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Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL-AC/P26) (C-type lectin domain family 2 member C) (EA1) (Early T-cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu-23) (MLR-3) (CD antigen CD69)

 CD69_HUMAN              Reviewed;         199 AA.
Q07108;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 1.
07-APR-2021, entry version 188.
RecName: Full=Early activation antigen CD69;
AltName: Full=Activation inducer molecule;
Short=AIM;
AltName: Full=BL-AC/P26;
AltName: Full=C-type lectin domain family 2 member C;
AltName: Full=EA1;
AltName: Full=Early T-cell activation antigen p60;
AltName: Full=GP32/28;
AltName: Full=Leukocyte surface antigen Leu-23;
AltName: Full=MLR-3;
AltName: CD_antigen=CD69;
Name=CD69; Synonyms=CLEC2C;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Blood;
PubMed=8496594;
Hamann J., Fiebig H., Strauss M.;
"Expression cloning of the early activation antigen CD69, a type II
integral membrane protein with a C-type lectin domain.";
J. Immunol. 150:4920-4927(1993).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 96-103; 128-146 AND
189-199.
TISSUE=Blood;
PubMed=8340758; DOI=10.1084/jem.178.2.537;
Lopez-Cabrera M., Santis A.G., Fernandez-Ruiz E., Blacher R., Esch F.,
Sanchez-Mateos P., Sanchez-Madrid F.;
"Molecular cloning, expression, and chromosomal localization of the human
earliest lymphocyte activation antigen AIM/CD69, a new member of the C-type
animal lectin superfamily of signal-transmitting receptors.";
J. Exp. Med. 178:537-547(1993).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=8100776; DOI=10.1002/eji.1830230737;
Ziegler S.F., Ramsdell F., Hjerrild K.A., Armitage R.J., Grabstein K.H.,
Hennen K.B., Farrah T., Fanslow W.C., Shevach E.M., Alderson M.R.;
"Molecular characterization of the early activation antigen CD69: a type II
membrane glycoprotein related to a family of natural killer cell activation
antigens.";
Eur. J. Immunol. 23:1643-1648(1993).
[4]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
TISSUE=Placenta;
PubMed=8026529; DOI=10.1002/eji.1830240735;
Santis A., Lopez-Cabrera M., Hamann J., Strauss M., Sanchez-Madrid F.;
"Structure of the gene coding for the human early lymphocyte activation
antigen CD69: a C-type lectin receptor evolutionarily related with the gene
families of natural killer cell-specific receptors.";
Eur. J. Immunol. 24:1692-1697(1994).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project:
the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
[7]
X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS), SUBUNIT, AND DISULFIDE BONDS.
PubMed=11101293; DOI=10.1021/bi0018180;
Natarajan K., Sawicki M.W., Margulies D.H., Mariuzza R.A.;
"Crystal structure of human CD69: a C-type lectin-like activation marker of
hematopoietic cells.";
Biochemistry 39:14779-14786(2000).
[8]
X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 82-199, SUBUNIT, AND DISULFIDE
BONDS.
PubMed=11036086; DOI=10.1074/jbc.m008573200;
Llera A.S., Viedma F., Sanchez-Madrid F., Tormo J.;
"Crystal structure of the C-type lectin-like domain from the human
hematopoietic cell receptor CD69.";
J. Biol. Chem. 276:7312-7319(2001).
[9]
X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 82-199, SUBUNIT, AND DISULFIDE
BONDS.
PubMed=18959746; DOI=10.1111/j.1742-4658.2008.06683.x;
Vanek O., Nalezkova M., Kavan D., Borovickova I., Pompach P., Novak P.,
Kumar V., Vannucci L., Hudecek J., Hofbauerova K., Kopecky V. Jr.,
Brynda J., Kolenko P., Dohnalek J., Kaderavek P., Chmelik J., Gorcik L.,
Zidek L., Sklenar V., Bezouska K.;
"Soluble recombinant CD69 receptors optimized to have an exceptional
physical and chemical stability display prolonged circulation and remain
intact in the blood of mice.";
FEBS J. 275:5589-5606(2008).
-!- FUNCTION: Involved in lymphocyte proliferation and functions as a
signal transmitting receptor in lymphocytes, natural killer (NK) cells,
and platelets.
-!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000269|PubMed:11036086,
ECO:0000269|PubMed:11101293, ECO:0000269|PubMed:18959746}.
-!- INTERACTION:
Q07108; P27449: ATP6V0C; NbExp=3; IntAct=EBI-2836595, EBI-721179;
Q07108; Q6PL45-2: BRICD5; NbExp=3; IntAct=EBI-2836595, EBI-12244618;
Q07108; O95832: CLDN1; NbExp=3; IntAct=EBI-2836595, EBI-723889;
Q07108; Q15125: EBP; NbExp=3; IntAct=EBI-2836595, EBI-3915253;
Q07108; P21145: MAL; NbExp=3; IntAct=EBI-2836595, EBI-3932027;
Q07108; Q9NZG7: NINJ2; NbExp=4; IntAct=EBI-2836595, EBI-10317425;
Q07108; Q01453: PMP22; NbExp=3; IntAct=EBI-2836595, EBI-2845982;
Q07108; Q9NS64: RPRM; NbExp=3; IntAct=EBI-2836595, EBI-1052363;
Q07108; P21453: S1PR1; NbExp=2; IntAct=EBI-2836595, EBI-2681920;
Q07108; Q8TB61: SLC35B2; NbExp=3; IntAct=EBI-2836595, EBI-1054782;
Q07108; P0DN84: STRIT1; NbExp=3; IntAct=EBI-2836595, EBI-12200293;
Q07108; Q8WZ59: TMEM190; NbExp=6; IntAct=EBI-2836595, EBI-10278423;
Q07108; Q5TGU0: TSPO2; NbExp=3; IntAct=EBI-2836595, EBI-12195249;
Q07108; O75841: UPK1B; NbExp=3; IntAct=EBI-2836595, EBI-12237619;
-!- SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
-!- TISSUE SPECIFICITY: Expressed on the surface of activated T-cells, B-
cells, natural killer cells, neutrophils, eosinophils, epidermal
Langerhans cells and platelets.
-!- DEVELOPMENTAL STAGE: Earliest inducible cell surface glycoprotein
acquired during lymphoid activation.
-!- INDUCTION: By antigens, mitogens or activators of PKC on the surface of
T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the
surface of NK cells.
-!- PTM: Constitutive Ser/Thr phosphorylation in both mature thymocytes and
activated T-lymphocytes.
-!- WEB RESOURCE: Name=Functional Glycomics Gateway - Glycan Binding;
Note=CD69;
URL="http://www.functionalglycomics.org/glycomics/GBPServlet?&operationType=view&cbpId=cbp_hum_Ctlect_235";
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EMBL; L07555; AAB46359.1; -; mRNA.
EMBL; Z22576; CAA80298.1; -; mRNA.
EMBL; Z30426; CAA83017.1; -; Genomic_DNA.
EMBL; Z30430; CAA83017.1; JOINED; Genomic_DNA.
EMBL; Z30427; CAA83017.1; JOINED; Genomic_DNA.
EMBL; Z30429; CAA83017.1; JOINED; Genomic_DNA.
EMBL; Z30428; CAA83017.1; JOINED; Genomic_DNA.
EMBL; BC007037; AAH07037.1; -; mRNA.
CCDS; CCDS8604.1; -.
PIR; JH0822; JH0822.
RefSeq; NP_001772.1; NM_001781.2.
PDB; 1E87; X-ray; 1.50 A; A=82-199.
PDB; 1E8I; X-ray; 1.95 A; A/B=82-199.
PDB; 1FM5; X-ray; 2.27 A; A=64-199.
PDB; 3CCK; X-ray; 1.80 A; A/B=82-199.
PDB; 3HUP; X-ray; 1.37 A; A/B=70-199.
PDBsum; 1E87; -.
PDBsum; 1E8I; -.
PDBsum; 1FM5; -.
PDBsum; 3CCK; -.
PDBsum; 3HUP; -.
BMRB; Q07108; -.
SMR; Q07108; -.
BioGRID; 107407; 21.
DIP; DIP-60426N; -.
ELM; Q07108; -.
IntAct; Q07108; 20.
STRING; 9606.ENSP00000228434; -.
BindingDB; Q07108; -.
ChEMBL; CHEMBL3308911; -.
GlyConnect; 2035; 1 N-Linked glycan (1 site).
GlyGen; Q07108; 1 site, 1 N-linked glycan (1 site).
iPTMnet; Q07108; -.
PhosphoSitePlus; Q07108; -.
SwissPalm; Q07108; -.
BioMuta; CD69; -.
DMDM; 584906; -.
jPOST; Q07108; -.
MassIVE; Q07108; -.
PaxDb; Q07108; -.
PeptideAtlas; Q07108; -.
PRIDE; Q07108; -.
ProteomicsDB; 58505; -.
Antibodypedia; 3741; 1221 antibodies.
DNASU; 969; -.
Ensembl; ENST00000228434; ENSP00000228434; ENSG00000110848.
GeneID; 969; -.
KEGG; hsa:969; -.
CTD; 969; -.
DisGeNET; 969; -.
GeneCards; CD69; -.
HGNC; HGNC:1694; CD69.
HPA; ENSG00000110848; Tissue enhanced (bone marrow, lymphoid tissue).
MIM; 107273; gene.
neXtProt; NX_Q07108; -.
OpenTargets; ENSG00000110848; -.
PharmGKB; PA26233; -.
VEuPathDB; HostDB:ENSG00000110848.8; -.
eggNOG; KOG4297; Eukaryota.
GeneTree; ENSGT00940000161987; -.
InParanoid; Q07108; -.
OMA; WFNFTGS; -.
OrthoDB; 1289964at2759; -.
PhylomeDB; Q07108; -.
TreeFam; TF351467; -.
PathwayCommons; Q07108; -.
SIGNOR; Q07108; -.
BioGRID-ORCS; 969; 7 hits in 995 CRISPR screens.
ChiTaRS; CD69; human.
EvolutionaryTrace; Q07108; -.
GeneWiki; CD69; -.
GenomeRNAi; 969; -.
Pharos; Q07108; Tbio.
PRO; PR:Q07108; -.
Proteomes; UP000005640; Chromosome 12.
RNAct; Q07108; protein.
Bgee; ENSG00000110848; Expressed in vermiform appendix and 171 other tissues.
ExpressionAtlas; Q07108; baseline and differential.
Genevisible; Q07108; HS.
GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0032991; C:protein-containing complex; IDA:CAFA.
GO; GO:0005509; F:calcium ion binding; IEA:Ensembl.
GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
GO; GO:0042802; F:identical protein binding; IDA:CAFA.
GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc.
CDD; cd03593; CLECT_NK_receptors_like; 1.
DisProt; DP00306; -.
Gene3D; 3.10.100.10; -; 1.
InterPro; IPR001304; C-type_lectin-like.
InterPro; IPR016186; C-type_lectin-like/link_sf.
InterPro; IPR016187; CTDL_fold.
InterPro; IPR033992; NKR-like_CTLD.
Pfam; PF00059; Lectin_C; 1.
SMART; SM00034; CLECT; 1.
SUPFAM; SSF56436; SSF56436; 1.
PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
1: Evidence at protein level;
3D-structure; Direct protein sequencing; Disulfide bond; Glycoprotein;
Lectin; Membrane; Phosphoprotein; Reference proteome; Signal-anchor;
Transmembrane; Transmembrane helix.
CHAIN 1..199
/note="Early activation antigen CD69"
/id="PRO_0000046583"
TOPO_DOM 1..40
/note="Cytoplasmic"
/evidence="ECO:0000255"
TRANSMEM 41..61
/note="Helical; Signal-anchor for type II membrane protein"
/evidence="ECO:0000255"
TOPO_DOM 62..199
/note="Extracellular"
/evidence="ECO:0000255"
DOMAIN 92..195
/note="C-type lectin"
/evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
CARBOHYD 166
/note="N-linked (GlcNAc...) asparagine"
/evidence="ECO:0000255"
DISULFID 68
/note="Interchain"
/evidence="ECO:0000305"
DISULFID 85..96
DISULFID 113..194
DISULFID 173..186
STRAND 90..92
/evidence="ECO:0007744|PDB:3HUP"
STRAND 95..99
/evidence="ECO:0007744|PDB:3HUP"
HELIX 106..114
/evidence="ECO:0007744|PDB:3HUP"
TURN 115..117
/evidence="ECO:0007744|PDB:3HUP"
HELIX 126..136
/evidence="ECO:0007744|PDB:3HUP"
STRAND 141..147
/evidence="ECO:0007744|PDB:3HUP"
STRAND 153..155
/evidence="ECO:0007744|PDB:3HUP"
STRAND 168..170
/evidence="ECO:0007744|PDB:1E87"
STRAND 172..177
/evidence="ECO:0007744|PDB:3HUP"
STRAND 180..184
/evidence="ECO:0007744|PDB:3HUP"
STRAND 190..197
/evidence="ECO:0007744|PDB:3HUP"
SEQUENCE 199 AA; 22559 MW; 172E2699D2FB8DFB CRC64;
MSSENCFVAE NSSLHPESGQ ENDATSPHFS TRHEGSFQVP VLCAVMNVVF ITILIIALIA
LSVGQYNCPG QYTFSMPSDS HVSSCSEDWV GYQRKCYFIS TVKRSWTSAQ NACSEHGATL
AVIDSEKDMN FLKRYAGREE HWVGLKKEPG HPWKWSNGKE FNNWFNVTGS DKCVFLKNTE
VSSMECEKNL YWICNKPYK


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