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Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (MmMRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)

 MRE11_MOUSE             Reviewed;         706 AA.
Q61216; Q62430;
26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
01-NOV-1996, sequence version 1.
23-FEB-2022, entry version 178.
RecName: Full=Double-strand break repair protein MRE11;
EC=3.1.-.- {ECO:0000250|UniProtKB:P49959};
AltName: Full=Double-strand break repair protein MRE11A;
Short=MmMRE11A;
AltName: Full=Meiotic recombination 11 homolog 1;
Short=MRE11 homolog 1;
AltName: Full=Meiotic recombination 11 homolog A;
Short=MRE11 homolog A;
Name=Mre11; Synonyms=Mre11a;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
STRAIN=CD-1; TISSUE=Testis;
Oshiumi H., Shinohara A., Ogawa H.;
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
STRAIN=C57BL/6J; TISSUE=Retina;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[3]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2, AND IDENTIFICATION BY MASS
SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Liver;
PubMed=17242355; DOI=10.1073/pnas.0609836104;
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
"Large-scale phosphorylation analysis of mouse liver.";
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
[4]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-640; SER-648 AND
SER-686, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
Spleen, and Testis;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and expression.";
Cell 143:1174-1189(2010).
[5]
INTERACTION WITH CYREN.
PubMed=30017584; DOI=10.1016/j.molcel.2018.06.018;
Hung P.J., Johnson B., Chen B.R., Byrum A.K., Bredemeyer A.L.,
Yewdell W.T., Johnson T.E., Lee B.J., Deivasigamani S., Hindi I.,
Amatya P., Gross M.L., Paull T.T., Pisapia D.J., Chaudhuri J.,
Petrini J.J.H., Mosammaparast N., Amarasinghe G.K., Zha S., Tyler J.K.,
Sleckman B.P.;
"MRI is a DNA damage response adaptor during classical non-homologous end
joining.";
Mol. Cell 71:332-342(2018).
-!- FUNCTION: Component of the MRN complex, which plays a central role in
double-strand break (DSB) repair, DNA recombination, maintenance of
telomere integrity and meiosis. The complex possesses single-strand
endonuclease activity and double-strand-specific 3'-5' exonuclease
activity, which are provided by MRE11. RAD50 may be required to bind
DNA ends and hold them in close proximity. This could facilitate
searches for short or long regions of sequence homology in the
recombining DNA templates, and may also stimulate the activity of DNA
ligases and/or restrict the nuclease activity of MRE11 to prevent
nucleolytic degradation past a given point. The complex may also be
required for DNA damage signaling via activation of the ATM kinase. In
telomeres the MRN complex may modulate t-loop formation.
{ECO:0000250|UniProtKB:P49959}.
-!- COFACTOR:
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
-!- ACTIVITY REGULATION: Interaction with SAMHD1 stimulates the double-
strand-specific 3'-5' exonuclease activity.
{ECO:0000250|UniProtKB:P49959}.
-!- SUBUNIT: Component of the MRN complex composed of two heterodimers
RAD50/MRE11 associated with a single NBN (By similarity). As part of
the MRN complex, interacts with MCM9; the interaction recruits the
complex to DNA repair sites (By similarity). Component of the BASC
complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50,
MRE11 and NBN (By similarity). Found in a complex with TERF2 (By
similarity). Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo (By
similarity). Interacts with ATF2 (By similarity). Interacts with EXD2
(By similarity). Interacts with MRNIP (By similarity). Interacts with
SAMHD1; leading to stimulate 3'-5' exonuclease activity (By
similarity). Interacts (when ubiquitinated) with UBQLN4 (via its UBA
domain) (By similarity). Interacts with CYREN (via XLF motif)
(PubMed:30017584). {ECO:0000250|UniProtKB:P49959,
ECO:0000269|PubMed:30017584}.
-!- INTERACTION:
Q61216; Q9R207: Nbn; NbExp=2; IntAct=EBI-2014813, EBI-2014862;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P49959}.
Chromosome, telomere {ECO:0000250|UniProtKB:P49959}. Chromosome
{ECO:0000250|UniProtKB:P49959}. Note=Localizes to discrete nuclear foci
after treatment with genotoxic agents. {ECO:0000250|UniProtKB:P49959}.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=2;
Name=1; Synonyms=A;
IsoId=Q61216-1; Sequence=Displayed;
Name=2; Synonyms=B;
IsoId=Q61216-2; Sequence=VSP_003263;
-!- PTM: Ubiquitinated following DNA damage. Ubiquitination triggers
interaction with UBQLN4, leading to MRE11 removal from chromatin and
degradation by the proteasome. {ECO:0000250|UniProtKB:P49959}.
-!- SIMILARITY: Belongs to the MRE11/RAD32 family. {ECO:0000305}.
---------------------------------------------------------------------------
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EMBL; U58987; AAB04955.1; -; mRNA.
EMBL; U60318; AAB03664.1; -; mRNA.
EMBL; BC065144; AAH65144.1; -; mRNA.
CCDS; CCDS22827.1; -. [Q61216-1]
CCDS; CCDS80958.1; -. [Q61216-2]
RefSeq; NP_001297657.1; NM_001310728.1. [Q61216-2]
RefSeq; NP_061206.1; NM_018736.3. [Q61216-1]
RefSeq; XP_006510111.1; XM_006510048.2. [Q61216-1]
RefSeq; XP_006510112.1; XM_006510049.2. [Q61216-2]
SMR; Q61216; -.
BioGRID; 201486; 11.
ComplexPortal; CPX-4703; MRN complex.
DIP; DIP-46803N; -.
IntAct; Q61216; 4.
STRING; 10090.ENSMUSP00000034405; -.
iPTMnet; Q61216; -.
PhosphoSitePlus; Q61216; -.
EPD; Q61216; -.
jPOST; Q61216; -.
MaxQB; Q61216; -.
PaxDb; Q61216; -.
PRIDE; Q61216; -.
ProteomicsDB; 290057; -. [Q61216-1]
ProteomicsDB; 290058; -. [Q61216-2]
Antibodypedia; 706; 706 antibodies from 41 providers.
DNASU; 17535; -.
Ensembl; ENSMUST00000034405; ENSMUSP00000034405; ENSMUSG00000031928. [Q61216-1]
Ensembl; ENSMUST00000115632; ENSMUSP00000111295; ENSMUSG00000031928. [Q61216-2]
GeneID; 17535; -.
KEGG; mmu:17535; -.
UCSC; uc009ofc.1; mouse. [Q61216-1]
UCSC; uc009ofd.1; mouse. [Q61216-2]
CTD; 17535; -.
MGI; MGI:1100512; Mre11a.
VEuPathDB; HostDB:ENSMUSG00000031928; -.
eggNOG; KOG2310; Eukaryota.
GeneTree; ENSGT00390000017288; -.
HOGENOM; CLU_009535_3_1_1; -.
InParanoid; Q61216; -.
OMA; NRPSRDC; -.
PhylomeDB; Q61216; -.
TreeFam; TF101105; -.
Reactome; R-MMU-1834949; Cytosolic sensors of pathogen-associated DNA.
Reactome; R-MMU-2559586; DNA Damage/Telomere Stress Induced Senescence.
Reactome; R-MMU-5685938; HDR through Single Strand Annealing (SSA).
Reactome; R-MMU-5685939; HDR through MMEJ (alt-NHEJ).
Reactome; R-MMU-5685942; HDR through Homologous Recombination (HRR).
Reactome; R-MMU-5693548; Sensing of DNA Double Strand Breaks.
Reactome; R-MMU-5693565; Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
Reactome; R-MMU-5693568; Resolution of D-loop Structures through Holliday Junction Intermediates.
Reactome; R-MMU-5693571; Nonhomologous End-Joining (NHEJ).
Reactome; R-MMU-5693579; Homologous DNA Pairing and Strand Exchange.
Reactome; R-MMU-5693607; Processing of DNA double-strand break ends.
Reactome; R-MMU-5693616; Presynaptic phase of homologous DNA pairing and strand exchange.
Reactome; R-MMU-6804756; Regulation of TP53 Activity through Phosphorylation.
Reactome; R-MMU-69473; G2/M DNA damage checkpoint.
BioGRID-ORCS; 17535; 30 hits in 99 CRISPR screens.
ChiTaRS; Mre11a; mouse.
PRO; PR:Q61216; -.
Proteomes; UP000000589; Chromosome 9.
RNAct; Q61216; protein.
Bgee; ENSMUSG00000031928; Expressed in ear and 288 other tissues.
ExpressionAtlas; Q61216; baseline and differential.
Genevisible; Q61216; MM.
GO; GO:0070533; C:BRCA1-C complex; IEA:Ensembl.
GO; GO:0000785; C:chromatin; ISO:MGI.
GO; GO:0000781; C:chromosome, telomeric region; ISO:MGI.
GO; GO:0000794; C:condensed nuclear chromosome; ISO:MGI.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0030870; C:Mre11 complex; ISO:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IDA:MGI.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
GO; GO:0016605; C:PML body; IDA:BHF-UCL.
GO; GO:0005657; C:replication fork; ISS:UniProtKB.
GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
GO; GO:0008408; F:3'-5' exonuclease activity; ISO:MGI.
GO; GO:0008296; F:3'-5'-exodeoxyribonuclease activity; IEA:InterPro.
GO; GO:0008409; F:5'-3' exonuclease activity; ISS:UniProtKB.
GO; GO:0003677; F:DNA binding; IEA:Ensembl.
GO; GO:0003678; F:DNA helicase activity; IEA:Ensembl.
GO; GO:0004520; F:endodeoxyribonuclease activity; ISO:MGI.
GO; GO:0042802; F:identical protein binding; ISO:MGI.
GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
GO; GO:0008022; F:protein C-terminus binding; ISO:MGI.
GO; GO:0000014; F:single-stranded DNA endodeoxyribonuclease activity; ISO:MGI.
GO; GO:0008283; P:cell population proliferation; IMP:MGI.
GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
GO; GO:0051276; P:chromosome organization; IMP:MGI.
GO; GO:0032508; P:DNA duplex unwinding; ISO:MGI.
GO; GO:0110025; P:DNA strand resection involved in replication fork processing; ISS:UniProtKB.
GO; GO:0006302; P:double-strand break repair; IMP:MGI.
GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; ISO:MGI.
GO; GO:0007129; P:homologous chromosome pairing at meiosis; IMP:MGI.
GO; GO:0042138; P:meiotic DNA double-strand break formation; IBA:GO_Central.
GO; GO:0097552; P:mitochondrial double-strand break repair via homologous recombination; IBA:GO_Central.
GO; GO:0007095; P:mitotic G2 DNA damage checkpoint signaling; IMP:MGI.
GO; GO:0031573; P:mitotic intra-S DNA damage checkpoint signaling; IMP:MGI.
GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI.
GO; GO:0046597; P:negative regulation of viral entry into host cell; ISO:MGI.
GO; GO:0033674; P:positive regulation of kinase activity; ISO:MGI.
GO; GO:0031954; P:positive regulation of protein autophosphorylation; ISO:MGI.
GO; GO:0032206; P:positive regulation of telomere maintenance; ISO:MGI.
GO; GO:0007062; P:sister chromatid cohesion; ISO:MGI.
GO; GO:0000723; P:telomere maintenance; IBA:GO_Central.
GO; GO:0031860; P:telomeric 3' overhang formation; ISO:MGI.
CDD; cd00840; MPP_Mre11_N; 1.
Gene3D; 3.30.110.110; -; 1.
Gene3D; 3.60.21.10; -; 1.
InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
InterPro; IPR029052; Metallo-depent_PP-like.
InterPro; IPR003701; Mre11.
InterPro; IPR038487; Mre11_capping_dom.
InterPro; IPR007281; Mre11_DNA-bd.
InterPro; IPR041796; Mre11_N.
Pfam; PF00149; Metallophos; 1.
Pfam; PF04152; Mre11_DNA_bind; 1.
PIRSF; PIRSF000882; DSB_repair_MRE11; 1.
SMART; SM01347; Mre11_DNA_bind; 1.
SUPFAM; SSF56300; SSF56300; 1.
TIGRFAMs; TIGR00583; mre11; 1.
1: Evidence at protein level;
Acetylation; Alternative splicing; Chromosome; DNA damage; DNA repair;
Endonuclease; Exonuclease; Hydrolase; Isopeptide bond; Manganese; Meiosis;
Nuclease; Nucleus; Phosphoprotein; Reference proteome; Telomere;
Ubl conjugation.
INIT_MET 1
/note="Removed"
/evidence="ECO:0000250|UniProtKB:P49959"
CHAIN 2..706
/note="Double-strand break repair protein MRE11"
/id="PRO_0000138674"
REGION 505..706
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 505..528
/note="Basic and acidic residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 529..563
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 584..638
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 658..681
/note="Polar residues"
/evidence="ECO:0000256|SAM:MobiDB-lite"
ACT_SITE 129
/note="Proton donor"
/evidence="ECO:0000250"
MOD_RES 2
/note="N-acetylserine"
/evidence="ECO:0000250|UniProtKB:P49959"
MOD_RES 2
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:17242355,
ECO:0007744|PubMed:21183079"
MOD_RES 275
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P49959"
MOD_RES 618
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P49959"
MOD_RES 640
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21183079"
MOD_RES 648
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21183079"
MOD_RES 676
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P49959"
MOD_RES 686
/note="Phosphoserine"
/evidence="ECO:0007744|PubMed:21183079"
MOD_RES 699
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P49959"
CROSSLNK 255
/note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
G-Cter in SUMO2)"
/evidence="ECO:0000250|UniProtKB:P49959"
VAR_SEQ 340..366
/note="Missing (in isoform 2)"
/evidence="ECO:0000303|Ref.1"
/id="VSP_003263"
SEQUENCE 706 AA; 80223 MW; 0F12F51902FC179A CRC64;
MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN EVDFILLGGD
LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEVISDQSVN FGFSKFPWVN YQDGNLNISI
PVFSIHGNHD DPTGADALCA LDVLSCAGFV NHFGRSMSVE KVDISPVLLQ KGSTKLALYG
LGSIPDERLY RMFVNKKVTM LRPKEDENSW FNLFVIHQNR SKHGNTNFIP EQFLDDFIDL
VIWGHEHECK IGPIKNEQQL FYVSQPGSSV VTSLSPGEAV KKHVGLLRIK GRKMNMQKLP
LRTVRRFFIE DVVLANHPNL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE RLGNPQQPGK
PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR HREQKGKTGE EINFGMLITK
PASEGATLRV EDLVKQYFQT AEKNVQLSLL TERGMGEAVQ EFVDKEEKDA IEELVKYQLE
KTQRFLKERH IDALEDKIDE EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSETSTSA
FSAEDLSFDT SEQTANDSDD SLSAVPSRGR GRGRGRRGAR GQSSAPRGGS QRGRDTGLEI
TTRGRSSKAT SSTSRNMSII DAFRSTRQQP SRNVAPKNYS ETIEVDDSDE DDIFPTNSRA
DQRWSGTTSS KRMSQSQTAK GVDFESDEDD DDDPFMSSSC PRRNRR


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WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1576: Homologous recombination
WP1201: Non-homologous end joining
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Related Genes :
[Mre11 Mre11a] Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (MmMRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
[MRE11 HNGS1 MRE11A] Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
[Mre11 Mre11a] Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog 1) (MRE11 homolog 1) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
[MRE11 MRE11A QtrA-18006] Double-strand break repair protein MRE11 (EC 3.1.-.-) (Double-strand break repair protein MRE11A) (Meiotic recombination 11 homolog A) (MRE11 homolog A)
[MRE11] Double-strand break repair protein MRE11 (EC 3.1.-.-)
[rad21a rad21 SCC1] Double-strand-break repair protein rad21 homolog A (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product)]
[RAD21 HR21 KIAA0078 NXP1 SCC1] Double-strand-break repair protein rad21 homolog (hHR21) (Nuclear matrix protein 1) (NXP-1) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product) (65-kDa carboxy-terminal product)]
[Rad21 Hr21 Scc1] Double-strand-break repair protein rad21 homolog (mHR21) (Pokeweed agglutinin-binding protein 29) (PW29) (SCC1 homolog) [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product)]
[Atm] Serine-protein kinase ATM (EC 2.7.11.1) (Ataxia telangiectasia mutated homolog) (A-T mutated homolog)
[mre11 VNG_0512G] DNA double-strand break repair protein Mre11 (EC 3.1.-.-)
[RAD21 SCC1] Double-strand-break repair protein rad21 homolog [Cleaved into: 64-kDa C-terminal product (64-kDa carboxy-terminal product)]
[SAE2 COM1 YGL175C G1639] DNA endonuclease SAE2 (EC 3.1.-.-) (Completion of meiotic recombination protein 1) (Sporulation in the absence of SPO11 protein 2)
[MLH1 COCA2] DNA mismatch repair protein Mlh1 (MutL protein homolog 1)
[brc-1 C36A4.8] Breast cancer type 1 susceptibility protein homolog (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BRCA1)
[Mlh1] DNA mismatch repair protein Mlh1 (MutL protein homolog 1)
[mei-41 CG4252] Serine/threonine-protein kinase ATR (EC 2.7.11.1) (Ataxia telangiectasia and Rad3-related protein homolog) (ATR homolog) (dATR) (Meiotic protein 41)
[DMC1 LIM15 At3g22880 F5N5.6] Meiotic recombination protein DMC1 homolog (AtDMC1)
[Brca1] Breast cancer type 1 susceptibility protein homolog (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BRCA1)
[RDH54 TID1 YBR073W YBR0715] DNA repair and recombination protein RDH54 (RAD homolog 54) (Recombination factor TID1) (Two hybrid interaction with DMC1 protein 1) [Includes: DNA topoisomerase (EC 5.99.1.-); Putative helicase (EC 3.6.4.12)]
[Rec8 Mei8 Rec8L1] Meiotic recombination protein REC8 homolog (Cohesin Rec8p)
[DCLRE1C ARTEMIS ASCID SCIDA SNM1C] Protein artemis (EC 3.1.-.-) (DNA cross-link repair 1C protein) (Protein A-SCID) (SNM1 homolog C) (hSNM1C) (SNM1-like protein)
[DMC1 DMC1H LIM15] Meiotic recombination protein DMC1/LIM15 homolog
[RAD54L RAD54A] DNA repair and recombination protein RAD54-like (EC 3.6.4.12) (RAD54 homolog) (hHR54) (hRAD54)
[MSH2] DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2)
[Rad21l1 Gm14160 Rad21l] Double-strand-break repair protein rad21-like protein 1
[SPO11-1 At3g13170 MJG19.19] Meiotic recombination protein SPO11-1 (AtSPO11-1) (EC 5.6.2.2)
[Brca1] Breast cancer type 1 susceptibility protein homolog (EC 2.3.2.27) (RING-type E3 ubiquitin transferase BRCA1)
[Rad51 Rad51a Reca] DNA repair protein RAD51 homolog 1 (RAD51 homolog A)
[herA STK_21060] DNA double-strand break repair helicase HerA (EC 3.6.4.12) (StoHerA)
[Msh2] DNA mismatch repair protein Msh2 (MutS protein homolog 2)

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