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Doublesex- and mab-3-related transcription factor C2 (Doublesex- and mab-3-related transcription factor 7)

 DMRTD_MOUSE             Reviewed;         370 AA.
Q8CGW9; A6H6T0;
27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
01-MAR-2003, sequence version 1.
13-FEB-2019, entry version 103.
RecName: Full=Doublesex- and mab-3-related transcription factor C2;
AltName: Full=Doublesex- and mab-3-related transcription factor 7;
Name=Dmrtc2; Synonyms=Dmrt7;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J; TISSUE=Testis;
PubMed=12609607; DOI=10.1016/S1567-133X(02)00071-6;
Kim S., Kettlewell J.R., Anderson R.C., Bardwell V.J., Zarkower D.;
"Sexually dimorphic expression of multiple doublesex-related genes in
the embryonic mouse gonad.";
Gene Expr. Patterns 3:77-82(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain, and Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: May be involved in sexual development.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
ProRule:PRU00070}.
-!- TISSUE SPECIFICITY: Expressed in testis. Highly expressed in
ovary.
-!- DEVELOPMENTAL STAGE: Expressed in gonads from 11.5 dpc.
-!- SIMILARITY: Belongs to the DMRT family. {ECO:0000305}.
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EMBL; AF542046; AAN77233.1; -; mRNA.
EMBL; BC100434; AAI00435.1; -; mRNA.
EMBL; BC138203; AAI38204.1; -; mRNA.
EMBL; BC145988; AAI45989.1; -; mRNA.
CCDS; CCDS20965.1; -.
RefSeq; NP_082008.1; NM_027732.2.
RefSeq; XP_006540422.1; XM_006540359.3.
UniGene; Mm.66855; -.
ProteinModelPortal; Q8CGW9; -.
SMR; Q8CGW9; -.
BioGrid; 214575; 8.
STRING; 10090.ENSMUSP00000011493; -.
PhosphoSitePlus; Q8CGW9; -.
PaxDb; Q8CGW9; -.
PRIDE; Q8CGW9; -.
Ensembl; ENSMUST00000011493; ENSMUSP00000011493; ENSMUSG00000011349.
GeneID; 71241; -.
KEGG; mmu:71241; -.
UCSC; uc009fqp.2; mouse.
CTD; 63946; -.
MGI; MGI:1918491; Dmrtc2.
eggNOG; KOG3815; Eukaryota.
eggNOG; ENOG410XSK9; LUCA.
GeneTree; ENSGT00940000161904; -.
HOGENOM; HOG000231505; -.
HOVERGEN; HBG081447; -.
InParanoid; Q8CGW9; -.
KO; K19493; -.
OMA; LPHTCST; -.
OrthoDB; 897429at2759; -.
PhylomeDB; Q8CGW9; -.
TreeFam; TF340713; -.
PRO; PR:Q8CGW9; -.
Proteomes; UP000000589; Chromosome 7.
Bgee; ENSMUSG00000011349; Expressed in 17 organ(s), highest expression level in testis.
Genevisible; Q8CGW9; MM.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0001741; C:XY body; IDA:MGI.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0042803; F:protein homodimerization activity; IDA:MGI.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
GO; GO:0007141; P:male meiosis I; IMP:MGI.
GO; GO:1900111; P:positive regulation of histone H3-K9 dimethylation; IMP:MGI.
GO; GO:1900114; P:positive regulation of histone H3-K9 trimethylation; IMP:MGI.
GO; GO:0007548; P:sex differentiation; IEA:UniProtKB-KW.
GO; GO:0007290; P:spermatid nucleus elongation; IMP:MGI.
Gene3D; 4.10.1040.10; -; 1.
InterPro; IPR001275; DM_DNA-bd.
InterPro; IPR036407; DM_DNA-bd_sf.
InterPro; IPR031577; DMRT-C1/C2_C.
InterPro; IPR026607; DMRT/dsx/mab-3.
PANTHER; PTHR12322; PTHR12322; 1.
Pfam; PF00751; DM; 1.
Pfam; PF15791; DMRT-like; 1.
SMART; SM00301; DM; 1.
SUPFAM; SSF82927; SSF82927; 1.
PROSITE; PS40000; DM_1; 1.
PROSITE; PS50809; DM_2; 1.
2: Evidence at transcript level;
Complete proteome; Differentiation; DNA-binding; Metal-binding;
Nucleus; Reference proteome; Sexual differentiation; Transcription;
Transcription regulation; Zinc.
CHAIN 1 370 Doublesex- and mab-3-related
transcription factor C2.
/FTId=PRO_0000244107.
DNA_BIND 42 89 DM. {ECO:0000255|PROSITE-
ProRule:PRU00070}.
COMPBIAS 123 352 Pro-rich.
SEQUENCE 370 AA; 39095 MW; F4DFCB23C94C8A6C CRC64;
MDPSETAALH HCSADSSPAD EARVPQSTEL IPRRPVSRSP TCARCRNHGV TAHLKGHKRL
CLFQACECHK CVLILERRRV MAAQVALRRQ QEAQLKRHLA QGLMKGATPL KAPLRVKKGA
IRPGIPSGKE NIAPQPQSPH GAVPLVLTPP GKENYGPLLL SRPPEALPLP WTPVPPGPWG
PGHWLPPGLS MPPPVVCRLL CQEPAVPLHP FPGFDPGTSL RLPTHGTLPT CPGSRSVLTA
PLSGEPQGPP NLPHTCSTLI LQSCGTPDSL LLQPQAPGAS CLAWTSGPSE RQLQREAAEA
LVGLKDSSQA PRLTPSVPPN PAWISLLHPC GPPAPPGGRG FQPVGPPLRP SPGSSVSLHI
GRLGSISLLS


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1046: Signaling of Hepatocyte Growth Factor Receptor
WP1066: Eukaryotic Transcription Initiation
WP1162: Signaling of Hepatocyte Growth Factor Receptor
WP1182: Eukaryotic Transcription Initiation
WP1206: Signaling of Hepatocyte Growth Factor Receptor
WP1235: Signaling of Hepatocyte Growth Factor Receptor
WP1238: Eukaryotic Transcription Initiation
WP1497: Hedgehog-related genes
WP1541: Energy Metabolism
WP1559: TFs Regulate miRNAs related to cardiac hypertrophy
WP177: Eukaryotic Transcription Initiation
WP1770: One carbon metabolism and related pathways
WP1789: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
WP1822: Generic Transcription Pathway
WP1899: Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
WP1905: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
WP1906: RNA Polymerase II Transcription
WP193: Signaling of Hepatocyte Growth Factor Receptor
WP1930: Transcription
WP1937: Transport of vitamins, nucleosides, and related molecules
WP1983: Splicing factor NOVA regulated synpatic proteins
WP201: Ptf1a related regulatory pathway
WP2080: TFs Regulate miRNAs related to cardiac hypertrophy
WP2148: Brain derived neurotrophic factor
WP2199: Seed Development

Related Genes :
[Dmrt2] Doublesex- and mab-3-related transcription factor 2 (Doublesex-like 2 protein) (Terra)
[DMRT1 DMT1] Doublesex- and mab-3-related transcription factor 1 (DM domain expressed in testis protein 1)
[DMRT3] Doublesex and mab-3 related transcription factor 3, truncated (Duplex and mab-3 related transcription factor 3 allele A)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[FOXC2 FKHL14 MFH1] Forkhead box protein C2 (Forkhead-related protein FKHL14) (Mesenchyme fork head protein 1) (MFH-1 protein) (Transcription factor FKH-14)
[DMRT3] Doublesex and mab-3 related transcription factor 3
[Pre C,C C core E PC pre-C pre-C/C PreC preC PreC/C preC/C precore-core HBVgp4] Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[DMRT2 DSXL2] Doublesex- and mab-3-related transcription factor 2 (Doublesex-like 2 protein) (DSXL-2)
[PIK3C2A] Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.154) (Phosphoinositide 3-kinase-C2-alpha)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[PIK3C2B] Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PI3K-C2-beta) (PtdIns-3-kinase C2 subunit beta) (EC 2.7.1.154) (C2-PI3K) (Phosphoinositide 3-kinase-C2-beta)
[tat] Protein Tat (Transactivating regulatory protein)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[C2] Complement C2 (EC 3.4.21.43) (C3/C5 convertase) [Cleaved into: Complement C2b fragment; Complement C2a fragment]
[AGO2 EIF2C2] Protein argonaute-2 (Argonaute2) (hAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (PAZ Piwi domain protein) (PPD) (Protein slicer)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[SUVR5 CZS SDG6 SET6 At2g23740/At2g23730/At2g23750 F27L4.8/F27L4.9/F27L4.7] Histone-lysine N-methyltransferase SUVR5 (EC 2.1.1.43) (C2H2 zinc finger-SET histone methyltransferase) (Protein C2H2 SET) (Protein SET DOMAIN GROUP 6) (Suppressor of variegation 3-9-related protein 5) (Su(var)3-9-related protein 5)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[Ago2 Eif2c2 Kiaa4215] Protein argonaute-2 (Argonaute2) (mAgo2) (EC 3.1.26.n2) (Argonaute RISC catalytic component 2) (Eukaryotic translation initiation factor 2C 2) (eIF-2C 2) (eIF2C 2) (Piwi/argonaute family protein meIF2C2) (Protein slicer)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[Pik3c2a Cpk] Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (PI3K-C2-alpha) (PtdIns-3-kinase C2 subunit alpha) (EC 2.7.1.154) (Cpk-m) (Phosphoinositide 3-kinase-C2-alpha) (p170)
[env] Envelope glycoprotein gp160 (Env polyprotein) [Cleaved into: Surface protein gp120 (SU) (Glycoprotein 120) (gp120); Transmembrane protein gp41 (TM) (Glycoprotein 41) (gp41)]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]
[nef] Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

Bibliography :