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Empty spiracles homeobox 2 (Emx2 protein)

 Q568U8_DANRE            Unreviewed;       247 AA.
Q568U8;
10-MAY-2005, integrated into UniProtKB/TrEMBL.
10-MAY-2005, sequence version 1.
16-JAN-2019, entry version 109.
SubName: Full=Empty spiracles homeobox 2 {ECO:0000313|EMBL:AAH92713.1};
SubName: Full=Emx2 protein {ECO:0000313|EMBL:AAI65103.1};
Name=emx2 {ECO:0000313|EMBL:AAH92713.1,
ECO:0000313|ZFIN:ZDB-GENE-990415-54};
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955 {ECO:0000313|EMBL:AAH92713.1};
[1] {ECO:0000313|EMBL:AAH92713.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Olfactory epithelium {ECO:0000313|EMBL:AAH92713.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:AAI65103.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=PCR rescue {ECO:0000313|EMBL:AAI65103.1};
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-
ProRule:PRU00108, ECO:0000256|RuleBase:RU000682,
ECO:0000256|SAAS:SAAS00860360}.
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EMBL; BC092713; AAH92713.1; -; mRNA.
EMBL; BC165103; AAI65103.1; -; mRNA.
RefSeq; NP_571355.2; NM_131280.2.
UniGene; Dr.75105; -.
GeneID; 30537; -.
KEGG; dre:30537; -.
CTD; 2018; -.
ZFIN; ZDB-GENE-990415-54; emx2.
eggNOG; KOG0843; Eukaryota.
eggNOG; ENOG4111SRW; LUCA.
HOGENOM; HOG000247032; -.
HOVERGEN; HBG005024; -.
KO; K09317; -.
OrthoDB; 1189098at2759; -.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
GO; GO:0007420; P:brain development; IEP:ZFIN.
GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
GO; GO:0060121; P:vestibular receptor cell stereocilium organization; IMP:ZFIN.
CDD; cd00086; homeodomain; 1.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR017970; Homeobox_CS.
InterPro; IPR001356; Homeobox_dom.
InterPro; IPR020479; Homeobox_metazoa.
InterPro; IPR000047; HTH_motif.
Pfam; PF00046; Homeodomain; 1.
PRINTS; PR00024; HOMEOBOX.
PRINTS; PR00031; HTHREPRESSR.
SMART; SM00389; HOX; 1.
SUPFAM; SSF46689; SSF46689; 1.
PROSITE; PS00027; HOMEOBOX_1; 1.
PROSITE; PS50071; HOMEOBOX_2; 1.
2: Evidence at transcript level;
DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00108,
ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00860283,
ECO:0000313|EMBL:AAH92713.1};
Homeobox {ECO:0000256|PROSITE-ProRule:PRU00108,
ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00860291,
ECO:0000313|EMBL:AAH92713.1};
Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
ECO:0000256|RuleBase:RU000682, ECO:0000256|SAAS:SAAS00860284}.
DOMAIN 147 207 Homeobox. {ECO:0000259|PROSITE:PS50071}.
DNA_BIND 149 208 Homeobox. {ECO:0000256|PROSITE-
ProRule:PRU00108}.
SEQUENCE 247 AA; 28012 MW; 9D892112A25188AC CRC64;
MFQPTPKRCF TIESLVAKDN PLPSSRSEEP IRPAALSYAN SSQMNPFLNG FHSSGRGVYS
NPGLVFAEAV SHPPNSAVPV HSVPPPHALA AHPLSSSHSP HPLFASQQRD PSTFYPWLIH
RYRYLGHRFQ GNETSPESFL LHNALARKPK RIRTAFSPSQ LLRLEHAFEK NHYVVGAERK
QLAHSLSLTE TQVKVWFQNR RTKFKRQKLE EEGSDSQQKK KGTHHINRWR LATKQGSPEE
IDVTSDD


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Kits Elisa; taq POLYMERASE

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Pathways :
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining
WP1678: Nucleotide excision repair

Related Genes :
[EIF4E EIF4EL1 EIF4F] Eukaryotic translation initiation factor 4E (eIF-4E) (eIF4E) (eIF-4F 25 kDa subunit) (mRNA cap-binding protein)
[NKX2-5 CSX NKX2.5 NKX2E] Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
[VSX1 RINX] Visual system homeobox 1 (Homeodomain protein RINX) (Retinal inner nuclear layer homeobox protein) (Transcription factor VSX1)
[Nkx2-5 Csx Nkx-2.5 Nkx2e] Homeobox protein Nkx-2.5 (Cardiac-specific homeobox) (Homeobox protein CSX) (Homeobox protein NK-2 homolog E)
[unc-4 ceh-4 F26C11.2] Homeobox protein unc-4 (Homeobox protein ceh-4) (Uncoordinated protein 4)
[PITX2 ARP1 RGS RIEG RIEG1] Pituitary homeobox 2 (ALL1-responsive protein ARP1) (Homeobox protein PITX2) (Paired-like homeodomain transcription factor 2) (RIEG bicoid-related homeobox transcription factor) (Solurshin)
[Pitx2 Arp1 Brx1 Otlx2 Ptx2 Rgs] Pituitary homeobox 2 (ALL1-responsive protein ARP1) (BRX1 homeoprotein) (Homeobox protein PITX2) (Orthodenticle-like homeobox 2) (Paired-like homeodomain transcription factor 2) (Paired-like homeodomain transcription factor Munc 30) (Solurshin)
[HAT4 ATHB-2 At4g16780 dl4415w FCAALL.101] Homeobox-leucine zipper protein HAT4 (HD-ZIP protein ATHB-2) (Homeodomain transcription factor ATHB-2) (Homeodomain-leucine zipper protein HAT4) (HD-ZIP protein 4)
[NKX2-1 NKX2A TITF1 TTF1] Homeobox protein Nkx-2.1 (Homeobox protein NK-2 homolog A) (Thyroid nuclear factor 1) (Thyroid transcription factor 1) (TTF-1) (Thyroid-specific enhancer-binding protein) (T/EBP)
[PHOX2A ARIX PMX2A] Paired mesoderm homeobox protein 2A (ARIX1 homeodomain protein) (Aristaless homeobox protein homolog) (Paired-like homeobox 2A)
[PHOX2B PMX2B] Paired mesoderm homeobox protein 2B (Neuroblastoma Phox) (NBPhox) (PHOX2B homeodomain protein) (Paired-like homeobox 2B)
[pal-1 ceh-3 C38D4.6] Homeobox protein pal-1 (Caudal homolog 1) (Homeobox protein ceh-3) (Posterior alae in males protein 1)
[Cdx2 Cdx-2] Homeobox protein CDX-2 (Caudal-type homeobox protein 2)
[MSX2 HOX8] Homeobox protein MSX-2 (Homeobox protein Hox-8)
[Hlx Hlx1] H2.0-like homeobox protein (Homeobox protein HLX1)
[HOXB5 HOX2A] Homeobox protein Hox-B5 (Homeobox protein HHO.C10) (Homeobox protein Hox-2A) (Homeobox protein Hu-1)
[HOXD9 HOX4C] Homeobox protein Hox-D9 (Homeobox protein Hox-4C) (Homeobox protein Hox-5.2)
[Nkx2-6 Nkx-2.6 Nkx2f] Homeobox protein Nkx-2.6 (Homeobox protein NK-2 homolog F)
[HOXA2 HOX1K] Homeobox protein Hox-A2 (Homeobox protein Hox-1K)
[Nanog Ecat4 Enk] Homeobox protein NANOG (ES cell-associated protein 4) (Early embryo specific expression NK-type homeobox protein) (Homeobox transcription factor Nanog)
[MSX1 HOX7] Homeobox protein MSX-1 (Homeobox protein Hox-7) (Msh homeobox 1-like protein)
[Vsx2 Chx10] Visual system homeobox 2 (Ceh-10 homeodomain-containing homolog) (Homeobox protein CHX10)
[CDX2 CDX3] Homeobox protein CDX-2 (CDX-3) (Caudal-type homeobox protein 2)
[ZEB2 KIAA0569 SIP1 ZFHX1B ZFX1B HRIHFB2411] Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)
[Hoxb1 Hox-2.9 Hoxb-1] Homeobox protein Hox-B1 (Homeobox protein Hox-2.9)
[Dmbx1 Cdmx Mbx Otx3 PaxB] Diencephalon/mesencephalon homeobox protein 1 (Diencephalon/mesencephalon-expressed brain homeobox gene 1 protein) (Orthodenticle homolog 3) (Paired-like homeobox protein DMBX1) (Paired-type homeobox Atx)
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Bibliography :
[30628007] Identification of Novel Binding Partners for Transcription Factor Emx2.
[30450775] Wnt and BMP signaling pathways co-operatively induce the differentiation of multiple myeloma mesenchymal stem cells into osteoblasts by upregulating EMX2.
[28830374] EMX2 gene expression predicts liver metastasis and survival in colorectal cancer.
[28673691] EMX2 activates slow myosin heavy chain 2 gene expression in embryonic muscle fibers.
[27712600] Empty Spiracles Homeobox 2 (EMX2) Inhibits the Invasion and Tumorigenesis in Colorectal Cancer Cells.
[27521061] Expression patterns of homeobox genes in the mouse vomeronasal organ at postnatal stages.
[26896429] HOXA10, EMX2 and TENM1 expression in the mid-secretory endometrium of infertile women with a Müllerian duct anomaly.
[26079439] Identification and expression of the target gene emx2 of miR-26a and miR-26b in Paralichthys olivaceus.
[25935411] Reevaluating Emx gene phylogeny: homopolymeric amino acid tracts as a potential factor obscuring orthology signals in cyclostome genes.
[25577462] Nonsense mutation of EMX2 is potential causative for uterus didelphysis: first molecular explanation for isolated incomplete müllerian fusion.
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