 0.1 mg
15-288-22011 Growth arrest and DNA-damage-inducible protein GADD45 gamma - Cytokine-responsive protein CR6 Polyclonal 0.1 mg
15-288-22011 Growth arrest and DNA-damage-inducible protein GADD45 gamma - Cytokine-responsive protein CR6 Polyclonal 0.05 mg
GADD45GIP1-1280H Protein Recombinant Human Growth Arrest And DNA-Damage-Inducible, Gamma Interacting Protein 1, His-tagged 50ug
GADD45GIP1-1280H Protein: Recombinant Human Growth Arrest And DNA-Damage-Inducible, Gamma Interacting Protein 1, His-tagged 50ug
EIAAB32159 Gadd34,Growth arrest and DNA damage-inducible protein GADD34,Myd116,Myeloid differentiation primary response protein MyD116 homolog,Peg3,PEG-3,Ppp1r15a,Progression elevated gene 3 protein,Protein phos
EIAAB32161 GADD34,Growth arrest and DNA damage-inducible protein GADD34,Homo sapiens,Human,Myeloid differentiation primary response protein MyD116 homolog,PPP1R15A,Protein phosphatase 1 regulatory subunit 15A
EIAAB41165 Mouse,Mus musculus,p53-dependent damage-inducible nuclear protein 1,p53DINP1,Sip,Stress-induced protein,TEAP,Thymus-expressed acidic protein,Trp53inp1,Tumor protein p53-inducible nuclear protein 1
EIAAB41166 p53-dependent damage-inducible nuclear protein 1,p53DINP1,Rat,Rattus norvegicus,Sip,Stress-induced protein,TEAP,Thymus-expressed acidic protein,Trp53inp1,Tumor protein p53-inducible nuclear protein 1
EIAAB10707 Damage-specific DNA-binding protein 1,DDB p127 subunit,DDB1,DDBa,DNA damage-binding protein 1,DNA damage-binding protein a,HBV X-associated protein 1,Homo sapiens,Human,UV-damaged DNA-binding factor,U
EIAAB32158 Gadd34,Growth arrest and DNA damage-inducible protein GADD34,Mouse,Mus musculus,Myd116,Myeloid differentiation primary response protein MyD116,Ppp1r15a,Protein phosphatase 1 regulatory subunit 15A
EIAAB10746 Ddit4l,DNA damage-inducible transcript 4-like protein,HIF-1 responsive protein RTP801-like,Mouse,Mus musculus,Rtp801l,Smhs1,Soleus muscle atrophied after hindlimb suspension protein 1
PC-GADD34 Growth arrest & DNA damage-inducible protein, WB control 100-150ul
Pathways :
WP1663: Homologous recombination
WP1676: Non-homologous end-joining
WP1531: Vitamin D synthesis
WP731: Sterol regulatory element binding protein related
WP2292: Chemokine signaling pathway
WP1616: ABC transporters
WP210: Cytoplasmic Ribosomal Proteins
WP1673: Naphthalene and anthracene degradation
WP2203: TSLP Signaling Pathway
WP1678: Nucleotide excision repair
WP2272: Pathogenic Escherichia coli infection
WP1613: 1,4-Dichlorobenzene degradation
WP73: G Protein Signaling Pathways
WP1625: Base excision repair
WP1371: G Protein Signaling Pathways
WP1690: Propanoate metabolism
WP2324: AGE/RAGE pathway
WP1694: Pyrimidine metabolism
WP1654: gamma-Hexachlorocyclohexane degradation
WP1939: Unfolded Protein Response
WP1661: Glyoxylate and dicarboxylate metabolism
WP1502: Mitochondrial biogenesis
WP1714: Tyrosine metabolism
WP1049: G Protein Signaling Pathways
WP1566: Citrate cycle (TCA cycle)

Related Genes :
[DDIT3 CHOP CHOP10 GADD153] DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)
[Ddit3 Chop Chop10 Gadd153] DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)
[Cebpb] CCAAT/enhancer-binding protein beta (C/EBP beta) (AGP/EBP) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched transcriptional activator) (LAP)
[Cebpa Cebp] CCAAT/enhancer-binding protein alpha (C/EBP alpha)
[CEBPB TCF5 PP9092] CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5)
[Cebpb Crp2 Nf-il6 Sfb] CCAAT/enhancer-binding protein beta (C/EBP beta) (C/EBP-related protein 2) (Interleukin-6-dependent-binding protein) (IL-6DBP) (Liver-enriched inhibitory protein) (LIP) (Liver-enriched transcriptional activator) (LAP) (Silencer factor B) (SF-B)
[Atf4 Creb2] Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (C/EBP-related ATF) (C/ATF) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2)
[Cebpa] CCAAT/enhancer-binding protein alpha (C/EBP alpha)
[Ddit4 Dig2 Redd1 Rtp801] DNA damage-inducible transcript 4 protein (Dexamethasone-induced gene 2 protein) (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)
[CEBPA CEBP] CCAAT/enhancer-binding protein alpha (C/EBP alpha)
[DDIT4L REDD2 RTP801L] DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)
[CEBPB] CCAAT/enhancer-binding protein beta (C/EBP beta)
[Nfkb1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (NF-kappa-B1 p84/NF-kappa-B1 p98) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[hchA A8C65_13880 A8X68_003796 ABT96_003721 ACW72_003908 ADS93_004744 AMK64_004563 AO169_004024 AT845_003071 AW086_18955 B2D52_004166 B5N24_004414 B6L15_004262 B9T59_01945 BF481_000399 BG944_002806 BJJ90_15205 BK272_05030 BKD45_004813 BM922_003014 BMC34_002412 BMT49_12710 BMT50_21300 BON65_01250 BON66_15955 BON86_06490 BON93_14110 BON95_14610 BOY03_000482 BUE81_10670 BvCmsKKP005_03878 BvCmsKKP057_02347 BvCmsKKP061_00566 BvCmsKSP067_02879 BvCmsSIP082_02402 BZL69_29425 C2U48_24800 C3F40_00665 C5715_19445 C5N07_21380 C5Y87_06915 C9Z43_06360 CBT22_003417 CCZ91_004170 CDC27_10055 CDL37_00765 CG831_003889 CLG78_003595 COD50_20045 CQP61_17160 CS116_003991 CY655_12940 D9D43_06110 D9D77_14400 D9H13_22385 DEN89_24995 DLW88_16170 DTL43_21780 DU321_04440 DXB10_02555 DXT73_20690 E2135_17195 E3N34_18700 E4K54_18520 E5S34_18005 E5S62_15980 EAX79_27320 EBP16_01985 EC95NR1_00961 ED648_25045 EH88_000903 EHD79_18540 ELV08_24970 ELX69_01215 ERS085386_05041 ETECE1373_01878 ExPECSC038_01920 EYX55_12230 F2N27_00930 F2N28_13090 F7F11_20115 F9407_21070 F9S83_26095 F9V07_22865 FDM60_13375 FHR00_11090 FOI11_003080 FOI11_16965 FQE77_07620 FWK02_18105 FZN26_21485 G3813_000471 G5696_13480 GFZ60_00075 GKZ24_21140 GQE64_12165 GQE87_19550 GQM04_17335 GQM10_10435 GQW80_12220 GRW05_22880 GRW57_10520 GTP88_06910 GUB08_10670 GUC01_04925 GXU05_000820 GXV26_000768 H0O72_18450 HH795_003783 HHH44_001696 HI055_003004 HIF90_003862 HIT56_001988 HJO75_002854 HJQ60_001626 HKA49_000011 HLU56_00030 HLZ50_02125 HMV95_17840 HNC52_06820 HND24_14805 HNO08_12550 HNV65_13940 HNY50_00190 HNY54_00190 HVV53_06790 HVW11_20930 HVW43_01085 HVX16_09450 HVY77_10520 HVZ33_09830 HZ71_003355 I6H02_04490 NCTC10082_04431 NCTC10418_03071 NCTC10767_03558 NCTC10974_02300 NCTC11022_01867 NCTC11126_04427 NCTC11181_05650 NCTC12950_02263 NCTC13216_04667 NCTC8985_00529 NCTC9048_02115 NCTC9111_05933 NCTC9703_00277 PGD_01271 PU06_24500 SAMEA3472043_00447 SAMEA3472056_01268 SAMEA3472080_04213 SAMEA3472112_00448 SAMEA3472117_00397 SAMEA3472120_00418 UN91_23615 WP4S18E07_18560 WQ89_10695] Protein/nucleic acid deglycase HchA (EC 3.1.2.-) (EC 3.5.1.124) (Maillard deglycase)
[RNR3 DIN1 YIL066C] Ribonucleoside-diphosphate reductase large chain 2 (EC 1.17.4.1) (Ribonucleotide reductase DNA damage-inducible regulatory subunit 2) (Ribonucleotide reductase R1 subunit 2) (Ribonucleotide reductase large subunit 2)
[ligD Rv0938 MTCY08D9.01c MTCY10D7.36c] Multifunctional non-homologous end joining DNA repair protein LigD (NHEJ DNA repair protein D) (Mt-Lig) (NHEJ DNA polymerase) [Includes: DNA repair polymerase (Pol) (Polymerase/primase); 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase) (PE); DNA ligase (Lig) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP])]
[TRIB3 C20orf97 NIPK SKIP3 TRB3] Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)
[Casp4 Casp11 Caspl Ich3] Caspase-4 (CASP-4) (EC 3.4.22.64) (Caspase-11) (CASP-11) (Protease ICH-3) [Cleaved into: Caspase-4 subunit p10; Caspase-4 subunit p20]
[NFKB1] Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
[CEBPA] CCAAT/enhancer-binding protein alpha (C/EBP alpha)
[ATF4 CREB2 TXREB] Cyclic AMP-dependent transcription factor ATF-4 (cAMP-dependent transcription factor ATF-4) (Activating transcription factor 4) (Cyclic AMP-responsive element-binding protein 2) (CREB-2) (cAMP-responsive element-binding protein 2) (Tax-responsive enhancer element-binding protein 67) (TaxREB67)
[EIF4EBP1] Eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I)
[ligD PA2138] Multifunctional non-homologous end joining protein LigD (NHEJ DNA polymerase) [Includes: 3'-phosphoesterase (3'-ribonuclease/3'-phosphatase); DNA ligase D (LigD) (EC 6.5.1.1) (Polydeoxyribonucleotide synthase [ATP]); DNA repair polymerase (Pol) (Polymerase/primase)]
[EP300 P300] Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)
[yaiE ppnP yaiE_1 yaiE_2 A5U30_004171 A6519_004168 A6583_19230 A6592_08565 A8499_002689 A8C65_08910 A8W81_002402 A8X68_002957 A9819_01890 A9X72_19070 AAG43_001684 AAS29_000851 ABE90_005680 ABT96_001030 ACN002_0406 ACN68_10320 ACN81_25005 ACU57_12035 ACW72_000537 AM270_02350 AM340_00170 AM464_18935 AMK64_000048 AML23_18615 AO169_001228 APX88_10995 AT845_004245 AUQ29_12220 AW059_14025 AW086_04940 AW118_21925 AZZ83_000156 B2D52_001288 B5N24_001418 B6L15_000900 B6R12_004630 B6R15_004744 B6R17_001763 B6R27_001430 B6R48_001853 B6R87_002119 B7C15_002412 B9T59_05995 BANRA_00925 BANRA_01371 BANRA_02015 BANRA_03594 BB545_15535 BE963_16095 BER14_23410 BF271_000352 BFL24_02350 BG821_003456 BG944_000956 BH692_02565 BHF52_11910 BHS81_02405 BHS87_02130 BIQ87_02175 BIZ41_26355 BJI68_13875 BJJ90_20310 BK272_17750 BK292_14635 BK373_01320 BK375_26975 BKD45_000677 BMC34_003941 BMC79_001982 BMR21_14190 BMT50_02930 BMT91_05310 BN17_01951 BO068_001728 BOB65_000444 BOH76_16090 BON63_11530 BON65_18745 BON66_09075 BON70_06170 BON72_15085 BON73_05975 BON76_23825 BON83_20655 BON86_03800 BON87_15370 BON91_23895 BON92_15465 BON93_19270 BON94_14845 BON95_06500 BON96_22295 BON98_18895 BR158_003623 BR331_05500 BRV34_002179 BRV41_001603 BTQ06_17790 BUE81_15520 BUE82_18690 BvCms2454_01767 BvCmsC61A_02990 BvCmsHHP019_02594 BvCmsHHP019_02735 BvCmsHHP056_01410 BvCmsKKP005_02375 BvCmsKKP036_04281 BvCmsKKP057_03186 BvCmsKKP061_04019 BvCmsKSNP073_05624 BvCmsKSP011_04945 BvCmsKSP067_05191 BvCmsKSP076_04759 BvCmsNSNP036_04163 BvCmsSIP024_01003 BvCmsSIP082_02880 BVL39_00880 BWI89_12535 BXT93_00165 BZL69_16805 C2M16_02670 C2U48_08110 C3F40_10585 C4952_000933 C4M78_16865 C5542_003745 C5715_13595 C5F72_20070 C5N07_12740 C5Y87_03235 C6B22_00620 C6L19_003123 C6N50_002569 C7B02_04545 C9114_16640 C9160_00550 C9E67_23765 C9Z62_15540 C9Z68_20485 CA593_01185 CBT22_001283 CCS08_21635 CCZ91_001256 CD42_000819 CDC27_00860 CDL36_14165 CDL37_09465 CF32_001327 CG692_05055 CG831_000443 CIG67_05475 CLG78_001395 CN875_002288 CO706_24355 COD50_07875 CQP61_20925 CR539_06140 CS116_000640 CT143_00140 CV83915_01183 CWS33_22875 CXJ73_003963 CY655_02075 D0X26_07420 D1912_23295 D3822_22465 D3C88_28950 D3G36_08025 D3O91_15305 D3Y67_14350 D4U49_03050 D4V09_04715 D5H22_03840 D6T60_09300 D9D31_21970 D9D43_14830 D9D77_05600 D9E34_09525 D9E49_06955 D9H13_03415 D9H94_24405 D9J03_17400 D9J11_02150 D9J61_02635 D9K17_07345 DAH18_14975 DAH23_10455 DAH34_21345 DAH37_05240 DAH50_14800 DB282_04950 DD762_07680 DEN86_05080 DEN89_14495 DEN95_09255 DEO15_17360 DIV22_26285 DL654_17660 DLX40_16565 DM968_04210 DN627_04525 DNQ45_00335 DP258_05110 DRW19_06400 DS732_06920 DS966_18475 DTL43_07415 DTL90_10740 DTM10_06080 DTM45_10960 DU321_19460 DXB10_13805 DXT69_08115 DXT71_02970 DXT73_01860 E0I42_07410 E0N24_10860 E0P28_09655 E2119_01725 E2123_04610 E2127_09375 E2128_04435 E2129_13975 E2135_01410 E3N34_04125 E4K51_12070 E4K54_07340 E5P52_05895 E5S34_07545 E5S35_14895 E5S38_06765 E5S43_12135 E5S47_09895 E5S52_06115 E5S61_09810 E5S62_19990 EA239_15730 EA435_05820 EAI46_25725 EAI46_25840 EAN77_07940 EAX79_06830 EBP16_12520 EC1094V2_3464 EC3234A_4c00610 EC95NR1_04612 ECs0441 ED648_16775 EGC08_04505 EH88_002240 EHD79_03470 EHH55_15815 EI021_16245 EI041_08145 EIA13_09645 EIZ93_00830 EKI52_09170 EL79_3454 EL80_3408 ELT17_22260 ELT29_22585 ELT31_00280 ELT33_03015 ELT48_00735 ELT49_21480 ELT58_21305 ELT72_05540 ELU83_10395 ELU85_08960 ELU95_12465 ELV08_00785 ELV13_00555 ELV15_22680 ELV22_01630 ELV24_16525 ELV28_08410 ELX56_03900 ELX68_02065 ELX69_19550 ELX70_07125 ELX76_05850 ELX79_24270 ELX83_01445 ELX96_14305 ELY05_09885 ELY23_04665 ELY24_07180 ELY32_22740 ELY41_15435 ELY48_07355 ELY50_04295 EO241_13835 EPS76_10515 EQO00_19840 ERS085366_04179 ERS085386_01096 ERS085406_02227 ERS139208_01812 Esc0902E_04100 ETECE1373_03601 ETECE36_04584 ETECE925_03600 EVY14_00050 EWK56_10245 ExPECSC038_04895 EXX13_09665 EXX79_08270 EYX47_16280 EYX55_13650 EYY34_27625 F2N27_03375 F2N28_02020 F2N31_18495 F3N40_11580 F6U69_13610 F7F11_06850 F9386_04870 F9400_03995 F9407_08955 F9571_08760 F9B07_11235 F9S76_00660 F9S83_01525 F9V07_00950 F9V24_00540 F9X20_010625 F9X20_10705 FA849_16230 FA868_02660 FC554_02980 FDM60_01545 FEL34_02665 FFF58_18140 FGG80_03620 FGY90_08925 FHD44_10100 FHR00_04660 FJQ51_13145 FKO60_24460 FMP09_15400 FNJ67_20330 FOI11_011505 FOI11_08540 FPI65_02250 FPS82_09410 FQ021_04720 FQE77_10330 FQF29_11270 FTV90_10360 FTV92_11870 FTV93_12360 FV293_06120 FWK02_29295 FZC17_02065 FZN26_02330 FZN30_08825 FZN31_18905 G3565_02860 G3813_001670 G4A38_05410 G5696_10795 G6P89_19245 G6Z99_23355 G7635_000369 G9448_08700 GAJ26_09340 GBE29_07095 GF147_12390 GF646_06625 GF699_04160 GFY34_04590 GFY48_03475 GFZ60_05015 GIB53_01735 GJ11_02375 GKE84_19495 GKF52_17565 GKF86_04910 GKF89_04055 GKG12_02940 GKZ24_03305 GNO40_22710 GNZ05_01665 GOP20_09010 GP650_16700 GP662_13045 GP711_02810 GP946_18990 GP954_12950 GP979_17585 GQE42_04900 GQE64_07505 GQE87_15550 GQF58_00730 GQF59_00790 GQM04_16295 GQM06_17115 GQM09_10135 GQM10_05275 GQM13_16755 GQR15_01785 GQW07_10130 GQW68_15010 GQW76_11855 GQW80_20255 GRC73_12510 GRO95_09290 GRQ19_02985 GRW05_15575 GRW57_16360 GRW80_21245 GRW81_04110 GSY44_11760 GTP88_03425 GUB08_22335 GUB92_14995 GUC01_07480 GUI33_03675 GW978_01435 GXV26_001683 H0O53_01395 H0O72_08355 H4P47_18630 H4P50_19265 H4P51_19115 H5C78_05615 HCF72_000699 HH795_003019 HHH44_001374 HI055_001796 HIE44_000773 HIF90_002068 HIN64_001318 HIR12_001426 HIT56_001577 HJ942_001977 HJM92_003231 HJN04_001825 HJO75_000225 HJQ60_002362 HJS37_002167 HJS41_003943 HJU54_001570 HKA49_002910 HL563_20960 HLU10_04740 HLU56_09785 HLV18_07370 HLZ50_17655 HmCms169_03669 HmCms184_01874 HmCmsJML074_04353 HMS79_05370 HMT08_08320 HMT08_28135 HMU06_13895 HMU48_14510 HMV41_12865 HMV95_11570 HNC30_09785 HNC36_06780 HNC38_21355 HNC52_05780 HNC59_10160 HNC66_06600 HNC75_03340 HNC99_09055 HND24_23650 HNO08_21040 HNV65_12835 HNY50_21730 HNY54_14805 HPE39_05435 HV109_18115 HVV39_18775 HVV53_22620 HVW11_04845 HVW22_00965 HVW43_10265 HVX16_19490 HVY77_19945 HVZ33_18480 HVZ71_18990 HX136_19525 HZ71_000860 HZ72_001928 I6H02_19720 IA00_002609 JE86ST02C_04160 JE86ST05C_04220 MJ49_04490 MS7163_00387 NCTC10082_01078 NCTC10089_03910 NCTC10418_05682 NCTC10429_03762 NCTC10764_05371 NCTC10767_04209 NCTC10865_04787 NCTC11022_05137 NCTC11126_00022 NCTC11181_01145 NCTC11341_03896 NCTC12950_04180 NCTC13127_05156 NCTC13216_02895 NCTC7922_06246 NCTC7927_04270 NCTC8008_03382 NCTC8009_07014 NCTC8179_01642 NCTC8450_01367 NCTC8500_04283 NCTC8621_03984 NCTC8622_02997 NCTC8959_05017 NCTC8960_01314 NCTC8985_02798 NCTC9001_00537 NCTC9036_03840 NCTC9044_03501 NCTC9045_04434 NCTC9048_04159 NCTC9050_01764 NCTC9075_05103 NCTC9077_04792 NCTC9081_02496 NCTC9111_03977 NCTC9117_04804 NCTC9434_02812 NCTC9702_04480 NCTC9703_03222 NCTC9706_01114 NCTC9775_02088 NCTC9777_00174 NCTC9969_04032 ND22_001447 PGD_02920 PU06_02955 RG28_02910 SAMEA3472043_02682 SAMEA3472044_00466 SAMEA3472056_03633 SAMEA3472064_01205 SAMEA3472080_01810 SAMEA3472112_02965 SAMEA3472117_02973 SAMEA3472120_01236 SAMEA3472147_04902 SAMEA3484427_03543 SAMEA3484429_01888 SAMEA3485101_03989 SAMEA3485110_03675 SAMEA3751407_02141 SAMEA3752312_01369 SAMEA3752386_01995 SAMEA3752557_00215 SAMEA3753064_01236 SAMEA3753290_01725 SAMEA3753300_00458 SM09_01165 THOESC010_34040 TUM18780_32860 UN91_18725 WP2S18E08_35360 WP4S18E07_34480 WP4S18E08_34230 WQ89_01420 WR15_04360] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[MEC3 PIP3 PSO9 YLR288C L8003.15] DNA damage checkpoint control protein MEC3
[Hspa5 Grp78] Endoplasmic reticulum chaperone BiP (EC 3.6.4.10) (78 kDa glucose-regulated protein) (GRP-78) (Binding-immunoglobulin protein) (BiP) (Heat shock protein 70 family protein 5) (HSP70 family protein 5) (Heat shock protein family A member 5) (Immunoglobulin heavy chain-binding protein)
[TCF7L2 TCF4] Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
[EIF4E2 EIF4EL3] Eukaryotic translation initiation factor 4E type 2 (eIF-4E type 2) (eIF4E type 2) (Eukaryotic translation initiation factor 4E homologous protein) (Eukaryotic translation initiation factor 4E-like 3) (eIF4E-like protein 4E-LP) (mRNA cap-binding protein 4EHP) (h4EHP) (mRNA cap-binding protein type 3)
[Tenm4 Doc4 Kiaa1302 Odz4 Tnm4] Teneurin-4 (Ten-4) (Downstream of CHOP4) (Protein Odd Oz/ten-m homolog 4) (Tenascin-M4) (Ten-m4) (Teneurin transmembrane protein 4)

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