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DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54)

 RAD54_HUMAN             Reviewed;         747 AA.
Q92698; Q5TE31; Q6IUY3;
16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
16-AUG-2004, sequence version 2.
29-SEP-2021, entry version 168.
RecName: Full=DNA repair and recombination protein RAD54-like;
EC=3.6.4.12 {ECO:0000269|PubMed:9774452};
AltName: Full=RAD54 homolog;
Short=hHR54;
Short=hRAD54;
Name=RAD54L; Synonyms=RAD54A;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, CELL CYCLE REGULATION,
AND MUTAGENESIS OF LYS-189.
TISSUE=Testis;
PubMed=8805304; DOI=10.1016/s0960-9822(02)00606-1;
Kanaar R., Troelstra C., Swagemakers S.M.A., Essers J., Smit B.,
Franssen J.-H., Pastink A., Bezzubova O.Y., Buerstedde J.-M., Clever B.,
Heyer W.-D., Hoeijmakers J.H.J.;
"Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair
gene: evidence for functional conservation.";
Curr. Biol. 6:828-838(1996).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS GLY-21; MET-74; CYS-202;
GLN-380; CYS-534 AND THR-583.
NIEHS SNPs program;
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
CHARACTERIZATION.
PubMed=9192813;
Rasio D., Murakumo Y., Robbins D., Roth T., Silver A., Negrini M.,
Schmidt C., Burczak J., Fishel R., Croce C.M.;
"Characterization of the human homologue of RAD54: a gene located on
chromosome 1p32 at a region of high loss of heterozygosity in breast
tumors.";
Cancer Res. 57:2378-2383(1997).
[6]
INTERACTION WITH RAD51.
PubMed=9321665; DOI=10.1093/nar/25.20.4106;
Golub E.I., Kovalenko O.V., Gupta R.C., Ward D.C., Radding C.M.;
"Interaction of human recombination proteins Rad51 and Rad54.";
Nucleic Acids Res. 25:4106-4110(1997).
[7]
FUNCTION, AND CATALYTIC ACTIVITY.
PubMed=9774452; DOI=10.1074/jbc.273.43.28292;
Swagemakers S.M.A., Essers J., de Wit J., Hoeijmakers J.H.J., Kanaar R.;
"The human RAD54 recombinational DNA repair protein is a double-stranded
DNA-dependent ATPase.";
J. Biol. Chem. 273:28292-28297(1998).
[8]
LACK OF INVOLVEMENT IN PARATHYROID ADENOMAS.
PubMed=10449612;
DOI=10.1002/(sici)1097-0215(19990924)83:1<80::aid-ijc15>3.0.co;2-e;
Carling T., Imanishi Y., Gaz R.D., Arnold A.;
"Analysis of the RAD54 gene on chromosome 1p as a potential tumor-
suppressor gene in parathyroid adenomas.";
Int. J. Cancer 83:80-82(1999).
[9]
FUNCTION.
PubMed=11459989; DOI=10.1073/pnas.151056798;
Ristic D., Wyman C., Paulusma C., Kanaar R.;
"The architecture of the human Rad54-DNA complex provides evidence for
protein translocation along DNA.";
Proc. Natl. Acad. Sci. U.S.A. 98:8454-8460(2001).
[10]
FUNCTION.
PubMed=12205100; DOI=10.1074/jbc.m208004200;
Sigurdsson S., Van Komen S., Petukhova G., Sung P.;
"Homologous DNA pairing by human recombination factors Rad51 and Rad54.";
J. Biol. Chem. 277:42790-42794(2002).
[11]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-38, AND IDENTIFICATION BY
MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[12]
FUNCTION, AND INTERACTION WITH NAP1L1.
PubMed=24798879; DOI=10.1038/srep04863;
Machida S., Takaku M., Ikura M., Sun J., Suzuki H., Kobayashi W.,
Kinomura A., Osakabe A., Tachiwana H., Horikoshi Y., Fukuto A., Matsuda R.,
Ura K., Tashiro S., Ikura T., Kurumizaka H.;
"Nap1 stimulates homologous recombination by RAD51 and RAD54 in higher-
ordered chromatin containing histone H1.";
Sci. Rep. 4:4863-4863(2014).
[13]
PHOSPHORYLATION AT SER-572, MUTAGENESIS OF SER-572, AND FUNCTION.
PubMed=27264870; DOI=10.1016/j.molcel.2016.04.032;
Spies J., Waizenegger A., Barton O., Suerder M., Wright W.D., Heyer W.D.,
Loebrich M.;
"Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and
Replication Fork Stability.";
Mol. Cell 62:903-917(2016).
[14]
ACETYLATION AT LYS-515, INTERACTION WITH BRD9, FUNCTION, AND MUTAGENESIS OF
LYS-515.
PubMed=32457312; DOI=10.1038/s41467-020-16443-x;
Zhou Q., Huang J., Zhang C., Zhao F., Kim W., Tu X., Zhang Y., Nowsheen S.,
Zhu Q., Deng M., Chen Y., Qin B., Luo K., Liu B., Lou Z., Mutter R.W.,
Yuan J.;
"The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex
formation and regulates homologous recombination-mediated repair.";
Nat. Commun. 11:2639-2639(2020).
[15]
VARIANTS HIS-63; GLU-151; ARG-325 AND GLU-444.
PubMed=10362365; DOI=10.1038/sj.onc.1202692;
Matsuda M., Miyagawa K., Takahashi M., Fukuda T., Kataoka T., Asahara T.,
Inui H., Watatani M., Yasutomi M., Kamada N., Dohi K., Kamiya K.;
"Mutations in the RAD54 recombination gene in primary cancers.";
Oncogene 18:3427-3430(1999).
-!- FUNCTION: Plays an essential role in homologous recombination (HR)
which is a major pathway for repairing DNA double-strand breaks (DSBs),
single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication
forks (PubMed:9774452, PubMed:24798879, PubMed:32457312,
PubMed:11459989, PubMed:12205100, PubMed:27264870). Acts as a molecular
motor during the homology search and guides RAD51 ssDNA along a donor
dsDNA thereby changing the homology search from the diffusion-based
mechanism to a motor-guided mechanism. Plays also an essential role in
RAD51-mediated synaptic complex formation which consists of three
strands encased in a protein filament formed once homology is
recognized. Once DNA strand exchange occured, dissociates RAD51 from
nucleoprotein filaments formed on dsDNA (By similarity).
{ECO:0000250|UniProtKB:P32863, ECO:0000269|PubMed:11459989,
ECO:0000269|PubMed:12205100, ECO:0000269|PubMed:24798879,
ECO:0000269|PubMed:27264870, ECO:0000269|PubMed:32457312,
ECO:0000269|PubMed:9774452}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
Evidence={ECO:0000269|PubMed:9774452};
-!- SUBUNIT: Homohexamer (By similarity). Interacts (via N-terminus) with
RAD51 (PubMed:9321665). Interacts with NAP1L1 (PubMed:24798879).
Interacts with BRD9; this interaction orchestrates RAD51-RAD54 complex
formation (PubMed:32457312). {ECO:0000250|UniProtKB:Q7ZV09,
ECO:0000269|PubMed:24798879, ECO:0000269|PubMed:32457312,
ECO:0000269|PubMed:9321665}.
-!- INTERACTION:
Q92698; Q96HA8: NTAQ1; NbExp=4; IntAct=EBI-5333483, EBI-741158;
Q92698; Q9H2K2: TNKS2; NbExp=3; IntAct=EBI-5333483, EBI-4398527;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8805304}.
-!- INDUCTION: Expression increases approximately 3-fold in late G1 phase
compared to other phases of the cell cycle.
-!- PTM: Acetylated. Acetylation promotes interaction with BRD9, and
subsequently with RAD54, which is essential for homologous
recombination (HR). {ECO:0000269|PubMed:32457312}.
-!- PTM: Phosphorylated. Phosphorylation at Ser-572 by NEK1 specifically in
G2 phase allows efficient removal of RAD51 filaments from DNA.
{ECO:0000269|PubMed:27264870}.
-!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family. {ECO:0000305}.
-!- WEB RESOURCE: Name=NIEHS-SNPs;
URL="http://egp.gs.washington.edu/data/rad54l/";
---------------------------------------------------------------------------
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EMBL; X97795; CAA66379.1; -; mRNA.
EMBL; AY623117; AAT38113.1; -; Genomic_DNA.
EMBL; AL121602; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC121059; AAI21060.1; -; mRNA.
EMBL; BC121060; AAI21061.1; -; mRNA.
CCDS; CCDS532.1; -.
RefSeq; NP_001136020.1; NM_001142548.1.
RefSeq; NP_003570.2; NM_003579.3.
SMR; Q92698; -.
BioGRID; 114018; 8.
DIP; DIP-48628N; -.
ELM; Q92698; -.
IntAct; Q92698; 9.
STRING; 9606.ENSP00000361043; -.
BindingDB; Q92698; -.
ChEMBL; CHEMBL2146297; -.
iPTMnet; Q92698; -.
PhosphoSitePlus; Q92698; -.
BioMuta; RAD54L; -.
DMDM; 51316508; -.
EPD; Q92698; -.
jPOST; Q92698; -.
MassIVE; Q92698; -.
MaxQB; Q92698; -.
PaxDb; Q92698; -.
PeptideAtlas; Q92698; -.
PRIDE; Q92698; -.
ProteomicsDB; 75414; -.
Antibodypedia; 18708; 263 antibodies.
DNASU; 8438; -.
Ensembl; ENST00000371975; ENSP00000361043; ENSG00000085999.
Ensembl; ENST00000442598; ENSP00000396113; ENSG00000085999.
Ensembl; ENST00000671528; ENSP00000499652; ENSG00000085999.
GeneID; 8438; -.
KEGG; hsa:8438; -.
UCSC; uc001cpl.3; human.
CTD; 8438; -.
DisGeNET; 8438; -.
GeneCards; RAD54L; -.
HGNC; HGNC:9826; RAD54L.
HPA; ENSG00000085999; Group enriched (lymphoid tissue, testis).
MalaCards; RAD54L; -.
MIM; 603615; gene.
neXtProt; NX_Q92698; -.
OpenTargets; ENSG00000085999; -.
Orphanet; 227535; Hereditary breast cancer.
PharmGKB; PA34181; -.
VEuPathDB; HostDB:ENSG00000085999; -.
eggNOG; KOG0390; Eukaryota.
GeneTree; ENSGT00940000156897; -.
HOGENOM; CLU_000315_10_5_1; -.
InParanoid; Q92698; -.
OMA; YTEHERM; -.
OrthoDB; 93727at2759; -.
PhylomeDB; Q92698; -.
TreeFam; TF101224; -.
BRENDA; 3.6.4.B9; 2681.
PathwayCommons; Q92698; -.
BioGRID-ORCS; 8438; 38 hits in 1024 CRISPR screens.
ChiTaRS; RAD54L; human.
GeneWiki; DNA_repair_and_recombination_protein_RAD54-like; -.
GenomeRNAi; 8438; -.
Pharos; Q92698; Tbio.
PRO; PR:Q92698; -.
Proteomes; UP000005640; Chromosome 1.
RNAct; Q92698; protein.
Bgee; ENSG00000085999; Expressed in ventricular zone and 131 other tissues.
ExpressionAtlas; Q92698; baseline and differential.
Genevisible; Q92698; HS.
GO; GO:0005654; C:nucleoplasm; IDA:HPA.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0032991; C:protein-containing complex; IMP:UniProtKB.
GO; GO:0036310; F:annealing helicase activity; IDA:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0140603; F:ATP hydrolysis activity; IEA:RHEA.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
GO; GO:0015616; F:DNA translocase activity; IBA:GO_Central.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0070615; F:nucleosome-dependent ATPase activity; IEA:InterPro.
GO; GO:0008340; P:determination of adult lifespan; IEA:Ensembl.
GO; GO:0006310; P:DNA recombination; TAS:ProtInc.
GO; GO:0006281; P:DNA repair; TAS:ProtInc.
GO; GO:0045003; P:double-strand break repair via synthesis-dependent strand annealing; IBA:GO_Central.
GO; GO:0051321; P:meiotic cell cycle; TAS:ProtInc.
GO; GO:0007131; P:reciprocal meiotic recombination; IBA:GO_Central.
GO; GO:0042493; P:response to drug; IEA:Ensembl.
GO; GO:0010212; P:response to ionizing radiation; IEA:Ensembl.
Gene3D; 3.40.50.10810; -; 1.
Gene3D; 3.40.50.300; -; 1.
InterPro; IPR014001; Helicase_ATP-bd.
InterPro; IPR001650; Helicase_C.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR038718; SNF2-like_sf.
InterPro; IPR000330; SNF2_N.
Pfam; PF00271; Helicase_C; 1.
Pfam; PF00176; SNF2_N; 1.
SMART; SM00487; DEXDc; 1.
SMART; SM00490; HELICc; 1.
SUPFAM; SSF52540; SSF52540; 2.
PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PROSITE; PS51194; HELICASE_CTER; 1.
1: Evidence at protein level;
Acetylation; ATP-binding; DNA damage; DNA repair; DNA-binding; Helicase;
Hydrolase; Metal-binding; Nucleotide-binding; Nucleus; Phosphoprotein;
Reference proteome; Zinc.
CHAIN 1..747
/note="DNA repair and recombination protein RAD54-like"
/id="PRO_0000074337"
DOMAIN 170..345
/note="Helicase ATP-binding"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
DOMAIN 500..653
/note="Helicase C-terminal"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
NP_BIND 183..190
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
REGION 1..41
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
REGION 2..9
/note="Required for chromatin remodeling, strand pairing
activities and coupling of ATPase activity"
/evidence="ECO:0000250"
MOTIF 296..299
/note="DEGH box"
COMPBIAS 14..30
/note="Basic and acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
MOD_RES 38
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:23186163"
MOD_RES 515
/note="N6-acetyllysine"
/evidence="ECO:0000269|PubMed:32457312"
MOD_RES 572
/note="Phosphoserine; by NEK1"
/evidence="ECO:0000269|PubMed:27264870"
VARIANT 21
/note="D -> G (in dbSNP:rs28363192)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_055363"
VARIANT 63
/note="P -> H (in a colon adenocarcinoma sample;
dbSNP:rs121908688)"
/evidence="ECO:0000269|PubMed:10362365"
/id="VAR_019559"
VARIANT 74
/note="I -> M (in dbSNP:rs28363209)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_055364"
VARIANT 151
/note="K -> E (in dbSNP:rs2295466)"
/evidence="ECO:0000269|PubMed:10362365"
/id="VAR_019560"
VARIANT 202
/note="R -> C (in dbSNP:rs28363218)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_055365"
VARIANT 325
/note="G -> R (in a breast cancer sample; invasive ductal;
dbSNP:rs121908690)"
/evidence="ECO:0000269|PubMed:10362365"
/id="VAR_019561"
VARIANT 380
/note="R -> Q (in dbSNP:rs28363234)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_055366"
VARIANT 444
/note="V -> E (in a non-Hodgkin lymphoma sample;
dbSNP:rs121908689)"
/evidence="ECO:0000269|PubMed:10362365"
/id="VAR_019562"
VARIANT 534
/note="R -> C (in dbSNP:rs28363240)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_055367"
VARIANT 583
/note="I -> T (in dbSNP:rs28363243)"
/evidence="ECO:0000269|Ref.2"
/id="VAR_055368"
MUTAGEN 189
/note="K->R: Unable to rescue the MMS-sensitive phenotype
of S cerevisiae rad54delta cells."
/evidence="ECO:0000269|PubMed:8805304"
MUTAGEN 515
/note="K->R: Loss of acetylation."
/evidence="ECO:0000269|PubMed:32457312"
MUTAGEN 572
/note="S->A: Defect in homologous recombination (HR)."
/evidence="ECO:0000269|PubMed:27264870"
MUTAGEN 572
/note="S->E: Promotes homologous recombination (HR), but
causes RAD51 removal from chromatin."
/evidence="ECO:0000269|PubMed:27264870"
CONFLICT 738
/note="R -> H (in Ref. 1; CAA66379)"
/evidence="ECO:0000305"
SEQUENCE 747 AA; 84352 MW; 718100974CA6687B CRC64;
MRRSLAPSQL AKRKPEGRSC DDEDWQPGLV TPRKRKSSSE TQIQECFLSP FRKPLSQLTN
QPPCLDSSQH EAFIRSILSK PFKVPIPNYQ GPLGSRALGL KRAGVRRALH DPLEKDALVL
YEPPPLSAHD QLKLDKEKLP VHVVVDPILS KVLRPHQREG VKFLWECVTS RRIPGSHGCI
MADEMGLGKT LQCITLMWTL LRQSPECKPE IDKAVVVSPS SLVKNWYNEV GKWLGGRIQP
LAIDGGSKDE IDQKLEGFMN QRGARVSSPI LIISYETFRL HVGVLQKGSV GLVICDEGHR
LKNSENQTYQ ALDSLNTSRR VLISGTPIQN DLLEYFSLVH FVNSGILGTA HEFKKHFELP
ILKGRDAAAS EADRQLGEER LRELTSIVNR CLIRRTSDIL SKYLPVKIEQ VVCCRLTPLQ
TELYKRFLRQ AKPAEELLEG KMSVSSLSSI TSLKKLCNHP ALIYDKCVEE EDGFVGALDL
FPPGYSSKAL EPQLSGKMLV LDYILAVTRS RSSDKVVLVS NYTQTLDLFE KLCRARRYLY
VRLDGTMSIK KRAKVVERFN SPSSPDFVFM LSSKAGGCGL NLIGANRLVM FDPDWNPAND
EQAMARVWRD GQKKTCYIYR LLSAGTIEEK IFQRQSHKKA LSSCVVDEEQ DVERHFSLGE
LKELFILDEA SLSDTHDRLH CRRCVNSRQI RPPPDGSDCT SDLAGWNHCT DKWGLRDEVL
QAAWDAASTA ITFVFHQRSH EEQRGLR


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RAD54_HUMAN ELISA Kit FOR DNA repair and recombination protein RAD54-like; organism: Human; gene name: RAD54L 96T
EIAAB33416 Chicken,DNA repair and recombination protein RAD54B,Gallus gallus,RAD54 homolog B,RAD54B
25-356 RAD54B belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This 0.05 mg
25-355 RAD54B belongs to the DEAD-like helicase superfamily. It shares similarity with Saccharomyces cerevisiae RAD54 and RDH54, both of which are involved in homologous recombination and repair of DNA. This 0.05 mg
P-5003-RAD54-96 QuantiSir Specific Gene Knockdown Quantification Kit For DNA Damage_Repair - Rad54 (96 assays)
P-5003-RAD54-96 QuantiSir Specific Gene Knockdown Quantification Kit For DNA Damage_Repair _ Rad54 96 assays 96 assays
  P-5003-RAD54-96  QuantiSir Specific Gene Knockdown Quantification Kit For DNA Damage_Repair _ Rad54 (96 assays)
ASAKAM-CC254E RAD54 mAb (Rad54 3E3_1) 100 µg
ASAKAM-CC254C RAD54 mAb (Rad54 4E3_1) 25 µg
EIAAB25369 Double-strand break repair protein MRE11A,HNGS1,Homo sapiens,Human,Meiotic recombination 11 homolog 1,Meiotic recombination 11 homolog A,MRE11,MRE11 homolog 1,MRE11 homolog A,MRE11A
ARP36408_P050 RAD54B(RAD54 homolog B (S. cerevisiae)) 50 µg
Pathways :
WP1663: Homologous recombination
WP1678: Nucleotide excision repair
WP1625: Base excision repair
WP1672: Mismatch repair
WP1035: Mismatch repair
WP1657: Glycerolipid metabolism
WP2203: TSLP Signaling Pathway
WP1361: Mismatch repair
WP1700: Selenoamino acid metabolism
WP731: Sterol regulatory element binding protein related
WP1438: Influenza A virus infection
WP1787: Base Excision Repair
WP802: Mismatch repair
WP1152: Mismatch repair
WP2292: Chemokine signaling pathway
WP1204: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1531: Vitamin D synthesis
WP186: Homologous recombination
WP916: Mismatch repair
WP1613: 1,4-Dichlorobenzene degradation
WP1909: Signal regulatory protein (SIRP) family interactions
WP1216: Homologous recombination
WP32: Translation Factors

Related Genes :
[RAD54L RAD54A] DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54)
[Rad54l Rad54] DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (mHR54) (mRAD54)
[RAD54B] DNA repair and recombination protein RAD54B (EC 3.6.4.-) (RAD54 homolog B)
[okr RAD54 CG3736] DNA repair and recombination protein RAD54-like (DmRAD54) (EC 3.6.4.-) (Protein okra) (RAD54 DNA repair protein)
[RAD54 YGL163C G1821] DNA repair and recombination protein RAD54 (EC 3.6.4.12)
[rhp54 rad54 SPAC15A10.03c] DNA repair protein rhp54 (EC 3.6.4.12) (RAD54 homolog 1)
[Rad54l2 Arip4 Srisnf2l] Helicase ARIP4 (EC 3.6.4.12) (Androgen receptor-interacting protein 4) (RAD54-like protein 2) (Steroid receptor-interacting SNF2 domain-containing protein-like)
[rad54l] DNA repair and recombination protein RAD54-like (EC 3.6.4.12)
[ATRX RAD54L XH2] Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)
[RAD54L RAD54] DNA repair and recombination protein RAD54-like (EC 3.6.4.-) (Putative recombination factor GdRad54) (RAD54 homolog) (Fragment)
[RDH54 TID1 YBR073W YBR0715] DNA repair and recombination protein RDH54 (RAD homolog 54) (Recombination factor TID1) (Two hybrid interaction with DMC1 protein 1) [Includes: DNA topoisomerase (EC 5.99.1.-); Putative helicase (EC 3.6.4.12)]
[Rad51 Rad51a Reca] DNA repair protein RAD51 homolog 1 (RAD51 homolog A)
[STH1 NPS1 YIL126W] Nuclear protein STH1/NPS1 (EC 3.6.4.12) (ATP-dependent helicase STH1) (Chromatin structure-remodeling complex protein STH1) (SNF2 homolog)
[RAD51 RAD51A RECA] DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A)
[Ercc6 Csb] DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)
[Ino80 Inoc1 Kiaa1259] Chromatin-remodeling ATPase INO80 (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80)
[ERCC6 CSB] DNA excision repair protein ERCC-6 (EC 3.6.4.-) (ATP-dependent helicase ERCC6) (Cockayne syndrome protein CSB)
[Mi-2 CG8103] Chromodomain-helicase-DNA-binding protein Mi-2 homolog (EC 3.6.4.12) (ATP-dependent helicase Mi-2) (dMi-2)
[INO80 INO80A INOC1 KIAA1259] Chromatin-remodeling ATPase INO80 (hINO80) (EC 3.6.4.-) (DNA helicase-related INO80 complex homolog 1) (DNA helicase-related protein INO80) (INO80 complex subunit A)
[xnp-1 B0041.7] Transcriptional regulator ATRX homolog (EC 3.6.4.12) (ATP-dependent helicase xnp-1) (X-linked nuclear protein 1)
[Atrx Hp1bp2 Xnp] Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (HP1 alpha-interacting protein) (HP1-BP38 protein) (Heterochromatin protein 2) (X-linked nuclear protein)
[RAD5A RAD5 At5g22750 MDJ22.17] DNA repair protein RAD5A (EC 3.6.4.-) (Putative SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3-like 2) (SMARCA3-like protein 2) (RAD5 homolog A) (AtRAD5a)
[RAD51] DNA repair protein RAD51 homolog 1 (cRad51)
[RAD51 RAD51A] DNA repair protein RAD51 homolog 1
[RAD51] DNA repair protein RAD51 homolog 1
[yaiE ppnP yaiE_1 yaiE_2 A5U30_004171 A6519_004168 A6583_19230 A6592_08565 A8499_002689 A8C65_08910 A8W81_002402 A8X68_002957 A9819_01890 A9X72_19070 AAG43_001684 AAS29_000851 ABE90_005680 ABT96_001030 ACN002_0406 ACN68_10320 ACN81_25005 ACU57_12035 ACW72_000537 AM270_02350 AM340_00170 AM464_18935 AMK64_000048 AML23_18615 AO169_001228 APX88_10995 AT845_004245 AUQ29_12220 AW059_14025 AW086_04940 AW118_21925 AZZ83_000156 B2D52_001288 B5N24_001418 B6L15_000900 B6R12_004630 B6R15_004744 B6R17_001763 B6R27_001430 B6R48_001853 B6R87_002119 B7C15_002412 B9T59_05995 BANRA_00925 BANRA_01371 BANRA_02015 BANRA_03594 BB545_15535 BE963_16095 BER14_23410 BF271_000352 BFL24_02350 BG821_003456 BG944_000956 BH692_02565 BHF52_11910 BHS81_02405 BHS87_02130 BIQ87_02175 BIZ41_26355 BJI68_13875 BJJ90_20310 BK272_17750 BK292_14635 BK373_01320 BK375_26975 BKD45_000677 BMC34_003941 BMC79_001982 BMR21_14190 BMT50_02930 BMT91_05310 BN17_01951 BO068_001728 BOB65_000444 BOH76_16090 BON63_11530 BON65_18745 BON66_09075 BON70_06170 BON72_15085 BON73_05975 BON76_23825 BON83_20655 BON86_03800 BON87_15370 BON91_23895 BON92_15465 BON93_19270 BON94_14845 BON95_06500 BON96_22295 BON98_18895 BR158_003623 BR331_05500 BRV34_002179 BRV41_001603 BTQ06_17790 BUE81_15520 BUE82_18690 BvCms2454_01767 BvCmsC61A_02990 BvCmsHHP019_02594 BvCmsHHP019_02735 BvCmsHHP056_01410 BvCmsKKP005_02375 BvCmsKKP036_04281 BvCmsKKP057_03186 BvCmsKKP061_04019 BvCmsKSNP073_05624 BvCmsKSP011_04945 BvCmsKSP067_05191 BvCmsKSP076_04759 BvCmsNSNP036_04163 BvCmsSIP024_01003 BvCmsSIP082_02880 BVL39_00880 BWI89_12535 BXT93_00165 BZL69_16805 C2M16_02670 C2U48_08110 C3F40_10585 C4952_000933 C4M78_16865 C5542_003745 C5715_13595 C5F72_20070 C5N07_12740 C5Y87_03235 C6B22_00620 C6L19_003123 C6N50_002569 C7B02_04545 C9114_16640 C9160_00550 C9E67_23765 C9Z62_15540 C9Z68_20485 CA593_01185 CBT22_001283 CCS08_21635 CCZ91_001256 CD42_000819 CDC27_00860 CDL36_14165 CDL37_09465 CF32_001327 CG692_05055 CG831_000443 CIG67_05475 CLG78_001395 CN875_002288 CO706_24355 COD50_07875 CQP61_20925 CR539_06140 CS116_000640 CT143_00140 CV83915_01183 CWS33_22875 CXJ73_003963 CY655_02075 D0X26_07420 D1912_23295 D3822_22465 D3C88_28950 D3G36_08025 D3O91_15305 D3Y67_14350 D4U49_03050 D4V09_04715 D5H22_03840 D6T60_09300 D9D31_21970 D9D43_14830 D9D77_05600 D9E34_09525 D9E49_06955 D9H13_03415 D9H94_24405 D9J03_17400 D9J11_02150 D9J61_02635 D9K17_07345 DAH18_14975 DAH23_10455 DAH34_21345 DAH37_05240 DAH50_14800 DB282_04950 DD762_07680 DEN86_05080 DEN89_14495 DEN95_09255 DEO15_17360 DIV22_26285 DL654_17660 DLX40_16565 DM968_04210 DN627_04525 DNQ45_00335 DP258_05110 DRW19_06400 DS732_06920 DS966_18475 DTL43_07415 DTL90_10740 DTM10_06080 DTM45_10960 DU321_19460 DXB10_13805 DXT69_08115 DXT71_02970 DXT73_01860 E0I42_07410 E0N24_10860 E0P28_09655 E2119_01725 E2123_04610 E2127_09375 E2128_04435 E2129_13975 E2135_01410 E3N34_04125 E4K51_12070 E4K54_07340 E5P52_05895 E5S34_07545 E5S35_14895 E5S38_06765 E5S43_12135 E5S47_09895 E5S52_06115 E5S61_09810 E5S62_19990 EA239_15730 EA435_05820 EAI46_25725 EAI46_25840 EAN77_07940 EAX79_06830 EBP16_12520 EC1094V2_3464 EC3234A_4c00610 EC95NR1_04612 ECs0441 ED648_16775 EGC08_04505 EH88_002240 EHD79_03470 EHH55_15815 EI021_16245 EI041_08145 EIA13_09645 EIZ93_00830 EKI52_09170 EL79_3454 EL80_3408 ELT17_22260 ELT29_22585 ELT31_00280 ELT33_03015 ELT48_00735 ELT49_21480 ELT58_21305 ELT72_05540 ELU83_10395 ELU85_08960 ELU95_12465 ELV08_00785 ELV13_00555 ELV15_22680 ELV22_01630 ELV24_16525 ELV28_08410 ELX56_03900 ELX68_02065 ELX69_19550 ELX70_07125 ELX76_05850 ELX79_24270 ELX83_01445 ELX96_14305 ELY05_09885 ELY23_04665 ELY24_07180 ELY32_22740 ELY41_15435 ELY48_07355 ELY50_04295 EO241_13835 EPS76_10515 EQO00_19840 ERS085366_04179 ERS085386_01096 ERS085406_02227 ERS139208_01812 Esc0902E_04100 ETECE1373_03601 ETECE36_04584 ETECE925_03600 EVY14_00050 EWK56_10245 ExPECSC038_04895 EXX13_09665 EXX79_08270 EYX47_16280 EYX55_13650 EYY34_27625 F2N27_03375 F2N28_02020 F2N31_18495 F3N40_11580 F6U69_13610 F7F11_06850 F9386_04870 F9400_03995 F9407_08955 F9571_08760 F9B07_11235 F9S76_00660 F9S83_01525 F9V07_00950 F9V24_00540 F9X20_010625 F9X20_10705 FA849_16230 FA868_02660 FC554_02980 FDM60_01545 FEL34_02665 FFF58_18140 FGG80_03620 FGY90_08925 FHD44_10100 FHR00_04660 FJQ51_13145 FKO60_24460 FMP09_15400 FNJ67_20330 FOI11_011505 FOI11_08540 FPI65_02250 FPS82_09410 FQ021_04720 FQE77_10330 FQF29_11270 FTV90_10360 FTV92_11870 FTV93_12360 FV293_06120 FWK02_29295 FZC17_02065 FZN26_02330 FZN30_08825 FZN31_18905 G3565_02860 G3813_001670 G4A38_05410 G5696_10795 G6P89_19245 G6Z99_23355 G7635_000369 G9448_08700 GAJ26_09340 GBE29_07095 GF147_12390 GF646_06625 GF699_04160 GFY34_04590 GFY48_03475 GFZ60_05015 GIB53_01735 GJ11_02375 GKE84_19495 GKF52_17565 GKF86_04910 GKF89_04055 GKG12_02940 GKZ24_03305 GNO40_22710 GNZ05_01665 GOP20_09010 GP650_16700 GP662_13045 GP711_02810 GP946_18990 GP954_12950 GP979_17585 GQE42_04900 GQE64_07505 GQE87_15550 GQF58_00730 GQF59_00790 GQM04_16295 GQM06_17115 GQM09_10135 GQM10_05275 GQM13_16755 GQR15_01785 GQW07_10130 GQW68_15010 GQW76_11855 GQW80_20255 GRC73_12510 GRO95_09290 GRQ19_02985 GRW05_15575 GRW57_16360 GRW80_21245 GRW81_04110 GSY44_11760 GTP88_03425 GUB08_22335 GUB92_14995 GUC01_07480 GUI33_03675 GW978_01435 GXV26_001683 H0O53_01395 H0O72_08355 H4P47_18630 H4P50_19265 H4P51_19115 H5C78_05615 HCF72_000699 HH795_003019 HHH44_001374 HI055_001796 HIE44_000773 HIF90_002068 HIN64_001318 HIR12_001426 HIT56_001577 HJ942_001977 HJM92_003231 HJN04_001825 HJO75_000225 HJQ60_002362 HJS37_002167 HJS41_003943 HJU54_001570 HKA49_002910 HL563_20960 HLU10_04740 HLU56_09785 HLV18_07370 HLZ50_17655 HmCms169_03669 HmCms184_01874 HmCmsJML074_04353 HMS79_05370 HMT08_08320 HMT08_28135 HMU06_13895 HMU48_14510 HMV41_12865 HMV95_11570 HNC30_09785 HNC36_06780 HNC38_21355 HNC52_05780 HNC59_10160 HNC66_06600 HNC75_03340 HNC99_09055 HND24_23650 HNO08_21040 HNV65_12835 HNY50_21730 HNY54_14805 HPE39_05435 HV109_18115 HVV39_18775 HVV53_22620 HVW11_04845 HVW22_00965 HVW43_10265 HVX16_19490 HVY77_19945 HVZ33_18480 HVZ71_18990 HX136_19525 HZ71_000860 HZ72_001928 I6H02_19720 IA00_002609 JE86ST02C_04160 JE86ST05C_04220 MJ49_04490 MS7163_00387 NCTC10082_01078 NCTC10089_03910 NCTC10418_05682 NCTC10429_03762 NCTC10764_05371 NCTC10767_04209 NCTC10865_04787 NCTC11022_05137 NCTC11126_00022 NCTC11181_01145 NCTC11341_03896 NCTC12950_04180 NCTC13127_05156 NCTC13216_02895 NCTC7922_06246 NCTC7927_04270 NCTC8008_03382 NCTC8009_07014 NCTC8179_01642 NCTC8450_01367 NCTC8500_04283 NCTC8621_03984 NCTC8622_02997 NCTC8959_05017 NCTC8960_01314 NCTC8985_02798 NCTC9001_00537 NCTC9036_03840 NCTC9044_03501 NCTC9045_04434 NCTC9048_04159 NCTC9050_01764 NCTC9075_05103 NCTC9077_04792 NCTC9081_02496 NCTC9111_03977 NCTC9117_04804 NCTC9434_02812 NCTC9702_04480 NCTC9703_03222 NCTC9706_01114 NCTC9775_02088 NCTC9777_00174 NCTC9969_04032 ND22_001447 PGD_02920 PU06_02955 RG28_02910 SAMEA3472043_02682 SAMEA3472044_00466 SAMEA3472056_03633 SAMEA3472064_01205 SAMEA3472080_01810 SAMEA3472112_02965 SAMEA3472117_02973 SAMEA3472120_01236 SAMEA3472147_04902 SAMEA3484427_03543 SAMEA3484429_01888 SAMEA3485101_03989 SAMEA3485110_03675 SAMEA3751407_02141 SAMEA3752312_01369 SAMEA3752386_01995 SAMEA3752557_00215 SAMEA3753064_01236 SAMEA3753290_01725 SAMEA3753300_00458 SM09_01165 THOESC010_34040 TUM18780_32860 UN91_18725 WP2S18E08_35360 WP4S18E07_34480 WP4S18E08_34230 WQ89_01420 WR15_04360] Pyrimidine/purine nucleoside phosphorylase (EC 2.4.2.1) (EC 2.4.2.2) (Adenosine phosphorylase) (Cytidine phosphorylase) (Guanosine phosphorylase) (EC 2.4.2.15) (Inosine phosphorylase) (Thymidine phosphorylase) (EC 2.4.2.4) (Uridine phosphorylase) (EC 2.4.2.3) (Xanthosine phosphorylase)
[Smarca5 Snf2h] SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (mSnf2h)
[DDM1 CHA1 CHR1 SOM1 SOM4 At5g66750 MSN2.14] ATP-dependent DNA helicase DDM1 (EC 3.6.4.12) (Protein CHROMATIN REMODELING 1) (AtCHR1) (CHR01) (Protein DECREASED DNA METHYLATION 1) (AtDDM1) (Protein SOMNIFEROUS 1) (SWI/SNF2-related matrix-associated actin-dependent regulator of chromatin DDM1)
[ORF1ab orf1ab] 2'-O-methyltransferase (EC 2.7.7.48) (EC 3.4.19.12) (EC 3.4.22.69) (EC 3.6.4.12) (EC 3.6.4.13) (3C-like proteinase) (Growth factor-like peptide) (Guanine-N7 methyltransferase) (Helicase) (Host translation inhibitor nsp1) (Leader protein) (NendoU) (Non-structural protein 10) (Non-structural protein 2) (Non-structural protein 3) (Non-structural protein 4) (Non-structural protein 6) (Non-structural protein 7) (Non-structural protein 8) (Non-structural protein 9) (ORF1ab polyprotein) (Papain-like proteinase) (RNA-directed RNA polymerase) (Replicase polyprotein 1ab) (Uridylate-specific endoribonuclease) (p65 homolog)
[Chd8 Kiaa1564] Chromodomain-helicase-DNA-binding protein 8 (CHD-8) (EC 3.6.4.12) (ATP-dependent helicase CHD8) (Axis duplication inhibitor) (Duplin)

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