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Dual specificity mitogen-activated protein kinase kinase 4

 Q4KSH6_RAT              Unreviewed;       397 AA.
Q4KSH6;
02-AUG-2005, integrated into UniProtKB/TrEMBL.
02-AUG-2005, sequence version 1.
26-FEB-2020, entry version 118.
SubName: Full=Dual specificity mitogen-activated protein kinase kinase 4 {ECO:0000313|EMBL:AAX61181.1};
Name=Map2k4 {ECO:0000313|EMBL:AAX61181.1, ECO:0000313|RGD:1307040};
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
Murinae; Rattus.
NCBI_TaxID=10116 {ECO:0000313|EMBL:AAX61181.1};
[1] {ECO:0000313|EMBL:AAX61181.1}
NUCLEOTIDE SEQUENCE.
STRAIN=Sprague-Dawley {ECO:0000313|EMBL:AAX61181.1};
Itoh T., Horiuchi M., Itoh A.;
Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases.
-!- SIMILARITY: Belongs to the protein kinase superfamily.
{ECO:0000256|RuleBase:RU000304}.
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EMBL; AY880882; AAX61181.1; -; mRNA.
RefSeq; NP_001025194.1; NM_001030023.1.
SMR; Q4KSH6; -.
IntAct; Q4KSH6; 3.
MINT; Q4KSH6; -.
iPTMnet; Q4KSH6; -.
PhosphoSitePlus; Q4KSH6; -.
PRIDE; Q4KSH6; -.
GeneID; 287398; -.
KEGG; rno:287398; -.
UCSC; RGD:1307040; rat.
CTD; 6416; -.
RGD; 1307040; Map2k4.
eggNOG; KOG0984; Eukaryota.
eggNOG; ENOG410XT3F; LUCA.
KO; K04430; -.
OrthoDB; 688282at2759; -.
PhylomeDB; Q4KSH6; -.
Genevisible; Q4KSH6; RN.
GO; GO:0030424; C:axon; IDA:RGD.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0005829; C:cytosol; IDA:RGD.
GO; GO:0032839; C:dendrite cytoplasm; IDA:RGD.
GO; GO:0005634; C:nucleus; IDA:RGD.
GO; GO:0043204; C:perikaryon; IDA:RGD.
GO; GO:0005524; F:ATP binding; IDA:RGD.
GO; GO:0008545; F:JUN kinase kinase activity; IDA:RGD.
GO; GO:0004708; F:MAP kinase kinase activity; IDA:RGD.
GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:RGD.
GO; GO:0004674; F:protein serine/threonine kinase activity; IBA:GO_Central.
GO; GO:0007257; P:activation of JUN kinase activity; IDA:RGD.
GO; GO:0000187; P:activation of MAPK activity; IBA:GO_Central.
GO; GO:0032147; P:activation of protein kinase activity; IBA:GO_Central.
GO; GO:0061049; P:cell growth involved in cardiac muscle cell development; IMP:RGD.
GO; GO:0071260; P:cellular response to mechanical stimulus; ISO:RGD.
GO; GO:0072709; P:cellular response to sorbitol; IEP:RGD.
GO; GO:0007254; P:JNK cascade; IDA:RGD.
GO; GO:0000165; P:MAPK cascade; ISO:RGD.
GO; GO:2000672; P:negative regulation of motor neuron apoptotic process; ISO:RGD.
GO; GO:0043065; P:positive regulation of apoptotic process; IMP:RGD.
GO; GO:0045740; P:positive regulation of DNA replication; IMP:RGD.
GO; GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.
GO; GO:0051770; P:positive regulation of nitric-oxide synthase biosynthetic process; IMP:RGD.
GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:RGD.
GO; GO:0034393; P:positive regulation of smooth muscle cell apoptotic process; ISO:RGD.
GO; GO:0006468; P:protein phosphorylation; IDA:RGD.
GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
GO; GO:0009611; P:response to wounding; ISO:RGD.
GO; GO:0023014; P:signal transduction by protein phosphorylation; IBA:GO_Central.
GO; GO:0031098; P:stress-activated protein kinase signaling cascade; IBA:GO_Central.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
Pfam; PF00069; Pkinase; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
2: Evidence at transcript level;
ATP-binding {ECO:0000256|RuleBase:RU000304};
Kinase {ECO:0000256|RuleBase:RU000304};
Nucleotide-binding {ECO:0000256|RuleBase:RU000304};
Serine/threonine-protein kinase {ECO:0000256|RuleBase:RU000304};
Transferase {ECO:0000256|RuleBase:RU000304}.
DOMAIN 100..365
/note="Protein kinase"
/evidence="ECO:0000259|PROSITE:PS50011"
REGION 1..38
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 397 AA; 44114 MW; B99C6688184E5B3D CRC64;
MAAPSPSGGG GSGGGGGTPG PIGPPASGHP AVSSMQGKRK ALKLNFANPP VKSTARFTLN
PNTTGVQNPH IERLRTHSIE SSGKLKISPE QHWDFTAEDL KDLGEIGRGA YGSVNKMVHK
PSGQIMAVKR IRSTVDEKEQ KQLLMDLDVV MRSSDCPYIV QFYGALFREG DCWICMELMS
TSFDKFYKYV YSVLDDVIPE EILGKITLAT VKALNHLKEN LKIIHRDIKP SNILLDRSGN
IKLCDFGISG QLVDSIAKTR DAGCRPYMAP ERIDPSASRQ GYDVRSDVWS LGITLYELAT
GRFPYPKWNS VFDQLTQVVK GDPPQLSNSE EREFSPSFIN FVNLCLTKDE SKRPKYKELL
KHPFILMYEE RTVEVACYVC KILDQMPATP SSPMYVD


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WP2341: vitamin B1 (thiamin) biosynthesis and salvage pathway
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Related Genes :
[MAP2K4 JNKK1 MEK4 MKK4 PRKMK4 SEK1 SERK1 SKK1] Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)
[MAP2K7 JNKK2 MEK7 MKK7 PRKMK7 SKK4] Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (Stress-activated protein kinase kinase 4) (SAPK kinase 4) (SAPKK-4) (SAPKK4) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
[DUSP26 DUSP24 LDP4 MKP8 NATA1 SKRP3] Dual specificity protein phosphatase 26 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity phosphatase SKRP3) (Low-molecular-mass dual-specificity phosphatase 4) (DSP-4) (LDP-4) (Mitogen-activated protein kinase phosphatase 8) (MAP kinase phosphatase 8) (MKP-8) (Novel amplified gene in thyroid anaplastic cancer)
[DUSP4 MKP2 VH2] Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)
[Map2k4 Jnkk1 Mek4 Mkk4 Prkmk4 Sek1 Serk1 Skk1] Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (C-JUN N-terminal kinase kinase 1) (JNK kinase 1) (JNKK 1) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1)
[MAP2K6 MEK6 MKK6 PRKMK6 SKK3] Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
[mekA MEK1 DDB_G0269152] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (DdMEK1) (MEK1) (MAPK/ERK kinase A) (MEKA)
[MAP2K3 MEK3 MKK3 PRKMK3 SKK2] Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3) (Stress-activated protein kinase kinase 2) (SAPK kinase 2) (SAPKK-2) (SAPKK2)
[Dsor1 CG15793] Dual specificity mitogen-activated protein kinase kinase dSOR1 (Downstream of RAF) (MAPKK) (EC 2.7.12.2)
[map2k6 map2k3] Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (Mitogen-activated protein kinase kinase 3) (zMKK3)
[Map2k7 Mkk7] Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Map2k1 Mek1 Prkmk1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Dusp4 Mkp2] Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)
[Map2k6 Prkmk6 Sapkk3] Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (SAPKK3)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[DUSP9 MKP4] Dual specificity protein phosphatase 9 (EC 3.1.3.16) (EC 3.1.3.48) (Mitogen-activated protein kinase phosphatase 4) (MAP kinase phosphatase 4) (MKP-4)
[Map2k1 Mek1 Prkmk1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Map2k7] Dual specificity mitogen-activated protein kinase kinase 7 (MAP kinase kinase 7) (MAPKK 7) (EC 2.7.12.2) (JNK-activating kinase 2) (MAPK/ERK kinase 7) (MEK 7) (c-Jun N-terminal kinase kinase 2) (JNK kinase 2) (JNKK 2)
[sek-1 R03G5.2] Dual specificity mitogen-activated protein kinase kinase sek-1 (MAP kinase kinase sek-1) (EC 2.7.12.2)
[Map2k3 Mkk3 Prkmk3] Dual specificity mitogen-activated protein kinase kinase 3 (MAP kinase kinase 3) (MAPKK 3) (EC 2.7.12.2) (MAPK/ERK kinase 3) (MEK 3)
[MAP2K5 MEK5 MKK5 PRKMK5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[jkk-1 F35C8.3] Dual specificity mitogen-activated protein kinase kinase jkk-1 (MAP kinase kinase jkk-1) (EC 2.7.12.2) (JNK-1 activator kinase) (JNK kinase)
[MAP2K2 MEK2 MKK2 PRKMK2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[DUSP1 CL100 MKP1 PTPN10 VH1] Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)
[MAP2K1 MEK1 PRKMK1] Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
[Mkp3 CG14080] Dual specificity protein phosphatase Mpk3 (EC 3.1.3.16) (EC 3.1.3.48) (Drosophila MKP3) (DMKP3) (Mitogen-activated protein kinase phosphatase 3) (MAP kinase phosphatase 3) (MKP-3)
[Map2k2 Mek2 Mkk2 Prkmk2] Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)
[Map2k5 Mek5 Mkk5 Prkmk5] Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
[mek-1 K08A8.1] Dual specificity mitogen-activated protein kinase kinase mek-1 (EC 2.7.12.2)

Bibliography :
[31480854] GFAP alternative splicing regulates glioma cell-ECM interaction in a DUSP4-dependent manner.
[30897501] Downregulation of microsomal prostaglandin E synthase-1 (mPGES-1) expression in chondrocytes is regulated by MAP kinase phosphatase-1 (MKP-1).
[30850364] Serum Proteomic Signatures of Male Breast Cancer.
[30504726] Hyperglycaemia Stress-Induced Renal Injury is Caused by Extensive Mitochondrial Fragmentation, Attenuated MKP1 Signalling, and Activated JNK-CaMKII-Fis1 Biological Axis.
[30191967] DUSP1 recuses diabetic nephropathy via repressing JNK-Mff-mitochondrial fission pathways.
[30138595] DUSP1 alleviates cerebral ischaemia reperfusion injury via inactivating JNK-Mff pathways and repressing mitochondrial fission.
[30087184] DUSP6 mediates T cell receptor-engaged glycolysis and restrains T cell differentiation.
[29856104] The PPARĪ³ agonist rosiglitazone sensitizes the BH3 mimetic (-)-gossypol to induce apoptosis in cancer cells with high level of Bcl-2.
[29797567] TANK-binding kinase 1 and Janus kinase 2 play important roles in the regulation of mitogen-activated protein kinase phosphatase-1 expression after toll-like receptor 4 activation.
[29317435] Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance.