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E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)

 LYAM2_CANLF             Reviewed;         611 AA.
P33730;
01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
01-FEB-1994, sequence version 1.
23-MAY-2018, entry version 121.
RecName: Full=E-selectin;
AltName: Full=CD62 antigen-like family member E;
AltName: Full=Endothelial leukocyte adhesion molecule 1;
Short=ELAM-1;
AltName: Full=Leukocyte-endothelial cell adhesion molecule 2;
Short=LECAM2;
AltName: CD_antigen=CD62E;
Flags: Precursor;
Name=SELE;
Canis lupus familiaris (Dog) (Canis familiaris).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae;
Canis.
NCBI_TaxID=9615;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Jugular vein;
Manning A.M., Lane C.L., Auchampach J.A., Kukielka G.L.,
Rosenbloom C.L., Anderson D.C.;
"Molecular cloning of canine E-selectin and regulation of
expression.";
Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Cell-surface glycoprotein having a role in
immunoadhesion. Mediates in the adhesion of blood neutrophils in
cytokine-activated endothelium through interaction with
SELPLG/PSGL1. May have a role in capillary morphogenesis.
{ECO:0000250|UniProtKB:P16581}.
-!- SUBUNIT: Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl
Lewis X epitope. SELPLG sulfation appears not to be required for
this interaction. {ECO:0000250|UniProtKB:P16581}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:P16581}; Single-pass type I membrane
protein {ECO:0000250|UniProtKB:P16581}.
-!- SIMILARITY: Belongs to the selectin/LECAM family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; L23087; AAA30843.1; -; mRNA.
UniGene; Cfa.3868; -.
ProteinModelPortal; P33730; -.
SMR; P33730; -.
STRING; 9615.ENSCAFP00000022350; -.
PaxDb; P33730; -.
PRIDE; P33730; -.
eggNOG; KOG4297; Eukaryota.
eggNOG; ENOG410XPJ1; LUCA.
HOGENOM; HOG000236254; -.
HOVERGEN; HBG052375; -.
InParanoid; P33730; -.
Proteomes; UP000002254; Unplaced.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
CDD; cd00033; CCP; 6.
CDD; cd03592; CLECT_selectins_like; 1.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR018378; C-type_lectin_CS.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR033991; Selectin_CTLD.
InterPro; IPR002396; Selectin_superfamily.
InterPro; IPR035976; Sushi/SCR/CCP_sf.
InterPro; IPR000436; Sushi_SCR_CCP_dom.
Pfam; PF00008; EGF; 1.
Pfam; PF00059; Lectin_C; 1.
Pfam; PF00084; Sushi; 6.
PRINTS; PR00343; SELECTIN.
SMART; SM00032; CCP; 6.
SMART; SM00034; CLECT; 1.
SMART; SM00181; EGF; 3.
SMART; SM00179; EGF_CA; 1.
SUPFAM; SSF56436; SSF56436; 1.
SUPFAM; SSF57535; SSF57535; 6.
PROSITE; PS00615; C_TYPE_LECTIN_1; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PROSITE; PS00022; EGF_1; 1.
PROSITE; PS01186; EGF_2; 1.
PROSITE; PS50026; EGF_3; 1.
PROSITE; PS50923; SUSHI; 6.
2: Evidence at transcript level;
Calcium; Cell adhesion; Cell membrane; Complete proteome;
Disulfide bond; EGF-like domain; Glycoprotein; Lectin; Membrane;
Metal-binding; Reference proteome; Repeat; Signal; Sushi;
Transmembrane; Transmembrane helix.
SIGNAL 1 22 {ECO:0000250}.
CHAIN 23 611 E-selectin.
/FTId=PRO_0000017490.
TOPO_DOM 23 557 Extracellular. {ECO:0000255}.
TRANSMEM 558 579 Helical. {ECO:0000255}.
TOPO_DOM 580 611 Cytoplasmic. {ECO:0000255}.
DOMAIN 23 140 C-type lectin. {ECO:0000255|PROSITE-
ProRule:PRU00040}.
DOMAIN 141 176 EGF-like. {ECO:0000255|PROSITE-
ProRule:PRU00076}.
DOMAIN 179 240 Sushi 1. {ECO:0000255|PROSITE-
ProRule:PRU00302}.
DOMAIN 241 302 Sushi 2. {ECO:0000255|PROSITE-
ProRule:PRU00302}.
DOMAIN 316 365 Sushi 3. {ECO:0000255|PROSITE-
ProRule:PRU00302}.
DOMAIN 367 428 Sushi 4. {ECO:0000255|PROSITE-
ProRule:PRU00302}.
DOMAIN 430 491 Sushi 5. {ECO:0000255|PROSITE-
ProRule:PRU00302}.
DOMAIN 492 550 Sushi 6. {ECO:0000255|PROSITE-
ProRule:PRU00302}.
REGION 102 110 Carbohydrate binding.
{ECO:0000250|UniProtKB:P16581}.
REGION 114 119 Carbohydrate binding.
{ECO:0000250|UniProtKB:P16581}.
REGION 127 129 Carbohydrate binding.
{ECO:0000250|UniProtKB:P16581}.
METAL 102 102 Calcium. {ECO:0000250|UniProtKB:P16581}.
METAL 104 104 Calcium. {ECO:0000250|UniProtKB:P16581}.
METAL 110 110 Calcium. {ECO:0000250|UniProtKB:P16581}.
METAL 127 127 Calcium. {ECO:0000250|UniProtKB:P16581}.
METAL 128 128 Calcium. {ECO:0000250|UniProtKB:P16581}.
CARBOHYD 26 26 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 161 161 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 204 204 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 266 266 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 313 313 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 333 333 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 528 528 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 41 139 {ECO:0000250|UniProtKB:P16581}.
DISULFID 112 131 {ECO:0000250|UniProtKB:P16581}.
DISULFID 144 155 {ECO:0000250|UniProtKB:P16581}.
DISULFID 149 164 {ECO:0000250|UniProtKB:P16581}.
DISULFID 166 175 {ECO:0000250|UniProtKB:P16581}.
DISULFID 181 225 {ECO:0000250|UniProtKB:P16581}.
DISULFID 194 207 {ECO:0000250|UniProtKB:P16581}.
DISULFID 211 238 {ECO:0000250|UniProtKB:P16581}.
DISULFID 243 287 {ECO:0000250|UniProtKB:P16581}.
DISULFID 256 269 {ECO:0000250|UniProtKB:P16581}.
DISULFID 273 300 {ECO:0000250|UniProtKB:P16581}.
DISULFID 305 350 {ECO:0000250}.
DISULFID 336 363 {ECO:0000250}.
DISULFID 368 413 {ECO:0000250}.
DISULFID 399 426 {ECO:0000250}.
DISULFID 431 476 {ECO:0000250}.
DISULFID 462 489 {ECO:0000250}.
DISULFID 494 535 {ECO:0000250}.
DISULFID 521 548 {ECO:0000250}.
SEQUENCE 611 AA; 66315 MW; 35DA9E3DF225E4F6 CRC64;
MITSQLLPAL TLVLLLFKEG GAWSYNASTE AMTFDEASTY CQQRYTHLVA IQNQEEIKYL
NSMFTYTPTY YWIGIRKVNK KWTWIGTQKL LTEEAKNWAP GEPNNKQNDE DCVEIYIKRD
KDSGKWNDER CDKKKLALCY TAACTPTSCS GHGECVETVN NYTCKCHPGF RGLRCEQVVT
CQAQEAPEHG SLVCTHPLGT FSYNSSCFVS CDKGYLPSST EATQCTSTGE WSASPPACNV
VECSALTNPC HGVMDCLQSS GNFPWNMTCT FECEEGFELM GPKRLQCTSS GNWDNRKPTC
KAVTCGAIGH PQNGSVSCSH SPAGEFSVRS SCNFTCNEGF LMQGPAQIEC TAQGQWSQQV
PVCKASQCKA LSSPERGYMS CLPGASGSFQ SGSSCEFFCE KGFVLKGSKT LQCGLTGKWD
SEEPTCEAVK CDAVQQPQDG LVRCAHSSTG EFTYKSSCAF SCEEGFELHG SAQLECTSQG
QGVTGGPSCQ VVQCFKSGSF RKDEHKLQGE PVFGAVCAFA CPEGWTLNGS AALMCDATGH
WSGMLPTCEA PTESSIPLAV GLTAGGTSLL TVASFLLWLL KRLRKRAKKF VPASSCQSLQ
SDGSYHMPCS I


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Pathways :
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Related Genes :
[SELE ELAM1] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[Sele Elam-1] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[SELE] E-selectin (CD62 antigen-like family member E) (Endothelial leukocyte adhesion molecule 1) (ELAM-1) (Leukocyte-endothelial cell adhesion molecule 2) (LECAM2) (CD antigen CD62E)
[SELL LNHR LYAM1] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte surface antigen Leu-8) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (TQ1) (gp90-MEL) (CD antigen CD62L)
[Sell Lnhr Ly-22 Ly22] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)
[Sell Lnhr Ly-22] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (Lymphocyte antigen 22) (Ly-22) (Lymphocyte surface MEL-14 antigen) (CD antigen CD62L)
[SELP GMRP GRMP] P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
[Selp Grmp] P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
[Selp] P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
[SELL] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (CD antigen CD62L)
[SELP] P-selectin (CD62 antigen-like family member P) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62P)
[SELP] P-selectin (CD62 antigen-like family member P) (CD62P antigen) (Granule membrane protein 140) (GMP-140) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3) (Platelet activation dependent granule-external membrane protein) (PADGEM) (CD antigen CD62)
[SELL] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (CD antigen CD62L)
[SELL] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (CD antigen CD62L)
[SELL] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (CD antigen CD62L)
[SELL] L-selectin (CD62 antigen-like family member L) (Leukocyte adhesion molecule 1) (LAM-1) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (Lymph node homing receptor) (CD antigen CD62L)
[ITGAL CD11A] Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
[ALCAM MEMD] CD166 antigen (Activated leukocyte cell adhesion molecule) (CD antigen CD166)
[Ceacam1 Bgp Bgp1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a)
[Alcam] CD166 antigen (Activated leukocyte cell adhesion molecule) (BEN) (Protein DM-GRASP) (CD antigen CD166)
[PECAM1] Platelet endothelial cell adhesion molecule (PECAM-1) (EndoCAM) (GPIIA') (PECA1) (CD antigen CD31)
[Alcam] CD166 antigen (Activated leukocyte cell adhesion molecule) (HB2) (KG-CAM) (Protein MEMD) (SB-10 antigen) (CD antigen CD166)
[CEACAM1 BGP BGP1] Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (CD antigen CD66a)
[CD84 SLAMF5] SLAM family member 5 (Cell surface antigen MAX.3) (Hly9-beta) (Leukocyte differentiation antigen CD84) (Signaling lymphocytic activation molecule 5) (CD antigen CD84)
[EPCAM GA733-2 M1S2 M4S1 MIC18 TACSTD1 TROP1] Epithelial cell adhesion molecule (Ep-CAM) (Adenocarcinoma-associated antigen) (Cell surface glycoprotein Trop-1) (Epithelial cell surface antigen) (Epithelial glycoprotein) (EGP) (Epithelial glycoprotein 314) (EGP314) (hEGP314) (KS 1/4 antigen) (KSA) (Major gastrointestinal tumor-associated protein GA733-2) (Tumor-associated calcium signal transducer 1) (CD antigen CD326)
[Pecam1 Pecam Pecam-1] Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31)
[ITGAM CD11B CR3A] Integrin alpha-M (CD11 antigen-like family member B) (CR-3 alpha chain) (Cell surface glycoprotein MAC-1 subunit alpha) (Leukocyte adhesion receptor MO1) (Neutrophil adherence receptor) (CD antigen CD11b)
[Ceacam1] Carcinoembryonic antigen-related cell adhesion molecule 1 (ATP-dependent taurocolate-carrier protein) (Cell-CAM 105) (C-CAM 105) (Ecto-ATPase) (GP110) (pp120) (CD antigen CD66a)
[psbA] Photosystem II protein D1 (PSII D1 protein) (EC 1.10.3.9) (Photosystem II Q(B) protein)
[Pecam1 Pecam] Platelet endothelial cell adhesion molecule (PECAM-1) (CD antigen CD31)

Bibliography :
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