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Dickkopf WNT signaling pathway inhibitor 1

 F7G5A5_ORNAN            Unreviewed;       260 AA.
F7G5A5;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
09-JAN-2013, sequence version 2.
31-JUL-2019, entry version 45.
SubName: Full=Dickkopf WNT signaling pathway inhibitor 1 {ECO:0000313|Ensembl:ENSOANP00000011195};
Name=DKK1 {ECO:0000313|Ensembl:ENSOANP00000011195};
Ornithorhynchus anatinus (Duckbill platypus).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000011195, ECO:0000313|Proteomes:UP000002279};
[1] {ECO:0000313|Ensembl:ENSOANP00000011195, ECO:0000313|Proteomes:UP000002279}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011195,
ECO:0000313|Proteomes:UP000002279};
PubMed=18464734; DOI=10.1038/nature06936;
Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
Wilson R.K.;
"Genome analysis of the platypus reveals unique signatures of
evolution.";
Nature 453:175-183(2008).
[2] {ECO:0000313|Ensembl:ENSOANP00000011195}
IDENTIFICATION.
STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011195};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
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EMBL; AAPN01031208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_007658977.1; XM_007660787.1.
STRING; 9258.ENSOANP00000011195; -.
Ensembl; ENSOANT00000011197; ENSOANP00000011195; ENSOANG00000007031.
GeneID; 100073484; -.
KEGG; oaa:100073484; -.
CTD; 22943; -.
eggNOG; KOG1218; Eukaryota.
eggNOG; ENOG410XQWV; LUCA.
GeneTree; ENSGT00940000161319; -.
InParanoid; F7G5A5; -.
KO; K02165; -.
OrthoDB; 1139517at2759; -.
TreeFam; TF330916; -.
Proteomes; UP000002279; Chromosome 3.
Bgee; ENSOANG00000007031; Expressed in 4 organ(s), highest expression level in female gonad.
GO; GO:0005615; C:extracellular space; IBA:GO_Central.
GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
GO; GO:0039706; F:co-receptor binding; IBA:GO_Central.
GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IEA:Ensembl.
GO; GO:0048019; F:receptor antagonist activity; IBA:GO_Central.
GO; GO:0000904; P:cell morphogenesis involved in differentiation; IEA:Ensembl.
GO; GO:0030326; P:embryonic limb morphogenesis; IEA:Ensembl.
GO; GO:0001706; P:endoderm formation; IEA:Ensembl.
GO; GO:0060325; P:face morphogenesis; IEA:Ensembl.
GO; GO:0030900; P:forebrain development; IEA:Ensembl.
GO; GO:0001942; P:hair follicle development; IEA:Ensembl.
GO; GO:0001707; P:mesoderm formation; IEA:Ensembl.
GO; GO:0090647; P:modulation of age-related behavioral decline; IEA:Ensembl.
GO; GO:0061743; P:motor learning; IEA:Ensembl.
GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
GO; GO:1901296; P:negative regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment; IEA:Ensembl.
GO; GO:0042662; P:negative regulation of mesodermal cell fate specification; IEA:Ensembl.
GO; GO:0010977; P:negative regulation of neuron projection development; IEA:Ensembl.
GO; GO:0030279; P:negative regulation of ossification; IEA:Ensembl.
GO; GO:0060394; P:negative regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0033137; P:negative regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:1905607; P:negative regulation of presynapse assembly; IEA:Ensembl.
GO; GO:0032091; P:negative regulation of protein binding; IEA:Ensembl.
GO; GO:0048642; P:negative regulation of skeletal muscle tissue development; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:1904723; P:negative regulation of Wnt-Frizzled-LRP5/6 complex assembly; IEA:Ensembl.
GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
GO; GO:0090082; P:positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0043507; P:positive regulation of JUN kinase activity; IEA:Ensembl.
GO; GO:1904958; P:positive regulation of midbrain dopaminergic neuron differentiation; IEA:Ensembl.
GO; GO:1902949; P:positive regulation of tau-protein kinase activity; IEA:Ensembl.
GO; GO:0042663; P:regulation of endodermal cell fate specification; IEA:Ensembl.
GO; GO:0002090; P:regulation of receptor internalization; IEA:Ensembl.
GO; GO:0051966; P:regulation of synaptic transmission, glutamatergic; IEA:Ensembl.
GO; GO:0032526; P:response to retinoic acid; IEA:Ensembl.
GO; GO:0090244; P:Wnt signaling pathway involved in somitogenesis; IEA:Ensembl.
InterPro; IPR006796; Dickkopf_N.
InterPro; IPR039863; DKK-like.
PANTHER; PTHR12113; PTHR12113; 1.
Pfam; PF04706; Dickkopf_N; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000002279};
Reference proteome {ECO:0000313|Proteomes:UP000002279};
Signal {ECO:0000256|SAM:SignalP}.
SIGNAL 1 22 {ECO:0000256|SAM:SignalP}.
CHAIN 23 260 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5003359465.
DOMAIN 82 132 Dickkopf_N. {ECO:0000259|Pfam:PF04706}.
REGION 52 83 Disordered. {ECO:0000256|SAM:MobiDB-
lite}.
SEQUENCE 260 AA; 27863 MW; 61C62F29E00172D6 CRC64;
MPTRLLLALA LALGHLSPLT VATSPSGSAS GPPVHSNAIK IAPPVAPGAP VAPLAPLPGG
TAASPAPPKH QPLDARKPGS PRCAEDGHCP PDEFCAGPGG SHLCQACRKR RKRCLRHAMC
CPGNVCSNGI CVPSDHDHFQ QPEIDETVIE SFTRDHSTLD VHSKRTTLSS KMYHSKGQES
SVCLRSSDCA AGLCCARHFW SKICKPVLKE GQVCTKHRRK GSHGLEIFQR CYCGEGLSCR
IQKDHHLASN SSRLHTCQRQ


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