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DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)

 DDT4L_HUMAN             Reviewed;         193 AA.
Q96D03; B2R7C3;
23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
01-DEC-2001, sequence version 1.
07-OCT-2020, entry version 135.
RecName: Full=DNA damage-inducible transcript 4-like protein;
AltName: Full=HIF-1 responsive protein RTP801-like;
AltName: Full=Protein regulated in development and DNA damage response 2;
Short=REDD-2;
Name=DDIT4L; Synonyms=REDD2, RTP801L;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Cerebellum, and Tongue;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lymph node;
PubMed=17974005; DOI=10.1186/1471-2164-8-399;
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
Wiemann S., Schupp I.;
"The full-ORF clone resource of the German cDNA consortium.";
BMC Genomics 8:399-399(2007).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
Hunkapiller M.W., Myers E.W., Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Lung;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION.
PubMed=12453409; DOI=10.1016/s1097-2765(02)00706-2;
Ellisen L.W., Ramsayer K.D., Johannessen C.M., Yang A., Beppu H., Minda K.,
Oliner J.D., McKeon F., Haber D.A.;
"REDD1, a developmentally regulated transcriptional target of p63 and p53,
links p63 to regulation of reactive oxygen species.";
Mol. Cell 10:995-1005(2002).
[6]
TISSUE SPECIFICITY, AND INDUCTION.
PubMed=15308555; DOI=10.1161/01.atv.0000142366.69080.c3;
Cuaz-Perolin C., Furman C., Larigauderie G., Legedz L., Lasselin C.,
Copin C., Jaye M., Searfoss G., Yu K.T., Duverger N., Negre-Salvayre A.,
Fruchart J.-C., Rouis M.;
"REDD2 gene is upregulated by modified LDL or hypoxia and mediates human
macrophage cell death.";
Arterioscler. Thromb. Vasc. Biol. 24:1830-1835(2004).
[7]
FUNCTION.
PubMed=15545625; DOI=10.1101/gad.1256804;
Brugarolas J., Lei K., Hurley R.L., Manning B.D., Reiling J.H., Hafen E.,
Witters L.A., Ellisen L.W., Kaelin W.G. Jr.;
"Regulation of mTOR function in response to hypoxia by REDD1 and the
TSC1/TSC2 tumor suppressor complex.";
Genes Dev. 18:2893-2904(2004).
[8]
FUNCTION.
PubMed=15632201; DOI=10.1074/jbc.c400557200;
Corradetti M.N., Inoki K., Guan K.-L.;
"The stress-inducted proteins RTP801 and RTP801L are negative regulators of
the mammalian target of rapamycin pathway.";
J. Biol. Chem. 280:9769-9772(2005).
-!- FUNCTION: Inhibits cell growth by regulating the TOR signaling pathway
upstream of the TSC1-TSC2 complex and downstream of AKT1.
{ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201}.
-!- INTERACTION:
Q96D03; O95342: ABCB11; NbExp=3; IntAct=EBI-742054, EBI-3914067;
Q96D03; Q96HD9: ACY3; NbExp=5; IntAct=EBI-742054, EBI-3916242;
Q96D03; Q63HM1: AFMID; NbExp=5; IntAct=EBI-742054, EBI-13286382;
Q96D03; Q96BJ3: AIDA; NbExp=3; IntAct=EBI-742054, EBI-4401674;
Q96D03; P31749: AKT1; NbExp=3; IntAct=EBI-742054, EBI-296087;
Q96D03; Q9NR81: ARHGEF3; NbExp=3; IntAct=EBI-742054, EBI-10312733;
Q96D03; Q7Z6K5: ARPIN; NbExp=3; IntAct=EBI-742054, EBI-10258086;
Q96D03; O14525-2: ASTN1; NbExp=3; IntAct=EBI-742054, EBI-21977454;
Q96D03; O95429: BAG4; NbExp=3; IntAct=EBI-742054, EBI-2949658;
Q96D03; Q9H503-2: BANF2; NbExp=3; IntAct=EBI-742054, EBI-11977289;
Q96D03; Q9BZR8: BCL2L14; NbExp=3; IntAct=EBI-742054, EBI-1385773;
Q96D03; P55957: BID; NbExp=3; IntAct=EBI-742054, EBI-519672;
Q96D03; Q9NWQ9: C14orf119; NbExp=3; IntAct=EBI-742054, EBI-725606;
Q96D03; Q96B23: C18orf25; NbExp=3; IntAct=EBI-742054, EBI-742108;
Q96D03; Q9UFG5: C19orf25; NbExp=3; IntAct=EBI-742054, EBI-741214;
Q96D03; Q49AR2: C5orf22; NbExp=3; IntAct=EBI-742054, EBI-746224;
Q96D03; Q9NP86: CABP5; NbExp=3; IntAct=EBI-742054, EBI-10311131;
Q96D03; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-742054, EBI-739580;
Q96D03; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-742054, EBI-11530605;
Q96D03; Q7Z7H3: CATIP; NbExp=3; IntAct=EBI-742054, EBI-10258233;
Q96D03; P51946: CCNH; NbExp=3; IntAct=EBI-742054, EBI-741406;
Q96D03; O75909-2: CCNK; NbExp=3; IntAct=EBI-742054, EBI-12010594;
Q96D03; P32320: CDA; NbExp=5; IntAct=EBI-742054, EBI-9250559;
Q96D03; O75419: CDC45; NbExp=3; IntAct=EBI-742054, EBI-374969;
Q96D03; P55273: CDKN2D; NbExp=3; IntAct=EBI-742054, EBI-745859;
Q96D03; Q6NVV7: CDPF1; NbExp=3; IntAct=EBI-742054, EBI-2802782;
Q96D03; Q96LK0: CEP19; NbExp=3; IntAct=EBI-742054, EBI-741885;
Q96D03; Q9HD42: CHMP1A; NbExp=3; IntAct=EBI-742054, EBI-1057156;
Q96D03; O95833: CLIC3; NbExp=3; IntAct=EBI-742054, EBI-10192241;
Q96D03; P49760: CLK2; NbExp=3; IntAct=EBI-742054, EBI-750020;
Q96D03; P49761: CLK3; NbExp=3; IntAct=EBI-742054, EBI-745579;
Q96D03; Q9UBL6-2: CPNE7; NbExp=5; IntAct=EBI-742054, EBI-12012272;
Q96D03; Q10570: CPSF1; NbExp=3; IntAct=EBI-742054, EBI-347859;
Q96D03; Q8IUI8: CRLF3; NbExp=3; IntAct=EBI-742054, EBI-2872414;
Q96D03; P53674: CRYBB1; NbExp=3; IntAct=EBI-742054, EBI-7519424;
Q96D03; P41240: CSK; NbExp=3; IntAct=EBI-742054, EBI-1380630;
Q96D03; P78358: CTAG1B; NbExp=3; IntAct=EBI-742054, EBI-1188472;
Q96D03; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-742054, EBI-11962928;
Q96D03; P07108-2: DBI; NbExp=3; IntAct=EBI-742054, EBI-12847580;
Q96D03; Q9H773: DCTPP1; NbExp=3; IntAct=EBI-742054, EBI-723569;
Q96D03; Q05D60: DEUP1; NbExp=3; IntAct=EBI-742054, EBI-748597;
Q96D03; O43598: DNPH1; NbExp=5; IntAct=EBI-742054, EBI-748674;
Q96D03; Q8TEW6: DOK4; NbExp=3; IntAct=EBI-742054, EBI-6918542;
Q96D03; Q68J44: DUPD1; NbExp=3; IntAct=EBI-742054, EBI-1054321;
Q96D03; Q9BVJ7: DUSP23; NbExp=3; IntAct=EBI-742054, EBI-724940;
Q96D03; Q14240-2: EIF4A2; NbExp=3; IntAct=EBI-742054, EBI-10232522;
Q96D03; P38919: EIF4A3; NbExp=3; IntAct=EBI-742054, EBI-299104;
Q96D03; Q13541: EIF4EBP1; NbExp=3; IntAct=EBI-742054, EBI-74090;
Q96D03; Q15056-2: EIF4H; NbExp=3; IntAct=EBI-742054, EBI-12222405;
Q96D03; Q9Y6C2-2: EMILIN1; NbExp=3; IntAct=EBI-742054, EBI-11748557;
Q96D03; Q32P44: EML3; NbExp=3; IntAct=EBI-742054, EBI-1046713;
Q96D03; O15197-2: EPHB6; NbExp=3; IntAct=EBI-742054, EBI-10182490;
Q96D03; Q9Y3B2: EXOSC1; NbExp=3; IntAct=EBI-742054, EBI-371892;
Q96D03; Q9NQT4: EXOSC5; NbExp=3; IntAct=EBI-742054, EBI-371876;
Q96D03; Q96B26: EXOSC8; NbExp=3; IntAct=EBI-742054, EBI-371922;
Q96D03; Q6NZ36-4: FAAP20; NbExp=3; IntAct=EBI-742054, EBI-12013806;
Q96D03; Q13158: FADD; NbExp=3; IntAct=EBI-742054, EBI-494804;
Q96D03; P49789: FHIT; NbExp=3; IntAct=EBI-742054, EBI-741760;
Q96D03; Q14192: FHL2; NbExp=3; IntAct=EBI-742054, EBI-701903;
Q96D03; O75344: FKBP6; NbExp=3; IntAct=EBI-742054, EBI-744771;
Q96D03; P21333-2: FLNA; NbExp=5; IntAct=EBI-742054, EBI-9641086;
Q96D03; O95257: GADD45G; NbExp=3; IntAct=EBI-742054, EBI-448202;
Q96D03; Q8WXD5: GEMIN6; NbExp=3; IntAct=EBI-742054, EBI-752301;
Q96D03; O43681: GET3; NbExp=3; IntAct=EBI-742054, EBI-2515857;
Q96D03; Q92917: GPKOW; NbExp=3; IntAct=EBI-742054, EBI-746309;
Q96D03; P62993: GRB2; NbExp=3; IntAct=EBI-742054, EBI-401755;
Q96D03; Q6ZYL4: GTF2H5; NbExp=3; IntAct=EBI-742054, EBI-6380438;
Q96D03; Q969Y2: GTPBP3; NbExp=5; IntAct=EBI-742054, EBI-740290;
Q96D03; P43080: GUCA1A; NbExp=3; IntAct=EBI-742054, EBI-6873005;
Q96D03; Q8WUI4-6: HDAC7; NbExp=3; IntAct=EBI-742054, EBI-12094670;
Q96D03; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-742054, EBI-740641;
Q96D03; Q9UBY9: HSPB7; NbExp=5; IntAct=EBI-742054, EBI-739361;
Q96D03; Q9UBH0: IL36RN; NbExp=3; IntAct=EBI-742054, EBI-465156;
Q96D03; P20839-3: IMPDH1; NbExp=3; IntAct=EBI-742054, EBI-12188657;
Q96D03; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-742054, EBI-2556193;
Q96D03; Q7L273: KCTD9; NbExp=3; IntAct=EBI-742054, EBI-4397613;
Q96D03; Q8N371-3: KDM8; NbExp=3; IntAct=EBI-742054, EBI-12161375;
Q96D03; O76011: KRT34; NbExp=3; IntAct=EBI-742054, EBI-1047093;
Q96D03; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-742054, EBI-10250562;
Q96D03; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-742054, EBI-726510;
Q96D03; Q8TCE9: LGALS14; NbExp=3; IntAct=EBI-742054, EBI-10274069;
Q96D03; P47929: LGALS7B; NbExp=3; IntAct=EBI-742054, EBI-357504;
Q96D03; Q3ZCW2: LGALSL; NbExp=3; IntAct=EBI-742054, EBI-10241423;
Q96D03; P25800: LMO1; NbExp=3; IntAct=EBI-742054, EBI-8639312;
Q96D03; Q96KN1: LRATD2; NbExp=3; IntAct=EBI-742054, EBI-9057780;
Q96D03; P62310: LSM3; NbExp=3; IntAct=EBI-742054, EBI-348239;
Q96D03; Q9Y4Y9: LSM5; NbExp=3; IntAct=EBI-742054, EBI-373007;
Q96D03; Q9UK45: LSM7; NbExp=10; IntAct=EBI-742054, EBI-348372;
Q96D03; O15479: MAGEB2; NbExp=3; IntAct=EBI-742054, EBI-1057615;
Q96D03; P57077-4: MAP3K7CL; NbExp=3; IntAct=EBI-742054, EBI-10215880;
Q96D03; Q15555: MAPRE2; NbExp=3; IntAct=EBI-742054, EBI-739717;
Q96D03; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-742054, EBI-726739;
Q96D03; Q9Y316: MEMO1; NbExp=3; IntAct=EBI-742054, EBI-1104564;
Q96D03; Q9BRT3: MIEN1; NbExp=3; IntAct=EBI-742054, EBI-6137472;
Q96D03; Q13064: MKRN3; NbExp=3; IntAct=EBI-742054, EBI-2340269;
Q96D03; Q9UH92-3: MLX; NbExp=3; IntAct=EBI-742054, EBI-8852072;
Q96D03; Q9UBU8-2: MORF4L1; NbExp=3; IntAct=EBI-742054, EBI-10288852;
Q96D03; Q15014: MORF4L2; NbExp=6; IntAct=EBI-742054, EBI-399257;
Q96D03; Q8N339: MT1M; NbExp=3; IntAct=EBI-742054, EBI-3911571;
Q96D03; Q969H8: MYDGF; NbExp=3; IntAct=EBI-742054, EBI-718622;
Q96D03; Q9HB07: MYG1; NbExp=3; IntAct=EBI-742054, EBI-709754;
Q96D03; P60660: MYL6; NbExp=3; IntAct=EBI-742054, EBI-300817;
Q96D03; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-742054, EBI-6952711;
Q96D03; P41227: NAA10; NbExp=4; IntAct=EBI-742054, EBI-747693;
Q96D03; Q8NEY1-3: NAV1; NbExp=5; IntAct=EBI-742054, EBI-11953718;
Q96D03; Q9GZM8: NDEL1; NbExp=3; IntAct=EBI-742054, EBI-928842;
Q96D03; Q9ULP0-2: NDRG4; NbExp=3; IntAct=EBI-742054, EBI-11978907;
Q96D03; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-742054, EBI-11750983;
Q96D03; Q8TDX7: NEK7; NbExp=3; IntAct=EBI-742054, EBI-1055945;
Q96D03; Q9NPG2: NGB; NbExp=3; IntAct=EBI-742054, EBI-10311409;
Q96D03; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-742054, EBI-12868744;
Q96D03; Q9BZQ8: NIBAN1; NbExp=3; IntAct=EBI-742054, EBI-6916466;
Q96D03; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-742054, EBI-744782;
Q96D03; P16083: NQO2; NbExp=3; IntAct=EBI-742054, EBI-358466;
Q96D03; Q86WQ0: NR2C2AP; NbExp=3; IntAct=EBI-742054, EBI-10260040;
Q96D03; Q96G61: NUDT11; NbExp=3; IntAct=EBI-742054, EBI-1043825;
Q96D03; P50583: NUDT2; NbExp=3; IntAct=EBI-742054, EBI-10096247;
Q96D03; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-742054, EBI-10297093;
Q96D03; O95989: NUDT3; NbExp=3; IntAct=EBI-742054, EBI-713708;
Q96D03; Q9NPJ8-3: NXT2; NbExp=4; IntAct=EBI-742054, EBI-10698339;
Q96D03; Q6TGC4: PADI6; NbExp=3; IntAct=EBI-742054, EBI-10892722;
Q96D03; Q9HBI0: PARVG; NbExp=3; IntAct=EBI-742054, EBI-3921217;
Q96D03; Q96KB5: PBK; NbExp=3; IntAct=EBI-742054, EBI-536853;
Q96D03; P57721-2: PCBP3; NbExp=3; IntAct=EBI-742054, EBI-11983983;
Q96D03; Q08493-2: PDE4C; NbExp=3; IntAct=EBI-742054, EBI-12169289;
Q96D03; P16118: PFKFB1; NbExp=3; IntAct=EBI-742054, EBI-709807;
Q96D03; Q99697-2: PITX2; NbExp=3; IntAct=EBI-742054, EBI-12138495;
Q96D03; Q9Y263: PLAA; NbExp=3; IntAct=EBI-742054, EBI-1994037;
Q96D03; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-742054, EBI-769257;
Q96D03; Q8IYS1: PM20D2; NbExp=3; IntAct=EBI-742054, EBI-11339910;
Q96D03; Q15126: PMVK; NbExp=3; IntAct=EBI-742054, EBI-1055562;
Q96D03; P28069: POU1F1; NbExp=3; IntAct=EBI-742054, EBI-8673859;
Q96D03; Q96CD2: PPCDC; NbExp=3; IntAct=EBI-742054, EBI-724333;
Q96D03; Q9Y3C6: PPIL1; NbExp=3; IntAct=EBI-742054, EBI-2557649;
Q96D03; Q86WC6: PPP1R27; NbExp=3; IntAct=EBI-742054, EBI-5235602;
Q96D03; O43741: PRKAB2; NbExp=3; IntAct=EBI-742054, EBI-1053424;
Q96D03; Q99633: PRPF18; NbExp=3; IntAct=EBI-742054, EBI-2798416;
Q96D03; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-742054, EBI-5280197;
Q96D03; P60891: PRPS1; NbExp=3; IntAct=EBI-742054, EBI-749195;
Q96D03; P25786: PSMA1; NbExp=3; IntAct=EBI-742054, EBI-359352;
Q96D03; P28065: PSMB9; NbExp=3; IntAct=EBI-742054, EBI-603300;
Q96D03; Q03393: PTS; NbExp=3; IntAct=EBI-742054, EBI-712344;
Q96D03; Q9UHX1-2: PUF60; NbExp=3; IntAct=EBI-742054, EBI-11529177;
Q96D03; Q13637: RAB32; NbExp=3; IntAct=EBI-742054, EBI-9837586;
Q96D03; P40937: RFC5; NbExp=5; IntAct=EBI-742054, EBI-712376;
Q96D03; O75679: RFPL3; NbExp=3; IntAct=EBI-742054, EBI-10188956;
Q96D03; O76064: RNF8; NbExp=3; IntAct=EBI-742054, EBI-373337;
Q96D03; P49247: RPIA; NbExp=3; IntAct=EBI-742054, EBI-744831;
Q96D03; P35268: RPL22; NbExp=3; IntAct=EBI-742054, EBI-354533;
Q96D03; Q9NQG5: RPRD1B; NbExp=3; IntAct=EBI-742054, EBI-747925;
Q96D03; Q9UIL1-3: SCOC; NbExp=3; IntAct=EBI-742054, EBI-10692913;
Q96D03; Q12765-2: SCRN1; NbExp=3; IntAct=EBI-742054, EBI-12027936;
Q96D03; P55735-3: SEC13; NbExp=3; IntAct=EBI-742054, EBI-12235008;
Q96D03; Q96IW7: SEC22A; NbExp=3; IntAct=EBI-742054, EBI-8652744;
Q96D03; Q8WYJ6: SEPTIN1; NbExp=3; IntAct=EBI-742054, EBI-693002;
Q96D03; Q9UH03: SEPTIN3; NbExp=3; IntAct=EBI-742054, EBI-727037;
Q96D03; Q99719: SEPTIN5; NbExp=3; IntAct=EBI-742054, EBI-373345;
Q96D03; O60880: SH2D1A; NbExp=3; IntAct=EBI-742054, EBI-6983382;
Q96D03; O14796: SH2D1B; NbExp=3; IntAct=EBI-742054, EBI-3923013;
Q96D03; Q9H299: SH3BGRL3; NbExp=3; IntAct=EBI-742054, EBI-5234893;
Q96D03; P09012: SNRPA; NbExp=3; IntAct=EBI-742054, EBI-607085;
Q96D03; P62308: SNRPG; NbExp=10; IntAct=EBI-742054, EBI-624585;
Q96D03; Q92673: SORL1; NbExp=3; IntAct=EBI-742054, EBI-1171329;
Q96D03; Q8N9Q2: SREK1IP1; NbExp=3; IntAct=EBI-742054, EBI-10268630;
Q96D03; Q96MF2: STAC3; NbExp=3; IntAct=EBI-742054, EBI-745680;
Q96D03; O75716: STK16; NbExp=3; IntAct=EBI-742054, EBI-749295;
Q96D03; Q13043-2: STK4; NbExp=3; IntAct=EBI-742054, EBI-14280485;
Q96D03; O00204: SULT2B1; NbExp=3; IntAct=EBI-742054, EBI-749441;
Q96D03; P51687: SUOX; NbExp=3; IntAct=EBI-742054, EBI-3921347;
Q96D03; Q9BW92: TARS2; NbExp=3; IntAct=EBI-742054, EBI-1045099;
Q96D03; Q9NU19: TBC1D22B; NbExp=3; IntAct=EBI-742054, EBI-8787464;
Q96D03; Q9Y242: TCF19; NbExp=3; IntAct=EBI-742054, EBI-7413767;
Q96D03; P56279: TCL1A; NbExp=3; IntAct=EBI-742054, EBI-749995;
Q96D03; Q9NUJ3: TCP11L1; NbExp=3; IntAct=EBI-742054, EBI-2555179;
Q96D03; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-742054, EBI-750487;
Q96D03; Q8IWB6: TEX14; NbExp=3; IntAct=EBI-742054, EBI-6674697;
Q96D03; A0A024R4Q5: TFPT; NbExp=4; IntAct=EBI-742054, EBI-11527449;
Q96D03; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-742054, EBI-74615;
Q96D03; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-742054, EBI-11525489;
Q96D03; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-742054, EBI-10259086;
Q96D03; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-742054, EBI-372432;
Q96D03; Q96PN8: TSSK3; NbExp=4; IntAct=EBI-742054, EBI-3918381;
Q96D03; Q8N0Z6: TTC5; NbExp=3; IntAct=EBI-742054, EBI-9526213;
Q96D03; P10599: TXN; NbExp=5; IntAct=EBI-742054, EBI-594644;
Q96D03; P83876: TXNL4A; NbExp=3; IntAct=EBI-742054, EBI-746539;
Q96D03; Q6IPR3: TYW3; NbExp=3; IntAct=EBI-742054, EBI-10974426;
Q96D03; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-742054, EBI-7353612;
Q96D03; P63146: UBE2B; NbExp=3; IntAct=EBI-742054, EBI-712629;
Q96D03; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-742054, EBI-17208936;
Q96D03; P61758: VBP1; NbExp=3; IntAct=EBI-742054, EBI-357430;
Q96D03; Q3SXR9: VCX2; NbExp=3; IntAct=EBI-742054, EBI-11983741;
Q96D03; Q14119: VEZF1; NbExp=3; IntAct=EBI-742054, EBI-11980193;
Q96D03; Q9P202: WHRN; NbExp=3; IntAct=EBI-742054, EBI-310886;
Q96D03; Q9NQW7-3: XPNPEP1; NbExp=3; IntAct=EBI-742054, EBI-12079490;
Q96D03; P07947: YES1; NbExp=3; IntAct=EBI-742054, EBI-515331;
Q96D03; Q5VVQ6: YOD1; NbExp=3; IntAct=EBI-742054, EBI-2510804;
Q96D03; P62699: YPEL5; NbExp=3; IntAct=EBI-742054, EBI-11721624;
Q96D03; Q8IZ13: ZBED8; NbExp=3; IntAct=EBI-742054, EBI-7186123;
Q96D03; Q15915: ZIC1; NbExp=3; IntAct=EBI-742054, EBI-11963196;
Q96D03; Q86VK4-3: ZNF410; NbExp=5; IntAct=EBI-742054, EBI-11741890;
Q96D03; O00488: ZNF593; NbExp=3; IntAct=EBI-742054, EBI-726769;
Q96D03; P36508: ZNF76; NbExp=3; IntAct=EBI-742054, EBI-7254550;
Q96D03; Q7L2R6-2: ZNF765; NbExp=3; IntAct=EBI-742054, EBI-12834294;
Q96D03; Q3MJ62: ZSCAN23; NbExp=3; IntAct=EBI-742054, EBI-5667532;
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
-!- TISSUE SPECIFICITY: Up-regulated in atherosclerotic plaques relative to
healthy segments of the same artery. {ECO:0000269|PubMed:15308555}.
-!- INDUCTION: Up-regulated by oxidized LDL and hypoxia in macrophages.
{ECO:0000269|PubMed:15308555}.
-!- SIMILARITY: Belongs to the DDIT4 family. {ECO:0000305}.
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EMBL; AK094236; BAC04315.1; -; mRNA.
EMBL; AK312926; BAG35770.1; -; mRNA.
EMBL; AL832277; CAI46176.1; -; mRNA.
EMBL; CH471057; EAX06119.1; -; Genomic_DNA.
EMBL; BC013592; AAH13592.1; -; mRNA.
CCDS; CCDS34036.1; -.
RefSeq; NP_660287.1; NM_145244.3.
SMR; Q96D03; -.
BioGRID; 125421; 157.
IntAct; Q96D03; 210.
STRING; 9606.ENSP00000354830; -.
MoonDB; Q96D03; Predicted.
iPTMnet; Q96D03; -.
PhosphoSitePlus; Q96D03; -.
BioMuta; DDIT4L; -.
DMDM; 74731396; -.
MassIVE; Q96D03; -.
PaxDb; Q96D03; -.
PeptideAtlas; Q96D03; -.
PRIDE; Q96D03; -.
ProteomicsDB; 76241; -.
Antibodypedia; 25978; 237 antibodies.
DNASU; 115265; -.
Ensembl; ENST00000273990; ENSP00000354830; ENSG00000145358.
GeneID; 115265; -.
KEGG; hsa:115265; -.
UCSC; uc003hvq.4; human.
CTD; 115265; -.
DisGeNET; 115265; -.
EuPathDB; HostDB:ENSG00000145358.6; -.
GeneCards; DDIT4L; -.
HGNC; HGNC:30555; DDIT4L.
HPA; ENSG00000145358; Tissue enriched (skeletal).
MIM; 607730; gene.
neXtProt; NX_Q96D03; -.
OpenTargets; ENSG00000145358; -.
PharmGKB; PA128394749; -.
eggNOG; ENOG502R3EE; Eukaryota.
GeneTree; ENSGT00530000063652; -.
InParanoid; Q96D03; -.
OMA; AKMFENC; -.
OrthoDB; 1588396at2759; -.
PhylomeDB; Q96D03; -.
TreeFam; TF105007; -.
PathwayCommons; Q96D03; -.
BioGRID-ORCS; 115265; 3 hits in 864 CRISPR screens.
GenomeRNAi; 115265; -.
Pharos; Q96D03; Tbio.
PRO; PR:Q96D03; -.
Proteomes; UP000005640; Chromosome 4.
RNAct; Q96D03; protein.
Bgee; ENSG00000145358; Expressed in quadriceps femoris and 173 other tissues.
ExpressionAtlas; Q96D03; baseline and differential.
Genevisible; Q96D03; HS.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0009968; P:negative regulation of signal transduction; IEA:InterPro.
Gene3D; 1.10.490.100; -; 1.
InterPro; IPR012918; RTP801-like.
InterPro; IPR038281; RTP801-like_C_sf.
PANTHER; PTHR12478; PTHR12478; 1.
Pfam; PF07809; RTP801_C; 1.
1: Evidence at protein level;
Cytoplasm; Polymorphism; Reference proteome.
CHAIN 1..193
/note="DNA damage-inducible transcript 4-like protein"
/id="PRO_0000307204"
VARIANT 161
/note="S -> F (in dbSNP:rs11553154)"
/id="VAR_053971"
SEQUENCE 193 AA; 21740 MW; 3BEEB3D0530C5BFF CRC64;
MVATGSLSSK NPASISELLD CGYHPESLLS DFDYWDYVVP EPNLNEVIFE ESTCQNLVKM
LENCLSKSKQ TKLGCSKVLV PEKLTQRIAQ DVLRLSSTEP CGLRGCVMHV NLEIENVCKK
LDRIVCDSSV VPTFELTLVF KQENCSWTSF RDFFFSRGRF SSGFRRTLIL SSGFRLVKKK
LYSLIGTTVI EGS


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EIAAB10729 C_EBP-homologous protein,C_EBP-homologous protein 10,CHOP,CHOP,CHOP10,CHOP-10,DDIT3,DDIT-3,DNA damage-inducible transcript 3 protein,GADD153,Growth arrest and DNA damage-inducible protein GADD153,Homo
EIAAB10726 C_EBP-homologous protein,C_EBP-homologous protein 10,CHOP,Chop,Chop10,CHOP-10,Ddit3,DDIT-3,DNA damage-inducible transcript 3 protein,Gadd153,Growth arrest and DNA-damage-inducible protein GADD153,Mous
EIAAB10728 C_EBP-homologous protein,C_EBP-homologous protein 10,CHOP,Chop,Chop10,CHOP-10,Ddit3,DDIT-3,DNA damage-inducible transcript 3 protein,Gadd153,Growth arrest and DNA-damage-inducible protein GADD153,Rat,
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Pathways :
WP525: Mitochondrial Unfolded-Protein Response
WP2199: Seed Development
WP1939: Unfolded Protein Response
WP346: Protein Modifications
WP1663: Homologous recombination
WP211: BMP signaling pathway
WP731: Sterol regulatory element binding protein related
WP1566: Citrate cycle (TCA cycle)
WP1888: Post-translational protein modification
WP1673: Naphthalene and anthracene degradation
WP2203: TSLP Signaling Pathway
WP1678: Nucleotide excision repair
WP1613: 1,4-Dichlorobenzene degradation
WP1625: Base excision repair
WP1371: G Protein Signaling Pathways
WP1690: Propanoate metabolism
WP2272: Pathogenic Escherichia coli infection
WP1694: Pyrimidine metabolism
WP232: G Protein Signaling Pathways
WP1654: gamma-Hexachlorocyclohexane degradation
WP1661: Glyoxylate and dicarboxylate metabolism
WP73: G Protein Signaling Pathways
WP1502: Mitochondrial biogenesis
WP1714: Tyrosine metabolism
WP1531: Vitamin D synthesis

Related Genes :
[Ddit4 Dig2 Redd1 Rtp801] DNA damage-inducible transcript 4 protein (Dexamethasone-induced gene 2 protein) (HIF-1 responsive protein RTP801) (Protein regulated in development and DNA damage response 1) (REDD-1)
[DDIT4L REDD2 RTP801L] DNA damage-inducible transcript 4-like protein (HIF-1 responsive protein RTP801-like) (Protein regulated in development and DNA damage response 2) (REDD-2)
[Ddit3 Chop Chop10 Gadd153] DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA-damage-inducible protein GADD153)
[DDIT3 CHOP CHOP10 GADD153] DNA damage-inducible transcript 3 protein (DDIT-3) (C/EBP zeta) (C/EBP-homologous protein) (CHOP) (C/EBP-homologous protein 10) (CHOP-10) (CCAAT/enhancer-binding protein homologous protein) (Growth arrest and DNA damage-inducible protein GADD153)
[Egln3] Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3) (SM-20)
[RNR3 DIN1 YIL066C] Ribonucleoside-diphosphate reductase large chain 2 (EC 1.17.4.1) (Ribonucleotide reductase DNA damage-inducible regulatory subunit 2) (Ribonucleotide reductase R1 subunit 2) (Ribonucleotide reductase large subunit 2)
[Egln1] Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)
[Epas1 Hif2a] Endothelial PAS domain-containing protein 1 (EPAS-1) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha)
[egl-9 F22E12.4] Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) (EC 1.14.11.29) (Egg-laying defective protein 9) (Hypoxia-inducible factor-proline dioxygenase)
[Egln1] Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (Fragment)
[EPAS1 BHLHE73 HIF2A MOP2 PASD2] Endothelial PAS domain-containing protein 1 (EPAS-1) (Basic-helix-loop-helix-PAS protein MOP2) (Class E basic helix-loop-helix protein 73) (bHLHe73) (HIF-1-alpha-like factor) (HLF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha) (Member of PAS protein 2) (PAS domain-containing protein 2)
[Epas1 Hif2a] Endothelial PAS domain-containing protein 1 (EPAS-1) (HIF-1-alpha-like factor) (HLF) (mHLF) (HIF-related factor) (HRF) (Hypoxia-inducible factor 2-alpha) (HIF-2-alpha) (HIF2-alpha)
[EGLN3] Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (HPH-1) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3)
[Egln2] Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Falkor) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)
[mdb1 SPAC2E11.14 SPACUNK4.14] DNA damage response protein Mdb1 (BRCT domain protein Mdb1) (Midzone and DNA break-localizing protein 1)
[DDB1 XAP1] DNA damage-binding protein 1 (DDB p127 subunit) (DNA damage-binding protein a) (DDBa) (Damage-specific DNA-binding protein 1) (HBV X-associated protein 1) (XAP-1) (UV-damaged DNA-binding factor) (UV-damaged DNA-binding protein 1) (UV-DDB 1) (XPE-binding factor) (XPE-BF) (Xeroderma pigmentosum group E-complementing protein) (XPCe)
[Egln3 Sm20] Prolyl hydroxylase EGLN3 (EC 1.14.11.-) (Egl nine homolog 3) (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 3) (HIF-PH3) (HIF-prolyl hydroxylase 3) (HPH-3) (Prolyl hydroxylase domain-containing protein 3) (PHD3) (SM-20)
[DDR48 FSP YMR173W YM8010.03] Stress protein DDR48 (DNA damage-responsive protein 48) (DDRP 48) (Flocculent-specific protein) (YP 75)
[HIF1A BHLHE78 MOP1 PASD8] Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha) (ARNT-interacting protein) (Basic-helix-loop-helix-PAS protein MOP1) (Class E basic helix-loop-helix protein 78) (bHLHe78) (Member of PAS protein 1) (PAS domain-containing protein 8)
[EGLN2 EIT6] Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)
[DDB2] DNA damage-binding protein 2 (DDB p48 subunit) (DDBb) (Damage-specific DNA-binding protein 2) (UV-damaged DNA-binding protein 2) (UV-DDB 2)
[IER3 DIF2 IEX1 PRG1] Radiation-inducible immediate-early gene IEX-1 (Differentiation-dependent gene 2 protein) (Protein DIF-2) (Immediate early protein GLY96) (Immediate early response 3 protein) (PACAP-responsive gene 1 protein) (Protein PRG1)
[DRAM2 TMEM77 PSEC0031 UNQ154/PRO180] DNA damage-regulated autophagy modulator protein 2 (Transmembrane protein 77)
[Ddias Noxin] DNA damage-induced apoptosis suppressor protein (Nitric oxide-inducible gene protein)
[DRAM1 DRAM] DNA damage-regulated autophagy modulator protein 1 (Damage-regulated autophagy modulator)
[IQCB1 KIAA0036 NPHP5 OK/SW-cl.85] IQ calmodulin-binding motif-containing protein 1 (Nephrocystin-5) (p53 and DNA damage-regulated IQ motif protein) (PIQ)
[WSS1 YHR134W] DNA-dependent metalloprotease WSS1 (EC 3.4.24.-) (DNA damage response protein WSS1) (SUMO-dependent isopeptidase WSS1) (Weak suppressor of SMT3 protein 1)
[EGLN1 C1orf12 PNAS-118 PNAS-137] Egl nine homolog 1 (EC 1.14.11.29) (Hypoxia-inducible factor prolyl hydroxylase 2) (HIF-PH2) (HIF-prolyl hydroxylase 2) (HPH-2) (Prolyl hydroxylase domain-containing protein 2) (PHD2) (SM-20)
[Hif1a] Hypoxia-inducible factor 1-alpha (HIF-1-alpha) (HIF1-alpha)
[MEC1 ESR1 SAD3 YBR136W YBR1012] Serine/threonine-protein kinase MEC1 (EC 2.7.11.1) (ATR homolog) (DNA-damage checkpoint kinase MEC1) (Mitosis entry checkpoint protein 1)

Bibliography :