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Endogenous retroviral envelope protein HEMO (Endogenous retrovirus group MER34 member 1 Env polyprotein) (HERV-MER_4q12 provirus ancestral Env polyprotein) (Human endogenous MER34 (medium-reiteration-frequency-family-34) open reading frame) (Human endogenous MER34 ORF) (HEMO) [Cleaved into: Endogenous retroviral envelope protein HEMO, secreted form (Endogenous retroviral envelope protein HEMO, 48 kDa form)]

 MER34_HUMAN             Reviewed;         563 AA.
Q9H9K5; B3KTB4; Q0P5R3; Q6NWN0;
10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
10-APR-2019, entry version 111.
RecName: Full=Endogenous retroviral envelope protein HEMO {ECO:0000305};
AltName: Full=Endogenous retrovirus group MER34 member 1 Env polyprotein {ECO:0000305};
AltName: Full=HERV-MER_4q12 provirus ancestral Env polyprotein;
AltName: Full=Human endogenous MER34 (medium-reiteration-frequency-family-34) open reading frame {ECO:0000303|PubMed:28739914};
AltName: Full=Human endogenous MER34 ORF {ECO:0000303|PubMed:28739914};
Short=HEMO {ECO:0000303|PubMed:28739914};
Contains:
RecName: Full=Endogenous retroviral envelope protein HEMO, secreted form {ECO:0000305};
AltName: Full=Endogenous retroviral envelope protein HEMO, 48 kDa form;
Flags: Precursor;
Name=ERVMER34-1 {ECO:0000312|HGNC:HGNC:42970};
Synonyms=HEMO {ECO:0000303|PubMed:28739914}; ORFNames=LP9056;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Tongue;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15498874; DOI=10.1073/pnas.0404089101;
Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H.,
Qiu X., Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y.,
Shu H., Chen X., Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S.,
Gu J.;
"Large-scale cDNA transfection screening for genes related to cancer
development and progression.";
Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE
SPECIFICITY, GLYCOSYLATION, PROTEOLYTIC PROCESSING, AND MUTAGENESIS OF
352-CYS--GLY-355; 433-ARG--LEU-563; 472-PRO--LEU-563 AND
489-SER--LEU-563.
PubMed=28739914; DOI=10.1073/pnas.1702204114;
Heidmann O., Beguin A., Paternina J., Berthier R., Deloger M.,
Bawa O., Heidmann T.;
"HEMO, an ancestral endogenous retroviral envelope protein shed in the
blood of pregnant women and expressed in pluripotent stem cells and
tumors.";
Proc. Natl. Acad. Sci. U.S.A. 114:E6642-E6651(2017).
-!- FUNCTION: Endogenous envelope proteins originate from retroviral
envelope proteins, which mediate receptor recognition and membrane
fusion during early infection. Endogenous envelope proteins may
have kept, lost or modified their original function during
evolution. {ECO:0000305}.
-!- SUBCELLULAR LOCATION: Endogenous retroviral envelope protein HEMO:
Cell membrane {ECO:0000269|PubMed:28739914}; Single-pass type I
membrane protein {ECO:0000255}. Note=This uncleaved form present
at the cell surface represents the major form (PubMed:28739914).
{ECO:0000269|PubMed:28739914}.
-!- SUBCELLULAR LOCATION: Endogenous retroviral envelope protein HEMO,
secreted form: Secreted {ECO:0000269|PubMed:28739914}. Note=This
secreted form, which is released in the extracellular medium
following cleavage, constitutes a minor form (PubMed:28739914).
{ECO:0000269|PubMed:28739914}.
-!- TISSUE SPECIFICITY: Expressed at high level in the placenta and
stem cells (at protein level) (PubMed:28739914). Also expressed in
the kidney but at a lower level (PubMed:28739914). Endogenous
retroviral envelope protein HEMO, secreted form: Present in the
blood of pregnant women (at protein level) (PubMed:28739914).
{ECO:0000269|PubMed:28739914}.
-!- PTM: N-glycosylated. {ECO:0000269|PubMed:28739914}.
-!- PTM: Endogenous retroviral envelope protein HEMO: Cleaved by some
metalloproteinase at 432-Gln-Arg-433 (mainly) or 433-Arg-Gln-434,
leading to release the secreted form (Endogenous retroviral
envelope protein HEMO, secreted form) in the extracellular medium.
{ECO:0000269|PubMed:28739914}.
-!- SIMILARITY: Belongs to the gamma type-C retroviral envelope
protein family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAH69998.1; Type=Frameshift; Positions=298; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AY189288; AAO86732.1; -; mRNA.
EMBL; AK022746; BAB14220.1; -; mRNA.
EMBL; AK095318; BAG53026.1; -; mRNA.
EMBL; CH471057; EAX05439.1; -; Genomic_DNA.
EMBL; BC067526; AAH67526.1; -; mRNA.
EMBL; BC067528; AAH67528.1; -; mRNA.
EMBL; BC067529; AAH67529.1; -; mRNA.
EMBL; BC069998; AAH69998.1; ALT_FRAME; mRNA.
RefSeq; NP_001229619.1; NM_001242690.1.
RefSeq; NP_078810.1; NM_024534.5.
UniGene; Hs.363087; -.
ProteinModelPortal; Q9H9K5; -.
STRING; 9606.ENSP00000460602; -.
iPTMnet; Q9H9K5; -.
PhosphoSitePlus; Q9H9K5; -.
BioMuta; ERVMER34-1; -.
DMDM; 74734033; -.
EPD; Q9H9K5; -.
PaxDb; Q9H9K5; -.
PeptideAtlas; Q9H9K5; -.
PRIDE; Q9H9K5; -.
ProteomicsDB; 81327; -.
TopDownProteomics; Q9H9K5; -.
Ensembl; ENST00000440542; ENSP00000460255; ENSG00000226887.
Ensembl; ENST00000443173; ENSP00000460602; ENSG00000226887.
GeneID; 100288413; -.
KEGG; hsa:100288413; -.
UCSC; uc003gzr.4; human.
CTD; 100288413; -.
EuPathDB; HostDB:ENSG00000226887.7; -.
GeneCards; ERVMER34-1; -.
H-InvDB; HIX0004213; -.
HGNC; HGNC:42970; ERVMER34-1.
HPA; HPA011423; -.
HPA; HPA024053; -.
neXtProt; NX_Q9H9K5; -.
OpenTargets; ENSG00000226887; -.
eggNOG; ENOG410J8IS; Eukaryota.
eggNOG; ENOG4111C12; LUCA.
GeneTree; ENSGT00870000136875; -.
InParanoid; Q9H9K5; -.
OMA; GKWRCAD; -.
OrthoDB; 389221at2759; -.
TreeFam; TF344098; -.
GenomeRNAi; 100288413; -.
PRO; PR:Q9H9K5; -.
Proteomes; UP000005640; Chromosome 4.
Bgee; ENSG00000226887; Expressed in 89 organ(s), highest expression level in chorionic villus.
Genevisible; Q9H9K5; HS.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
InterPro; IPR018154; TLV/ENV_coat_polyprotein.
PANTHER; PTHR10424; PTHR10424; 1.
1: Evidence at protein level;
Cell membrane; Complete proteome; ERV; Glycoprotein; Membrane;
Reference proteome; Secreted; Signal; Transmembrane;
Transmembrane helix; Transposable element.
SIGNAL 1 26 {ECO:0000269|PubMed:28739914}.
CHAIN 27 563 Endogenous retroviral envelope protein
HEMO.
/FTId=PRO_0000341352.
CHAIN 27 432 Endogenous retroviral envelope protein
HEMO, secreted form.
{ECO:0000305|PubMed:28739914}.
/FTId=PRO_0000443800.
TOPO_DOM 27 488 Extracellular. {ECO:0000255}.
TRANSMEM 489 509 Helical. {ECO:0000255}.
TOPO_DOM 510 563 Cytoplasmic. {ECO:0000255}.
COMPBIAS 171 174 Poly-Asp.
CARBOHYD 122 122 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 192 192 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
MUTAGEN 352 355 CTQG->RTKR: Introduction of a furin
cleavage site, promoting proteolytic
cleavage of the protein by furin and
release in the extracellular medium.
{ECO:0000269|PubMed:28739914}.
MUTAGEN 433 563 Missing: Promotes release in the
extracellular medium.
{ECO:0000269|PubMed:28739914}.
MUTAGEN 472 563 Missing: Promotes release in the
extracellular medium.
{ECO:0000269|PubMed:28739914}.
MUTAGEN 489 563 Missing: Promotes release in the
extracellular medium.
{ECO:0000269|PubMed:28739914}.
CONFLICT 34 34 T -> A (in Ref. 4; AAH69998).
{ECO:0000305}.
CONFLICT 81 81 W -> R (in Ref. 4; AAH67529).
{ECO:0000305}.
CONFLICT 418 418 S -> P (in Ref. 4; AAH67529).
{ECO:0000305}.
CONFLICT 434 434 Q -> R (in Ref. 4; AAH67529).
{ECO:0000305}.
CONFLICT 459 459 Q -> H (in Ref. 4; AAH69998).
{ECO:0000305}.
SEQUENCE 563 AA; 63547 MW; D8D0B75216FDF8B7 CRC64;
MGSLSNYALL QLTLTAFLTI LVQPQHLLAP VFRTLSILTN QSNCWLCEHL DNAEQPELVF
VPASASTWWT YSGQWMYERV WYPQAEVQNH STSSYRKVTW HWEASMEAQG LSFAQVRLLE
GNFSLCVENK NGSGPFLGNI PKQYCNQILW FDSTDGTFMP SIDVTNESRN DDDDTSVCLG
TRQCSWFAGC TNRTWNSSAV PLIGLPNTQD YKWVDRNSGL TWSGNDTCLY SCQNQTKGLL
YQLFRNLFCS YGLTEAHGKW RCADASITND KGHDGHRTPT WWLTGSNLTL SVNNSGLFFL
CGNGVYKGFP PKWSGRCGLG YLVPSLTRYL TLNASQITNL RSFIHKVTPH RCTQGDTDNP
PLYCNPKDNS TIRALFPSLG TYDLEKAILN ISKAMEQEFS ATKQTLEAHQ SKVSSLASAS
RKDHVLDIPT TQRQTACGTV GKQCCLYINY SEEIKSNIQR LHEASENLKN VPLLDWQGIF
AKVGDWFRSW GYVLLIVLFC LFIFVLIYVR VFRKSRRSLN SQPLNLALSP QQSAQLLVSE
TSCQVSNRAM KGLTTHQYDT SLL


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