GENTAUR Belgium BVBA BE0473327336 Voortstraat 49, 1910 Kampenhout BELGIUM Tel 0032 16 58 90 45
GENTAUR U.S.A Genprice Inc,Logistics 547 Yurok Circle, SanJose, CA 95123
Tel (408) 780-0908, Fax (408) 780-0908, [email protected]

Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, Gentaur another in time delivery

Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2 7 12 2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)

 MP2K2_RAT               Reviewed;         400 AA.
P36506; A0JN15;
01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
01-JUN-1994, sequence version 1.
17-JUN-2020, entry version 168.
RecName: Full=Dual specificity mitogen-activated protein kinase kinase 2;
Short=MAP kinase kinase 2;
Short=MAPKK 2;
EC=2.7.12.2 {ECO:0000250|UniProtKB:P36507};
AltName: Full=ERK activator kinase 2;
AltName: Full=MAPK/ERK kinase 2;
Short=MEK 2;
Name=Map2k2; Synonyms=Mek2, Mkk2, Prkmk2;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8462694; DOI=10.1016/0014-5793(93)80596-m;
Otsu M., Terada Y., Okayama H.;
"Isolation of two members of the rat MAP kinase kinase gene family.";
FEBS Lett. 320:246-250(1993).
[2]
ERRATUM OF PUBMED:8462694.
PubMed=8397117;
Otsu M., Terada Y., Okayama H.;
FEBS Lett. 331:307-307(1993).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8393135; DOI=10.1128/mcb.13.8.4539;
Wu J., Harrison J.K., Dent P., Lynch K.R., Weber M.J., Sturgill T.W.;
"Identification and characterization of a new mammalian mitogen-activated
protein kinase kinase, MKK2.";
Mol. Cell. Biol. 13:4539-4548(1993).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Liver;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14 different rat
organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine and
a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases.
Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF
in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases
the inhibitory intramolecular interaction between KSR1 or KSR2 protein
kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF
dimerization and BRAF activation (By similarity).
{ECO:0000250|UniProtKB:P36507, ECO:0000250|UniProtKB:Q63932}.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
[protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.12.2;
Evidence={ECO:0000250|UniProtKB:P36507};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
EC=2.7.12.2; Evidence={ECO:0000250|UniProtKB:P36507};
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.12.2;
Evidence={ECO:0000250|UniProtKB:P36507};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000305};
-!- SUBUNIT: Interacts with MORG1 (By similarity). Interacts with SGK1 (By
similarity). Interacts with KSR1. Interacts with KSR1 and BRAF; the
interaction with KSR1 mediates KSR1-BRAF dimerization. Interacts with
GLS (By similarity). {ECO:0000250|UniProtKB:P36507,
ECO:0000250|UniProtKB:Q63932}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P36507}.
Membrane {ECO:0000250|UniProtKB:P36507}; Peripheral membrane protein
{ECO:0000250|UniProtKB:P36507}. Note=Membrane localization is probably
regulated by its interaction with KSR1. {ECO:0000250|UniProtKB:P36507}.
-!- TISSUE SPECIFICITY: Expressed abundantly in the adult brain and muscle.
-!- PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for activity
catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated
by MAP2K1/MEK1 (By similarity). {ECO:0000250}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
protein kinase family. MAP kinase kinase subfamily. {ECO:0000305}.
---------------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
---------------------------------------------------------------------------
EMBL; D14592; BAA03442.1; -; mRNA.
EMBL; L14936; AAA41620.1; -; mRNA.
EMBL; BC126084; AAI26085.1; -; mRNA.
PIR; A48081; A48081.
RefSeq; NP_579817.1; NM_133283.1.
SMR; P36506; -.
BioGRID; 248693; 7.
IntAct; P36506; 1.
STRING; 10116.ENSRNOP00000027272; -.
ChEMBL; CHEMBL3430876; -.
iPTMnet; P36506; -.
PhosphoSitePlus; P36506; -.
jPOST; P36506; -.
PaxDb; P36506; -.
PRIDE; P36506; -.
Ensembl; ENSRNOT00000027272; ENSRNOP00000027272; ENSRNOG00000020005.
GeneID; 58960; -.
KEGG; rno:58960; -.
UCSC; RGD:61888; rat.
CTD; 5605; -.
RGD; 61888; Map2k2.
eggNOG; KOG0581; Eukaryota.
eggNOG; ENOG410XQ5A; LUCA.
GeneTree; ENSGT00940000153487; -.
HOGENOM; CLU_000288_63_23_1; -.
InParanoid; P36506; -.
KO; K04369; -.
OMA; CHDMYER; -.
OrthoDB; 688282at2759; -.
PhylomeDB; P36506; -.
BRENDA; 2.7.12.2; 5301.
Reactome; R-RNO-112411; MAPK1 (ERK2) activation.
Reactome; R-RNO-170968; Frs2-mediated activation.
Reactome; R-RNO-445144; Signal transduction by L1.
Reactome; R-RNO-5673000; RAF activation.
Reactome; R-RNO-5674135; MAP2K and MAPK activation.
Reactome; R-RNO-5674499; Negative feedback regulation of MAPK pathway.
PRO; PR:P36506; -.
Proteomes; UP000002494; Chromosome 7.
Bgee; ENSRNOG00000020005; Expressed in skeletal muscle tissue and 9 other tissues.
Genevisible; P36506; RN.
GO; GO:0005938; C:cell cortex; IDA:RGD.
GO; GO:0005911; C:cell-cell junction; ISO:RGD.
GO; GO:0005737; C:cytoplasm; ISO:RGD.
GO; GO:0009898; C:cytoplasmic side of plasma membrane; ISO:RGD.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0005769; C:early endosome; TAS:UniProtKB.
GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
GO; GO:0005925; C:focal adhesion; TAS:UniProtKB.
GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
GO; GO:0005770; C:late endosome; TAS:UniProtKB.
GO; GO:0005874; C:microtubule; ISO:RGD.
GO; GO:0005739; C:mitochondrion; TAS:UniProtKB.
GO; GO:0005634; C:nucleus; TAS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
GO; GO:0005524; F:ATP binding; IDA:RGD.
GO; GO:0004708; F:MAP kinase kinase activity; IDA:RGD.
GO; GO:0005078; F:MAP-kinase scaffold activity; ISO:RGD.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0060090; F:molecular adaptor activity; ISO:RGD.
GO; GO:0030165; F:PDZ domain binding; ISO:RGD.
GO; GO:0043539; F:protein serine/threonine kinase activator activity; ISO:RGD.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0004712; F:protein serine/threonine/tyrosine kinase activity; TAS:UniProtKB.
GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
GO; GO:0097110; F:scaffold protein binding; ISO:RGD.
GO; GO:0000187; P:activation of MAPK activity; IBA:GO_Central.
GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
GO; GO:0060502; P:epithelial cell proliferation involved in lung morphogenesis; ISO:RGD.
GO; GO:0070371; P:ERK1 and ERK2 cascade; ISO:RGD.
GO; GO:0060324; P:face development; ISO:RGD.
GO; GO:0007507; P:heart development; ISO:RGD.
GO; GO:0060425; P:lung morphogenesis; ISO:RGD.
GO; GO:0010629; P:negative regulation of gene expression; IGI:BHF-UCL.
GO; GO:0036289; P:peptidyl-serine autophosphorylation; ISO:RGD.
GO; GO:0050772; P:positive regulation of axonogenesis; ISO:RGD.
GO; GO:2000147; P:positive regulation of cell motility; ISO:RGD.
GO; GO:1903800; P:positive regulation of production of miRNAs involved in gene silencing by miRNA; ISO:RGD.
GO; GO:0071902; P:positive regulation of protein serine/threonine kinase activity; ISO:RGD.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
GO; GO:0006468; P:protein phosphorylation; IDA:RGD.
GO; GO:0048679; P:regulation of axon regeneration; ISO:RGD.
GO; GO:2000641; P:regulation of early endosome to late endosome transport; TAS:UniProtKB.
GO; GO:0090170; P:regulation of Golgi inheritance; TAS:UniProtKB.
GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
GO; GO:0032872; P:regulation of stress-activated MAPK cascade; TAS:UniProtKB.
GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IBA:GO_Central.
GO; GO:0048538; P:thymus development; ISO:RGD.
GO; GO:0030878; P:thyroid gland development; ISO:RGD.
GO; GO:0060440; P:trachea formation; ISO:RGD.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
1: Evidence at protein level;
Acetylation; ATP-binding; Cytoplasm; Kinase; Magnesium; Membrane;
Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
CHAIN 1..400
/note="Dual specificity mitogen-activated protein kinase
kinase 2"
/id="PRO_0000086374"
DOMAIN 72..369
/note="Protein kinase"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
NP_BIND 78..86
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
COMPBIAS 266..315
/note="Pro-rich"
ACT_SITE 194
/note="Proton acceptor"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159,
ECO:0000255|PROSITE-ProRule:PRU10027"
BINDING 101
/note="ATP"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SITE 10..11
/note="Cleavage; by anthrax lethal factor"
/evidence="ECO:0000250"
MOD_RES 1
/note="N-acetylmethionine"
/evidence="ECO:0000250|UniProtKB:P36507"
MOD_RES 23
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P36507"
MOD_RES 222
/note="Phosphoserine; by RAF"
/evidence="ECO:0000250|UniProtKB:P36507"
MOD_RES 226
/note="Phosphoserine; by RAF"
/evidence="ECO:0000250|UniProtKB:P36507"
MOD_RES 293
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P36507"
MOD_RES 295
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:P36507"
MOD_RES 306
/note="Phosphoserine"
/evidence="ECO:0000250|UniProtKB:Q02750"
MOD_RES 394
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P36507"
MOD_RES 396
/note="Phosphothreonine"
/evidence="ECO:0000250|UniProtKB:P36507"
SEQUENCE 400 AA; 44282 MW; B4E6AB15DEAA82A4 CRC64;
MLARRKPVLP ALTINPTIAE GPSPTSEGAS EAHLVDLQKK LEELDLDEQQ RKRLEAFLTQ
KAKVGELKDD DFERISELGA GNGGVVTKAR HRPSGLIMAR KLIHLEIKPA VRNQIIRELQ
VLHECNSPYI VGFYGAFYSD GEISICMEHM DGGSLDQVLK EAKRIPEDIL GKVSIAVLRG
LAYLREKHQI MHRDVKPSNI LVNSRGEIKL CDFGVSGQLI DSMANSFVGT RSYMSPERLQ
GTHYSVQSDI WSMGLSLVEL AIGRYPIPPP DAKELEASFG RPVVDGADGE PHSVSPRPRP
PGRPISGHGM DSRPAMAIFE LLDYIVNEPP PKLPSGVFSS DFQEFVNKCL IKNPAERADL
KLLTNHAFIK RSEGEDVDFA GWLCRTLRLK QPSTPTRTAV


Related products :

Catalog number Product name Quantity
EIAAB25239 C-JUN N-terminal kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 4,JNK kinase 1,JNK-activating kinase 1,JNKK 1,Jnkk1,MAP kinase kinase 4,Map2k4,MAPK_ERK kinase 4,MAPKK 4,MEK 4
EIAAB25244 c-Jun N-terminal kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 7,JNK kinase 2,JNK-activating kinase 2,JNKK 2,MAP kinase kinase 7,Map2k7,MAPK_ERK kinase 7,MAPKK 7,MEK 7,Mkk7,
EIAAB25245 c-Jun N-terminal kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 7,JNK kinase 2,JNK-activating kinase 2,JNKK 2,MAP kinase kinase 7,Map2k7,MAPK_ERK kinase 7,MAPKK 7,MEK 7,Rat,R
18-662-20090 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
18-662-20092 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
15-288-21068 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 mg
18-662-20091 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.1 ml
15-288-21068 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 Polyclonal 0.05 mg
10-782-55048 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.02 mg
10-782-55047 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.05 mg
10-782-55047 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.02 mg
10-782-55048 Dual specificity mitogen-activated protein kinase kinase 1 - EC 2.7.12.2; MAP kinase kinase 1; MAPKK 1; ERK activator kinase 1; MAPK_ERK kinase 1; MEK1 N_A 0.05 mg
EIAAB25230 Dual specificity mitogen-activated protein kinase kinase 1,ERK activator kinase 1,MAP kinase kinase 1,Map2k1,MAPK_ERK kinase 1,MAPKK 1,MEK 1,Mek1,Mouse,Mus musculus,Prkmk1
EIAAB25228 Dual specificity mitogen-activated protein kinase kinase 1,ERK activator kinase 1,MAP kinase kinase 1,Map2k1,MAPK_ERK kinase 1,MAPKK 1,MEK 1,Mek1,Prkmk1,Rat,Rattus norvegicus
EIAAB25234 Dual specificity mitogen-activated protein kinase kinase 2,ERK activator kinase 2,MAP kinase kinase 2,Map2k2,MAPK_ERK kinase 2,MAPKK 2,MEK 2,Mek2,Mkk2,Prkmk2,Rat,Rattus norvegicus
EIAAB25236 Dual specificity mitogen-activated protein kinase kinase 2,ERK activator kinase 2,MAP kinase kinase 2,Map2k2,MAPK_ERK kinase 2,MAPKK 2,MEK 2,Mek2,Mkk2,Mouse,Mus musculus,Prkmk2
EIAAB25229 Dual specificity mitogen-activated protein kinase kinase 1,ERK activator kinase 1,MAP kinase kinase 1,MAP2K1,MAPK_ERK kinase 1,MAPKK 1,MEK 1,MEK1,Oryctolagus cuniculus,PRKMK1,Rabbit
EIAAB25231 Dual specificity mitogen-activated protein kinase kinase 1,ERK activator kinase 1,Homo sapiens,Human,MAP kinase kinase 1,MAP2K1,MAPK_ERK kinase 1,MAPKK 1,MEK 1,MEK1,MKK1,PRKMK1
EIAAB25235 Dual specificity mitogen-activated protein kinase kinase 2,ERK activator kinase 2,Homo sapiens,Human,MAP kinase kinase 2,MAP2K2,MAPK_ERK kinase 2,MAPKK 2,MEK 2,MEK2,MKK2,PRKMK2
EIAAB25240 c-Jun N-terminal kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 4,Homo sapiens,Human,JNK-activating kinase 1,JNKK,JNKK1,MAP kinase kinase 4,MAP2K4,MAPK_ERK kinase 4,MAPKK 4,M
EIAAB25232 Chicken,Dual specificity mitogen-activated protein kinase kinase 2,ERK activator kinase 2,Gallus gallus,MAP kinase kinase 2,MAP2K2,MAPK_ERK kinase 2,MAPKK 2,MEK2,MEK2,MKK2,PRKMK2
EIAAB25233 Canis familiaris,Canis lupus familiaris,Dog,Dual specificity mitogen-activated protein kinase kinase 2,ERK activator kinase 2,MAP kinase kinase 2,MAP2K2,MAPK_ERK kinase 2,MAPKK 2,MEK 2,MEK2
E1721b ELISA kit Bos taurus,Bovine,Dual specificity mitogen-activated protein kinase kinase 6,MAP kinase kinase 6,MAP2K6,MAPK_ERK kinase 6,MAPKK 6,MEK 6 96T
E1721b ELISA Bos taurus,Bovine,Dual specificity mitogen-activated protein kinase kinase 6,MAP kinase kinase 6,MAP2K6,MAPK_ERK kinase 6,MAPKK 6,MEK 6 96T
U1721b CLIA Bos taurus,Bovine,Dual specificity mitogen-activated protein kinase kinase 6,MAP kinase kinase 6,MAP2K6,MAPK_ERK kinase 6,MAPKK 6,MEK 6 96T
Pathways :
WP1493: Carbon assimilation C4 pathway
WP1619: Amino sugar and nucleotide sugar metabolism
WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
WP1701: Starch and sucrose metabolism
WP2340: Thiamine (vitamin B1) biosynthesis and salvage
WP1653: Galactose metabolism
WP253: Glycolysis
WP32: Translation Factors
WP1681: Pantothenate and CoA biosynthesis
WP1946: Cori Cycle
WP1703: Streptomycin biosynthesis
WP1844: MAP kinase cascade
WP1567: Glycolysis and Gluconeogenesis
WP2292: Chemokine signaling pathway
WP1678: Nucleotide excision repair
WP232: G Protein Signaling Pathways
WP799: NLR proteins
WP1009: MAPK Cascade
WP1892: Protein folding
WP382: MAPK signaling pathway
WP1337: MAPK signaling pathway
WP1939: Unfolded Protein Response
WP402: ERK1 - ERK2 MAPK cascade
WP1363: p38 MAPK Signaling Pathway
WP1689: Porphyrin and chlorophyll metabolism

Related Genes :
[MAP2K2 MEK2 MKK2 PRKMK2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[Map2k2 Mek2 Mkk2 Prkmk2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Map2k1 Mek1 Prkmk1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Map2k1 Mek1 Prkmk1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Map2k2 Mek2 Mkk2 Prkmk2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Map2k5 Mek5 Mkk5 Prkmk5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[mekA MEK1 DDB_G0269152] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (DdMEK1) (MEK1) (MAPK/ERK kinase A) (MEKA)
[Map2k5 Mek5 Mkk5 Prkmk5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[MAP2K6 MEK6 MKK6 PRKMK6 SKK3] Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
[MAP2K5 MEK5 MKK5 PRKMK5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[MAP2K2 MEK2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[MAPK1 ERK2 PRKM1 PRKM2] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[MAPK3 ERK1 PRKM3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[map2k1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1)
[MAP3K5 ASK1 MAPKKK5 MEKK5] Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 1) (ASK-1) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Mapk1 Erk2 Mapk Prkm1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Map3k1 Mekk Mekk1] Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[MAPK1 ERK2 PRKM1] Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
[Mapk3 Erk1 Prkm3] Mitogen-activated protein kinase 3 (MAP kinase 3) (MAPK 3) (EC 2.7.11.24) (ERT2) (Extracellular signal-regulated kinase 1) (ERK-1) (Insulin-stimulated MAP2 kinase) (MAP kinase isoform p44) (p44-MAPK) (MNK1) (Microtubule-associated protein 2 kinase) (p44-ERK1)
[Map3k2 Mekk2] Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)
[MAPK12 ERK6 SAPK3] Mitogen-activated protein kinase 12 (MAP kinase 12) (MAPK 12) (EC 2.7.11.24) (Extracellular signal-regulated kinase 6) (ERK-6) (Mitogen-activated protein kinase p38 gamma) (MAP kinase p38 gamma) (Stress-activated protein kinase 3)
[MAP4K2 GCK RAB8IP] Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)
[Map3k1 Mekk Mekk1] Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)
[MAPK7 BMK1 ERK5 PRKM7] Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5)

Bibliography :