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Doublesex- and mab-3-related transcription factor 1Y (Y-linked doublesex- and mab-3-related transcription factor) (Y-specific doublesex- and mab-3-related transcription factor) (DMY)

 DMT1Y_ORYLA             Reviewed;         267 AA.
Q8JIR6; Q8AY26;
18-APR-2012, integrated into UniProtKB/Swiss-Prot.
01-OCT-2002, sequence version 1.
16-JAN-2019, entry version 65.
RecName: Full=Doublesex- and mab-3-related transcription factor 1Y;
AltName: Full=Y-linked doublesex- and mab-3-related transcription factor;
AltName: Full=Y-specific doublesex- and mab-3-related transcription factor;
Short=DMY;
Name=dmrt1y; Synonyms=dmy;
Oryzias latipes (Japanese rice fish) (Japanese killifish).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae;
Oryziinae; Oryzias.
NCBI_TaxID=8090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND
DISRUPTION PHENOTYPE.
STRAIN=HNI;
PubMed=12037570; DOI=10.1038/nature751;
Matsuda M., Nagahama Y., Shinomiya A., Sato T., Matsuda C.,
Kobayashi T., Morrey C.E., Shibata N., Asakawa S., Shimizu N.,
Hori H., Hamaguchi S., Sakaizumi M.;
"DMY is a Y-specific DM-domain gene required for male development in
the medaka fish.";
Nature 417:559-563(2002).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
STRAIN=HNI;
PubMed=12193652; DOI=10.1073/pnas.182314699;
Nanda I., Kondo M., Hornung U., Asakawa S., Winkler C., Shimizu A.,
Shan Z., Haaf T., Shimizu N., Shima A., Schmid M., Schartl M.;
"A duplicated copy of DMRT1 in the sex-determining region of the Y
chromosome of the medaka, Oryzias latipes.";
Proc. Natl. Acad. Sci. U.S.A. 99:11778-11783(2002).
-!- FUNCTION: Transcription factor that plays a key role in male sex
determination and differentiation by controlling testis
development and germ cell proliferation. Acts both as a
transcription repressor and activator.
{ECO:0000269|PubMed:12037570}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00070}.
-!- TISSUE SPECIFICITY: Testis-specific. Localizes to Sertoli cells.
{ECO:0000269|PubMed:12193652}.
-!- DEVELOPMENTAL STAGE: Expression starts at the neurula stage and
persists during embryogenesis and larval stages until adulthood.
At hatching and 5 days after hatching, present in XY embryos, but
not in XX embryos. Detected only in the somatic cells surrounding
germ cells in XY embryos. {ECO:0000269|PubMed:12037570}.
-!- DISRUPTION PHENOTYPE: Feminization of XY offsprings.
{ECO:0000269|PubMed:12037570}.
-!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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EMBL; AB071534; BAB92012.1; -; mRNA.
EMBL; AY129240; AAN05398.1; -; mRNA.
EMBL; AY129241; AAN05399.1; -; Genomic_DNA.
RefSeq; NP_001098150.1; NM_001104680.1.
UniGene; Ola.109; -.
UniGene; Ola.17762; -.
UniGene; Ola.18143; -.
UniGene; Ola.9867; -.
ProteinModelPortal; Q8JIR6; -.
SMR; Q8JIR6; -.
PRIDE; Q8JIR6; -.
GeneID; 101161472; -.
CTD; 101161472; -.
HOGENOM; HOG000059585; -.
HOVERGEN; HBG055845; -.
InParanoid; Q8JIR6; -.
OrthoDB; 1209937at2759; -.
Proteomes; UP000001038; Unplaced.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0030238; P:male sex determination; IMP:UniProtKB.
GO; GO:0046661; P:male sex differentiation; IMP:UniProtKB.
Gene3D; 4.10.1040.10; -; 1.
InterPro; IPR001275; DM_DNA-bd.
InterPro; IPR036407; DM_DNA-bd_sf.
InterPro; IPR026607; DMRT/dsx/mab-3.
InterPro; IPR022114; DMRT1-like.
PANTHER; PTHR12322; PTHR12322; 1.
Pfam; PF00751; DM; 1.
Pfam; PF12374; Dmrt1; 1.
SMART; SM00301; DM; 1.
SUPFAM; SSF82927; SSF82927; 1.
PROSITE; PS40000; DM_1; 1.
PROSITE; PS50809; DM_2; 1.
2: Evidence at transcript level;
Activator; Complete proteome; Developmental protein; Differentiation;
DNA-binding; Metal-binding; Nucleus; Reference proteome; Repressor;
Sexual differentiation; Transcription; Transcription regulation; Zinc.
CHAIN 1 267 Doublesex- and mab-3-related
transcription factor 1Y.
/FTId=PRO_0000416901.
DNA_BIND 16 63 DM. {ECO:0000255|PROSITE-
ProRule:PRU00070}.
COMPBIAS 119 128 Poly-Ser.
CONFLICT 23 23 S -> G (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 41 50 HCLKCKLIVD -> QCFKCEQIMV (in Ref. 2;
AAN05398). {ECO:0000305}.
CONFLICT 61 61 L -> D (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 105 110 PAPPPN -> LAIPPS (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 116 116 V -> A (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 135 135 S -> G (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 141 142 QP -> CL (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 164 164 Y -> H (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 198 198 A -> T (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 219 219 G -> D (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 251 251 K -> R (in Ref. 2; AAN05398).
{ECO:0000305}.
CONFLICT 262 267 SSRPTP -> VFPADSMSSETK (in Ref. 2;
AAN05398). {ECO:0000305}.
SEQUENCE 267 AA; 29299 MW; CAB91367AEF48FB7 CRC64;
MSKEKQCRPG PRVPKCSRCR NHSLKTPLKG HKRFCRWKDC HCLKCKLIVD RQRVMAAQVA
LRRQQAQEEE LGICSPEASS GPEVVVKNEA GADCLFSVEG RSGTPAPPPN PNPLSVAGSY
SASSSSPSAA ARVYSEEASD QPLETSYYNF YQPSRYSSYY GNLYNYQQYQ QMPPSDGRLS
GHSMPSQYRM HSFYPGTAYL PQGLGSPVPP YFSLEDNDGA AASFFPSSLT STHDSTLTYR
SISSLVNDGV KAEFESGGQP PSSRPTP


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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1066: Eukaryotic Transcription Initiation
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1182: Eukaryotic Transcription Initiation
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1238: Eukaryotic Transcription Initiation
WP1497: Hedgehog-related genes
WP1541: Energy Metabolism
WP1559: TFs Regulate miRNAs related to cardiac hypertrophy
WP177: Eukaryotic Transcription Initiation
WP1770: One carbon metabolism and related pathways
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1822: Generic Transcription Pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1906: RNA Polymerase II Transcription
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1930: Transcription
WP1937: Transport of vitamins, nucleosides, and related molecules
WP1983: Splicing factor NOVA regulated synpatic proteins
WP201: Ptf1a related regulatory pathway
WP2080: TFs Regulate miRNAs related to cardiac hypertrophy
WP2148: Brain derived neurotrophic factor
WP2199: Seed Development

Related Genes :
[Dmrt2] Doublesex- and mab-3-related transcription factor 2 (Doublesex-like 2 protein) (Terra)
[DMRT1 DMT1] Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1)
[DMRT3] Doublesex and mab-3 related transcription factor 3, truncated (Duplex and mab-3 related transcription factor 3 allele A)
[DMRT3] Doublesex and mab-3 related transcription factor 3
[DMRT2 DSXL2] Doublesex- and mab-3-related transcription factor 2 (Doublesex-like 2 protein) (DSXL-2)
[Uba1y Sby Ube1ay Ube1y Ube1y1] Ubiquitin-like modifier-activating enzyme 1 Y (EC 6.2.1.45) (Ubiquitin-activating enzyme E1) (Ubiquitin-activating enzyme E1 Y)
[nnrE nnrD PP1Y_AT30034] Multifunctional fusion protein [Includes: ADP-dependent (S)-NAD(P)H-hydrate dehydratase (EC 4.2.1.136) (ADP-dependent NAD(P)HX dehydratase); NAD(P)H-hydrate epimerase (EC 5.1.99.6) (NAD(P)HX epimerase)]
[RUNX2 AML3 CBFA1 OSF2 PEBP2A] Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)
[Nfe2l1 Nrf1] Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) [Cleaved into: Transcription factor NRF1]
[NFE2L1 HBZ17 NRF1 TCF11] Endoplasmic reticulum membrane sensor NFE2L1 (Locus control region-factor 1) (LCR-F1) (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) (Protein NRF1, p120 form) (Transcription factor 11) (TCF-11) [Cleaved into: Transcription factor NRF1 (Protein NRF1, p110 form)]
[gag-pol] Gag-Pol polyprotein (Pr160Gag-Pol) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer peptide 1 (SP1) (p2); Nucleocapsid protein p7 (NC); Transframe peptide (TF); p6-pol (p6*); Protease (EC 3.4.23.16) (PR) (Retropepsin); Reverse transcriptase/ribonuclease H (EC 2.7.7.49) (EC 2.7.7.7) (EC 3.1.26.13) (Exoribonuclease H) (EC 3.1.13.2) (p66 RT); p51 RT; p15; Integrase (IN) (EC 2.7.7.-) (EC 3.1.-.-)]
[DMRT1] Doublesex- and mab-3-related transcription factor 1
[Foxc1 Fkh1 Fkhl7 Freac3 Mf1] Forkhead box protein C1 (Forkhead-related protein FKHL7) (Forkhead-related transcription factor 3) (FREAC-3) (Mesoderm/mesenchyme forkhead 1) (MF-1) (Transcription factor FKH-1)
[Elf3 Ert Esx Jen] ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)
[RUNX1 AML1 CBFA2] Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)
[mtm-1 Y110A7A.5] Myotubularin-related protein 1 (Phosphatidylinositol-3,5-bisphosphate 3-phosphatase) (EC 3.1.3.95) (Phosphatidylinositol-3-phosphate phosphatase) (EC 3.1.3.64)
[RUNX3 AML2 CBFA3 PEBP2A3] Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)
[pyrG PP1Y_AT27040] CTP synthase (EC 6.3.4.2) (Cytidine 5'-triphosphate synthase) (Cytidine triphosphate synthetase) (CTP synthetase) (CTPS) (UTP--ammonia ligase)
[Runx3 Aml2 Cbfa3 Pebp2a3] Runt-related transcription factor 3 (Acute myeloid leukemia 2 protein) (Core-binding factor subunit alpha-3) (CBF-alpha-3) (Oncogene AML-2) (Polyomavirus enhancer-binding protein 2 alpha C subunit) (PEA2-alpha C) (PEBP2-alpha C) (SL3-3 enhancer factor 1 alpha C subunit) (SL3/AKV core-binding factor alpha C subunit)
[strd-1 Y52D3.1] STE20-related kinase adapter protein strd-1 (STRAD STE20-related adapter homolog)
[HEY1 BHLHB31 CHF2 HERP2 HESR1 HRT1] Hairy/enhancer-of-split related with YRPW motif protein 1 (Cardiovascular helix-loop-helix factor 2) (CHF-2) (Class B basic helix-loop-helix protein 31) (bHLHb31) (HES-related repressor protein 1) (Hairy and enhancer of split-related protein 1) (HESR-1) (Hairy-related transcription factor 1) (HRT-1) (hHRT1)
[Runx1 Aml1 Cbfa2 Pebp2ab] Runt-related transcription factor 1 (Acute myeloid leukemia 1 protein) (Core-binding factor subunit alpha-2) (CBF-alpha-2) (Oncogene AML-1) (Polyomavirus enhancer-binding protein 2 alpha B subunit) (PEA2-alpha B) (PEBP2-alpha B) (SL3-3 enhancer factor 1 alpha B subunit) (SL3/AKV core-binding factor alpha B subunit)
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[coaX PP1Y_AT27282] Type III pantothenate kinase (EC 2.7.1.33) (PanK-III) (Pantothenic acid kinase)
[crn-1 Y47G6A.8] Flap endonuclease 1 (FEN-1) (EC 3.1.-.-) (Cell death-related nuclease 1) (Flap structure-specific endonuclease 1)
[TCF3 BHLHB21 E2A ITF1] Transcription factor E2-alpha (Class B basic helix-loop-helix protein 21) (bHLHb21) (Immunoglobulin enhancer-binding factor E12/E47) (Immunoglobulin transcription factor 1) (Kappa-E2-binding factor) (Transcription factor 3) (TCF-3) (Transcription factor ITF-1)
[leuB PP1Y_AT20167] 3-isopropylmalate dehydrogenase (EC 1.1.1.85) (3-IPM-DH) (Beta-IPM dehydrogenase) (IMDH)
[NFE2L1 NRF1 RCJMB04_7g14] Endoplasmic reticulum membrane sensor NFE2L1 (Nuclear factor erythroid 2-related factor 1) (NF-E2-related factor 1) (NFE2-related factor 1) (Nuclear factor, erythroid derived 2, like 1) [Cleaved into: Transcription factor NRF1]
[Hey2 Chf1 Herp Herp1 Hesr2 Hrt2] Hairy/enhancer-of-split related with YRPW motif protein 2 (HES-related repressor protein 2) (Hairy and enhancer of split-related protein 2) (HESR-2) (Hairy-related transcription factor 2) (HRT-2) (mHRT2) (Protein gridlock homolog)
[SMARCA4 BAF190A BRG1 SNF2B SNF2L4] Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)

Bibliography :
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