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DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)

 RA51C_CRIGR             Reviewed;         366 AA.
Q8R2J9; Q8VDE9;
30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
01-JUN-2002, sequence version 1.
16-JAN-2019, entry version 75.
RecName: Full=DNA repair protein RAD51 homolog 3;
Short=R51H3;
AltName: Full=RAD51 homolog C;
AltName: Full=RAD51-like protein 2;
Name=RAD51C; Synonyms=RAD51L2;
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Cricetidae; Cricetinae; Cricetulus.
NCBI_TaxID=10029;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
PubMed=11912211; DOI=10.1074/jbc.M201402200;
French C.A., Masson J.Y., Griffin C.S., O'Regan P., West S.C.,
Thacker J.;
"Role of mammalian RAD51L2 (RAD51C) in recombination and genetic
stability.";
J. Biol. Chem. 277:19322-19330(2002).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 45-349 (ISOFORM 1), IDENTIFICATION OF
ISOFORM 2, AND FUNCTION.
TISSUE=Lung;
PubMed=12000837; DOI=10.1093/nar/30.10.2172;
Godthelp B.C., Wiegant W.W., van Duijn-Goedhart A., Scharer O.D.,
van Buul P.P.W., Kanaar R., Zdzienicka M.Z.;
"Mammalian Rad51C contributes to DNA cross-link resistance, sister
chromatid cohesion and genomic stability.";
Nucleic Acids Res. 30:2172-2182(2002).
[3]
FUNCTION.
PubMed=17268176; DOI=10.1159/000097416;
Renglin Lindh A., Schultz N., Saleh-Gohari N., Helleday T.;
"RAD51C (RAD51L2) is involved in maintaining centrosome number in
mitosis.";
Cytogenet. Genome Res. 116:38-45(2007).
[4]
FUNCTION.
PubMed=20471405; DOI=10.1016/j.mrfmmm.2010.05.001;
Smeenk G., de Groot A.J., Romeijn R.J., van Buul P.P.,
Zdzienicka M.Z., Mullenders L.H., Pastink A., Godthelp B.C.;
"Rad51C is essential for embryonic development and haploinsufficiency
causes increased DNA damage sensitivity and genomic instability.";
Mutat. Res. 689:50-58(2010).
-!- FUNCTION: Essential for the homologous recombination (HR) pathway
of DNA repair. Involved in the homologous recombination repair
(HRR) pathway of double-stranded DNA breaks arising during DNA
replication or induced by DNA-damaging agents. Part of the RAD21
paralog protein complexes BCDX2 and CX3 which act at different
stages of the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage,
BCDX2 seems to act downstream of BRCA2 recruitment and upstream of
RAD51 recruitment; CX3 seems to act downstream of RAD51
recruitment; both complexes bind predominantly to the intersection
of the four duplex arms of the Holliday junction (HJ) and to
junction of replication forks. The BCDX2 complex was originally
reported to bind single-stranded DNA, single-stranded gaps in
duplex DNA and specifically to nicks in duplex DNA. The BCDX2
subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent
ATPase activity suggesting an involvement in early stages of the
HR pathway. Involved in RAD51 foci formation in response to DNA
damage suggesting an involvement in early stages of HR probably in
the invasion step. Has an early function in DNA repair in
facilitating phosphorylation of the checkpoint kinase CHEK2 and
thereby transduction of the damage signal, leading to cell cycle
arrest and HR activation. Participates in branch migration and HJ
resolution and thus is important for processing HR intermediates
late in the DNA repair process; the function may be linked to the
CX3 complex. Part of a PALB2-scaffolded HR complex containing
BRCA2 and which is thought to play a role in DNA repair by HR.
Protects RAD51 from ubiquitin-mediated degradation that is
enhanced following DNA damage. Plays a role in regulating
mitochondrial DNA copy number under conditions of oxidative stress
in the presence of RAD51 and XRCC3. Contributes to DNA cross-link
resistance, sister chromatid cohesion and genomic stability.
Involved in maintaining centrosome number in mitosis.
{ECO:0000269|PubMed:11912211, ECO:0000269|PubMed:12000837,
ECO:0000269|PubMed:17268176, ECO:0000269|PubMed:20471405}.
-!- SUBUNIT: Part of the Rad21 paralog protein complexes BCDX2 and
CX3; the complexes have a ring-like structure arranged into a flat
disc around a central channel. The BCDX2 complex consits of
RAD51B, RAD51C, RAD51D and XRCC2; the CX3 complex consists of
RAD51C and XRCC3. The BCDX2 subcomplex RAD51B:RAD51C interacts
with RAD51. Interacts with SWSAP1; involved in homologous
recombination repair. Interacts directly with PALB2 which may
serve as a scaffold for a HR complex containing PALB2, BRCA2,
RAD51C, RAD51 and XRCC3 (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm
{ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}.
Mitochondrion {ECO:0000250}. Note=DNA damage induces an increase
in nuclear levels. Accumulates in DNA damage induced nuclear foci
or RAD51C foci which is formed during the S or G2 phase of cell
cycle. Accumulation at DNA lesions requires the presence of
NBN/NBS1, ATM and RPA (By similarity). {ECO:0000250}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1;
IsoId=Q8R2J9-1; Sequence=Displayed;
Name=2;
IsoId=Q8R2J9-2; Sequence=VSP_040285;
-!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily.
{ECO:0000305}.
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EMBL; AJ413202; CAC88355.1; -; mRNA.
EMBL; AJ428572; CAD21699.1; -; mRNA.
RefSeq; NP_001231005.1; NM_001244076.1. [Q8R2J9-1]
RefSeq; XP_007642544.1; XM_007644354.2. [Q8R2J9-1]
RefSeq; XP_007642545.1; XM_007644355.2. [Q8R2J9-1]
RefSeq; XP_007642546.1; XM_007644356.2. [Q8R2J9-1]
ProteinModelPortal; Q8R2J9; -.
SMR; Q8R2J9; -.
PRIDE; Q8R2J9; -.
Ensembl; ENSCGRT00000023494; ENSCGRP00000023175; ENSCGRG00000016784. [Q8R2J9-1]
Ensembl; ENSCGRT00001010694; ENSCGRP00001006776; ENSCGRG00001009215. [Q8R2J9-1]
GeneID; 100689078; -.
KEGG; cge:100689078; -.
CTD; 5889; -.
HOVERGEN; HBG055764; -.
KO; K10870; -.
OrthoDB; 1345899at2759; -.
GO; GO:0030054; C:cell junction; IEA:Ensembl.
GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0048476; C:Holliday junction resolvase complex; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0033063; C:Rad51B-Rad51C-Rad51D-XRCC2 complex; ISS:UniProtKB.
GO; GO:0033065; C:Rad51C-XRCC3 complex; ISS:UniProtKB.
GO; GO:0005657; C:replication fork; ISS:UniProtKB.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008821; F:crossover junction endodeoxyribonuclease activity; IEA:Ensembl.
GO; GO:0008094; F:DNA-dependent ATPase activity; IEA:InterPro.
GO; GO:0000400; F:four-way junction DNA binding; IEA:Ensembl.
GO; GO:0006310; P:DNA recombination; ISS:UniProtKB.
GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
GO; GO:0007066; P:female meiosis sister chromatid cohesion; IEA:Ensembl.
GO; GO:0007141; P:male meiosis I; IEA:Ensembl.
GO; GO:0010971; P:positive regulation of G2/M transition of mitotic cell cycle; ISS:UniProtKB.
GO; GO:0007131; P:reciprocal meiotic recombination; IEA:Ensembl.
GO; GO:0007062; P:sister chromatid cohesion; IMP:UniProtKB.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0000722; P:telomere maintenance via recombination; IEA:Ensembl.
CDD; cd01123; Rad51_DMC1_radA; 1.
InterPro; IPR013632; DNA_recomb/repair_Rad51_C.
InterPro; IPR016467; DNA_recomb/repair_RecA-like.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR033925; Rad51_DMC1_RadA.
InterPro; IPR020588; RecA_ATP-bd.
Pfam; PF08423; Rad51; 1.
PIRSF; PIRSF005856; Rad51; 1.
SUPFAM; SSF52540; SSF52540; 1.
PROSITE; PS50162; RECA_2; 1.
2: Evidence at transcript level;
Alternative splicing; ATP-binding; Cytoplasm; DNA damage;
DNA recombination; DNA repair; DNA-binding; Mitochondrion;
Nucleotide-binding; Nucleus; Phosphoprotein.
CHAIN 1 366 DNA repair protein RAD51 homolog 3.
/FTId=PRO_0000402422.
NP_BIND 116 123 ATP. {ECO:0000255}.
REGION 1 117 Required for Holliday junction resolution
activity.
REGION 70 127 Interaction with RAD51B, RAD51D and
XRCC3.
MOTIF 356 360 Nuclear localization signal.
{ECO:0000255}.
MOD_RES 11 11 Phosphoserine.
{ECO:0000250|UniProtKB:O43502}.
VAR_SEQ 227 270 Missing (in isoform 2). {ECO:0000305}.
/FTId=VSP_040285.
SEQUENCE 366 AA; 40381 MW; 150835C21F8619FA CRC64;
MQRELVSFPL SPTVRVKLVA AGFQTAEDVL GVKPSELSKE VGISKEEALE TLQIVRRESL
TDKPRCAGAS VAGKKYTALE LLEQEHTQGF IITFCSALDN ILGGGIPLMK TTEVCGVPGV
GKTQLCMQLA VDVQIPECFG GVAGEAVFID TEGSFMVDRV VTLANACIQH LHLIAGTHKD
EEHQKALEGF TLENILSHIY YFRCHDYTEL LAQVYLLPDF LSNHSKVQLV IIDGIALPFR
HDLDDLSLRT RLLNGLAQQM ISLANNHRLA VILTNQMTTK IDKNQALLVP ALGESWGHAA
TIRLIFHWEQ KQRFATLYKS PSQKESTIPF QITPQGFRDA AVTASSSQTE GSSNLRKRSR
EPEEGC


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Pathways :
WP1234: Homologous recombination
WP1258: Homologous recombination
WP1296: Homologous recombination
WP1362: Homologous recombination
WP1530: miRNA regulation of DNA Damage Response
WP1576: Homologous recombination
WP1579: DNA damage response
WP1625: Base excision repair
WP1672: Mismatch repair
WP1678: Nucleotide excision repair
WP186: Homologous recombination
WP2087: miRNA regulation of DNA Damage Response
WP2256: Integrated Pancreatic Cancer Pathway
WP2377: Integrated Pancreatic Cancer Pathway
WP377: Genes of Meiotic Recombination
WP707: DNA damage response
WP917: Homologous recombination
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)

Related Genes :
[RAD51D RAD51L3] DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3) (TRAD)
[Rad51d R51h3 Rad51l3] DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3)
[Rad51c Rad51l2] DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)
[RAD51C RAD51L2] DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)
[RAD51C RAD51L2] DNA repair protein RAD51 homolog 3 (R51H3) (RAD51 homolog C) (RAD51-like protein 2)
[RAD51B RAD51L1 REC2] DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (Rad51B) (RAD51-like protein 1)
[Rad51 Rad51a Reca] DNA repair protein RAD51 homolog 1 (RAD51 homolog A)
[RAD51 RAD51A RECA] DNA repair protein RAD51 homolog 1 (HsRAD51) (hRAD51) (RAD51 homolog A)
[RAD51] DNA repair protein RAD51 homolog 1 (cRad51)
[RAD51] DNA repair protein RAD51 homolog 1
[RAD51 RAD51A] DNA repair protein RAD51 homolog 1
[rad-51 rad51 CELE_Y43C5A.6 Y43C5A.6] DNA repair protein RAD51 homolog
[RAD51AP1 PIR51] RAD51-associated protein 1 (RAD51-interacting protein)
[RAD51] DNA repair protein RAD51 homolog 1
[Rad51b Rad51l1 Rec2] DNA repair protein RAD51 homolog 2 (R51H2) (RAD51 homolog B) (RAD51-like protein 1)
[rad-51 CELE_Y43C5A.6 Y43C5A.6] DNA repair protein RAD51 homolog
[RAD51D RAD51L3] DNA repair protein RAD51 homolog 4 (R51H3) (RAD51 homolog D) (RAD51-like protein 3)
[RAD51A] DNA repair protein RAD51 homolog A (Rad51-like protein A) (RAD51A) (ZmRAD51a)
[RAD51C At2g45280 F4L23.21] DNA repair protein RAD51 homolog 3 (DNA repair-recombination protein RAD51C) (AtRAD51C)
[Rad51ap1] RAD51-associated protein 1 (RAB22) (RAD51-interacting protein)
[RAD51B At2g28560 T17D12.12] DNA repair protein RAD51 homolog 2 (AtRAD51B)
[RAD51D At1g07745 F24B9.14] DNA repair protein RAD51 homolog 4 (AtRAD51D)
[rad-51 Cbr-rad-51 CBG04405 CBG_04405] DNA repair protein RAD51 homolog
[mei-3 NCU02741] DNA repair protein RAD51 homolog
[Tb11.01.0360] DNA repair protein RAD51 homolog
[WBGene00091627 PRIPAC_38323] DNA repair protein RAD51 homolog
[RDH54 TID1 YBR073W YBR0715] DNA repair and recombination protein RDH54 (RAD homolog 54) (Recombination factor TID1) (Two hybrid interaction with DMC1 protein 1) [Includes: DNA topoisomerase (EC 5.99.1.-); Putative helicase (EC 3.6.4.12)]
[Brca2 Fancd1] Breast cancer type 2 susceptibility protein homolog (Fanconi anemia group D1 protein homolog)
[rad51c DDB_G0284507] DNA repair protein RAD51 homolog 3
[rad51d DDB_G0285287] Probable DNA repair protein RAD51 homolog 4

Bibliography :
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