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ETS domain-containing protein Elk-4 (Serum response factor accessory protein 1) (SAP-1) (SRF accessory protein 1)

 ELK4_MOUSE              Reviewed;         430 AA.
P41158; A6H693;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
27-JUL-2011, sequence version 2.
13-FEB-2019, entry version 137.
RecName: Full=ETS domain-containing protein Elk-4;
AltName: Full=Serum response factor accessory protein 1;
Short=SAP-1;
Short=SRF accessory protein 1;
Name=Elk4; Synonyms=Sap1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Embryo;
PubMed=7958835; DOI=10.1101/gad.8.13.1502;
Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.;
"Net, a new ets transcription factor that is activated by Ras.";
Genes Dev. 8:1502-1513(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
-!- FUNCTION: Involved in both transcriptional activation and
repression. Interaction with SIRT7 leads to recruitment and
stabilization of SIRT7 at promoters, followed by deacetylation of
histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription
repression. Forms a ternary complex with the serum response factor
(SRF). Requires DNA-bound SRF for ternary complex formation and
makes extensive DNA contacts to the 5'side of SRF, but does not
bind DNA autonomously (By similarity). {ECO:0000250}.
-!- SUBUNIT: Interacts with SIRT7. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Nucleus.
-!- TISSUE SPECIFICITY: Lung and liver.
-!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
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EMBL; Z36885; CAA85358.1; -; mRNA.
EMBL; CH466520; EDL39692.1; -; Genomic_DNA.
EMBL; BC144844; AAI44845.1; -; mRNA.
EMBL; BC145795; AAI45796.1; -; mRNA.
CCDS; CCDS35704.1; -.
PIR; I48755; I48755.
RefSeq; NP_031949.2; NM_007923.2.
RefSeq; XP_006529189.1; XM_006529126.3.
RefSeq; XP_006529190.1; XM_006529127.3.
RefSeq; XP_006529191.1; XM_006529128.3.
RefSeq; XP_006529192.1; XM_006529129.3.
RefSeq; XP_006529193.1; XM_006529130.3.
UniGene; Mm.254233; -.
UniGene; Mm.482266; -.
ProteinModelPortal; P41158; -.
SMR; P41158; -.
BioGrid; 199431; 1.
STRING; 10090.ENSMUSP00000027696; -.
iPTMnet; P41158; -.
PhosphoSitePlus; P41158; -.
EPD; P41158; -.
MaxQB; P41158; -.
PaxDb; P41158; -.
PRIDE; P41158; -.
Ensembl; ENSMUST00000027696; ENSMUSP00000027696; ENSMUSG00000026436.
Ensembl; ENSMUST00000086556; ENSMUSP00000083743; ENSMUSG00000026436.
GeneID; 13714; -.
KEGG; mmu:13714; -.
UCSC; uc007cob.1; mouse.
CTD; 2005; -.
MGI; MGI:102853; Elk4.
eggNOG; KOG3806; Eukaryota.
eggNOG; ENOG410Z0ZF; LUCA.
GeneTree; ENSGT00940000158900; -.
HOGENOM; HOG000237332; -.
HOVERGEN; HBG004344; -.
InParanoid; P41158; -.
KO; K04376; -.
OMA; KMDPMTV; -.
OrthoDB; 981551at2759; -.
TreeFam; TF317732; -.
PRO; PR:P41158; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000026436; Expressed in 291 organ(s), highest expression level in saccule of membranous labyrinth.
ExpressionAtlas; P41158; baseline and differential.
Genevisible; P41158; MM.
GO; GO:0005829; C:cytosol; ISO:MGI.
GO; GO:0005654; C:nucleoplasm; ISO:MGI.
GO; GO:0005634; C:nucleus; IBA:GO_Central.
GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; ISO:MGI.
GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
GO; GO:0070932; P:histone H3 deacetylation; ISS:UniProtKB.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:MGI.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR000418; Ets_dom.
InterPro; IPR036388; WH-like_DNA-bd_sf.
InterPro; IPR036390; WH_DNA-bd_sf.
Pfam; PF00178; Ets; 1.
PRINTS; PR00454; ETSDOMAIN.
SMART; SM00413; ETS; 1.
SUPFAM; SSF46785; SSF46785; 1.
PROSITE; PS00345; ETS_DOMAIN_1; 1.
PROSITE; PS00346; ETS_DOMAIN_2; 1.
PROSITE; PS50061; ETS_DOMAIN_3; 1.
2: Evidence at transcript level;
Activator; Complete proteome; DNA-binding; Isopeptide bond; Nucleus;
Reference proteome; Repressor; Transcription;
Transcription regulation; Ubl conjugation.
CHAIN 1 430 ETS domain-containing protein Elk-4.
/FTId=PRO_0000204100.
DNA_BIND 5 85 ETS. {ECO:0000255|PROSITE-
ProRule:PRU00237}.
CROSSLNK 166 166 Glycyl lysine isopeptide (Lys-Gly)
(interchain with G-Cter in SUMO2).
{ECO:0000250|UniProtKB:P28324}.
CONFLICT 99 99 G -> A (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 206 206 F -> C (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 228 228 S -> F (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 307 307 P -> A (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 340 340 L -> S (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 395 395 T -> M (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 409 409 F -> L (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 415 415 D -> E (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 419 419 T -> L (in Ref. 1; CAA85358).
{ECO:0000305}.
CONFLICT 426 426 D -> R (in Ref. 1; CAA85358).
{ECO:0000305}.
SEQUENCE 430 AA; 46826 MW; 76CF28AB7627AB5F CRC64;
MDSAITLWQF LLQLLQEPQN EHMICWTSNN GEFKLLQAEE VARLWGIRKN KPNMNYDKLS
RALRYYYVKN IIKKVNGQKF VYKFVSYPEI LKMDPLTVGR IEGDCEALNS IETSSSKDVE
YGGKERPPQP GAKTSSRNDY IHSGLYSSFT LNSLNTSNKK LFKSIKIENP AEKLAEKKAQ
EPTPSVIKFV TTPAKKPPIE PVAAAFATSP SLSPSSEETI QALETLVSPT LPSLETPASI
SILATTFNPT PPVPSTPLPL KEPPRTPSPP LSSNPDIDTD IESVASQPME LPENLSLEPK
NEDSALPEKD KTNNSSRSKK PKGLELTPAL VVTGSDPSPL GILSPSLPTA SLTPALFSQT
PILLTPSPLL SSIHFWSTLS PFAPLSPARL QGANTLFQFP SVLNSHGPFT LSGLDGPSTP
GPFSPDLQKT


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Pathways :
WP1689: Porphyrin and chlorophyll metabolism
WP1939: Unfolded Protein Response
WP525: Mitochondrial Unfolded-Protein Response
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation

Related Genes :
[ELK3 NET SAP2] ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET) (Serum response factor accessory protein 2) (SAP-2) (SRF accessory protein 2)
[ELK1] ETS domain-containing protein Elk-1
[Elk1] ETS domain-containing protein Elk-1
[Elk1] ETS domain-containing protein Elk-1
[Elk3 Erp Net] ETS domain-containing protein Elk-3 (ETS-related protein ERP) (ETS-related protein NET)
[HCFC1 HCF1 HFC1] Host cell factor 1 (HCF) (HCF-1) (C1 factor) (CFF) (VCAF) (VP16 accessory protein) [Cleaved into: HCF N-terminal chain 1; HCF N-terminal chain 2; HCF N-terminal chain 3; HCF N-terminal chain 4; HCF N-terminal chain 5; HCF N-terminal chain 6; HCF C-terminal chain 1; HCF C-terminal chain 2; HCF C-terminal chain 3; HCF C-terminal chain 4; HCF C-terminal chain 5; HCF C-terminal chain 6]
[Mrtfa Bsac Mal Mkl1] Myocardin-related transcription factor A (MRTF-A) (Basic SAP coiled-coil transcription activator) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein homolog) (Megakaryocytic acute leukemia protein homolog)
[Myocd Bsac2 Mycd Srfcp] Myocardin (Basic SAP coiled-coil transcription activator 2) (SRF cofactor protein)
[IL1RAP C3orf13 IL1R3] Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-1 receptor 3) (IL-1R-3) (IL-1R3)
[ARID4B BRCAA1 RBBP1L1 RBP1L1 SAP180] AT-rich interactive domain-containing protein 4B (ARID domain-containing protein 4B) (180 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p180) (Breast cancer-associated antigen BRCAA1) (Histone deacetylase complex subunit SAP180) (Retinoblastoma-binding protein 1-like 1)
[APCS PTX2] Serum amyloid P-component (SAP) (9.5S alpha-1-glycoprotein) [Cleaved into: Serum amyloid P-component(1-203)]
[IL1RAPL1 OPHN4] Interleukin-1 receptor accessory protein-like 1 (IL-1-RAPL-1) (IL-1RAPL-1) (IL1RAPL-1) (Oligophrenin-4) (Three immunoglobulin domain-containing IL-1 receptor-related 2) (TIGIRR-2) (X-linked interleukin-1 receptor accessory protein-like 1)
[Il1rap] Interleukin-1 receptor accessory protein (IL-1 receptor accessory protein) (IL-1RAcP) (Interleukin-33 receptot beta chain)
[IL18RAP IL1R7] Interleukin-18 receptor accessory protein (IL-18 receptor accessory protein) (IL-18RAcP) (Accessory protein-like) (AcPL) (CD218 antigen-like family member B) (CDw218b) (IL-1R accessory protein-like) (IL-1RAcPL) (Interleukin-1 receptor 7) (IL-1R-7) (IL-1R7) (Interleukin-18 receptor accessory protein-like) (Interleukin-18 receptor beta) (IL-18R-beta) (IL-18Rbeta) (CD antigen CD218b)
[3a] Protein 3a (Accessory protein 3a) (Protein U274) (Protein X1)
[SP Acp70A PAPB CG17673] Accessory gland-specific peptide 70A (Paragonial peptide B) (Sex peptide) (SP)
[Elf3 Ert Esx Jen] ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)
[ATP6AP1 ATP6IP1 ATP6S1 VATPS1 XAP3] V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1)
[] Genome polyprotein [Cleaved into: Core protein p21 (Capsid protein C) (p21); Core protein p19; Envelope glycoprotein E1 (gp32) (gp35); Envelope glycoprotein E2 (NS1) (gp68) (gp70); p7; Protease NS2-3 (p23) (EC 3.4.22.-); Serine protease NS3 (EC 3.4.21.98) (EC 3.6.1.15) (EC 3.6.4.13) (Hepacivirin) (NS3P) (p70); Non-structural protein 4A (NS4A) (p8); Non-structural protein 4B (NS4B) (p27); Non-structural protein 5A (NS5A) (p56); RNA-directed RNA polymerase (EC 2.7.7.48) (NS5B) (p68)]
[MRTFA KIAA1438 MAL MKL1] Myocardin-related transcription factor A (MRTF-A) (MKL/myocardin-like protein 1) (Megakaryoblastic leukemia 1 protein) (Megakaryocytic acute leukemia protein)
[ETS1 EWSR2] Protein C-ets-1 (p54)
[AHK4 CRE1 RAW1 WOL At2g01830 T23K3.2] Histidine kinase 4 (EC 2.7.13.3) (Arabidopsis histidine kinase 4) (AtHK4) (Cytokinin receptor CYTOKININ RESPONSE 1) (AtCRE1) (Cytokinin receptor CRE1) (Phosphoprotein phosphatase AHK4) (EC 3.1.3.16) (Protein AUTHENTIC HIS-KINASE 4) (Protein ROOT AS IN WOL 1) (Protein WOODEN LEG)
[MEF2A MEF2] Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1)
[ETV6 TEL TEL1] Transcription factor ETV6 (ETS translocation variant 6) (ETS-related protein Tel1) (Tel)
[Pre C,C C core E PC pre-C pre-C/C PreC preC PreC/C preC/C precore-core HBVgp4] Capsid protein (Core antigen) (Core protein) (HBcAg) (p21.5)
[DAXX BING2 DAP6] Death domain-associated protein 6 (Daxx) (hDaxx) (ETS1-associated protein 1) (EAP1) (Fas death domain-associated protein)
[US11] Accessory factor US11 (Vmw21)
[] Genome polyprotein [Cleaved into: Capsid protein C (Capsid protein) (Core protein); Protein prM (Precursor membrane protein); Peptide pr (Peptide precursor); Small envelope protein M (Matrix protein); Envelope protein E; Non-structural protein 1 (NS1); Non-structural protein 2A (NS2A); Serine protease subunit NS2B (Flavivirin protease NS2B regulatory subunit) (Non-structural protein 2B); Serine protease NS3 (EC 3.4.21.91) (EC 3.6.1.15) (EC 3.6.4.13) (Flavivirin protease NS3 catalytic subunit) (Non-structural protein 3); Non-structural protein 4A (NS4A); Peptide 2k; Non-structural protein 4B (NS4B); RNA-directed RNA polymerase NS5 (EC 2.1.1.56) (EC 2.1.1.57) (EC 2.7.7.48) (Non-structural protein 5)]
[1a] Replicase polyprotein 1a (pp1a) (ORF1a polyprotein) [Cleaved into: Non-structural protein 1 (nsp1) (Leader protein); Non-structural protein 2 (nsp2) (p65 homolog); Non-structural protein 3 (nsp3) (EC 3.4.19.12) (EC 3.4.22.69) (PL2-PRO) (Papain-like proteinase) (PL-PRO) (SARS coronavirus main proteinase); Non-structural protein 4 (nsp4); 3C-like proteinase (3CL-PRO) (3CLp) (EC 3.4.22.-) (nsp5); Non-structural protein 6 (nsp6); Non-structural protein 7 (nsp7); Non-structural protein 8 (nsp8); Non-structural protein 9 (nsp9); Non-structural protein 10 (nsp10) (Growth factor-like peptide) (GFL); Non-structural protein 11 (nsp11)]
[ERF] ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2)

Bibliography :
[20847520] Identification of important regulatory region of Th-POK.
[20554967] Ternary complex factors SAP-1 and Elk-1, but not net, are functionally equivalent in thymocyte development.
[17982074] Raf signaling but not the ERK effector SAP-1 is required for regulatory T cell development.
[17200232] Serum response factor binding sites differ in three human cell types.
[16466398] Serum response factor, its cofactors, and epithelial-mesenchymal signaling in urinary bladder smooth muscle formation.
[15808854] Modulating the DNA affinity of Elk-1 with computationally selected mutations.
[14770179] Ternary complex factor SAP-1 is required for Erk-mediated thymocyte positive selection.
[12907712] Regulation of TCF ETS-domain transcription factors by helix-loop-helix motifs.
[11846562] Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.
[11786537] Specificity determinants in MAPK signaling to transcription factors.
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