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Endoglin

 A0A2R9AKB4_PANPA        Unreviewed;       658 AA.
A0A2R9AKB4;
20-JUN-2018, integrated into UniProtKB/TrEMBL.
20-JUN-2018, sequence version 1.
17-JUN-2020, entry version 12.
RecName: Full=ZP domain-containing protein {ECO:0000259|Pfam:PF00100};
Name=ENG {ECO:0000313|Ensembl:ENSPPAP00000016080};
Pan paniscus (Pygmy chimpanzee) (Bonobo).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
Pan.
NCBI_TaxID=9597 {ECO:0000313|Ensembl:ENSPPAP00000016080, ECO:0000313|Proteomes:UP000240080};
[1] {ECO:0000313|Ensembl:ENSPPAP00000016080, ECO:0000313|Proteomes:UP000240080}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=22722832; DOI=10.1038/nature11128;
Prufer K., Munch K., Hellmann I., Akagi K., Miller J.R., Walenz B.,
Koren S., Sutton G., Kodira C., Winer R., Knight J.R., Mullikin J.C.,
Meader S.J., Ponting C.P., Lunter G., Higashino S., Hobolth A., Dutheil J.,
Karakoc E., Alkan C., Sajjadian S., Catacchio C.R., Ventura M.,
Marques-Bonet T., Eichler E.E., Andre C., Atencia R., Mugisha L.,
Junhold J., Patterson N., Siebauer M., Good J.M., Fischer A., Ptak S.E.,
Lachmann M., Symer D.E., Mailund T., Schierup M.H., Andres A.M., Kelso J.,
Paabo S.;
"The bonobo genome compared with the chimpanzee and human genomes.";
Nature 486:527-531(2012).
[2] {ECO:0000313|Ensembl:ENSPPAP00000016080}
IDENTIFICATION.
Ensembl;
Submitted (APR-2018) to UniProtKB.
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EMBL; AJFE02077463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJFE02077464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJFE02077465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJFE02077466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJFE02077467; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJFE02077468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJFE02077469; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AJFE02077470; -; NOT_ANNOTATED_CDS; Genomic_DNA.
RefSeq; XP_003822349.1; XM_003822301.2.
Ensembl; ENSPPAT00000038773; ENSPPAP00000016080; ENSPPAG00000031135.
GeneID; 100994069; -.
KEGG; pps:100994069; -.
CTD; 2022; -.
GeneTree; ENSGT00530000063861; -.
KO; K06526; -.
Proteomes; UP000240080; Chromosome 9.
GO; GO:0072563; C:endothelial microparticle; IEA:Ensembl.
GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016604; C:nuclear body; IEA:Ensembl.
GO; GO:0043235; C:receptor complex; IEA:Ensembl.
GO; GO:0036122; F:BMP binding; IEA:Ensembl.
GO; GO:0005534; F:galactose binding; IEA:Ensembl.
GO; GO:0005539; F:glycosaminoglycan binding; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
GO; GO:0005072; F:transforming growth factor beta receptor, cytoplasmic mediator activity; IEA:Ensembl.
GO; GO:0034713; F:type I transforming growth factor beta receptor binding; IEA:Ensembl.
GO; GO:0005114; F:type II transforming growth factor beta receptor binding; IEA:Ensembl.
GO; GO:0055009; P:atrial cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:1905222; P:atrioventricular canal morphogenesis; IEA:Ensembl.
GO; GO:0001569; P:branching involved in blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0003273; P:cell migration involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0022009; P:central nervous system vasculogenesis; IEA:Ensembl.
GO; GO:0001300; P:chronological cell aging; IEA:Ensembl.
GO; GO:0035912; P:dorsal aorta morphogenesis; IEA:Ensembl.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0001947; P:heart looping; IEA:Ensembl.
GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
GO; GO:0010629; P:negative regulation of gene expression; IEA:Ensembl.
GO; GO:0031953; P:negative regulation of protein autophosphorylation; IEA:Ensembl.
GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
GO; GO:0045766; P:positive regulation of angiogenesis; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:1905007; P:positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0051897; P:positive regulation of protein kinase B signaling; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:1905065; P:positive regulation of vascular smooth muscle cell differentiation; IEA:Ensembl.
GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
GO; GO:0048745; P:smooth muscle tissue development; IEA:Ensembl.
GO; GO:0097084; P:vascular smooth muscle cell development; IEA:Ensembl.
GO; GO:0048845; P:venous blood vessel morphogenesis; IEA:Ensembl.
GO; GO:0003222; P:ventricular trabecula myocardium morphogenesis; IEA:Ensembl.
InterPro; IPR001507; ZP_dom.
Pfam; PF00100; Zona_pellucida; 1.
4: Predicted;
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000240080};
Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
SIGNAL 1..25
/evidence="ECO:0000256|SAM:SignalP"
CHAIN 26..658
/note="ZP domain-containing protein"
/evidence="ECO:0000256|SAM:SignalP"
/id="PRO_5015306414"
TRANSMEM 587..614
/note="Helical"
/evidence="ECO:0000256|SAM:Phobius"
DOMAIN 363..532
/note="ZP"
/evidence="ECO:0000259|Pfam:PF00100"
REGION 626..658
/note="Disordered"
/evidence="ECO:0000256|SAM:MobiDB-lite"
COMPBIAS 632..658
/note="Polar"
/evidence="ECO:0000256|SAM:MobiDB-lite"
SEQUENCE 658 AA; 70512 MW; 286BF17F6AE6F6E7 CRC64;
MDRGTLPLAV ALLLAGCSLS PTSLAETVHC DLQPVGPERG EVTYTTSQVS KGCVAQAPNA
ILEVHVLFLE FPTGPSQLEL TLQASKQNGT RPREVLLVLS VNSSVFLHLQ ALGIPLHLAY
NSSLVTFQEP PGVNTTELPS FPKTQILEWA AERGPITSAA ELNDPQSILL RLGQAQGSLS
FCMLEASQDM GRTLEWRPRT PALVRGCHLE GVAGHKEAHI LRVLPGHSAG PRTVTVKVEL
SCAPGDLDAV LILQGPPYVS WLIDANHNMQ IWTTGEYSLK IFPEKNIRGF KLPDTPQGLL
GEARMLNASI VASFVELPLA SIVSLHASSC GGRLQTSPAP IQTTPPKDTC SPELLMSLIQ
TKCADDAMTL VLKKELVAHL KCTITGLTFW DPSCEAEDRG DKFVLRSAYS SCGMQVSASM
ISNEAVVNIL SSSSPQRKKV HCLNMDSLSF QLGLYLSPHF LQASNTIEPG QQSFVQVRVS
PSISEFLLQL DSCHLDLGPE GGTVELIQGR AAKGNCVSLL SPSPEGDPRF SFLLHFYTVP
IPKTGTLSCT VALRPKTGSQ DQEVHRTVFM RLNIITPDLS GCTSKGLVLP AVLGITFGAF
LIGALLTAAL WYIYSHTRSP SKREPVVAVA APASSESSST NHSIGSTQST PCSTSSMA


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Catalog number Product name Quantity
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103-M60 CD105_Endoglin , Host: Rat, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 100 ug
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103-PA60 CD105_Endoglin, Host: Rabbit, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 200 ug
103-PA60S CD105_Endoglin, Host: Rabbit, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 100 ug
103-PA60AG CD105_Endoglin, Host: Rabbit, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 50 ug
103-M102 CD105, Host: Rat, Species: Anti-Mouse, Synonyms: Eng endoglin; CD105; AI528660; AI662476; S-endoglin 200 ug
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Pathways :
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Related Genes :
[ENG END] Endoglin (CD antigen CD105)
[Eng Edg] Endoglin (Cell surface MJ7/18 antigen) (CD antigen CD105)
[ENG] Endoglin (CD antigen CD105)
[Eng rCG_45763] Endoglin
[eng] Endoglin
[Eng] Endoglin
[Eng] Endoglin
[ENG] Endoglin
[ENG hCG_18549] Endoglin (Osler-Rendu-Weber syndrome 1), isoform CRA_a
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[ENG] Endoglin
[GDF2 BMP9] Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)
[ENG] Endoglin
[Gdf2 Bmp9] Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)

Bibliography :
[32643086] Salivary and serum markers of angiogenesis in periodontitis in relation to smoking.
[32611689] Correction for Kwon et al., "Hepatitis C Virus Core Protein Modulates Endoglin (CD105) Signaling Pathway for Liver Pathogenesis".
[32592434] Repeatable and objective method for evaluating angiogenesis using real-time RT-PCR of endoglin expression in canine tumors.
[32587778] Bevacizumab promotes active biological behaviors of human umbilical vein endothelial cells by activating TGFβ1 pathways off-VEGF signaling.
[32573726] Mutational and phenotypic characterisation of hereditary hemorrhagic telangiectasia.
[32550557] (CD166) as a gene expression marker for human mesenchymal stromal cell characterisation.
[32541930] PS1 FAD mutants decrease ephrinB2-regulated angiogenic functions, ischemia-induced brain neovascularization and neuronal survival.
[32538908] Whole-Mount In Situ Hybridization in Zebrafish Embryos and Tube Formation Assay in iPSC-ECs to Study the Role of Endoglin in Vascular Development.
[32530126] The Follistatin-like Protein 1 Pathway Is Important for Maintaining Healthy Articular Cartilage.
[32523017] Association of Alk1 and Endoglin Polymorphisms with Cardiovascular Damage.